Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

EEF1A lysine methyltransferase 2

Gene

EEF1AKMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.UniRule annotation1 Publication

GO - Molecular functioni

  • methyltransferase activity Source: UniProtKB
  • protein-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • peptidyl-lysine methylation Source: UniProtKB
  • protein methylation Source: Reactome

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 2UniRule annotationImported (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 10UniRule annotation
Protein-lysine N-methyltransferase METTL10UniRule annotation
Gene namesi
Name:EEF1AKMT2UniRule annotationImported
Synonyms:C10orf138, METTL10UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000203791.13
HGNCiHGNC:33787 EEF1AKMT2
MIMi617794 gene
neXtProtiNX_Q5JPI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85 – 91DIGTGNG → AIATANA: Highly reduces methylation activity toward EEF1A1. 1 Publication7

Organism-specific databases

OpenTargetsiENSG00000203791
PharmGKBiPA162395769

Polymorphism and mutation databases

BioMutaiMETTL10
DMDMi172044620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003258822 – 291EEF1A lysine methyltransferase 2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei21PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5JPI9
MaxQBiQ5JPI9
PaxDbiQ5JPI9
PeptideAtlasiQ5JPI9
PRIDEiQ5JPI9
ProteomicsDBi63019

PTM databases

iPTMnetiQ5JPI9
PhosphoSitePlusiQ5JPI9

Expressioni

Gene expression databases

BgeeiENSG00000203791
CleanExiHS_METTL10
ExpressionAtlasiQ5JPI9 baseline and differential
GenevisibleiQ5JPI9 HS

Organism-specific databases

HPAiHPA050138

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357829

Structurei

3D structure databases

ProteinModelPortaliQ5JPI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1271 Eukaryota
ENOG4111PXE LUCA
GeneTreeiENSGT00390000013399
HOGENOMiHOG000184298
InParanoidiQ5JPI9
OMAiNEFSEGW
OrthoDBiEOG091G0T79
PhylomeDBiQ5JPI9
TreeFamiTF313057

Family and domain databases

HAMAPiMF_03188 Methyltr_EFM4, 1 hit
InterProiView protein in InterPro
IPR026635 Efm4/METTL10
IPR025714 Methyltranfer_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF13847 Methyltransf_31, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGADGGGG AAVAARSDKG SPGEDGFVPS ALGTREHWDA VYERELQTFR
60 70 80 90 100
EYGDTGEIWF GEESMNRLIR WMQKHKIPLD ASVLDIGTGN GVFLVELAKF
110 120 130 140 150
GFSNITGIDY SPSAIQLSGS IIEKEGLSNI KLKVEDFLNL STQLSGFHIC
160 170 180 190 200
IDKGTFDAIS LNPDNAIEKR KQYVKSLSRV LKVKGFFLIT SCNWTKEELL
210 220 230 240 250
NEFSEGWSTV AGFWLTAALT SWAQAIFSTS ASRVGGTTGT HHHAWIIFVF
260 270 280 290
LAETRFCHVV QAGLELLGSS DSPTWPPKVL GLYHARPSLA F
Length:291
Mass (Da):31,830
Last modified:March 18, 2008 - v2
Checksum:iE7A4486A4D1CCA50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → S in CAI46179 (PubMed:17974005).Curated1
Sequence conflicti97L → LL in CAI46179 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05029567R → Q. Corresponds to variant dbSNP:rs4347339Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832292 mRNA Translation: CAI46179.1
AC068896 Genomic DNA No translation available.
CCDSiCCDS31307.1
RefSeqiNP_001291396.1, NM_001304467.1
NP_997719.2, NM_212554.3
UniGeneiHs.720819
Hs.741365

Genome annotation databases

EnsembliENST00000368836; ENSP00000357829; ENSG00000203791
GeneIDi399818
KEGGihsa:399818
UCSCiuc001lhy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEFMT2_HUMAN
AccessioniPrimary (citable) accession number: Q5JPI9
Secondary accession number(s): A8MPY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health