EARS2

Functionⁱ

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).By similarity

Catalytic activityⁱ

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	50	ATPBy similarity	1
Binding siteⁱ	76	GlutamateBy similarity	1
Binding siteⁱ	246	GlutamateBy similarity	1
Binding siteⁱ	249	ATPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	284 – 288	ATPBy similarity		5

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
glutamate-tRNA(Gln) ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19805282
glutamate-tRNA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19805282
tRNA binding Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glutamyl-tRNA aminoacylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19805282
tRNA aminoacylation for mitochondrial protein translation
Source: UniProtKB
Inferred from direct assayⁱ
- 19805282

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase, RNA-binding
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-379726 Mitochondrial tRNA aminoacylation

Reactomeⁱ

R-HSA-379726 Mitochondrial tRNA aminoacylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable glutamate--tRNA ligase, mitochondrial (EC:6.1.1.17) Alternative name(s): Glutamyl-tRNA synthetase Short name: GluRS
Gene namesⁱ	Name:EARS2 Synonyms:KIAA1970
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103356.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29419 EARS2
MIMⁱ	612799 gene
neXtProtⁱ	NX_Q5JPH6

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Combined oxidative phosphorylation deficiency 12 (COXPD12)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive, mitochondrial, neurologic disorder characterized by onset in infancy of hypotonia and delayed psychomotor development, or early developmental regression, associated with T2-weighted hyperintensities in the deep cerebral white matter, brainstem, and cerebellar white matter. Serum lactate is increased due to a defect in mitochondrial respiration. There are 2 main phenotypic groups: those with a milder disease course and some recovery of skills after age 2 years, and those with a severe disease course resulting in marked disability.

Keywords - Diseaseⁱ

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	124454
MalaCards human disease database More...MalaCardsⁱ	EARS2
MIMⁱ	614924 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000103356
Orphanetⁱ	314051 Leukoencephalopathy - thalamus and brainstem anomalies - high lactate
PharmGKBⁱ	PA144596439

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00142 L-Glutamic Acid

DrugBankⁱ

DB00142 L-Glutamic Acid

Polymorphism and mutation databases

BioMutaⁱ	EARS2
DMDMⁱ	117949790

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 41	MitochondrionSequence analysisAdd BLAST		41
ChainⁱPRO_0000254560	42 – 523	Probable glutamate--tRNA ligase, mitochondrialAdd BLAST		482

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	256	N6-succinyllysineBy similarity		1
Modified residueⁱ	486	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q5JPH6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5JPH6
PaxDbⁱ	Q5JPH6
PeptideAtlas More...PeptideAtlasⁱ	Q5JPH6
PRIDEⁱ	Q5JPH6
ProteomicsDBⁱ	63015

PTM databases

iPTMnetⁱ	Q5JPH6
PhosphoSitePlusⁱ	Q5JPH6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000103356 Expressed in 183 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_EARS2
ExpressionAtlasⁱ	Q5JPH6 baseline and differential
Genevisibleⁱ	Q5JPH6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043289 HPA043633

HPAⁱ

HPA043289
HPA043633

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	125866, 3 interactors
IntActⁱ	Q5JPH6, 1 interactor
STRINGⁱ	9606.ENSP00000343488

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5JPH6
SMRⁱ	Q5JPH6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	40 – 42	Glutamate bindingBy similarity		3
Regionⁱ	228 – 232	Glutamate bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	45 – 53	"HIGH" region		9
Motifⁱ	284 – 288	"KMSKS" region		5

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1149 Eukaryota COG0008 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009759
HOGENOMⁱ	HOG000252720
HOVERGENⁱ	HBG056174
InParanoidⁱ	Q5JPH6
KEGG Orthology (KO) More...KOⁱ	K01885
OMAⁱ	HYINTLP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PN
PhylomeDBⁱ	Q5JPH6
TreeFamⁱ	TF313268

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00808 GluRS_core, 1 hit
Gene3Dⁱ	1.10.10.350, 1 hit 3.40.50.620, 1 hit
HAMAPⁱ	MF_00022 Glu_tRNA_synth_type1, 1 hit
InterProⁱ	View protein in InterPro IPR008925 aa-tRNA-synth_I_codon-bd IPR020751 aa-tRNA-synth_I_codon-bd_sub2 IPR001412 aa-tRNA-synth_I_CS IPR004527 Glu-tRNA-ligase_bac/mito IPR000924 Glu/Gln-tRNA-synth IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom IPR033910 GluRS_core IPR014729 Rossmann-like_a/b/a_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00749 tRNA-synt_1c, 1 hit
PRINTSⁱ	PR00987 TRNASYNTHGLU
SUPFAMⁱ	SSF48163 SSF48163, 1 hit
TIGRFAMsⁱ	TIGR00464 gltX_bact, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5JPH6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALLRRLLQ RERPSAASGR PVGRREANLG TDAGVAVRVR FAPSPTGFLH 
        60         70         80         90        100
LGGLRTALYN YIFAKKYQGS FILRLEDTDQ TRVVPGAAEN IEDMLEWAGI 
       110        120        130        140        150
PPDESPRRGG PAGPYQQSQR LELYAQATEA LLKTGAAYPC FCSPQRLELL 
       160        170        180        190        200
KKEALRNHQT PRYDNRCRNM SQEQVAQKLA KDPKPAIRFR LEQVVPAFQD 
       210        220        230        240        250
LVYGWNRHEV ASVEGDPVIM KSDGFPTYHL ACVVDDHHMG ISHVLRGSEW 
       260        270        280        290        300
LVSTAKHLLL YQALGWQPPH FAHLPLLLNR DGSKLSKRQG DVFLEHFAAD 
       310        320        330        340        350
GFLPDSLLDI ITNCGSGFAE NQMGRTLPEL ITQFNLTQVT CHSALLDLEK 
       360        370        380        390        400
LPEFNRLHLQ RLVSNESQRR QLVGKLQVLV EEAFGCQLQN RDVLNPVYVE 
       410        420        430        440        450
RILLLRQGHI CRLQDLVSPV YSYLWTRPAV GRAQLDAISE KVDVIAKRVL 
       460        470        480        490        500
GLLERSSMSL TQDMLNGELK KLSEGLEGTK YSNVMKLLRM ALSGQQQGPP 
       510        520 
VAEMMLALGP KEVRERIQKV VSS

Length:523

Mass (Da):58,689

Last modified:October 31, 2006 - v2

Checksum:ⁱFA9B19569AD9F5DB

GO

Isoform 2 (identifier: Q5JPH6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
497-523: QGPPVAEMMLALGPKEVRERIQKVVSS → VRQGHGLDCSLEPLIDPLNLHFLAGTELNIEYTKVNET

« Hide

        10         20         30         40         50
MAALLRRLLQ RERPSAASGR PVGRREANLG TDAGVAVRVR FAPSPTGFLH 
        60         70         80         90        100
LGGLRTALYN YIFAKKYQGS FILRLEDTDQ TRVVPGAAEN IEDMLEWAGI 
       110        120        130        140        150
PPDESPRRGG PAGPYQQSQR LELYAQATEA LLKTGAAYPC FCSPQRLELL 
       160        170        180        190        200
KKEALRNHQT PRYDNRCRNM SQEQVAQKLA KDPKPAIRFR LEQVVPAFQD 
       210        220        230        240        250
LVYGWNRHEV ASVEGDPVIM KSDGFPTYHL ACVVDDHHMG ISHVLRGSEW 
       260        270        280        290        300
LVSTAKHLLL YQALGWQPPH FAHLPLLLNR DGSKLSKRQG DVFLEHFAAD 
       310        320        330        340        350
GFLPDSLLDI ITNCGSGFAE NQMGRTLPEL ITQFNLTQVT CHSALLDLEK 
       360        370        380        390        400
LPEFNRLHLQ RLVSNESQRR QLVGKLQVLV EEAFGCQLQN RDVLNPVYVE 
       410        420        430        440        450
RILLLRQGHI CRLQDLVSPV YSYLWTRPAV GRAQLDAISE KVDVIAKRVL 
       460        470        480        490        500
GLLERSSMSL TQDMLNGELK KLSEGLEGTK YSNVMKLLRM ALSGQQVRQG 
       510        520        530 
HGLDCSLEPL IDPLNLHFLA GTELNIEYTK VNET

Note: No experimental confirmation available.

Show »

Length:534

Mass (Da):59,989

Checksum:ⁱ02E8698C0991B801

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BTB7	H3BTB7_HUMAN	Probable glutamate--tRNA ligase, mi... Probable glutamate--tRNA ligase, mitochondrial	EARS2	506	Annotation score:
H3BQI0	H3BQI0_HUMAN	Probable glutamate--tRNA ligase, mi... Probable glutamate--tRNA ligase, mitochondrial	EARS2	99	Annotation score:
H3BQP8	H3BQP8_HUMAN	Probable glutamate--tRNA ligase, mi... Probable glutamate--tRNA ligase, mitochondrial	EARS2	79	Annotation score:
I3L166	I3L166_HUMAN	Probable glutamate--tRNA ligase, mi... Probable glutamate--tRNA ligase, mitochondrial	EARS2	112	Annotation score:
H3BPY3	H3BPY3_HUMAN	Probable glutamate--tRNA ligase, mi... Probable glutamate--tRNA ligase, mitochondrial	EARS2	54	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069235	55	R → H in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs770862902Ensembl.	1
Natural variantⁱVAR_069236	65	K → E in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs397514595EnsemblClinVar.	1
Natural variantⁱVAR_069237	96	E → K in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs397514593EnsemblClinVar.	1
Natural variantⁱVAR_076183	107	R → C in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs1355685453Ensembl.	1
Natural variantⁱVAR_069238	107	R → H in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs1021330566Ensembl.	1
Natural variantⁱVAR_069239	108	R → W in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs376103091EnsemblClinVar.	1
Natural variantⁱVAR_069240	110	G → S in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs201842633EnsemblClinVar.	1
Natural variantⁱVAR_069241	167	C → Y in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs397514594EnsemblClinVar.	1
Natural variantⁱVAR_069242	168	R → G in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs397514591EnsemblClinVar.	1
Natural variantⁱVAR_069243	204	G → S in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs397514592EnsemblClinVar.	1
Natural variantⁱVAR_069244	224	G → S in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs141129877EnsemblClinVar.	1
Natural variantⁱVAR_069245	317	G → C in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs746838793EnsemblClinVar.	1
Natural variantⁱVAR_069246	426 – 427	TR → L in COXPD12. 1 Publication	2
Natural variantⁱVAR_028840	457	S → G3 PublicationsCorresponds to variant dbSNP:rs6497671EnsemblClinVar.	1
Natural variantⁱVAR_076184	489	R → Q in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs757965573Ensembl.	1
Natural variantⁱVAR_069247	516	R → Q in COXPD12. 1 PublicationCorresponds to variant dbSNP:rs201727231EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057203	497 – 523	QGPPV…KVVSS → VRQGHGLDCSLEPLIDPLNL HFLAGTELNIEYTKVNET in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK095998 mRNA Translation: BAG53194.1 AL832489 mRNA Translation: CAI46121.1 CH471145 Genomic DNA Translation: EAW55822.1 CH471145 Genomic DNA Translation: EAW55824.1 BC040013 mRNA Translation: AAH40013.1 AB075850 mRNA Translation: BAB85556.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42132.1 [Q5JPH6-1] CCDS76844.1 [Q5JPH6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001077083.1, NM_001083614.1 [Q5JPH6-1] NP_001295140.1, NM_001308211.1 [Q5JPH6-2]
UniGeneⁱ	Hs.620541

Genome annotation databases

Ensemblⁱ	ENST00000449606; ENSP00000395196; ENSG00000103356 [Q5JPH6-1] ENST00000563232; ENSP00000456218; ENSG00000103356 [Q5JPH6-2] ENST00000563459; ENSP00000456467; ENSG00000103356 [Q5JPH6-1]
GeneIDⁱ	124454
KEGGⁱ	hsa:124454
UCSC genome browser More...UCSCⁱ	uc002dlt.5 human [Q5JPH6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5JPH6	EARS2 isoform 1		PONAB		523	UniRef90_Q5JPH6
EARS2 isoform 2		PANTR		523
Uncharacterized protein		PANPA		523
Putative glutamyl-tRNA synthetase, mitochondrial (Fragment)		MACMU		505
UPI0005D01A5E		HUMAN		499
+7
Q5JPH6-2	Probable glutamate--tRNA ligase, mitochondrial		MACFA		506	UniRef90_Q5JPH6-2
Uncharacterized protein		CALJA		534
EARS2 isoform 7		PONAB		534
EARS2 isoform 10		PANTR		534
Uncharacterized protein		AOTNA		534
+40

Protein	Similar proteins		Species	Score	Length	Source
Q5JPH6	Probable glutamate--tRNA ligase, mitochondrial		DANRE		503	UniRef50_Q5JPH6
Probable glutamate--tRNA ligase, mitochondrial		CHICK		502
Probable glutamate--tRNA ligase, mitochondrial		MOUSE		523
Probable glutamate--tRNA ligase, mitochondrial		XENTR		516
Probable glutamate--tRNA ligase, mitochondrial		MACFA		506
+394

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK095998 mRNA Translation: BAG53194.1 AL832489 mRNA Translation: CAI46121.1 CH471145 Genomic DNA Translation: EAW55822.1 CH471145 Genomic DNA Translation: EAW55824.1 BC040013 mRNA Translation: AAH40013.1 AB075850 mRNA Translation: BAB85556.1
CCDSⁱ	CCDS42132.1 [Q5JPH6-1] CCDS76844.1 [Q5JPH6-2]
RefSeqⁱ	NP_001077083.1, NM_001083614.1 [Q5JPH6-1] NP_001295140.1, NM_001308211.1 [Q5JPH6-2]
UniGeneⁱ	Hs.620541

3D structure databases

ProteinModelPortalⁱ	Q5JPH6
SMRⁱ	Q5JPH6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125866, 3 interactors
IntActⁱ	Q5JPH6, 1 interactor
STRINGⁱ	9606.ENSP00000343488

Chemistry databases

DrugBankⁱ	DB00142 L-Glutamic Acid

DrugBankⁱ

DB00142 L-Glutamic Acid

PTM databases

iPTMnetⁱ	Q5JPH6
PhosphoSitePlusⁱ	Q5JPH6

Polymorphism and mutation databases

BioMutaⁱ	EARS2
DMDMⁱ	117949790

Proteomic databases

EPDⁱ	Q5JPH6
MaxQBⁱ	Q5JPH6
PaxDbⁱ	Q5JPH6
PeptideAtlasⁱ	Q5JPH6
PRIDEⁱ	Q5JPH6
ProteomicsDBⁱ	63015

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	124454
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000449606; ENSP00000395196; ENSG00000103356 [Q5JPH6-1] ENST00000563232; ENSP00000456218; ENSG00000103356 [Q5JPH6-2] ENST00000563459; ENSP00000456467; ENSG00000103356 [Q5JPH6-1]
GeneIDⁱ	124454
KEGGⁱ	hsa:124454
UCSCⁱ	uc002dlt.5 human [Q5JPH6-1]

Organism-specific databases

CTDⁱ	124454
DisGeNETⁱ	124454
EuPathDBⁱ	HostDB:ENSG00000103356.15
GeneCardsⁱ	EARS2
HGNCⁱ	HGNC:29419 EARS2
HPAⁱ	HPA043289 HPA043633
MalaCardsⁱ	EARS2
MIMⁱ	612799 gene 614924 phenotype
neXtProtⁱ	NX_Q5JPH6
OpenTargetsⁱ	ENSG00000103356
Orphanetⁱ	314051 Leukoencephalopathy - thalamus and brainstem anomalies - high lactate
PharmGKBⁱ	PA144596439
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1149 Eukaryota COG0008 LUCA
GeneTreeⁱ	ENSGT00390000009759
HOGENOMⁱ	HOG000252720
HOVERGENⁱ	HBG056174
InParanoidⁱ	Q5JPH6
KOⁱ	K01885
OMAⁱ	HYINTLP
OrthoDBⁱ	EOG091G08PN
PhylomeDBⁱ	Q5JPH6
TreeFamⁱ	TF313268

Enzyme and pathway databases

Reactomeⁱ	R-HSA-379726 Mitochondrial tRNA aminoacylation

Reactomeⁱ

R-HSA-379726 Mitochondrial tRNA aminoacylation

Miscellaneous databases

ChiTaRSⁱ	EARS2 human
GenomeRNAiⁱ	124454
Protein Ontology More...PROⁱ	PR:Q5JPH6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103356 Expressed in 183 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_EARS2
ExpressionAtlasⁱ	Q5JPH6 baseline and differential
Genevisibleⁱ	Q5JPH6 HS

Family and domain databases

CDDⁱ	cd00808 GluRS_core, 1 hit
Gene3Dⁱ	1.10.10.350, 1 hit 3.40.50.620, 1 hit
HAMAPⁱ	MF_00022 Glu_tRNA_synth_type1, 1 hit
InterProⁱ	View protein in InterPro IPR008925 aa-tRNA-synth_I_codon-bd IPR020751 aa-tRNA-synth_I_codon-bd_sub2 IPR001412 aa-tRNA-synth_I_CS IPR004527 Glu-tRNA-ligase_bac/mito IPR000924 Glu/Gln-tRNA-synth IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom IPR033910 GluRS_core IPR014729 Rossmann-like_a/b/a_fold
Pfamⁱ	View protein in Pfam PF00749 tRNA-synt_1c, 1 hit
PRINTSⁱ	PR00987 TRNASYNTHGLU
SUPFAMⁱ	SSF48163 SSF48163, 1 hit
TIGRFAMsⁱ	TIGR00464 gltX_bact, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYEM_HUMAN
Accessionⁱ	Q5JPH6Primary (citable) accession number: Q5JPH6 Secondary accession number(s): B3KTT2 , D3DWF1, Q86YH3, Q8TF31
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	October 31, 2006
	Last modified:	October 10, 2018
	This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5JPH6 (SYEM_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Probable glutamate--tRNA ligase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ