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Entry version 128 (12 Aug 2020)
Sequence version 1 (15 Feb 2005)
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Protein

A-kinase anchor protein 4

Gene

AKAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major structural component of sperm fibrous sheath. Plays a role in sperm motility.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5JQC9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 4
Short name:
AKAP-4
Alternative name(s):
A-kinase anchor protein 82 kDa
Short name:
AKAP 82
Short name:
hAKAP82
Major sperm fibrous sheath protein
Short name:
HI
Protein kinase A-anchoring protein 4
Short name:
PRKA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP4Imported
Synonyms:AKAP82
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147081.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:374, AKAP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300185, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JQC9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8852

Open Targets

More...
OpenTargetsi
ENSG00000147081

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24668

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5JQC9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKAP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74741729

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00002482301 – 188Sequence analysisAdd BLAST188
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000248231189 – 854A-kinase anchor protein 4By similarityAdd BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei96PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei300PhosphoserineCombined sources1
Modified residuei303PhosphotyrosineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1
Modified residuei447PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei464PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1
Modified residuei506PhosphothreonineBy similarity1
Modified residuei536PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1
Modified residuei703PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5JQC9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5JQC9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JQC9

PeptideAtlas

More...
PeptideAtlasi
Q5JQC9

PRoteomics IDEntifications database

More...
PRIDEi
Q5JQC9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63039 [Q5JQC9-1]
63040 [Q5JQC9-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5JQC9-2 [Q5JQC9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JQC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JQC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific; only expressed in round spermatids.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Post-meiotic phase of spermatogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147081, Expressed in testis and 76 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JQC9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JQC9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147081, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRKAR1A and PRKAR2A.

Interacts with ENO4.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114377, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q5JQC9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351327

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5JQC9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5JQC9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 232PKA-RI and PKA-RII subunit binding domainBy similarityAdd BLAST14
Regioni336 – 345PKA-RI-alpha subunit binding domainBy similarity10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQXJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016756_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JQC9

KEGG Orthology (KO)

More...
KOi
K16521

Identification of Orthologs from Complete Genome Data

More...
OMAi
QERKVIC

Database of Orthologous Groups

More...
OrthoDBi
221175at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JQC9

TreeFam database of animal gene trees

More...
TreeFami
TF105403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020799, AKAP_110
IPR018292, AKAP_110_C
IPR018459, RII_binding_1
IPR008382, SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...
PANTHERi
PTHR10226, PTHR10226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05716, AKAP_110, 3 hits
PF10522, RII_binding_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00807, AKAP_110, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5JQC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAYSDTTMM SDDIDWLRSH RGVCKVDLYN PEGQQDQDRK VICFVDVSTL
60 70 80 90 100
NVEDKDYKDA ASSSSEGNLN LGSLEEKEII VIKDTEKKDQ SKTEGSVCLF
110 120 130 140 150
KQAPSDPVSV LNWLLSDLQK YALGFQHALS PSTSTCKHKV GDTEGEYHRA
160 170 180 190 200
SSENCYSVYA DQVNIDYLMN RPQNLRLEMT AAKNTNNNQS PSAPPAKPPS
210 220 230 240 250
TQRAVISPDG ECSIDDLSFY VNRLSSLVIQ MAHKEIKEKL EGKSKCLHHS
260 270 280 290 300
ICPSPGNKER ISPRTPASKI ASEMAYEAVE LTAAEMRGTG EESREGGQKS
310 320 330 340 350
FLYSELSNKS KSGDKQMSQR ESKEFADSIS KGLMVYANQV ASDMMVSLMK
360 370 380 390 400
TLKVHSSGKP IPASVVLKRV LLRHTKEIVS DLIDSCMKNL HNITGVLMTD
410 420 430 440 450
SDFVSAVKRN LFNQWKQNAT DIMEAMLKRL VSALIGEEKE TKSQSLSYAS
460 470 480 490 500
LKAGSHDPKC RNQSLEFSTM KAEMKERDKG KMKSDPCKSL TSAEKVGEHI
510 520 530 540 550
LKEGLTIWNQ KQGNSCKVAT KACSNKDEKG EKINASTDSL AKDLIVSALK
560 570 580 590 600
LIQYHLTQQT KGKDTCEEDC PGSTMGYMAQ STQYEKCGGG QSAKALSVKQ
610 620 630 640 650
LESHRAPGPS TCQKENQHLD SQKMDMSNIV LMLIQKLLNE NPFKCEDPCE
660 670 680 690 700
GENKCSEPRA SKAASMSNRS DKAEEQCQEH QELDCTSGMK QANGQFIDKL
710 720 730 740 750
VESVMKLCLI MAKYSNDGAA LAELEEQAAS ANKPNFRGTR CIHSGAMPQN
760 770 780 790 800
YQDSLGHEVI VNNQCSTNSL QKQLQAVLQW IAASQFNVPM LYFMGDKDGQ
810 820 830 840 850
LEKLPQVSAK AAEKGYSVGG LLQEVMKFAK ERQPDEAVGK VARKQLLDWL

LANL
Length:854
Mass (Da):94,477
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE440CBE8AB9394F4
GO
Isoform 21 Publication (identifier: Q5JQC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:845
Mass (Da):93,445
Checksum:iEBB124BFF6BF3C31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6R4A0A075B6R4_HUMAN
A-kinase anchor protein 4
AKAP4
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6Q6A0A075B6Q6_HUMAN
A-kinase anchor protein 4
AKAP4
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA75494 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123L → W in AAC79433 (PubMed:9822690).Curated1
Sequence conflicti128A → E in AAC79433 (PubMed:9822690).Curated1
Sequence conflicti146E → D in AAC79433 (PubMed:9822690).Curated1
Sequence conflicti369R → W in CAA75494 (PubMed:9514854).Curated1
Sequence conflicti428 – 429KR → IL in AAC79433 (PubMed:9822690).Curated2
Sequence conflicti517K → M in AAC79433 (PubMed:9822690).Curated1
Sequence conflicti560T → I in CAA75494 (PubMed:9514854).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048206233H → R. Corresponds to variant dbSNP:rs17174078Ensembl.1
Natural variantiVAR_027266673A → G. Corresponds to variant dbSNP:rs12012704Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0521421 – 9Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y15195 mRNA Translation: CAA75494.1 Sequence problems.
AF072756 mRNA Translation: AAC79433.1
FO393402 Genomic DNA No translation available.
BC126250 mRNA Translation: AAI26251.1
BC126252 mRNA Translation: AAI26253.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14329.1 [Q5JQC9-1]
CCDS14330.1 [Q5JQC9-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5986

NCBI Reference Sequences

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RefSeqi
NP_003877.2, NM_003886.2 [Q5JQC9-1]
NP_647450.1, NM_139289.1 [Q5JQC9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358526; ENSP00000351327; ENSG00000147081 [Q5JQC9-1]
ENST00000376064; ENSP00000365232; ENSG00000147081 [Q5JQC9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8852

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8852

UCSC genome browser

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UCSCi
uc004dou.2, human [Q5JQC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15195 mRNA Translation: CAA75494.1 Sequence problems.
AF072756 mRNA Translation: AAC79433.1
FO393402 Genomic DNA No translation available.
BC126250 mRNA Translation: AAI26251.1
BC126252 mRNA Translation: AAI26253.1
CCDSiCCDS14329.1 [Q5JQC9-1]
CCDS14330.1 [Q5JQC9-2]
PIRiJC5986
RefSeqiNP_003877.2, NM_003886.2 [Q5JQC9-1]
NP_647450.1, NM_139289.1 [Q5JQC9-2]

3D structure databases

SMRiQ5JQC9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114377, 5 interactors
IntActiQ5JQC9, 1 interactor
STRINGi9606.ENSP00000351327

PTM databases

iPTMnetiQ5JQC9
PhosphoSitePlusiQ5JQC9

Polymorphism and mutation databases

BioMutaiAKAP4
DMDMi74741729

Proteomic databases

MassIVEiQ5JQC9
MaxQBiQ5JQC9
PaxDbiQ5JQC9
PeptideAtlasiQ5JQC9
PRIDEiQ5JQC9
ProteomicsDBi63039 [Q5JQC9-1]
63040 [Q5JQC9-2]
TopDownProteomicsiQ5JQC9-2 [Q5JQC9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
470, 142 antibodies

Genome annotation databases

EnsembliENST00000358526; ENSP00000351327; ENSG00000147081 [Q5JQC9-1]
ENST00000376064; ENSP00000365232; ENSG00000147081 [Q5JQC9-2]
GeneIDi8852
KEGGihsa:8852
UCSCiuc004dou.2, human [Q5JQC9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8852
DisGeNETi8852
EuPathDBiHostDB:ENSG00000147081.14

GeneCards: human genes, protein and diseases

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GeneCardsi
AKAP4
HGNCiHGNC:374, AKAP4
HPAiENSG00000147081, Tissue enriched (testis)
MIMi300185, gene
neXtProtiNX_Q5JQC9
OpenTargetsiENSG00000147081
PharmGKBiPA24668

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QQXJ, Eukaryota
GeneTreeiENSGT00940000153313
HOGENOMiCLU_016756_1_0_1
InParanoidiQ5JQC9
KOiK16521
OMAiQERKVIC
OrthoDBi221175at2759
PhylomeDBiQ5JQC9
TreeFamiTF105403

Enzyme and pathway databases

PathwayCommonsiQ5JQC9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8852, 9 hits in 496 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AKAP4, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AKAP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8852
PharosiQ5JQC9, Tbio

Protein Ontology

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PROi
PR:Q5JQC9
RNActiQ5JQC9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147081, Expressed in testis and 76 other tissues
ExpressionAtlasiQ5JQC9, baseline and differential
GenevisibleiQ5JQC9, HS

Family and domain databases

InterProiView protein in InterPro
IPR020799, AKAP_110
IPR018292, AKAP_110_C
IPR018459, RII_binding_1
IPR008382, SPHK1-interactor_AKAP_110
PANTHERiPTHR10226, PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716, AKAP_110, 3 hits
PF10522, RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807, AKAP_110, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKAP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JQC9
Secondary accession number(s): A0AV85
, O60904, O95246, Q5JQD1, Q5JQD2, Q5JQD3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: February 15, 2005
Last modified: August 12, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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