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Entry version 136 (22 Apr 2020)
Sequence version 3 (22 Sep 2009)
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Protein

Microtubule-associated tumor suppressor candidate 2

Gene

MTUS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated tumor suppressor candidate 2
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name:
Tracking protein of 150 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTUS2
Synonyms:CAZIP, KIAA0774, TIP150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20595 MTUS2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JR59

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23281

Open Targets

More...
OpenTargetsi
ENSG00000132938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165505194

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5JR59 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTUS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016371

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002801111 – 1369Microtubule-associated tumor suppressor candidate 2Add BLAST1369

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5JR59

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5JR59

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5JR59

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JR59

PeptideAtlas

More...
PeptideAtlasi
Q5JR59

PRoteomics IDEntifications database

More...
PRIDEi
Q5JR59

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63070 [Q5JR59-2]
63071 [Q5JR59-3]
63072 [Q5JR59-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JR59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JR59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryonic stem cells differentiating to cardiomyocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132938 Expressed in heart and 136 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JR59 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JR59 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132938 Tissue enhanced (heart muscle, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5JR59
With#Exp.IntAct
A8K8Y53EBI-742948,EBI-10174635
Q6ZVW33EBI-742948,EBI-10255586
Q9H6F03EBI-742948,EBI-10307481
AEN [Q8WTP8]3EBI-742948,EBI-8637627
AFF4 [Q9UHB7]3EBI-742948,EBI-395282
AFF4 - isoform 2 [Q9UHB7-2]3EBI-742948,EBI-10261324
AQP1 [P29972]3EBI-742948,EBI-745213
BMP7 [A8K571]3EBI-742948,EBI-10174327
BYSL [Q13895]5EBI-742948,EBI-358049
C1orf109 [Q9NX04]3EBI-742948,EBI-8643161
C1orf216 [Q8TAB5]4EBI-742948,EBI-747505
C21orf58 [Q0VAL7]3EBI-742948,EBI-10226774
C2CD6 [Q53TS8]3EBI-742948,EBI-739879
CATIP [Q7Z7H3]3EBI-742948,EBI-10258233
CATSPER1 [Q8NEC5]3EBI-742948,EBI-744545
CBX8 [Q9HC52]3EBI-742948,EBI-712912
CCDC116 [Q8IYX3]4EBI-742948,EBI-744311
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-742948,EBI-10247802
CCDC17 [Q96LX7]3EBI-742948,EBI-719840
CCDC198 [Q9NVL8]3EBI-742948,EBI-10238351
CCDC60 [Q8IWA6]4EBI-742948,EBI-10262147
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-742948,EBI-10175300
CDC20B [Q86Y33]3EBI-742948,EBI-10260504
CDC73 [Q6P1J9]5EBI-742948,EBI-930143
CDK18 [Q07002]3EBI-742948,EBI-746238
CDK5R1 [Q15078]3EBI-742948,EBI-746189
CDK5R1 [Q8N619]3EBI-742948,EBI-10266998
CDK5R1 [Q8TAM4]3EBI-742948,EBI-10271838
CDKL3 [Q8IVW4]3EBI-742948,EBI-3919850
CEP57L1 [Q8IYX8]3EBI-742948,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-742948,EBI-10181988
CEP95 [Q96GE4]3EBI-742948,EBI-372775
CERK [Q8TCT0]3EBI-742948,EBI-10274247
COG2 - isoform 2 [Q14746-2]3EBI-742948,EBI-10233912
CREB5 - isoform 3 [Q02930-3]3EBI-742948,EBI-10192698
CRY2 [Q49AN0]3EBI-742948,EBI-2212355
CTSZ [Q9UBR2]3EBI-742948,EBI-8636823
CWF19L2 [Q2TBE0]3EBI-742948,EBI-5453285
CXCL11 [O14625]3EBI-742948,EBI-2871971
DCDC2B [A2VCK2]3EBI-742948,EBI-10173222
DCTN4 [Q9UJW0]4EBI-742948,EBI-2134033
DLGAP5 [Q15398]3EBI-742948,EBI-748280
DMRT3 [Q9NQL9]3EBI-742948,EBI-9679045
DOCK2 [Q92608]3EBI-742948,EBI-448771
DTNB [O60941]3EBI-742948,EBI-740402
FAM13C [Q8NE31]3EBI-742948,EBI-751248
FAM161A [Q3B820]3EBI-742948,EBI-719941
FAM74A6 [Q5TZK3]3EBI-742948,EBI-10247271
FAM90A1 [Q86YD7]3EBI-742948,EBI-6658203
FBXL18 [Q96D16]3EBI-742948,EBI-744419
FBXO34 [Q9NWN3]3EBI-742948,EBI-719816
FCHSD2 [O94868]4EBI-742948,EBI-1215612
FNDC11 [Q9BVV2]3EBI-742948,EBI-744935
GAL3ST2 [Q9H3Q3]3EBI-742948,EBI-10306373
GTPBP10 [A4D1E9]3EBI-742948,EBI-5453796
HAUS1 [Q96CS2]3EBI-742948,EBI-2514791
HCK [P08631]3EBI-742948,EBI-346340
HDAC4 [P56524]3EBI-742948,EBI-308629
HSF2 - isoform 2 [Q03933-2]3EBI-742948,EBI-10223348
ITGB5 [L7RT22]3EBI-742948,EBI-10178729
KAT5 [Q92993]3EBI-742948,EBI-399080
KIF2C [Q99661]4EBI-742948,EBI-1642317
LENG1 [Q96BZ8]3EBI-742948,EBI-726510
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-742948,EBI-10257651
LMO2 [P25791]3EBI-742948,EBI-739696
LNX1 [Q8TBB1]4EBI-742948,EBI-739832
LRR1 [Q96L50]3EBI-742948,EBI-2510106
LYSMD1 [Q96S90]3EBI-742948,EBI-10293291
MAGEA8 [P43361]3EBI-742948,EBI-10182930
MAPRE1 [Q15691]7EBI-742948,EBI-1004115
MARK4 [Q6IPE9]3EBI-742948,EBI-10250211
MFAP1 [P55081]3EBI-742948,EBI-1048159
MTMR6 [Q9Y217]3EBI-742948,EBI-766064
NDEL1 [Q9GZM8]3EBI-742948,EBI-928842
NDOR1 [Q9UHB4]4EBI-742948,EBI-10249760
NELFE [P18615]3EBI-742948,EBI-348444
NUDT10 [Q8NFP7]3EBI-742948,EBI-726826
ODF1 [Q14990]4EBI-742948,EBI-10234557
PDE4DIP [Q5VU43]3EBI-742948,EBI-1105124
PIN1 [Q13526]3EBI-742948,EBI-714158
PKP2 [Q99959]5EBI-742948,EBI-702235
PLSCR4 [Q9NRQ2]5EBI-742948,EBI-769257
POLDIP2 [Q9Y2S7]3EBI-742948,EBI-713000
POLDIP3 [Q8WUT1]3EBI-742948,EBI-10276663
PPHLN1 [Q8NEY8]3EBI-742948,EBI-474076
PPP1R18 [Q6NYC8]3EBI-742948,EBI-2557469
PRKAA1 [Q13131]3EBI-742948,EBI-1181405
PRPF31 [Q8WWY3]3EBI-742948,EBI-1567797
PSMA1 [P25786]6EBI-742948,EBI-359352
PTPMT1 [Q8WUK0]3EBI-742948,EBI-7199479
RAB3IL1 [Q8TBN0]3EBI-742948,EBI-743796
RGS2 [P41220]3EBI-742948,EBI-712388
RHPN1 [Q8TCX5]4EBI-742948,EBI-746325
ROBO3 [Q96HH0]3EBI-742948,EBI-10288358
RPA1 [P27694]3EBI-742948,EBI-621389
RPL9P9 [P32969]3EBI-742948,EBI-358122
RTP5 [Q14D33]3EBI-742948,EBI-10217913
SCEL [O95171]3EBI-742948,EBI-7543896
SDCBP [O00560]3EBI-742948,EBI-727004
SELENOM [Q8WWX9]3EBI-742948,EBI-10277687
SETD5 - isoform 2 [Q9C0A6-2]3EBI-742948,EBI-10303449
SH2D4A [Q9H788]3EBI-742948,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-742948,EBI-10308083
SH3RF2 [Q08AM8]3EBI-742948,EBI-10225873
SHFL [Q9NUL5]3EBI-742948,EBI-10313866
SLC23A1 [Q9UHI7]3EBI-742948,EBI-1759386
SLC25A6 [P12236]4EBI-742948,EBI-356254
SLIRP [Q9GZT3]3EBI-742948,EBI-1050793
SMARCE1 [Q969G3]3EBI-742948,EBI-455078
SNAI1 [O95863]3EBI-742948,EBI-1045459
SNRPA [P09012]3EBI-742948,EBI-607085
SNRPB2 [P08579]3EBI-742948,EBI-1053651
SNW1 [Q13573]3EBI-742948,EBI-632715
SPATA8 [Q6RVD6]3EBI-742948,EBI-8635958
SPG7 [Q9UQ90]4EBI-742948,EBI-717201
STK16 [O75716]3EBI-742948,EBI-749295
SYT6 - isoform 2 [Q5T7P8-2]3EBI-742948,EBI-10246152
TAF13 [Q15543]3EBI-742948,EBI-1026992
THAP7 [Q9BT49]3EBI-742948,EBI-741350
TLE5 [Q08117]3EBI-742948,EBI-717810
TP53RK [Q96S44]3EBI-742948,EBI-739588
TRIM42 [Q8IWZ5]3EBI-742948,EBI-5235829
TSGA10IP [Q3SY00]4EBI-742948,EBI-10241197
TSHZ3 [Q63HK5]3EBI-742948,EBI-9053916
TXN2 [Q99757]3EBI-742948,EBI-2932492
USP2 [O75604]3EBI-742948,EBI-743272
WAC [Q9BTA9]3EBI-742948,EBI-749118
WAC - isoform 2 [Q9BTA9-2]3EBI-742948,EBI-10298216
WDYHV1 [Q96HA8]3EBI-742948,EBI-741158
ZC2HC1C [Q53FD0]4EBI-742948,EBI-740767
ZFC3H1 [G3V1X1]3EBI-742948,EBI-6448783
ZFP2 [Q6ZN57]3EBI-742948,EBI-7236323
ZFYVE21 [Q9BQ24]3EBI-742948,EBI-2849569
ZMAT2 [Q96NC0]3EBI-742948,EBI-2682299
ZNF136 [P52737]4EBI-742948,EBI-749129
ZNF20 [P17024]3EBI-742948,EBI-717634
ZNF232 [Q9UNY5]3EBI-742948,EBI-749023
ZNF250 - isoform 3 [P15622-3]3EBI-742948,EBI-10177272
ZNF3 [P17036]3EBI-742948,EBI-1640965
ZNF3 [Q86U76]3EBI-742948,EBI-10258769
ZNF329 [Q86UD4]3EBI-742948,EBI-7233259
ZNF337 [Q9Y3M9]3EBI-742948,EBI-714987
ZNF410 [Q86VK4]3EBI-742948,EBI-720304
ZNF415 [Q09FC8]3EBI-742948,EBI-10226171
ZNF417 [Q8TAU3]3EBI-742948,EBI-740727
ZNF426 [Q9BUY5]3EBI-742948,EBI-743265
ZNF439 [Q8NDP4]4EBI-742948,EBI-747580
ZNF440 [Q8IYI8]3EBI-742948,EBI-726439
ZNF490 [Q9ULM2]5EBI-742948,EBI-1105370
ZNF572 [Q7Z3I7]6EBI-742948,EBI-10172590
ZNF581 [Q9P0T4]4EBI-742948,EBI-745520
ZNF587 [Q96SQ5]3EBI-742948,EBI-6427977
ZNF599 [Q96NL3]3EBI-742948,EBI-8653994
ZNF607 [Q96SK3]3EBI-742948,EBI-747175
ZNF624 [Q9P2J8]3EBI-742948,EBI-9116427
ZNF670 [Q9BS34]3EBI-742948,EBI-745276
ZNF785 [A8K8V0]4EBI-742948,EBI-3925400
ZNF844 [Q08AG5]3EBI-742948,EBI-10225757
ZSCAN12 [O43309]3EBI-742948,EBI-1210440
ZSCAN26 [Q16670]3EBI-742948,EBI-3920053
Isoform 2 [Q5JR59-3]
With#Exp.IntAct
ABHD15 [Q6UXT9]3EBI-11522433,EBI-2824666
ACSM1 [Q08AH1]3EBI-11522433,EBI-2818055
AKT1 [A0A0S2Z3D6]3EBI-11522433,EBI-16430470
ANKRD11 [X5D778]3EBI-11522433,EBI-17183751
ANKS1A [Q49AR9]3EBI-11522433,EBI-11954519
AQP1 [P29972]3EBI-11522433,EBI-745213
ARL4A [P40617]3EBI-11522433,EBI-2875746
AXIN1 [A0A0S2Z4M1]3EBI-11522433,EBI-16429430
AXIN1 [O15169]3EBI-11522433,EBI-710484
BANF2 - isoform 2 [Q9H503-2]3EBI-11522433,EBI-11977289
BARD1 [Q99728]3EBI-11522433,EBI-473181
BEX2 [Q9BXY8]3EBI-11522433,EBI-745073
BYSL [Q13895]3EBI-11522433,EBI-358049
C19orf44 - isoform 2 [Q9H6X5-2]3EBI-11522433,EBI-12061599
C1orf216 [Q8TAB5]3EBI-11522433,EBI-747505
C21orf58 [Q0VAL7]3EBI-11522433,EBI-10226774
CACNB3 [P54284]3EBI-11522433,EBI-1184651
CBX8 [Q9HC52]3EBI-11522433,EBI-712912
CCAR1 [Q8IX12]3EBI-11522433,EBI-356265
CCDC116 [Q8IYX3]3EBI-11522433,EBI-744311
CCDC120 [Q96HB5]3EBI-11522433,EBI-744556
CCDC146 [Q8IYE0]3EBI-11522433,EBI-10749669
CCDC151 [A5D8V7]3EBI-11522433,EBI-8466445
CCDC185 [Q8N715]3EBI-11522433,EBI-740814
CCDC198 [E9PSE9]3EBI-11522433,EBI-11748295
CCDC6 [Q16204]4EBI-11522433,EBI-1045350
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-11522433,EBI-10175300
CDC5L [Q99459]3EBI-11522433,EBI-374880
CDC7 [O00311]3EBI-11522433,EBI-374980
CDC73 [Q6P1J9]6EBI-11522433,EBI-930143
CDK18 [Q07002]3EBI-11522433,EBI-746238
CDKL3 [Q8IVW4]4EBI-11522433,EBI-3919850
CDKN1A [P38936]3EBI-11522433,EBI-375077
CDKN1B [P46527]3EBI-11522433,EBI-519280
CEP95 [Q96GE4]4EBI-11522433,EBI-372775
CHIC2 [Q9UKJ5]3EBI-11522433,EBI-741528
CNNM3 [Q8NE01]3EBI-11522433,EBI-741032
COG2 [Q14746]4EBI-11522433,EBI-389449
CRY2 [Q49AN0]5EBI-11522433,EBI-2212355
CSF1 [P09603]3EBI-11522433,EBI-2872294
CWF19L2 [Q2TBE0]3EBI-11522433,EBI-5453285
CYSLTR2 [Q9NS75]3EBI-11522433,EBI-3843579
DCX - isoform 2 [O43602-2]4EBI-11522433,EBI-14148644
DDX6 [P26196]4EBI-11522433,EBI-351257
DHRS1 [Q96LJ7]3EBI-11522433,EBI-746300
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-11522433,EBI-12000556
DMRT3 [Q9NQL9]3EBI-11522433,EBI-9679045
DOCK2 [Q92608]3EBI-11522433,EBI-448771
DTNB - isoform 5 [O60941-5]3EBI-11522433,EBI-11984733
EHHADH [Q08426]3EBI-11522433,EBI-2339219
EIF3D [O15371]3EBI-11522433,EBI-353818
ENKD1 [Q9H0I2]3EBI-11522433,EBI-744099
ENPP7 [Q6UWV6]3EBI-11522433,EBI-12047821
EXOC8 [Q8IYI6]3EBI-11522433,EBI-742102
FAM107A - isoform 4 [O95990-4]3EBI-11522433,EBI-11977223
FAM110A [Q9BQ89]4EBI-11522433,EBI-1752811
FAM124B - isoform 2 [Q9H5Z6-2]4EBI-11522433,EBI-11986315
FAM161A [Q3B820]5EBI-11522433,EBI-719941
FAM161B [Q96MY7]3EBI-11522433,EBI-7225287
FAM90A1 [Q86YD7]3EBI-11522433,EBI-6658203
FBXO34 [Q9NWN3]4EBI-11522433,EBI-719816
FBXW5 [Q969U6]3EBI-11522433,EBI-741068
FLYWCH1 [Q4VC44]3EBI-11522433,EBI-719415
GADD45GIP1 [Q8TAE8]3EBI-11522433,EBI-372506
GAS2L2 [Q8NHY3]3EBI-11522433,EBI-7960826
GEM [P55040]6EBI-11522433,EBI-744104
GGN [Q86UU5]3EBI-11522433,EBI-10259069
GNL3L [Q9NVN8]3EBI-11522433,EBI-746682
GPKOW [Q92917]3EBI-11522433,EBI-746309
GSTP1 [P09211]3EBI-11522433,EBI-353467
HAPLN2 [Q9GZV7]3EBI-11522433,EBI-11956675
HBZ [P02008]3EBI-11522433,EBI-719843
hCG_1987119 [A0A024R8L2]3EBI-11522433,EBI-14103818
HCK - isoform 2 [P08631-2]3EBI-11522433,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-11522433,EBI-11953488
HOXB5 [P09067]3EBI-11522433,EBI-3893317
HOXB9 [P17482]3EBI-11522433,EBI-745290
HSF2 [Q03933]3EBI-11522433,EBI-2556750
ICAM4 - isoform 3 [Q14773-3]3EBI-11522433,EBI-10233928
IL16 - isoform 2 [Q14005-2]3EBI-11522433,EBI-17178971
INO80B [Q9C086]3EBI-11522433,EBI-715611
ITGB4 - isoform Beta-4A [P16144-2]3EBI-11522433,EBI-11051601
ITGB5 [P18084]3EBI-11522433,EBI-1223434
JMY - isoform 2 [Q8N9B5-2]3EBI-11522433,EBI-10268138
JOSD1 [Q15040]3EBI-11522433,EBI-2510602
JRK - isoform 2 [O75564-2]3EBI-11522433,EBI-17181882
KANK2 [Q63ZY3]3EBI-11522433,EBI-2556193
KAT5 [Q92993]4EBI-11522433,EBI-399080
KIFC3 - isoform 4 [Q9BVG8-5]5EBI-11522433,EBI-14069005
KRT75 [O95678]3EBI-11522433,EBI-2949715
KRT76 [Q01546]3EBI-11522433,EBI-2952745
LENG1 [Q96BZ8]3EBI-11522433,EBI-726510
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11522433,EBI-11742507
LMO4 [P61968]4EBI-11522433,EBI-2798728
LNX1 [Q8TBB1]3EBI-11522433,EBI-739832
MBD3 - isoform 2 [O95983-2]3EBI-11522433,EBI-11978579
METTL17 - isoform 2 [Q9H7H0-2]3EBI-11522433,EBI-11098807
MGC50722 [Q8IVT4]3EBI-11522433,EBI-14086479
MMTAG2 [Q9BU76]3EBI-11522433,EBI-742459
MOS [P00540]4EBI-11522433,EBI-1757866
MRPL11 [Q9Y3B7]5EBI-11522433,EBI-5453723
MYOM1 - isoform 2 [P52179-2]3EBI-11522433,EBI-12010196
MYPOP [Q86VE0]5EBI-11522433,EBI-2858213
NDOR1 [Q9UHB4]3EBI-11522433,EBI-10249760
NEFL [I6L9F6]3EBI-11522433,EBI-10178578
NHSL2 [Q5HYW2]3EBI-11522433,EBI-2859639
NXF1 [Q9UBU9]3EBI-11522433,EBI-398874
PCDHB14 [Q9Y5E9]3EBI-11522433,EBI-10329013
PDZD4 [Q17RL8]3EBI-11522433,EBI-10239064
PIBF1 [Q4G0R1]3EBI-11522433,EBI-14066006
PIN1 [Q13526]3EBI-11522433,EBI-714158
PKN1 [Q16512]3EBI-11522433,EBI-602382
PKN3 [Q6P5Z2]3EBI-11522433,EBI-1384335
PKP2 - isoform 1 [Q99959-2]6EBI-11522433,EBI-10987518
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-11522433,EBI-12014286
POLDIP3 [Q8WUT1]3EBI-11522433,EBI-10276663
PPP1R18 [Q6NYC8]3EBI-11522433,EBI-2557469
PRKAA2 [P54646]4EBI-11522433,EBI-1383852
PRPF18 [Q99633]3EBI-11522433,EBI-2798416
PRPF31 [Q8WWY3]6EBI-11522433,EBI-1567797
PRR35 [P0CG20]3EBI-11522433,EBI-11986293
PSMA1 [P25786]3EBI-11522433,EBI-359352
PSMB1 [P20618]3EBI-11522433,EBI-372273
PTCD1 [O75127]3EBI-11522433,EBI-2560233
PTK7 [Q13308]3EBI-11522433,EBI-2803245
RAB3IL1 [Q8TBN0]4EBI-11522433,EBI-743796
RALY [Q53GL6]3EBI-11522433,EBI-9512693
RANBP3L [Q86VV4]3EBI-11522433,EBI-12028066
RAP1B [P61224]3EBI-11522433,EBI-358143
RASAL3 [Q86YV0]3EBI-11522433,EBI-3437896
RASD1 [Q9Y272]3EBI-11522433,EBI-740818
RBM41 [Q96IZ5]3EBI-11522433,EBI-740773
RCOR3 - isoform 2 [Q9P2K3-2]4EBI-11522433,EBI-1504830
RGS2 [P41220]3EBI-11522433,EBI-712388
RNF6 [A0A0S2Z4G9]4EBI-11522433,EBI-16428950
RPA1 [P27694]3EBI-11522433,EBI-621389
RPS19BP1 [Q86WX3]3EBI-11522433,EBI-4479407
RTP5 [Q14D33]3EBI-11522433,EBI-10217913
SAMD4A - isoform 3 [Q9UPU9-3]3EBI-11522433,EBI-11986417
SCNM1 [Q9BWG6]7EBI-11522433,EBI-748391
SDCBP [O00560]3EBI-11522433,EBI-727004
SH2D4A [Q9H788]5EBI-11522433,EBI-747035
SH3RF2 [Q8TEC5]4EBI-11522433,EBI-2130111
SHFL - isoform 4 [Q9NUL5-4]3EBI-11522433,EBI-11955083
SLC22A5 [O76082]3EBI-11522433,EBI-9846338
SLC25A42 [Q86VD7]3EBI-11522433,EBI-6598313
SLC25A48 - isoform 3 [Q6ZT89-3]3EBI-11522433,EBI-12065614
SMARCD1 [Q96GM5]3EBI-11522433,EBI-358489
SMARCE1 [Q969G3]3EBI-11522433,EBI-455078
SMG9 [Q9H0W8]3EBI-11522433,EBI-2872322
SNW1 [Q13573]3EBI-11522433,EBI-632715
SPATA8 [Q6RVD6]3EBI-11522433,EBI-8635958
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-11522433,EBI-11995806
SPG21 [Q9NZD8]3EBI-11522433,EBI-742688
TACO1 [Q9BSH4]3EBI-11522433,EBI-747797
TAF13 [Q15543]4EBI-11522433,EBI-1026992
TBC1D22B [Q9NU19]4EBI-11522433,EBI-8787464
TCEA2 [Q15560]3EBI-11522433,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-11522433,EBI-11955057
TCHP [Q9BT92]3EBI-11522433,EBI-740781
TEAD4 [A0A0S2Z4F2]3EBI-11522433,EBI-16429215
TEAD4 [Q15561]6EBI-11522433,EBI-747736
TEPSIN [Q96N21]3EBI-11522433,EBI-11139477
THAP7 [Q9BT49]6EBI-11522433,EBI-741350
TLE5 - isoform 2 [Q08117-2]6EBI-11522433,EBI-11741437
TNIP3 [Q96KP6]3EBI-11522433,EBI-2509913
TNNI1 [P19237]3EBI-11522433,EBI-746692
TRIM29 [Q14134]3EBI-11522433,EBI-702370
TSGA10IP [Q3SY00]4EBI-11522433,EBI-10241197
TSHZ3 [Q63HK5]3EBI-11522433,EBI-9053916
TTC23 - isoform 3 [Q5W5X9-3]4EBI-11522433,EBI-9090990
TTLL10 - isoform 3 [Q6ZVT0-3]3EBI-11522433,EBI-11979997
TXN2 [Q99757]3EBI-11522433,EBI-2932492
UBTFL1 [P0CB47]3EBI-11522433,EBI-17208936
USP2 [O75604]3EBI-11522433,EBI-743272
USP22 - isoform 2 [Q9UPT9-2]3EBI-11522433,EBI-12074414
UTP14C [Q5TAP6]3EBI-11522433,EBI-11737646
VASN [Q6EMK4]3EBI-11522433,EBI-10249550
WDYHV1 [Q96HA8]5EBI-11522433,EBI-741158
ZBTB16 [Q05516]3EBI-11522433,EBI-711925
ZBTB47 [Q9UFB7]3EBI-11522433,EBI-7781767
ZFHX3 - isoform B [Q15911-2]3EBI-11522433,EBI-10237226
ZFP1 [Q6P2D0]3EBI-11522433,EBI-2555749
ZMAT2 [Q96NC0]3EBI-11522433,EBI-2682299
ZMYND10 [O75800]3EBI-11522433,EBI-747061
ZNF124 [Q15973]3EBI-11522433,EBI-2555767
ZNF136 [P52737]4EBI-11522433,EBI-749129
ZNF17 [P17021]3EBI-11522433,EBI-1105334
ZNF20 [P17024]3EBI-11522433,EBI-717634
ZNF23 [P17027]3EBI-11522433,EBI-5657766
ZNF230 [Q9UIE0]3EBI-11522433,EBI-1105361
ZNF232 [Q9UNY5]3EBI-11522433,EBI-749023
ZNF239 [Q16600]3EBI-11522433,EBI-8787052
ZNF266 [Q14584]4EBI-11522433,EBI-7115319
ZNF329 [Q86UD4]4EBI-11522433,EBI-7233259
ZNF35 [P13682]3EBI-11522433,EBI-11041653
ZNF408 [Q9H9D4]3EBI-11522433,EBI-347633
ZNF414 [Q96IQ9]3EBI-11522433,EBI-744257
ZNF417 [Q8TAU3]3EBI-11522433,EBI-740727
ZNF438 [Q7Z4V0]3EBI-11522433,EBI-11962468
ZNF439 [Q8NDP4]3EBI-11522433,EBI-747580
ZNF440 [Q8IYI8]3EBI-11522433,EBI-726439
ZNF48 [Q96MX3]3EBI-11522433,EBI-12006434
ZNF490 [Q9ULM2]3EBI-11522433,EBI-1105370
ZNF497 [Q6ZNH5]3EBI-11522433,EBI-10486136
ZNF512B [Q96KM6]3EBI-11522433,EBI-1049952
ZNF557 - isoform 2 [Q8N988-2]3EBI-11522433,EBI-10699005
ZNF564 [Q8TBZ8]4EBI-11522433,EBI-10273713
ZNF572 [Q7Z3I7]3EBI-11522433,EBI-10172590
ZNF580 [Q9UK33]3EBI-11522433,EBI-746277
ZNF587 [Q96SQ5]5EBI-11522433,EBI-6427977
ZNF613 [Q6PF04]3EBI-11522433,EBI-12062855
ZNF624 [Q9P2J8]6EBI-11522433,EBI-9116427
ZNF648 [Q5T619]3EBI-11522433,EBI-11985915
ZNF669 [Q96BR6]3EBI-11522433,EBI-12006574
ZNF696 [Q9H7X3]3EBI-11522433,EBI-11090299
ZNF76 [P36508]3EBI-11522433,EBI-7254550
ZNF764 [Q96H86]3EBI-11522433,EBI-745775
ZNF774 [Q6NX45]3EBI-11522433,EBI-10251462
ZNF775 [Q96BV0]3EBI-11522433,EBI-7149881
ZNF785 [A8K8V0]3EBI-11522433,EBI-3925400
ZNF792 [Q3KQV3]3EBI-11522433,EBI-10240849
ZNF837 [Q96EG3]3EBI-11522433,EBI-11962574
ZSCAN26 [Q16670]3EBI-11522433,EBI-3920053

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116880, 232 interactors

Protein interaction database and analysis system

More...
IntActi
Q5JR59, 367 interactors

Molecular INTeraction database

More...
MINTi
Q5JR59

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483729

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5JR59 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5JR59

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni641 – 980Mediates interaction with MAPRE11 PublicationAdd BLAST340
Regioni801 – 1150Localization to the growing distal tip of microtubulesAdd BLAST350
Regioni801 – 890Sufficient for interaction with KIF2C1 PublicationAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili991 – 1335Sequence analysisAdd BLAST345

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJWE Eukaryota
ENOG411103Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183026

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029786_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JR59

Database of Orthologous Groups

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OrthoDBi
818881at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5JR59

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033339 MTUS2

The PANTHER Classification System

More...
PANTHERi
PTHR24200:SF14 PTHR24200:SF14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JR59-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE
60 70 80 90 100
SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL
110 120 130 140 150
SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR
160 170 180 190 200
DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL
210 220 230 240 250
DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE
260 270 280 290 300
SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
310 320 330 340 350
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG
360 370 380 390 400
EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS
410 420 430 440 450
ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL
460 470 480 490 500
DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK
510 520 530 540 550
EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT
560 570 580 590 600
PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
610 620 630 640 650
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR
660 670 680 690 700
NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK
710 720 730 740 750
PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY
760 770 780 790 800
AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP
810 820 830 840 850
GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA
860 870 880 890 900
AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
910 920 930 940 950
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP
960 970 980 990 1000
AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR
1010 1020 1030 1040 1050
LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL
1060 1070 1080 1090 1100
SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL
1110 1120 1130 1140 1150
EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN
1160 1170 1180 1190 1200
NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
1210 1220 1230 1240 1250
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN
1260 1270 1280 1290 1300
QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ
1310 1320 1330 1340 1350
LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV
1360
YRGSSSGPSS PARVSTTPR
Length:1,369
Mass (Da):150,195
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF7A754AB1ED7CF
GO
Isoform 2 (identifier: Q5JR59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1021: Missing.
     1022-1039: AICGFDALAVATQHFFRK → MGHCCCKPYNCLQCLDKT

Show »
Length:348
Mass (Da):40,746
Checksum:iD352305A4FA0566B
GO
Isoform 3 (identifier: Q5JR59-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1111: Missing.

Show »
Length:258
Mass (Da):30,064
Checksum:i83363B0586426D1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQA9J3KQA9_HUMAN
Microtubule-associated tumor suppre...
MTUS2
1,379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI50246 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34494 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti942Q → P in BAA34494 (PubMed:9872452).Curated1
Sequence conflicti942Q → P in AAI50246 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055941955P → H. Corresponds to variant dbSNP:rs12874207Ensembl.1
Natural variantiVAR_0588311071L → Q. Corresponds to variant dbSNP:rs17073511Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0235401 – 1111Missing in isoform 3. 2 PublicationsAdd BLAST1111
Alternative sequenceiVSP_0235411 – 1021Missing in isoform 2. 1 PublicationAdd BLAST1021
Alternative sequenceiVSP_0235431022 – 1039AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018317 mRNA Translation: BAA34494.2 Different initiation.
AK293970 mRNA Translation: BAG57342.1
AL160255 Genomic DNA No translation available.
AL596092 Genomic DNA No translation available.
AL596114 Genomic DNA No translation available.
AL607144 Genomic DNA No translation available.
BC032481 mRNA Translation: AAH32481.1
BC119654 mRNA Translation: AAI19655.1
BC119655 mRNA Translation: AAI19656.1
BC129985 mRNA Translation: AAI29986.1
BC150245 mRNA Translation: AAI50246.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41874.1 [Q5JR59-3]
CCDS45022.1 [Q5JR59-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001028774.2, NM_001033602.2 [Q5JR59-2]
NP_056048.1, NM_015233.5 [Q5JR59-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4]
ENST00000612955; ENSP00000483729; ENSG00000132938 [Q5JR59-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23281

UCSC genome browser

More...
UCSCi
uc001usm.5 human [Q5JR59-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018317 mRNA Translation: BAA34494.2 Different initiation.
AK293970 mRNA Translation: BAG57342.1
AL160255 Genomic DNA No translation available.
AL596092 Genomic DNA No translation available.
AL596114 Genomic DNA No translation available.
AL607144 Genomic DNA No translation available.
BC032481 mRNA Translation: AAH32481.1
BC119654 mRNA Translation: AAI19655.1
BC119655 mRNA Translation: AAI19656.1
BC129985 mRNA Translation: AAI29986.1
BC150245 mRNA Translation: AAI50246.1 Different initiation.
CCDSiCCDS41874.1 [Q5JR59-3]
CCDS45022.1 [Q5JR59-2]
RefSeqiNP_001028774.2, NM_001033602.2 [Q5JR59-2]
NP_056048.1, NM_015233.5 [Q5JR59-3]

3D structure databases

SMRiQ5JR59
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116880, 232 interactors
IntActiQ5JR59, 367 interactors
MINTiQ5JR59
STRINGi9606.ENSP00000483729

PTM databases

iPTMnetiQ5JR59
PhosphoSitePlusiQ5JR59

Polymorphism and mutation databases

BioMutaiMTUS2
DMDMi259016371

Proteomic databases

EPDiQ5JR59
jPOSTiQ5JR59
MassIVEiQ5JR59
PaxDbiQ5JR59
PeptideAtlasiQ5JR59
PRIDEiQ5JR59
ProteomicsDBi63070 [Q5JR59-2]
63071 [Q5JR59-3]
63072 [Q5JR59-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22727 88 antibodies

The DNASU plasmid repository

More...
DNASUi
23281

Genome annotation databases

EnsembliENST00000380808; ENSP00000370186; ENSG00000132938 [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938 [Q5JR59-4]
ENST00000612955; ENSP00000483729; ENSG00000132938 [Q5JR59-2]
GeneIDi23281
KEGGihsa:23281
UCSCiuc001usm.5 human [Q5JR59-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23281
DisGeNETi23281

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MTUS2
HGNCiHGNC:20595 MTUS2
HPAiENSG00000132938 Tissue enhanced (heart muscle, pituitary gland)
neXtProtiNX_Q5JR59
OpenTargetsiENSG00000132938
PharmGKBiPA165505194

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJWE Eukaryota
ENOG411103Z LUCA
GeneTreeiENSGT00950000183026
HOGENOMiCLU_029786_0_0_1
InParanoidiQ5JR59
OrthoDBi818881at2759
PhylomeDBiQ5JR59

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MTUS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23281
PharosiQ5JR59 Tbio

Protein Ontology

More...
PROi
PR:Q5JR59
RNActiQ5JR59 protein

Gene expression databases

BgeeiENSG00000132938 Expressed in heart and 136 other tissues
ExpressionAtlasiQ5JR59 baseline and differential
GenevisibleiQ5JR59 HS

Family and domain databases

InterProiView protein in InterPro
IPR033339 MTUS2
PANTHERiPTHR24200:SF14 PTHR24200:SF14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTUS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JR59
Secondary accession number(s): A7E292
, B4DF81, O94872, Q08E97, Q5JQR3, Q8N5E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 22, 2009
Last modified: April 22, 2020
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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