UniProtKB - Q5JQS5 (OR2BB_HUMAN)
Protein
Olfactory receptor 2B11
Gene
OR2B11
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q5JQS5 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 2B11 |
Gene namesi | Name:OR2B11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31249, OR2B11 |
neXtProti | NX_Q5JQS5 |
VEuPathDBi | HostDB:ENSG00000177535.7 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 53 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 54 – 61 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 62 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 84 – 104 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 105 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 125 – 143 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 144 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 163 – 199 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 200 – 223 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 224 – 240 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 241 – 263 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 264 – 276 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 277 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 297 – 317 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 127623 |
OpenTargetsi | ENSG00000177535 |
PharmGKBi | PA134961529 |
Miscellaneous databases
Pharosi | Q5JQS5, Tdark |
Genetic variation databases
BioMutai | OR2B11 |
DMDMi | 74762190 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150464 | 1 – 317 | Olfactory receptor 2B11Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 101 ↔ 193 | PROSITE-ProRule annotation | ||
Glycosylationi | 199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q5JQS5 |
PeptideAtlasi | Q5JQS5 |
PRIDEi | Q5JQS5 |
ProteomicsDBi | 63056 |
PTM databases
GlyGeni | Q5JQS5, 2 sites |
iPTMneti | Q5JQS5 |
PhosphoSitePlusi | Q5JQS5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177535, Expressed in granulocyte and 28 other tissues |
ExpressionAtlasi | Q5JQS5, baseline and differential |
Organism-specific databases
HPAi | ENSG00000177535, Tissue enhanced (bone) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000325682 |
Miscellaneous databases
RNActi | Q5JQS5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RTXN, Eukaryota |
GeneTreei | ENSGT01020000230425 |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | Q5JQS5 |
OMAi | IIMHRPL |
OrthoDBi | 979635at2759 |
PhylomeDBi | Q5JQS5 |
TreeFami | TF336512 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5JQS5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSDNHSFLG DSPKAFILLG VSDRPWLELP LFVVLLLSYV LAMLGNVAII
60 70 80 90 100
LASRVDPQLH SPMYIFLSHL SFLDLCYTTT TVPQMLVNMG SSQKTISYGG
110 120 130 140 150
CTVQYAVFHW LGCTECIVLA AMALDRYVAI CKPLHYAVLM HRALCQQLVA
160 170 180 190 200
LAWLSGFGNS FVQVVLTVQL PFCGRQVLNN FFCEVPAVIK LSCADTAVND
210 220 230 240 250
TILAVLVAFF VLVPLALILL SYGFIARAVL RIQSSKGRHK AFGTCSSHLM
260 270 280 290 300
IVSLFYLPAI YMYLQPPSSY SQEQGKFISL FYSIITPTLN PFTYTLRNKD
310
MKGALRRLLA RIWRLCG
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062015 | 130 | I → S. Corresponds to variant dbSNP:rs11583410Ensembl. | 1 | |
Natural variantiVAR_053132 | 198 | V → M2 PublicationsCorresponds to variant dbSNP:rs6695302Ensembl. | 1 | |
Natural variantiVAR_053133 | 223 | G → D. Corresponds to variant dbSNP:rs4925663Ensembl. | 1 | |
Natural variantiVAR_053134 | 293 | T → I. Corresponds to variant dbSNP:rs12065526Ensembl. | 1 | |
Natural variantiVAR_053135 | 300 | D → G. Corresponds to variant dbSNP:rs12070953Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL606804 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77188.1 BC137181 mRNA Translation: AAI37182.1 BC137205 mRNA Translation: AAI37206.1 |
CCDSi | CCDS31090.1 |
RefSeqi | NP_001004492.1, NM_001004492.1 |
Genome annotation databases
Ensembli | ENST00000318749; ENSP00000325682; ENSG00000177535 ENST00000641149; ENSP00000492892; ENSG00000177535 ENST00000641527; ENSP00000493421; ENSG00000177535 |
GeneIDi | 127623 |
KEGGi | hsa:127623 |
UCSCi | uc010pyx.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL606804 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77188.1 BC137181 mRNA Translation: AAI37182.1 BC137205 mRNA Translation: AAI37206.1 |
CCDSi | CCDS31090.1 |
RefSeqi | NP_001004492.1, NM_001004492.1 |
3D structure databases
SMRi | Q5JQS5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000325682 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q5JQS5, 2 sites |
iPTMneti | Q5JQS5 |
PhosphoSitePlusi | Q5JQS5 |
Genetic variation databases
BioMutai | OR2B11 |
DMDMi | 74762190 |
Proteomic databases
PaxDbi | Q5JQS5 |
PeptideAtlasi | Q5JQS5 |
PRIDEi | Q5JQS5 |
ProteomicsDBi | 63056 |
Protocols and materials databases
Antibodypediai | 52545, 77 antibodies |
Genome annotation databases
Ensembli | ENST00000318749; ENSP00000325682; ENSG00000177535 ENST00000641149; ENSP00000492892; ENSG00000177535 ENST00000641527; ENSP00000493421; ENSG00000177535 |
GeneIDi | 127623 |
KEGGi | hsa:127623 |
UCSCi | uc010pyx.2, human |
Organism-specific databases
CTDi | 127623 |
DisGeNETi | 127623 |
GeneCardsi | OR2B11 |
HGNCi | HGNC:31249, OR2B11 |
HPAi | ENSG00000177535, Tissue enhanced (bone) |
neXtProti | NX_Q5JQS5 |
OpenTargetsi | ENSG00000177535 |
PharmGKBi | PA134961529 |
VEuPathDBi | HostDB:ENSG00000177535.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RTXN, Eukaryota |
GeneTreei | ENSGT01020000230425 |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | Q5JQS5 |
OMAi | IIMHRPL |
OrthoDBi | 979635at2759 |
PhylomeDBi | Q5JQS5 |
TreeFami | TF336512 |
Enzyme and pathway databases
PathwayCommonsi | Q5JQS5 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 127623, 3 hits in 594 CRISPR screens |
GeneWikii | OR2B11 |
GenomeRNAii | 127623 |
Pharosi | Q5JQS5, Tdark |
PROi | PR:Q5JQS5 |
RNActi | Q5JQS5, protein |
Gene expression databases
Bgeei | ENSG00000177535, Expressed in granulocyte and 28 other tissues |
ExpressionAtlasi | Q5JQS5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OR2BB_HUMAN | |
Accessioni | Q5JQS5Primary (citable) accession number: Q5JQS5 Secondary accession number(s): B2RP03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families