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Protein

Protein phosphatase 1J

Gene

PPM1J

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

SIGNORiQ5JR12

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1J (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform zeta
Short name:
PP2C-zeta
Gene namesi
Name:PPM1J
Synonyms:PPP2CZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000155367.15
HGNCiHGNC:20785 PPM1J
MIMi609957 gene
neXtProtiNX_Q5JR12

Pathology & Biotechi

Organism-specific databases

DisGeNETi333926
OpenTargetsiENSG00000155367
PharmGKBiPA142671150

Polymorphism and mutation databases

BioMutaiPPM1J
DMDMi74741784

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890581 – 505Protein phosphatase 1JAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JR12
PaxDbiQ5JR12
PeptideAtlasiQ5JR12
PRIDEiQ5JR12
ProteomicsDBi63067
63068 [Q5JR12-2]

PTM databases

DEPODiQ5JR12
iPTMnetiQ5JR12
PhosphoSitePlusiQ5JR12

Expressioni

Gene expression databases

BgeeiENSG00000155367 Expressed in 86 organ(s), highest expression level in right testis
CleanExiHS_PPM1J
ExpressionAtlasiQ5JR12 baseline and differential
GenevisibleiQ5JR12 HS

Organism-specific databases

HPAiHPA046045

Interactioni

Subunit structurei

Interacts with UBE2I/UBC9.By similarity

Protein-protein interaction databases

BioGridi130612, 14 interactors
ELMiQ5JR12
IntActiQ5JR12, 4 interactors
STRINGi9606.ENSP00000308926

Structurei

3D structure databases

ProteinModelPortaliQ5JR12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 498PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST395

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG1323 Eukaryota
ENOG410XP4B LUCA
GeneTreeiENSGT00530000063231
HOGENOMiHOG000251606
HOVERGENiHBG105802
InParanoidiQ5JR12
KOiK17504
OMAiKVYNSNI
OrthoDBiEOG091G05FH
PhylomeDBiQ5JR12
TreeFamiTF314700

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 2 hits
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JR12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLNRVRSAVA HLVSSGGAPP PRPKSPDLPN AASAPPAAAP EAPRSPPAKA
60 70 80 90 100
GSGSATPAKA VEARASFSRP TFLQLSPGGL RRADDHAGRA VQSPPDTGRR
110 120 130 140 150
LPWSTGYAEV INAGKSRHNE DQACCEVVYV EGRRSVTGVP REPSRGQGLC
160 170 180 190 200
FYYWGLFDGH AGGGAAEMAS RLLHRHIREQ LKDLVEILQD PSPPPLCLPT
210 220 230 240 250
TPGTPDSSDP SHLLGPQSCW SSQKEVSHES LVVGAVENAF QLMDEQMARE
260 270 280 290 300
RRGHQVEGGC CALVVIYLLG KVYVANAGDS RAIIVRNGEI IPMSREFTPE
310 320 330 340 350
TERQRLQLLG FLKPELLGSE FTHLEFPRRV LPKELGQRML YRDQNMTGWA
360 370 380 390 400
YKKIELEDLR FPLVCGEGKK ARVMATIGVT RGLGDHSLKV CSSTLPIKPF
410 420 430 440 450
LSCFPEVRVY DLTQYEHCPD DVLVLGTDGL WDVTTDCEVA ATVDRVLSAY
460 470 480 490 500
EPNDHSRYTA LAQALVLGAR GTPRDRGWRL PNNKLGSGDD ISVFVIPLGG

PGSYS
Length:505
Mass (Da):54,834
Last modified:February 15, 2005 - v1
Checksum:i3A2329219D5823BF
GO
Isoform 2 (identifier: Q5JR12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     185-223: Missing.

Show »
Length:299
Mass (Da):33,464
Checksum:i89C79C8612037CF3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3I3S4R3I3_HUMAN
Protein phosphatase 1J
PPM1J
298Annotation score:
S4R3C3S4R3C3_HUMAN
HCG1997303, isoform CRA_b
PPM1J hCG_1997303
150Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032566213L → F. Corresponds to variant dbSNP:rs34611728Ensembl.1
Natural variantiVAR_032567236V → I4 PublicationsCorresponds to variant dbSNP:rs10857971Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258821 – 167Missing in isoform 2. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_025883185 – 223Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093270 mRNA Translation: BAG52679.1
AL133644 mRNA Translation: CAB63764.1
AL603832 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56543.1
BC011803 mRNA Translation: AAH11803.2
BC073828 mRNA Translation: AAH73828.1
CCDSiCCDS855.2 [Q5JR12-1]
PIRiT43442
RefSeqiNP_005158.5, NM_005167.5 [Q5JR12-1]
UniGeneiHs.655231

Genome annotation databases

EnsembliENST00000309276; ENSP00000308926; ENSG00000155367 [Q5JR12-1]
ENST00000464951; ENSP00000475711; ENSG00000155367 [Q5JR12-2]
GeneIDi333926
KEGGihsa:333926
UCSCiuc001ecs.2 human [Q5JR12-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093270 mRNA Translation: BAG52679.1
AL133644 mRNA Translation: CAB63764.1
AL603832 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56543.1
BC011803 mRNA Translation: AAH11803.2
BC073828 mRNA Translation: AAH73828.1
CCDSiCCDS855.2 [Q5JR12-1]
PIRiT43442
RefSeqiNP_005158.5, NM_005167.5 [Q5JR12-1]
UniGeneiHs.655231

3D structure databases

ProteinModelPortaliQ5JR12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130612, 14 interactors
ELMiQ5JR12
IntActiQ5JR12, 4 interactors
STRINGi9606.ENSP00000308926

PTM databases

DEPODiQ5JR12
iPTMnetiQ5JR12
PhosphoSitePlusiQ5JR12

Polymorphism and mutation databases

BioMutaiPPM1J
DMDMi74741784

Proteomic databases

EPDiQ5JR12
PaxDbiQ5JR12
PeptideAtlasiQ5JR12
PRIDEiQ5JR12
ProteomicsDBi63067
63068 [Q5JR12-2]

Protocols and materials databases

DNASUi333926
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309276; ENSP00000308926; ENSG00000155367 [Q5JR12-1]
ENST00000464951; ENSP00000475711; ENSG00000155367 [Q5JR12-2]
GeneIDi333926
KEGGihsa:333926
UCSCiuc001ecs.2 human [Q5JR12-1]

Organism-specific databases

CTDi333926
DisGeNETi333926
EuPathDBiHostDB:ENSG00000155367.15
GeneCardsiPPM1J
HGNCiHGNC:20785 PPM1J
HPAiHPA046045
MIMi609957 gene
neXtProtiNX_Q5JR12
OpenTargetsiENSG00000155367
PharmGKBiPA142671150
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1323 Eukaryota
ENOG410XP4B LUCA
GeneTreeiENSGT00530000063231
HOGENOMiHOG000251606
HOVERGENiHBG105802
InParanoidiQ5JR12
KOiK17504
OMAiKVYNSNI
OrthoDBiEOG091G05FH
PhylomeDBiQ5JR12
TreeFamiTF314700

Enzyme and pathway databases

SIGNORiQ5JR12

Miscellaneous databases

ChiTaRSiPPM1J human
GenomeRNAii333926
PROiPR:Q5JR12
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155367 Expressed in 86 organ(s), highest expression level in right testis
CleanExiHS_PPM1J
ExpressionAtlasiQ5JR12 baseline and differential
GenevisibleiQ5JR12 HS

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 2 hits
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1J_HUMAN
AccessioniPrimary (citable) accession number: Q5JR12
Secondary accession number(s): B3KSB7
, Q6DKJ7, Q96EZ7, Q9UF84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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