UniProtKB - Q5JPT6 (Q5JPT6_HUMAN)
Protein
Submitted name:
GIG10
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
GO - Biological processi
- actin filament organization Source: InterPro
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: GIG10ImportedSubmitted name: Migration-inducing gene 18 proteinImportedSubmitted name: cDNA, FLJ93821, Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1), mRNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000147010.17 |
Subcellular locationi
Other locations
- focal adhesion ARBA annotation
Other locations
- cell-cell junction Source: Ensembl
- endocytic vesicle Source: Ensembl
- focal adhesion Source: UniProtKB-SubCell
- membrane Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotation, MembraneARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotation, Ubl conjugationARBA annotationProteomic databases
PRIDEi | Q5JPT6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147010, Expressed in secondary oocyte and 221 other tissues |
ExpressionAtlasi | Q5JPT6, baseline and differential |
Interactioni
Binary interactionsi
Hide detailsQ5JPT6
Protein-protein interaction databases
IntActi | Q5JPT6, 6 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 58 | SH3InterPro annotationAdd BLAST | 58 | |
Domaini | 98 – 157 | SH3InterPro annotationAdd BLAST | 60 | |
Domaini | 267 – 328 | SH3InterPro annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 159 – 200 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 328 – 444 | DisorderedSequence analysisAdd BLAST | 117 | |
Regioni | 467 – 610 | DisorderedSequence analysisAdd BLAST | 144 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 200 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 353 – 390 | PolyampholyteSequence analysisAdd BLAST | 38 | |
Compositional biasi | 470 – 507 | PolarSequence analysisAdd BLAST | 38 | |
Compositional biasi | 509 – 531 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 532 – 548 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 569 – 587 | PolarSequence analysisAdd BLAST | 19 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_024255_1_0_1 |
OMAi | GSEIQPK |
OrthoDBi | 1577081at2759 |
Family and domain databases
CDDi | cd12052, SH3_CIN85_1, 1 hit cd12055, SH3_CIN85_2, 1 hit cd12057, SH3_CIN85_3, 1 hit |
InterProi | View protein in InterPro IPR035770, CIN85_SH3_1 IPR035771, CIN85_SH3_2 IPR035772, CIN85_SH3_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028506, Sorbin_SH3 |
PANTHERi | PTHR14167:SF6, PTHR14167:SF6, 2 hits |
Pfami | View protein in Pfam PF14604, SH3_9, 3 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 3 hits |
SUPFAMi | SSF50044, SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 3 hits |
i Sequence
Sequence statusi: Complete.
Q5JPT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVEAIVEFDY QAQHDDELTI SVGEIITNIR KEDGGWWEGQ INGRRGLFPD
60 70 80 90 100
NFVREIKKEM KKDPLTNKAP EKPLHEVPSG NSLLSSETIL RTNKRGERRR
110 120 130 140 150
RRCQVAFSYL PQNDDELELK VGDIIEVVGE VEEGWWEGVL NGKTGMFPSN
160 170 180 190 200
FIKELSGESD ELGISQDEQL SKSSLRETTG SESDGGDSSS TKSEGANGTV
210 220 230 240 250
ATAAIQPKKV KGVGFGDIFK DKPIKLRPRS IEVENDFLPV EKTIGKKLPA
260 270 280 290 300
TTATPDSSKT EMDSRTKSKD YCKVIFPYEA QNDDELTIKE GDIVTLINKD
310 320 330 340 350
CIDVGWWEGE LNGRRGVFPD NFVKLLPPDF EKEGNRPKKP PPPSAPVIKQ
360 370 380 390 400
GAGTTERKHE IKKIPPERPE MLPNRTEEKE RPEREPKLDL QKPSVPAIPP
410 420 430 440 450
KKPRPPKTNS LSRPGALPPR RPERPVGPLT HTRGDSPKID LAGSSLSGIL
460 470 480 490 500
DKDLSDRSND IDLEGFDSVV SSTEKLSHPT TSRPKATGRR PPSQSLTSSS
510 520 530 540 550
LSSPDIFDSP SPEEDKEEHI SLAHRGVDAS KKTSKTVTIS QVSDNKASLP
560 570 580 590 600
PKPGTMAAGG GGPAPLSSAA PSPLSSSLGT AGHRANSPSL FGTEGKPKME
610 620 630 640 650
PAASSQAAVE ELRTQVRELR SIIETMKDQQ KREIKQLLSE LDEEKKIRLR
660
LQMEVNDIKK ALQSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY423734 mRNA Translation: AAS00497.1 AY542305 mRNA Translation: AAT08174.1 AK313308 mRNA Translation: BAG36113.1 |
RefSeqi | NP_114098.1, NM_031892.2 |
Genome annotation databases
GeneIDi | 30011 |
KEGGi | hsa:30011 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY423734 mRNA Translation: AAS00497.1 AY542305 mRNA Translation: AAT08174.1 AK313308 mRNA Translation: BAG36113.1 |
RefSeqi | NP_114098.1, NM_031892.2 |
3D structure databases
SMRi | Q5JPT6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q5JPT6, 6 interactors |
Proteomic databases
PRIDEi | Q5JPT6 |
Protocols and materials databases
Antibodypediai | 521, 205 antibodies |
DNASUi | 30011 |
Genome annotation databases
GeneIDi | 30011 |
KEGGi | hsa:30011 |
Organism-specific databases
CTDi | 30011 |
PharmGKBi | PA37822 |
VEuPathDBi | HostDB:ENSG00000147010.17 |
Phylogenomic databases
HOGENOMi | CLU_024255_1_0_1 |
OMAi | GSEIQPK |
OrthoDBi | 1577081at2759 |
Miscellaneous databases
BioGRID-ORCSi | 30011, 5 hits in 500 CRISPR screens |
GenomeRNAii | 30011 |
Gene expression databases
Bgeei | ENSG00000147010, Expressed in secondary oocyte and 221 other tissues |
ExpressionAtlasi | Q5JPT6, baseline and differential |
Family and domain databases
CDDi | cd12052, SH3_CIN85_1, 1 hit cd12055, SH3_CIN85_2, 1 hit cd12057, SH3_CIN85_3, 1 hit |
InterProi | View protein in InterPro IPR035770, CIN85_SH3_1 IPR035771, CIN85_SH3_2 IPR035772, CIN85_SH3_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR028506, Sorbin_SH3 |
PANTHERi | PTHR14167:SF6, PTHR14167:SF6, 2 hits |
Pfami | View protein in Pfam PF14604, SH3_9, 3 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 3 hits |
SUPFAMi | SSF50044, SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JPT6_HUMAN | |
Accessioni | Q5JPT6Primary (citable) accession number: Q5JPT6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |