UniProtKB - Q5JR59 (MTUS2_HUMAN)
Protein
Microtubule-associated tumor suppressor candidate 2
Gene
MTUS2
Organism
Homo sapiens (Human)
Status
Functioni
Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.1 Publication
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q5JR59 |
Names & Taxonomyi
Protein namesi | Recommended name: Microtubule-associated tumor suppressor candidate 2Alternative name(s): Cardiac zipper protein Microtubule plus-end tracking protein TIP150 Short name: Tracking protein of 150 kDa |
Gene namesi | Name:MTUS2 Synonyms:CAZIP, KIAA0774, TIP150 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20595, MTUS2 |
neXtProti | NX_Q5JR59 |
VEuPathDBi | HostDB:ENSG00000132938.18 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Note: Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.
Cytoskeleton
- microtubule Source: UniProtKB-KW
Nucleus
- nucleus Source: CACAO
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 23281 |
OpenTargetsi | ENSG00000132938 |
PharmGKBi | PA165505194 |
Miscellaneous databases
Pharosi | Q5JR59, Tbio |
Genetic variation databases
BioMutai | MTUS2 |
DMDMi | 259016371 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280111 | 1 – 1369 | Microtubule-associated tumor suppressor candidate 2Add BLAST | 1369 |
Proteomic databases
EPDi | Q5JR59 |
MassIVEi | Q5JR59 |
PaxDbi | Q5JR59 |
PeptideAtlasi | Q5JR59 |
PRIDEi | Q5JR59 |
ProteomicsDBi | 63070 [Q5JR59-2] 63071 [Q5JR59-3] 63072 [Q5JR59-4] |
PTM databases
iPTMneti | Q5JR59 |
PhosphoSitePlusi | Q5JR59 |
Expressioni
Tissue specificityi
Detected in embryonic stem cells differentiating to cardiomyocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000132938, Expressed in heart and 155 other tissues |
ExpressionAtlasi | Q5JR59, baseline and differential |
Genevisiblei | Q5JR59, HS |
Organism-specific databases
HPAi | ENSG00000132938, Tissue enhanced (heart muscle, pituitary gland) |
Interactioni
Subunit structurei
Homodimer.
Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.
1 PublicationBinary interactionsi
Q5JR59
Isoform 2 [Q5JR59-3]
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116880, 376 interactors |
IntActi | Q5JR59, 368 interactors |
MINTi | Q5JR59 |
STRINGi | 9606.ENSP00000483729 |
Miscellaneous databases
RNActi | Q5JR59, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 641 – 980 | Mediates interaction with MAPRE11 PublicationAdd BLAST | 340 | |
Regioni | 801 – 1150 | Localization to the growing distal tip of microtubulesAdd BLAST | 350 | |
Regioni | 801 – 890 | Sufficient for interaction with KIF2C1 PublicationAdd BLAST | 90 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 991 – 1335 | Sequence analysisAdd BLAST | 345 |
Sequence similaritiesi
In the C-terminal section; belongs to the MTUS1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQFP, Eukaryota |
GeneTreei | ENSGT00950000183026 |
HOGENOMi | CLU_029786_0_0_1 |
InParanoidi | Q5JR59 |
OrthoDBi | 818881at2759 |
PhylomeDBi | Q5JR59 |
Family and domain databases
InterProi | View protein in InterPro IPR033339, MTUS2 |
PANTHERi | PTHR24200:SF14, PTHR24200:SF14, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5JR59-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE
60 70 80 90 100
SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL
110 120 130 140 150
SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR
160 170 180 190 200
DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL
210 220 230 240 250
DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE
260 270 280 290 300
SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
310 320 330 340 350
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG
360 370 380 390 400
EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS
410 420 430 440 450
ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL
460 470 480 490 500
DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK
510 520 530 540 550
EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT
560 570 580 590 600
PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
610 620 630 640 650
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR
660 670 680 690 700
NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK
710 720 730 740 750
PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY
760 770 780 790 800
AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP
810 820 830 840 850
GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA
860 870 880 890 900
AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
910 920 930 940 950
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP
960 970 980 990 1000
AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR
1010 1020 1030 1040 1050
LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL
1060 1070 1080 1090 1100
SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL
1110 1120 1130 1140 1150
EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN
1160 1170 1180 1190 1200
NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
1210 1220 1230 1240 1250
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN
1260 1270 1280 1290 1300
QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ
1310 1320 1330 1340 1350
LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV
1360
YRGSSSGPSS PARVSTTPR
Sequence cautioni
The sequence AAI50246 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34494 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 942 | Q → P in BAA34494 (PubMed:9872452).Curated | 1 | |
Sequence conflicti | 942 | Q → P in AAI50246 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055941 | 955 | P → H. Corresponds to variant dbSNP:rs12874207Ensembl. | 1 | |
Natural variantiVAR_058831 | 1071 | L → Q. Corresponds to variant dbSNP:rs17073511Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023540 | 1 – 1111 | Missing in isoform 3. 2 PublicationsAdd BLAST | 1111 | |
Alternative sequenceiVSP_023541 | 1 – 1021 | Missing in isoform 2. 1 PublicationAdd BLAST | 1021 | |
Alternative sequenceiVSP_023543 | 1022 – 1039 | AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018317 mRNA Translation: BAA34494.2 Different initiation. AK293970 mRNA Translation: BAG57342.1 AL160255 Genomic DNA No translation available. AL596092 Genomic DNA No translation available. AL596114 Genomic DNA No translation available. AL607144 Genomic DNA No translation available. BC032481 mRNA Translation: AAH32481.1 BC119654 mRNA Translation: AAI19655.1 BC119655 mRNA Translation: AAI19656.1 BC129985 mRNA Translation: AAI29986.1 BC150245 mRNA Translation: AAI50246.1 Different initiation. |
CCDSi | CCDS41874.1 [Q5JR59-3] CCDS45022.1 [Q5JR59-2] |
RefSeqi | NP_001028774.2, NM_001033602.2 [Q5JR59-2] NP_056048.1, NM_015233.5 [Q5JR59-3] |
Genome annotation databases
Ensembli | ENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3] ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4] ENST00000612955; ENSP00000483729; ENSG00000132938 [Q5JR59-2] |
GeneIDi | 23281 |
KEGGi | hsa:23281 |
UCSCi | uc001usm.5, human [Q5JR59-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018317 mRNA Translation: BAA34494.2 Different initiation. AK293970 mRNA Translation: BAG57342.1 AL160255 Genomic DNA No translation available. AL596092 Genomic DNA No translation available. AL596114 Genomic DNA No translation available. AL607144 Genomic DNA No translation available. BC032481 mRNA Translation: AAH32481.1 BC119654 mRNA Translation: AAI19655.1 BC119655 mRNA Translation: AAI19656.1 BC129985 mRNA Translation: AAI29986.1 BC150245 mRNA Translation: AAI50246.1 Different initiation. |
CCDSi | CCDS41874.1 [Q5JR59-3] CCDS45022.1 [Q5JR59-2] |
RefSeqi | NP_001028774.2, NM_001033602.2 [Q5JR59-2] NP_056048.1, NM_015233.5 [Q5JR59-3] |
3D structure databases
SMRi | Q5JR59 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116880, 376 interactors |
IntActi | Q5JR59, 368 interactors |
MINTi | Q5JR59 |
STRINGi | 9606.ENSP00000483729 |
PTM databases
iPTMneti | Q5JR59 |
PhosphoSitePlusi | Q5JR59 |
Genetic variation databases
BioMutai | MTUS2 |
DMDMi | 259016371 |
Proteomic databases
EPDi | Q5JR59 |
MassIVEi | Q5JR59 |
PaxDbi | Q5JR59 |
PeptideAtlasi | Q5JR59 |
PRIDEi | Q5JR59 |
ProteomicsDBi | 63070 [Q5JR59-2] 63071 [Q5JR59-3] 63072 [Q5JR59-4] |
Protocols and materials databases
Antibodypediai | 22727, 92 antibodies |
DNASUi | 23281 |
Genome annotation databases
Ensembli | ENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3] ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4] ENST00000612955; ENSP00000483729; ENSG00000132938 [Q5JR59-2] |
GeneIDi | 23281 |
KEGGi | hsa:23281 |
UCSCi | uc001usm.5, human [Q5JR59-2] |
Organism-specific databases
CTDi | 23281 |
DisGeNETi | 23281 |
GeneCardsi | MTUS2 |
HGNCi | HGNC:20595, MTUS2 |
HPAi | ENSG00000132938, Tissue enhanced (heart muscle, pituitary gland) |
neXtProti | NX_Q5JR59 |
OpenTargetsi | ENSG00000132938 |
PharmGKBi | PA165505194 |
VEuPathDBi | HostDB:ENSG00000132938.18 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQFP, Eukaryota |
GeneTreei | ENSGT00950000183026 |
HOGENOMi | CLU_029786_0_0_1 |
InParanoidi | Q5JR59 |
OrthoDBi | 818881at2759 |
PhylomeDBi | Q5JR59 |
Enzyme and pathway databases
PathwayCommonsi | Q5JR59 |
Miscellaneous databases
BioGRID-ORCSi | 23281, 3 hits in 875 CRISPR screens |
ChiTaRSi | MTUS2, human |
GenomeRNAii | 23281 |
Pharosi | Q5JR59, Tbio |
PROi | PR:Q5JR59 |
RNActi | Q5JR59, protein |
Gene expression databases
Bgeei | ENSG00000132938, Expressed in heart and 155 other tissues |
ExpressionAtlasi | Q5JR59, baseline and differential |
Genevisiblei | Q5JR59, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033339, MTUS2 |
PANTHERi | PTHR24200:SF14, PTHR24200:SF14, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTUS2_HUMAN | |
Accessioni | Q5JR59Primary (citable) accession number: Q5JR59 Secondary accession number(s): A7E292 Q8N5E2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | September 22, 2009 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families