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Protein

Microtubule-associated tumor suppressor candidate 2

Gene

MTUS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated tumor suppressor candidate 2
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name:
Tracking protein of 150 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTUS2
Synonyms:CAZIP, KIAA0774, TIP150
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132938.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20595 MTUS2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JR59

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23281

Open Targets

More...
OpenTargetsi
ENSG00000132938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165505194

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTUS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016371

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002801111 – 1369Microtubule-associated tumor suppressor candidate 2Add BLAST1369

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5JR59

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5JR59

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JR59

PeptideAtlas

More...
PeptideAtlasi
Q5JR59

PRoteomics IDEntifications database

More...
PRIDEi
Q5JR59

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63070
63071 [Q5JR59-3]
63072 [Q5JR59-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JR59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JR59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryonic stem cells differentiating to cardiomyocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132938 Expressed in 137 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_KIAA0774

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JR59 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JR59 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031473
HPA031474
HPA031475

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K8Y53EBI-742948,EBI-10174635
Q6ZVW33EBI-742948,EBI-10255586
Q9H6F03EBI-742948,EBI-10307481
AENQ8WTP83EBI-742948,EBI-8637627
AESQ081173EBI-742948,EBI-717810
AESQ08117-25EBI-11522433,EBI-11741437
AFF4Q9UHB73EBI-742948,EBI-395282
AFF4Q9UHB7-23EBI-742948,EBI-10261324
AKT1A0A0S2Z3D63EBI-11522433,EBI-16430470
AQP1P299723EBI-742948,EBI-745213
AXIN1A0A0S2Z4M13EBI-11522433,EBI-16429430
AXIN1O151693EBI-11522433,EBI-710484
BMP7A8K5713EBI-742948,EBI-10174327
BYSLQ138955EBI-742948,EBI-358049
C1orf109Q9NX043EBI-742948,EBI-8643161
C1orf216Q8TAB54EBI-742948,EBI-747505
C21orf58Q0VAL73EBI-742948,EBI-10226774
C2CD6Q53TS83EBI-742948,EBI-739879
CATIPQ7Z7H33EBI-742948,EBI-10258233
CATSPER1Q8NEC53EBI-742948,EBI-744545
CBX8Q9HC523EBI-742948,EBI-712912
CCDC116Q8IYX34EBI-742948,EBI-744311
CCDC146Q8IYE0-23EBI-742948,EBI-10247802
CCDC17Q96LX73EBI-742948,EBI-719840
CCDC198Q9NVL83EBI-742948,EBI-10238351
CCDC60Q8IWA63EBI-742948,EBI-10262147
CCHCR1Q8TD31-33EBI-742948,EBI-10175300
CDC20BQ86Y333EBI-742948,EBI-10260504
CDC73Q6P1J95EBI-742948,EBI-930143
CDK18Q070023EBI-742948,EBI-746238
CDK5R1Q150783EBI-742948,EBI-746189
CDK5R1Q8N6193EBI-742948,EBI-10266998
CDK5R1Q8TAM43EBI-742948,EBI-10271838
CDKL3Q8IVW43EBI-742948,EBI-3919850
CEP57L1Q8IYX83EBI-742948,EBI-1104570
CEP57L1Q8IYX8-23EBI-742948,EBI-10181988
CEP95Q96GE43EBI-742948,EBI-372775
CERKQ8TCT03EBI-742948,EBI-10274247
COG2Q14746-23EBI-742948,EBI-10233912
CREB5Q02930-33EBI-742948,EBI-10192698
CRY2Q49AN03EBI-742948,EBI-2212355
CTSZQ9UBR23EBI-742948,EBI-8636823
CWF19L2Q2TBE03EBI-742948,EBI-5453285
CXCL11O146253EBI-742948,EBI-2871971
DCDC2BA2VCK23EBI-742948,EBI-10173222
DCTN4Q9UJW04EBI-742948,EBI-2134033
DLGAP5Q153983EBI-742948,EBI-748280
DMRT3Q9NQL93EBI-742948,EBI-9679045
DOCK2Q926083EBI-742948,EBI-448771
DTNBO609413EBI-742948,EBI-740402
FAM13CQ8NE313EBI-742948,EBI-751248
FAM161AQ3B8204EBI-11522433,EBI-719941
FAM74A6Q5TZK33EBI-742948,EBI-10247271
FAM90A1Q86YD73EBI-742948,EBI-6658203
FBXL18Q96D163EBI-742948,EBI-744419
FBXO34Q9NWN33EBI-742948,EBI-719816
FCHSD2O948684EBI-742948,EBI-1215612
FNDC11Q9BVV23EBI-742948,EBI-744935
GAL3ST2Q9H3Q33EBI-742948,EBI-10306373
GTPBP10A4D1E93EBI-742948,EBI-5453796
HAUS1Q96CS23EBI-742948,EBI-2514791
HCKP086313EBI-742948,EBI-346340
HDAC4P565243EBI-742948,EBI-308629
HSF2Q03933-23EBI-742948,EBI-10223348
ITGB5L7RT223EBI-742948,EBI-10178729
KAT5Q929933EBI-742948,EBI-399080
KIF2CQ996614EBI-742948,EBI-1642317
LENG1Q96BZ83EBI-742948,EBI-726510
LIMS2Q7Z4I7-53EBI-742948,EBI-10257651
LMO2P257913EBI-742948,EBI-739696
LNX1Q8TBB13EBI-742948,EBI-739832
LRR1Q96L503EBI-742948,EBI-2510106
LYSMD1Q96S903EBI-742948,EBI-10293291
MAGEA8P433613EBI-742948,EBI-10182930
MAPRE1Q156917EBI-742948,EBI-1004115
MARK4Q6IPE93EBI-742948,EBI-10250211
MFAP1P550813EBI-742948,EBI-1048159
MRPL11Q9Y3B74EBI-11522433,EBI-5453723
MTMR6Q9Y2173EBI-742948,EBI-766064
NDEL1Q9GZM83EBI-742948,EBI-928842
NDOR1Q9UHB43EBI-742948,EBI-10249760
NEFLI6L9F63EBI-11522433,EBI-10178578
NELFEP186153EBI-742948,EBI-348444
NUDT10Q8NFP73EBI-742948,EBI-726826
ODF1Q149903EBI-742948,EBI-10234557
PDE4DIPQ5VU433EBI-742948,EBI-1105124
PIN1Q135263EBI-742948,EBI-714158
PKP2Q999594EBI-742948,EBI-702235
PKP2Q99959-25EBI-11522433,EBI-10987518
PLSCR4Q9NRQ24EBI-742948,EBI-769257
POLDIP2Q9Y2S73EBI-742948,EBI-713000
POLDIP3Q8WUT13EBI-742948,EBI-10276663
PPHLN1Q8NEY83EBI-742948,EBI-474076
PPP1R18Q6NYC83EBI-742948,EBI-2557469
PRKAA1Q131313EBI-742948,EBI-1181405
PRPF31Q8WWY35EBI-11522433,EBI-1567797
PSMA1P257866EBI-742948,EBI-359352
PTPMT1Q8WUK03EBI-742948,EBI-7199479
RAB3IL1Q8TBN03EBI-742948,EBI-743796
RGS2P412203EBI-742948,EBI-712388
RHPN1Q8TCX53EBI-742948,EBI-746325
RNF6A0A0S2Z4G94EBI-11522433,EBI-16428950
ROBO3Q96HH03EBI-742948,EBI-10288358
RPA1P276943EBI-742948,EBI-621389
RPL9P9P329693EBI-742948,EBI-358122
RTP5Q14D333EBI-742948,EBI-10217913
RYDENQ9NUL53EBI-742948,EBI-10313866
SCELO951713EBI-742948,EBI-7543896
SCNM1Q9BWG64EBI-11522433,EBI-748391
SDCBPO005603EBI-742948,EBI-727004
SELENOMQ8WWX93EBI-742948,EBI-10277687
SETD5Q9C0A6-23EBI-742948,EBI-10303449
SH2D4AQ9H7883EBI-742948,EBI-747035
SH2D4AQ9H788-23EBI-742948,EBI-10308083
SH3RF2Q08AM83EBI-742948,EBI-10225873
SLC23A1Q9UHI73EBI-742948,EBI-1759386
SLC25A6P122364EBI-742948,EBI-356254
SLIRPQ9GZT33EBI-742948,EBI-1050793
SMARCE1Q969G33EBI-742948,EBI-455078
SNAI1O958633EBI-742948,EBI-1045459
SNRPAP090123EBI-742948,EBI-607085
SNRPB2P085793EBI-742948,EBI-1053651
SNW1Q135733EBI-742948,EBI-632715
SPATA8Q6RVD63EBI-742948,EBI-8635958
SPG7Q9UQ904EBI-742948,EBI-717201
STK16O757163EBI-742948,EBI-749295
SYT6Q5T7P8-23EBI-742948,EBI-10246152
TAF13Q155433EBI-742948,EBI-1026992
TEAD4A0A0S2Z4F23EBI-11522433,EBI-16429215
TEAD4Q155615EBI-11522433,EBI-747736
THAP7Q9BT493EBI-742948,EBI-741350
TP53RKQ96S443EBI-742948,EBI-739588
TRIM42Q8IWZ53EBI-742948,EBI-5235829
TSGA10IPQ3SY003EBI-742948,EBI-10241197
TSHZ3Q63HK53EBI-742948,EBI-9053916
TXN2Q997573EBI-742948,EBI-2932492
USP2O756043EBI-742948,EBI-743272
WACQ9BTA93EBI-742948,EBI-749118
WACQ9BTA9-23EBI-742948,EBI-10298216
WDYHV1Q96HA84EBI-11522433,EBI-741158
ZC2HC1CQ53FD04EBI-742948,EBI-740767
ZFC3H1G3V1X13EBI-742948,EBI-6448783
ZFP2Q6ZN573EBI-742948,EBI-7236323
ZFYVE21Q9BQ243EBI-742948,EBI-2849569
ZMAT2Q96NC03EBI-742948,EBI-2682299
ZNF136P527374EBI-742948,EBI-749129
ZNF20P170243EBI-742948,EBI-717634
ZNF232Q9UNY53EBI-742948,EBI-749023
ZNF250P15622-33EBI-742948,EBI-10177272
ZNF3P170363EBI-742948,EBI-1640965
ZNF3Q86U763EBI-742948,EBI-10258769
ZNF329Q86UD43EBI-742948,EBI-7233259
ZNF337Q9Y3M93EBI-742948,EBI-714987
ZNF410Q86VK43EBI-742948,EBI-720304
ZNF415Q09FC83EBI-742948,EBI-10226171
ZNF417Q8TAU33EBI-742948,EBI-740727
ZNF426Q9BUY53EBI-742948,EBI-743265
ZNF439Q8NDP44EBI-742948,EBI-747580
ZNF440Q8IYI83EBI-742948,EBI-726439
ZNF490Q9ULM24EBI-742948,EBI-1105370
ZNF572Q7Z3I76EBI-742948,EBI-10172590
ZNF581Q9P0T43EBI-742948,EBI-745520
ZNF587Q96SQ53EBI-742948,EBI-6427977
ZNF599Q96NL33EBI-742948,EBI-8653994
ZNF607Q96SK33EBI-742948,EBI-747175
ZNF624Q9P2J85EBI-11522433,EBI-9116427
ZNF670Q9BS343EBI-742948,EBI-745276
ZNF785A8K8V03EBI-742948,EBI-3925400
ZNF844Q08AG53EBI-742948,EBI-10225757
ZSCAN12O433093EBI-742948,EBI-1210440
ZSCAN26Q166703EBI-742948,EBI-3920053

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116880, 221 interactors

Protein interaction database and analysis system

More...
IntActi
Q5JR59, 327 interactors

Molecular INTeraction database

More...
MINTi
Q5JR59

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392057

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5JR59

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5JR59

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni641 – 980Mediates interaction with MAPRE11 PublicationAdd BLAST340
Regioni801 – 1150Localization to the growing distal tip of microtubulesAdd BLAST350
Regioni801 – 890Sufficient for interaction with KIF2C1 PublicationAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili991 – 1335Sequence analysisAdd BLAST345

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJWE Eukaryota
ENOG411103Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153608

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JR59

Database of Orthologous Groups

More...
OrthoDBi
250283at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JR59

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033339 MTUS2

The PANTHER Classification System

More...
PANTHERi
PTHR24200:SF8 PTHR24200:SF8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JR59-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE
60 70 80 90 100
SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL
110 120 130 140 150
SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR
160 170 180 190 200
DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL
210 220 230 240 250
DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE
260 270 280 290 300
SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
310 320 330 340 350
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG
360 370 380 390 400
EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS
410 420 430 440 450
ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL
460 470 480 490 500
DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK
510 520 530 540 550
EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT
560 570 580 590 600
PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
610 620 630 640 650
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR
660 670 680 690 700
NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK
710 720 730 740 750
PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY
760 770 780 790 800
AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP
810 820 830 840 850
GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA
860 870 880 890 900
AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
910 920 930 940 950
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP
960 970 980 990 1000
AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR
1010 1020 1030 1040 1050
LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL
1060 1070 1080 1090 1100
SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL
1110 1120 1130 1140 1150
EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN
1160 1170 1180 1190 1200
NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
1210 1220 1230 1240 1250
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN
1260 1270 1280 1290 1300
QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ
1310 1320 1330 1340 1350
LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV
1360
YRGSSSGPSS PARVSTTPR
Length:1,369
Mass (Da):150,195
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF7A754AB1ED7CF
GO
Isoform 2 (identifier: Q5JR59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1021: Missing.
     1022-1039: AICGFDALAVATQHFFRK → MGHCCCKPYNCLQCLDKT

Note: No experimental confirmation available.
Show »
Length:348
Mass (Da):40,746
Checksum:iD352305A4FA0566B
GO
Isoform 3 (identifier: Q5JR59-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1111: Missing.

Show »
Length:258
Mass (Da):30,064
Checksum:i83363B0586426D1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQA9J3KQA9_HUMAN
Microtubule-associated tumor suppre...
MTUS2
1,379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI50246 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34494 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti942Q → P in BAA34494 (PubMed:9872452).Curated1
Sequence conflicti942Q → P in AAI50246 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055941955P → H. Corresponds to variant dbSNP:rs12874207Ensembl.1
Natural variantiVAR_0588311071L → Q. Corresponds to variant dbSNP:rs17073511Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0235401 – 1111Missing in isoform 3. 2 PublicationsAdd BLAST1111
Alternative sequenceiVSP_0235411 – 1021Missing in isoform 2. 1 PublicationAdd BLAST1021
Alternative sequenceiVSP_0235431022 – 1039AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018317 mRNA Translation: BAA34494.2 Different initiation.
AK293970 mRNA Translation: BAG57342.1
AL160255 Genomic DNA No translation available.
AL596092 Genomic DNA No translation available.
AL596114 Genomic DNA No translation available.
AL607144 Genomic DNA No translation available.
BC032481 mRNA Translation: AAH32481.1
BC119654 mRNA Translation: AAI19655.1
BC119655 mRNA Translation: AAI19656.1
BC129985 mRNA Translation: AAI29986.1
BC150245 mRNA Translation: AAI50246.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41874.1 [Q5JR59-3]
CCDS45022.1 [Q5JR59-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001028774.2, NM_001033602.2
NP_056048.1, NM_015233.5 [Q5JR59-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.22287

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23281

UCSC genome browser

More...
UCSCi
uc001usm.5 human [Q5JR59-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018317 mRNA Translation: BAA34494.2 Different initiation.
AK293970 mRNA Translation: BAG57342.1
AL160255 Genomic DNA No translation available.
AL596092 Genomic DNA No translation available.
AL596114 Genomic DNA No translation available.
AL607144 Genomic DNA No translation available.
BC032481 mRNA Translation: AAH32481.1
BC119654 mRNA Translation: AAI19655.1
BC119655 mRNA Translation: AAI19656.1
BC129985 mRNA Translation: AAI29986.1
BC150245 mRNA Translation: AAI50246.1 Different initiation.
CCDSiCCDS41874.1 [Q5JR59-3]
CCDS45022.1 [Q5JR59-2]
RefSeqiNP_001028774.2, NM_001033602.2
NP_056048.1, NM_015233.5 [Q5JR59-3]
UniGeneiHs.22287

3D structure databases

ProteinModelPortaliQ5JR59
SMRiQ5JR59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116880, 221 interactors
IntActiQ5JR59, 327 interactors
MINTiQ5JR59
STRINGi9606.ENSP00000392057

PTM databases

iPTMnetiQ5JR59
PhosphoSitePlusiQ5JR59

Polymorphism and mutation databases

BioMutaiMTUS2
DMDMi259016371

Proteomic databases

EPDiQ5JR59
jPOSTiQ5JR59
PaxDbiQ5JR59
PeptideAtlasiQ5JR59
PRIDEiQ5JR59
ProteomicsDBi63070
63071 [Q5JR59-3]
63072 [Q5JR59-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23281
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4]
GeneIDi23281
KEGGihsa:23281
UCSCiuc001usm.5 human [Q5JR59-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23281
DisGeNETi23281
EuPathDBiHostDB:ENSG00000132938.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MTUS2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0020942
HGNCiHGNC:20595 MTUS2
HPAiHPA031473
HPA031474
HPA031475
neXtProtiNX_Q5JR59
OpenTargetsiENSG00000132938
PharmGKBiPA165505194

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJWE Eukaryota
ENOG411103Z LUCA
GeneTreeiENSGT00940000153608
InParanoidiQ5JR59
OrthoDBi250283at2759
PhylomeDBiQ5JR59

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MTUS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23281

Protein Ontology

More...
PROi
PR:Q5JR59

Gene expression databases

BgeeiENSG00000132938 Expressed in 137 organ(s), highest expression level in heart
CleanExiHS_KIAA0774
ExpressionAtlasiQ5JR59 baseline and differential
GenevisibleiQ5JR59 HS

Family and domain databases

InterProiView protein in InterPro
IPR033339 MTUS2
PANTHERiPTHR24200:SF8 PTHR24200:SF8, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTUS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JR59
Secondary accession number(s): A7E292
, B4DF81, O94872, Q08E97, Q5JQR3, Q8N5E2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 22, 2009
Last modified: January 16, 2019
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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