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UniProtKB - Q5JR59 (MTUS2_HUMAN)

Entry version 137 (17 Jun 2020)
Sequence version 3 (22 Sep 2009)
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Protein

Microtubule-associated tumor suppressor candidate 2

Gene

MTUS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated tumor suppressor candidate 2
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name:
Tracking protein of 150 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTUS2
Synonyms:CAZIP, KIAA0774, TIP150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000132938.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:20595 MTUS2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5JR59

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23281

Open Targets

More...OpenTargetsi		ENSG00000132938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165505194

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5JR59 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTUS2

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016371

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002801111 – 1369Microtubule-associated tumor suppressor candidate 2Add BLAST1369

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5JR59

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5JR59

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5JR59

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5JR59

PeptideAtlas

More...PeptideAtlasi		Q5JR59

PRoteomics IDEntifications database

More...PRIDEi		Q5JR59

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63070 [Q5JR59-2]
63071 [Q5JR59-3]
63072 [Q5JR59-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5JR59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5JR59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryonic stem cells differentiating to cardiomyocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132938 Expressed in heart and 136 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5JR59 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5JR59 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132938 Tissue enhanced (heart muscle, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5JR59
With#Exp.IntAct
AEN [Q8WTP8]3EBI-742948,EBI-8637627
AFF4 [Q9UHB7]3EBI-742948,EBI-395282
AFF4 - isoform 2 [Q9UHB7-2]3EBI-742948,EBI-10261324
AQP1 [P29972]3EBI-742948,EBI-745213
BMP7 [A8K571]3EBI-742948,EBI-10174327
BYSL [Q13895]5EBI-742948,EBI-358049
C1orf109 [Q9NX04]3EBI-742948,EBI-8643161
C1orf216 [Q8TAB5]4EBI-742948,EBI-747505
C21orf58 [Q0VAL7]3EBI-742948,EBI-10226774
C2CD6 [Q53TS8]3EBI-742948,EBI-739879
CATIP [Q7Z7H3]3EBI-742948,EBI-10258233
CATSPER1 [Q8NEC5]3EBI-742948,EBI-744545
CBX8 [Q9HC52]3EBI-742948,EBI-712912
CCDC116 [Q8IYX3]4EBI-742948,EBI-744311
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-742948,EBI-10247802
CCDC17 [Q96LX7]3EBI-742948,EBI-719840
CCDC198 [Q9NVL8]3EBI-742948,EBI-10238351
CCDC60 [Q8IWA6]4EBI-742948,EBI-10262147
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-742948,EBI-10175300
CDC20B [Q86Y33]3EBI-742948,EBI-10260504
CDC73 [Q6P1J9]5EBI-742948,EBI-930143
CDK18 [Q07002]3EBI-742948,EBI-746238
CDK5R1 [Q15078]3EBI-742948,EBI-746189
CDK5R1 [Q8N619]3EBI-742948,EBI-10266998
CDK5R1 [Q8TAM4]3EBI-742948,EBI-10271838
CDKL3 [Q8IVW4]3EBI-742948,EBI-3919850
CEP57L1 [Q8IYX8]3EBI-742948,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-742948,EBI-10181988
CEP95 [Q96GE4]3EBI-742948,EBI-372775
CERK [Q8TCT0]3EBI-742948,EBI-10274247
COG2 - isoform 2 [Q14746-2]3EBI-742948,EBI-10233912
CREB5 - isoform 3 [Q02930-3]3EBI-742948,EBI-10192698
CRY2 [Q49AN0]3EBI-742948,EBI-2212355
CTSZ [Q9UBR2]3EBI-742948,EBI-8636823
CWF19L2 [Q2TBE0]3EBI-742948,EBI-5453285
CXCL11 [O14625]3EBI-742948,EBI-2871971
DCDC2B [A2VCK2]3EBI-742948,EBI-10173222
DCTN4 [Q9UJW0]4EBI-742948,EBI-2134033
DLGAP5 [Q15398]3EBI-742948,EBI-748280
DMRT3 [Q9NQL9]3EBI-742948,EBI-9679045
DOCK2 [Q92608]3EBI-742948,EBI-448771
DTNB [O60941]3EBI-742948,EBI-740402
FAM13C [Q8NE31]3EBI-742948,EBI-751248
FAM161A [Q3B820]3EBI-742948,EBI-719941
FAM74A6 [Q5TZK3]3EBI-742948,EBI-10247271
FAM90A1 [Q86YD7]3EBI-742948,EBI-6658203
FBXL18 [Q96D16]3EBI-742948,EBI-744419
FBXO34 [Q9NWN3]3EBI-742948,EBI-719816
FCHSD2 [O94868]4EBI-742948,EBI-1215612
FNDC11 [Q9BVV2]3EBI-742948,EBI-744935
GAL3ST2 [Q9H3Q3]3EBI-742948,EBI-10306373
GTPBP10 [A4D1E9]3EBI-742948,EBI-5453796
HAUS1 [Q96CS2]3EBI-742948,EBI-2514791
HCK [P08631]3EBI-742948,EBI-346340
HDAC4 [P56524]3EBI-742948,EBI-308629
HSF2 - isoform 2 [Q03933-2]3EBI-742948,EBI-10223348
ITGB5 [L7RT22]3EBI-742948,EBI-10178729
KAT5 [Q92993]3EBI-742948,EBI-399080
KIF2C [Q99661]4EBI-742948,EBI-1642317
LENG1 [Q96BZ8]3EBI-742948,EBI-726510
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-742948,EBI-10257651
LMO2 [P25791]3EBI-742948,EBI-739696
LNX1 [Q8TBB1]4EBI-742948,EBI-739832
LRR1 [Q96L50]3EBI-742948,EBI-2510106
LYSMD1 [Q96S90]3EBI-742948,EBI-10293291
MAGEA8 [P43361]3EBI-742948,EBI-10182930
MAPRE1 [Q15691]7EBI-742948,EBI-1004115
MARK4 [Q6IPE9]3EBI-742948,EBI-10250211
MFAP1 [P55081]3EBI-742948,EBI-1048159
MTMR6 [Q9Y217]3EBI-742948,EBI-766064
NDEL1 [Q9GZM8]3EBI-742948,EBI-928842
NDOR1 [Q9UHB4]4EBI-742948,EBI-10249760
NELFE [P18615]3EBI-742948,EBI-348444
NUDT10 [Q8NFP7]3EBI-742948,EBI-726826
ODF1 [Q14990]4EBI-742948,EBI-10234557
PDE4DIP [Q5VU43]3EBI-742948,EBI-1105124
PIN1 [Q13526]3EBI-742948,EBI-714158
PKP2 [Q99959]5EBI-742948,EBI-702235
PLSCR4 [Q9NRQ2]5EBI-742948,EBI-769257
POLDIP2 [Q9Y2S7]3EBI-742948,EBI-713000
POLDIP3 [Q8WUT1]3EBI-742948,EBI-10276663
PPHLN1 [Q8NEY8]3EBI-742948,EBI-474076
PPP1R18 [Q6NYC8]3EBI-742948,EBI-2557469
PRKAA1 [Q13131]3EBI-742948,EBI-1181405
PRPF31 [Q8WWY3]3EBI-742948,EBI-1567797
PSMA1 [P25786]6EBI-742948,EBI-359352
PTPMT1 [Q8WUK0]3EBI-742948,EBI-7199479
RAB3IL1 [Q8TBN0]3EBI-742948,EBI-743796
RGS2 [P41220]3EBI-742948,EBI-712388
RHPN1 [Q8TCX5]4EBI-742948,EBI-746325
ROBO3 [Q96HH0]3EBI-742948,EBI-10288358
RPA1 [P27694]3EBI-742948,EBI-621389
RPL9 [P32969]3EBI-742948,EBI-358122
RTP5 [Q14D33]3EBI-742948,EBI-10217913
SCEL [O95171]3EBI-742948,EBI-7543896
SDCBP [O00560]3EBI-742948,EBI-727004
SELENOM [Q8WWX9]3EBI-742948,EBI-10277687
SETD5 - isoform 2 [Q9C0A6-2]3EBI-742948,EBI-10303449
SH2D4A [Q9H788]3EBI-742948,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-742948,EBI-10308083
SH3RF2 [Q08AM8]3EBI-742948,EBI-10225873
SHFL [Q9NUL5]3EBI-742948,EBI-10313866
SLC23A1 [Q9UHI7]3EBI-742948,EBI-1759386
SLC25A6 [P12236]4EBI-742948,EBI-356254
SLIRP [Q9GZT3]3EBI-742948,EBI-1050793
SMARCE1 [Q969G3]3EBI-742948,EBI-455078
SNAI1 [O95863]3EBI-742948,EBI-1045459
SNRPA [P09012]3EBI-742948,EBI-607085
SNRPB2 [P08579]3EBI-742948,EBI-1053651
SNW1 [Q13573]3EBI-742948,EBI-632715
SPATA8 [Q6RVD6]3EBI-742948,EBI-8635958
SPG7 [Q9UQ90]4EBI-742948,EBI-717201
STK16 [O75716]3EBI-742948,EBI-749295
SYT6 - isoform 2 [Q5T7P8-2]3EBI-742948,EBI-10246152
TAF13 [Q15543]3EBI-742948,EBI-1026992
THAP7 [Q9BT49]3EBI-742948,EBI-741350
TLE5 [Q08117]3EBI-742948,EBI-717810
TP53RK [Q96S44]3EBI-742948,EBI-739588
TRIM42 [Q8IWZ5]3EBI-742948,EBI-5235829
TSGA10IP [Q3SY00]4EBI-742948,EBI-10241197
TSHZ3 [Q63HK5]3EBI-742948,EBI-9053916
TXN2 [Q99757]3EBI-742948,EBI-2932492
USP2 [O75604]3EBI-742948,EBI-743272
WAC [Q9BTA9]3EBI-742948,EBI-749118
WAC - isoform 2 [Q9BTA9-2]3EBI-742948,EBI-10298216
WDYHV1 [Q96HA8]3EBI-742948,EBI-741158
ZC2HC1C [Q53FD0]4EBI-742948,EBI-740767
ZFC3H1 [G3V1X1]3EBI-742948,EBI-6448783
ZFP2 [Q6ZN57]3EBI-742948,EBI-7236323
ZFYVE21 [Q9BQ24]3EBI-742948,EBI-2849569
ZMAT2 [Q96NC0]3EBI-742948,EBI-2682299
ZNF136 [P52737]4EBI-742948,EBI-749129
ZNF20 [P17024]3EBI-742948,EBI-717634
ZNF232 [Q9UNY5]3EBI-742948,EBI-749023
ZNF250 - isoform 3 [P15622-3]3EBI-742948,EBI-10177272
ZNF3 [P17036]3EBI-742948,EBI-1640965
ZNF3 [Q86U76]3EBI-742948,EBI-10258769
ZNF329 [Q86UD4]3EBI-742948,EBI-7233259
ZNF337 [Q9Y3M9]3EBI-742948,EBI-714987
ZNF410 [Q86VK4]3EBI-742948,EBI-720304
ZNF415 [Q09FC8]3EBI-742948,EBI-10226171
ZNF417 [Q8TAU3]3EBI-742948,EBI-740727
ZNF426 [Q9BUY5]3EBI-742948,EBI-743265
ZNF439 [Q8NDP4]4EBI-742948,EBI-747580
ZNF440 [Q8IYI8]3EBI-742948,EBI-726439
ZNF490 [Q9ULM2]5EBI-742948,EBI-1105370
ZNF572 [Q7Z3I7]6EBI-742948,EBI-10172590
ZNF581 [Q9P0T4]4EBI-742948,EBI-745520
ZNF587 [Q96SQ5]3EBI-742948,EBI-6427977
ZNF599 [Q96NL3]3EBI-742948,EBI-8653994
ZNF607 [Q96SK3]3EBI-742948,EBI-747175
ZNF624 [Q9P2J8]3EBI-742948,EBI-9116427
ZNF670 [Q9BS34]3EBI-742948,EBI-745276
ZNF785 [A8K8V0]4EBI-742948,EBI-3925400
ZNF844 [Q08AG5]3EBI-742948,EBI-10225757
ZSCAN12 [O43309]3EBI-742948,EBI-1210440
ZSCAN26 [Q16670]3EBI-742948,EBI-3920053
A8K8Y53EBI-742948,EBI-10174635
Q6ZVW33EBI-742948,EBI-10255586
Q9H6F03EBI-742948,EBI-10307481
Isoform 2 [Q5JR59-3]
With#Exp.IntAct
ABHD15 [Q6UXT9]3EBI-11522433,EBI-2824666
ACSM1 [Q08AH1]3EBI-11522433,EBI-2818055
AKT1 [A0A0S2Z3D6]3EBI-11522433,EBI-16430470
ANKRD11 [X5D778]3EBI-11522433,EBI-17183751
ANKS1A [Q49AR9]3EBI-11522433,EBI-11954519
AQP1 [P29972]3EBI-11522433,EBI-745213
ARL4A [P40617]3EBI-11522433,EBI-2875746
AXIN1 [A0A0S2Z4M1]3EBI-11522433,EBI-16429430
AXIN1 [O15169]3EBI-11522433,EBI-710484
BANF2 - isoform 2 [Q9H503-2]3EBI-11522433,EBI-11977289
BARD1 [Q99728]3EBI-11522433,EBI-473181
BEX2 [Q9BXY8]3EBI-11522433,EBI-745073
BYSL [Q13895]3EBI-11522433,EBI-358049
C19orf44 - isoform 2 [Q9H6X5-2]3EBI-11522433,EBI-12061599
C1orf216 [Q8TAB5]3EBI-11522433,EBI-747505
C21orf58 [Q0VAL7]3EBI-11522433,EBI-10226774
CACNB3 [P54284]3EBI-11522433,EBI-1184651
CBX8 [Q9HC52]3EBI-11522433,EBI-712912
CCAR1 [Q8IX12]3EBI-11522433,EBI-356265
CCDC116 [Q8IYX3]3EBI-11522433,EBI-744311
CCDC120 [Q96HB5]3EBI-11522433,EBI-744556
CCDC146 [Q8IYE0]3EBI-11522433,EBI-10749669
CCDC151 [A5D8V7]3EBI-11522433,EBI-8466445
CCDC185 [Q8N715]3EBI-11522433,EBI-740814
CCDC198 [E9PSE9]3EBI-11522433,EBI-11748295
CCDC6 [Q16204]4EBI-11522433,EBI-1045350
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-11522433,EBI-10175300
CDC5L [Q99459]3EBI-11522433,EBI-374880
CDC7 [O00311]3EBI-11522433,EBI-374980
CDC73 [Q6P1J9]6EBI-11522433,EBI-930143
CDK18 [Q07002]3EBI-11522433,EBI-746238
CDKL3 [Q8IVW4]4EBI-11522433,EBI-3919850
CDKN1A [P38936]3EBI-11522433,EBI-375077
CDKN1B [P46527]3EBI-11522433,EBI-519280
CEP95 [Q96GE4]4EBI-11522433,EBI-372775
CHIC2 [Q9UKJ5]3EBI-11522433,EBI-741528
CNNM3 [Q8NE01]3EBI-11522433,EBI-741032
COG2 [Q14746]4EBI-11522433,EBI-389449
CRY2 [Q49AN0]5EBI-11522433,EBI-2212355
CSF1 [P09603]3EBI-11522433,EBI-2872294
CWF19L2 [Q2TBE0]3EBI-11522433,EBI-5453285
CYSLTR2 [Q9NS75]3EBI-11522433,EBI-3843579
DCX - isoform 2 [O43602-2]4EBI-11522433,EBI-14148644
DDX6 [P26196]4EBI-11522433,EBI-351257
DHRS1 [Q96LJ7]3EBI-11522433,EBI-746300
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-11522433,EBI-12000556
DMRT3 [Q9NQL9]3EBI-11522433,EBI-9679045
DOCK2 [Q92608]3EBI-11522433,EBI-448771
DTNB - isoform 5 [O60941-5]3EBI-11522433,EBI-11984733
EHHADH [Q08426]3EBI-11522433,EBI-2339219
EIF3D [O15371]3EBI-11522433,EBI-353818
ENKD1 [Q9H0I2]3EBI-11522433,EBI-744099
ENPP7 [Q6UWV6]3EBI-11522433,EBI-12047821
EXOC8 [Q8IYI6]3EBI-11522433,EBI-742102
FAM107A - isoform 4 [O95990-4]3EBI-11522433,EBI-11977223
FAM110A [Q9BQ89]4EBI-11522433,EBI-1752811
FAM124B - isoform 2 [Q9H5Z6-2]4EBI-11522433,EBI-11986315
FAM161A [Q3B820]5EBI-11522433,EBI-719941
FAM161B [Q96MY7]3EBI-11522433,EBI-7225287
FAM90A1 [Q86YD7]3EBI-11522433,EBI-6658203
FBXO34 [Q9NWN3]4EBI-11522433,EBI-719816
FBXW5 [Q969U6]3EBI-11522433,EBI-741068
FLYWCH1 [Q4VC44]3EBI-11522433,EBI-719415
GADD45GIP1 [Q8TAE8]3EBI-11522433,EBI-372506
GAS2L2 [Q8NHY3]3EBI-11522433,EBI-7960826
GEM [P55040]6EBI-11522433,EBI-744104
GGN [Q86UU5]3EBI-11522433,EBI-10259069
GNL3L [Q9NVN8]3EBI-11522433,EBI-746682
GPKOW [Q92917]3EBI-11522433,EBI-746309
GSTP1 [P09211]3EBI-11522433,EBI-353467
HAPLN2 [Q9GZV7]3EBI-11522433,EBI-11956675
HBZ [P02008]3EBI-11522433,EBI-719843
hCG_1987119 [A0A024R8L2]3EBI-11522433,EBI-14103818
HCK - isoform 2 [P08631-2]3EBI-11522433,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-11522433,EBI-11953488
HOXB5 [P09067]3EBI-11522433,EBI-3893317
HOXB9 [P17482]3EBI-11522433,EBI-745290
HSF2 [Q03933]3EBI-11522433,EBI-2556750
ICAM4 - isoform 3 [Q14773-3]3EBI-11522433,EBI-10233928
IL16 - isoform 2 [Q14005-2]3EBI-11522433,EBI-17178971
INO80B [Q9C086]3EBI-11522433,EBI-715611
ITGB4 - isoform Beta-4A [P16144-2]3EBI-11522433,EBI-11051601
ITGB5 [P18084]3EBI-11522433,EBI-1223434
JMY - isoform 2 [Q8N9B5-2]3EBI-11522433,EBI-10268138
JOSD1 [Q15040]3EBI-11522433,EBI-2510602
JRK - isoform 2 [O75564-2]3EBI-11522433,EBI-17181882
KANK2 [Q63ZY3]3EBI-11522433,EBI-2556193
KAT5 [Q92993]4EBI-11522433,EBI-399080
KIFC3 - isoform 4 [Q9BVG8-5]5EBI-11522433,EBI-14069005
KRT75 [O95678]3EBI-11522433,EBI-2949715
KRT76 [Q01546]3EBI-11522433,EBI-2952745
LENG1 [Q96BZ8]3EBI-11522433,EBI-726510
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11522433,EBI-11742507
LMO4 [P61968]4EBI-11522433,EBI-2798728
LNX1 [Q8TBB1]3EBI-11522433,EBI-739832
MBD3 - isoform 2 [O95983-2]3EBI-11522433,EBI-11978579
METTL17 - isoform 2 [Q9H7H0-2]3EBI-11522433,EBI-11098807
MGC50722 [Q8IVT4]3EBI-11522433,EBI-14086479
MMTAG2 [Q9BU76]3EBI-11522433,EBI-742459
MOS [P00540]4EBI-11522433,EBI-1757866
MRPL11 [Q9Y3B7]5EBI-11522433,EBI-5453723
MYOM1 - isoform 2 [P52179-2]3EBI-11522433,EBI-12010196
MYPOP [Q86VE0]5EBI-11522433,EBI-2858213
NDOR1 [Q9UHB4]3EBI-11522433,EBI-10249760
NEFL [I6L9F6]3EBI-11522433,EBI-10178578
NHSL2 [Q5HYW2]3EBI-11522433,EBI-2859639
NXF1 [Q9UBU9]3EBI-11522433,EBI-398874
PCDHB14 [Q9Y5E9]3EBI-11522433,EBI-10329013
PDZD4 [Q17RL8]3EBI-11522433,EBI-10239064
PIBF1 [Q4G0R1]3EBI-11522433,EBI-14066006
PIN1 [Q13526]3EBI-11522433,EBI-714158
PKN1 [Q16512]3EBI-11522433,EBI-602382
PKN3 [Q6P5Z2]3EBI-11522433,EBI-1384335
PKP2 - isoform 1 [Q99959-2]6EBI-11522433,EBI-10987518
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-11522433,EBI-12014286
POLDIP3 [Q8WUT1]3EBI-11522433,EBI-10276663
PPP1R18 [Q6NYC8]3EBI-11522433,EBI-2557469
PRKAA2 [P54646]4EBI-11522433,EBI-1383852
PRPF18 [Q99633]3EBI-11522433,EBI-2798416
PRPF31 [Q8WWY3]6EBI-11522433,EBI-1567797
PRR35 [P0CG20]3EBI-11522433,EBI-11986293
PSMA1 [P25786]3EBI-11522433,EBI-359352
PSMB1 [P20618]3EBI-11522433,EBI-372273
PTCD1 [O75127]3EBI-11522433,EBI-2560233
PTK7 [Q13308]3EBI-11522433,EBI-2803245
RAB3IL1 [Q8TBN0]4EBI-11522433,EBI-743796
RALY [Q53GL6]3EBI-11522433,EBI-9512693
RANBP3L [Q86VV4]3EBI-11522433,EBI-12028066
RAP1B [P61224]3EBI-11522433,EBI-358143
RASAL3 [Q86YV0]3EBI-11522433,EBI-3437896
RASD1 [Q9Y272]3EBI-11522433,EBI-740818
RBM41 [Q96IZ5]3EBI-11522433,EBI-740773
RCOR3 - isoform 2 [Q9P2K3-2]4EBI-11522433,EBI-1504830
RGS2 [P41220]3EBI-11522433,EBI-712388
RNF6 [A0A0S2Z4G9]4EBI-11522433,EBI-16428950
RPA1 [P27694]3EBI-11522433,EBI-621389
RPS19BP1 [Q86WX3]3EBI-11522433,EBI-4479407
RTP5 [Q14D33]3EBI-11522433,EBI-10217913
SAMD4A - isoform 3 [Q9UPU9-3]3EBI-11522433,EBI-11986417
SCNM1 [Q9BWG6]7EBI-11522433,EBI-748391
SDCBP [O00560]3EBI-11522433,EBI-727004
SH2D4A [Q9H788]5EBI-11522433,EBI-747035
SH3RF2 [Q8TEC5]4EBI-11522433,EBI-2130111
SHFL - isoform 4 [Q9NUL5-4]3EBI-11522433,EBI-11955083
SLC22A5 [O76082]3EBI-11522433,EBI-9846338
SLC25A42 [Q86VD7]3EBI-11522433,EBI-6598313
SLC25A48 - isoform 3 [Q6ZT89-3]3EBI-11522433,EBI-12065614
SMARCD1 [Q96GM5]3EBI-11522433,EBI-358489
SMARCE1 [Q969G3]3EBI-11522433,EBI-455078
SMG9 [Q9H0W8]3EBI-11522433,EBI-2872322
SNW1 [Q13573]3EBI-11522433,EBI-632715
SPATA8 [Q6RVD6]3EBI-11522433,EBI-8635958
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-11522433,EBI-11995806
SPG21 [Q9NZD8]3EBI-11522433,EBI-742688
TACO1 [Q9BSH4]3EBI-11522433,EBI-747797
TAF13 [Q15543]4EBI-11522433,EBI-1026992
TBC1D22B [Q9NU19]4EBI-11522433,EBI-8787464
TCEA2 [Q15560]3EBI-11522433,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-11522433,EBI-11955057
TCHP [Q9BT92]3EBI-11522433,EBI-740781
TEAD4 [A0A0S2Z4F2]3EBI-11522433,EBI-16429215
TEAD4 [Q15561]6EBI-11522433,EBI-747736
TEPSIN [Q96N21]3EBI-11522433,EBI-11139477
THAP7 [Q9BT49]6EBI-11522433,EBI-741350
TLE5 - isoform 2 [Q08117-2]6EBI-11522433,EBI-11741437
TNIP3 [Q96KP6]3EBI-11522433,EBI-2509913
TNNI1 [P19237]3EBI-11522433,EBI-746692
TRIM29 [Q14134]3EBI-11522433,EBI-702370
TSGA10IP [Q3SY00]4EBI-11522433,EBI-10241197
TSHZ3 [Q63HK5]3EBI-11522433,EBI-9053916
TTC23 - isoform 3 [Q5W5X9-3]4EBI-11522433,EBI-9090990
TTLL10 - isoform 3 [Q6ZVT0-3]3EBI-11522433,EBI-11979997
TXN2 [Q99757]3EBI-11522433,EBI-2932492
UBTFL1 [P0CB47]3EBI-11522433,EBI-17208936
USP2 [O75604]3EBI-11522433,EBI-743272
USP22 - isoform 2 [Q9UPT9-2]3EBI-11522433,EBI-12074414
UTP14C [Q5TAP6]3EBI-11522433,EBI-11737646
VASN [Q6EMK4]3EBI-11522433,EBI-10249550
WDYHV1 [Q96HA8]5EBI-11522433,EBI-741158
ZBTB16 [Q05516]3EBI-11522433,EBI-711925
ZBTB47 [Q9UFB7]3EBI-11522433,EBI-7781767
ZFHX3 - isoform B [Q15911-2]3EBI-11522433,EBI-10237226
ZFP1 [Q6P2D0]3EBI-11522433,EBI-2555749
ZMAT2 [Q96NC0]3EBI-11522433,EBI-2682299
ZMYND10 [O75800]3EBI-11522433,EBI-747061
ZNF124 [Q15973]3EBI-11522433,EBI-2555767
ZNF136 [P52737]4EBI-11522433,EBI-749129
ZNF17 [P17021]3EBI-11522433,EBI-1105334
ZNF20 [P17024]3EBI-11522433,EBI-717634
ZNF23 [P17027]3EBI-11522433,EBI-5657766
ZNF230 [Q9UIE0]3EBI-11522433,EBI-1105361
ZNF232 [Q9UNY5]3EBI-11522433,EBI-749023
ZNF239 [Q16600]3EBI-11522433,EBI-8787052
ZNF266 [Q14584]4EBI-11522433,EBI-7115319
ZNF329 [Q86UD4]4EBI-11522433,EBI-7233259
ZNF35 [P13682]3EBI-11522433,EBI-11041653
ZNF408 [Q9H9D4]3EBI-11522433,EBI-347633
ZNF414 [Q96IQ9]3EBI-11522433,EBI-744257
ZNF417 [Q8TAU3]3EBI-11522433,EBI-740727
ZNF438 [Q7Z4V0]3EBI-11522433,EBI-11962468
ZNF439 [Q8NDP4]3EBI-11522433,EBI-747580
ZNF440 [Q8IYI8]3EBI-11522433,EBI-726439
ZNF48 [Q96MX3]3EBI-11522433,EBI-12006434
ZNF490 [Q9ULM2]3EBI-11522433,EBI-1105370
ZNF497 [Q6ZNH5]3EBI-11522433,EBI-10486136
ZNF512B [Q96KM6]3EBI-11522433,EBI-1049952
ZNF557 - isoform 2 [Q8N988-2]3EBI-11522433,EBI-10699005
ZNF564 [Q8TBZ8]4EBI-11522433,EBI-10273713
ZNF572 [Q7Z3I7]3EBI-11522433,EBI-10172590
ZNF580 [Q9UK33]3EBI-11522433,EBI-746277
ZNF587 [Q96SQ5]5EBI-11522433,EBI-6427977
ZNF613 [Q6PF04]3EBI-11522433,EBI-12062855
ZNF624 [Q9P2J8]6EBI-11522433,EBI-9116427
ZNF648 [Q5T619]3EBI-11522433,EBI-11985915
ZNF669 [Q96BR6]3EBI-11522433,EBI-12006574
ZNF696 [Q9H7X3]3EBI-11522433,EBI-11090299
ZNF76 [P36508]3EBI-11522433,EBI-7254550
ZNF764 [Q96H86]3EBI-11522433,EBI-745775
ZNF774 [Q6NX45]3EBI-11522433,EBI-10251462
ZNF775 [Q96BV0]3EBI-11522433,EBI-7149881
ZNF785 [A8K8V0]3EBI-11522433,EBI-3925400
ZNF792 [Q3KQV3]3EBI-11522433,EBI-10240849
ZNF837 [Q96EG3]3EBI-11522433,EBI-11962574
ZSCAN26 [Q16670]3EBI-11522433,EBI-3920053

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116880, 232 interactors

Protein interaction database and analysis system

More...IntActi		Q5JR59, 367 interactors

Molecular INTeraction database

More...MINTi		Q5JR59

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483729

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5JR59 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5JR59

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni641 – 980Mediates interaction with MAPRE11 PublicationAdd BLAST340
Regioni801 – 1150Localization to the growing distal tip of microtubulesAdd BLAST350
Regioni801 – 890Sufficient for interaction with KIF2C1 PublicationAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili991 – 1335Sequence analysisAdd BLAST345

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJWE Eukaryota
ENOG411103Z LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183026

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029786_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5JR59

Database of Orthologous Groups

More...OrthoDBi		818881at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5JR59

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033339 MTUS2

The PANTHER Classification System

More...PANTHERi		PTHR24200:SF14 PTHR24200:SF14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JR59-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE 
        60         70         80         90        100
SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL 
       110        120        130        140        150
SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR 
       160        170        180        190        200
DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL 
       210        220        230        240        250
DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE 
       260        270        280        290        300
SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ 
       310        320        330        340        350
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG 
       360        370        380        390        400
EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS 
       410        420        430        440        450
ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL 
       460        470        480        490        500
DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK 
       510        520        530        540        550
EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT 
       560        570        580        590        600
PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP 
       610        620        630        640        650
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR 
       660        670        680        690        700
NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK 
       710        720        730        740        750
PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY 
       760        770        780        790        800
AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP 
       810        820        830        840        850
GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA 
       860        870        880        890        900
AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK 
       910        920        930        940        950
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP 
       960        970        980        990       1000
AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR 
      1010       1020       1030       1040       1050
LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL 
      1060       1070       1080       1090       1100
SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL 
      1110       1120       1130       1140       1150
EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN 
      1160       1170       1180       1190       1200
NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT 
      1210       1220       1230       1240       1250
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN 
      1260       1270       1280       1290       1300
QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ 
      1310       1320       1330       1340       1350
LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV 
      1360 
YRGSSSGPSS PARVSTTPR
Length:1,369
Mass (Da):150,195
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF7A754AB1ED7CF
GO
Isoform 2 (identifier: Q5JR59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1021: Missing.
     1022-1039: AICGFDALAVATQHFFRK → MGHCCCKPYNCLQCLDKT

Show »
Length:348
Mass (Da):40,746
Checksum:iD352305A4FA0566B
GO
Isoform 3 (identifier: Q5JR59-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1111: Missing.

Show »
Length:258
Mass (Da):30,064
Checksum:i83363B0586426D1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQA9J3KQA9_HUMAN
Microtubule-associated tumor suppre...
MTUS2
1,379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI50246 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34494 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti942Q → P in BAA34494 (PubMed:9872452).Curated1
Sequence conflicti942Q → P in AAI50246 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055941955P → H. Corresponds to variant dbSNP:rs12874207Ensembl.1
Natural variantiVAR_0588311071L → Q. Corresponds to variant dbSNP:rs17073511Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0235401 – 1111Missing in isoform 3. 2 PublicationsAdd BLAST1111
Alternative sequenceiVSP_0235411 – 1021Missing in isoform 2. 1 PublicationAdd BLAST1021
Alternative sequenceiVSP_0235431022 – 1039AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB018317 mRNA Translation: BAA34494.2 Different initiation.
AK293970 mRNA Translation: BAG57342.1
AL160255 Genomic DNA No translation available.
AL596092 Genomic DNA No translation available.
AL596114 Genomic DNA No translation available.
AL607144 Genomic DNA No translation available.
BC032481 mRNA Translation: AAH32481.1
BC119654 mRNA Translation: AAI19655.1
BC119655 mRNA Translation: AAI19656.1
BC129985 mRNA Translation: AAI29986.1
BC150245 mRNA Translation: AAI50246.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41874.1 [Q5JR59-3]
CCDS45022.1 [Q5JR59-2]

NCBI Reference Sequences

More...RefSeqi		NP_001028774.2, NM_001033602.2 [Q5JR59-2]
NP_056048.1, NM_015233.5 [Q5JR59-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4]
ENST00000612955; ENSP00000483729; ENSG00000132938 [Q5JR59-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23281

UCSC genome browser

More...UCSCi		uc001usm.5 human [Q5JR59-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018317 mRNA Translation: BAA34494.2 Different initiation.
AK293970 mRNA Translation: BAG57342.1
AL160255 Genomic DNA No translation available.
AL596092 Genomic DNA No translation available.
AL596114 Genomic DNA No translation available.
AL607144 Genomic DNA No translation available.
BC032481 mRNA Translation: AAH32481.1
BC119654 mRNA Translation: AAI19655.1
BC119655 mRNA Translation: AAI19656.1
BC129985 mRNA Translation: AAI29986.1
BC150245 mRNA Translation: AAI50246.1 Different initiation.
CCDSiCCDS41874.1 [Q5JR59-3]
CCDS45022.1 [Q5JR59-2]
RefSeqiNP_001028774.2, NM_001033602.2 [Q5JR59-2]
NP_056048.1, NM_015233.5 [Q5JR59-3]

3D structure databases

SMRiQ5JR59
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116880, 232 interactors
IntActiQ5JR59, 367 interactors
MINTiQ5JR59
STRINGi9606.ENSP00000483729

PTM databases

iPTMnetiQ5JR59
PhosphoSitePlusiQ5JR59

Polymorphism and mutation databases

BioMutaiMTUS2
DMDMi259016371

Proteomic databases

EPDiQ5JR59
jPOSTiQ5JR59
MassIVEiQ5JR59
PaxDbiQ5JR59
PeptideAtlasiQ5JR59
PRIDEiQ5JR59
ProteomicsDBi63070 [Q5JR59-2]
63071 [Q5JR59-3]
63072 [Q5JR59-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22727 88 antibodies

The DNASU plasmid repository

More...DNASUi		23281

Genome annotation databases

EnsembliENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4]
ENST00000612955; ENSP00000483729; ENSG00000132938 [Q5JR59-2]
GeneIDi23281
KEGGihsa:23281
UCSCiuc001usm.5 human [Q5JR59-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23281
DisGeNETi23281
EuPathDBiHostDB:ENSG00000132938.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTUS2
HGNCiHGNC:20595 MTUS2
HPAiENSG00000132938 Tissue enhanced (heart muscle, pituitary gland)
neXtProtiNX_Q5JR59
OpenTargetsiENSG00000132938
PharmGKBiPA165505194

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJWE Eukaryota
ENOG411103Z LUCA
GeneTreeiENSGT00950000183026
HOGENOMiCLU_029786_0_0_1
InParanoidiQ5JR59
OrthoDBi818881at2759
PhylomeDBiQ5JR59

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23281 2 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTUS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23281
PharosiQ5JR59 Tbio

Protein Ontology

More...PROi		PR:Q5JR59
RNActiQ5JR59 protein

Gene expression databases

BgeeiENSG00000132938 Expressed in heart and 136 other tissues
ExpressionAtlasiQ5JR59 baseline and differential
GenevisibleiQ5JR59 HS

Family and domain databases

InterProiView protein in InterPro
IPR033339 MTUS2
PANTHERiPTHR24200:SF14 PTHR24200:SF14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTUS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JR59
Secondary accession number(s): A7E292
, B4DF81, O94872, Q08E97, Q5JQR3, Q8N5E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 22, 2009
Last modified: June 17, 2020
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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