UniProtKB - Q5JNW7 (Q5JNW7_HUMAN)
Protein
Submitted name:
Proteasome subunit beta type-8
Gene
PSMB8
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- threonine-type endopeptidase activity Source: InterPro
GO - Biological processi
- proteolysis involved in cellular protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, ProteaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Proteasome subunit beta type-8Imported |
Gene namesi | Name:PSMB8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9545, PSMB8 |
VEuPathDBi | HostDB:ENSG00000204264.8 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- proteasome core complex Source: InterPro
Keywords - Cellular componenti
CytoplasmARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000204264, Expressed in granulocyte and 199 other tissues |
ExpressionAtlasi | Q5JNW7, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Phylogenomic databases
GeneTreei | ENSGT00940000157293 |
Family and domain databases
Gene3Di | 3.60.20.10, 2 hits |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR035705, Proteasome_beta8 IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF53, PTHR11599:SF53, 2 hits |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS51476, PROTEASOME_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q5JNW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP
60 70 80 90 100
TEFFQSLGGD GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYINC
110 120 130 140 150
QYWERLLAKE CRLYYLRNGE RISVSAASKL LSNMMCQYRG MGLSMGSMIC
160 170 180 190 200
GWDKKGPGLY YVDEHGTRLS GNMFSTGSGN TYAYGVMDSG YRPNLSPEEA
210 220 230 240 250
YDLGRRAIAY ATHRDSYSGG VVNMYHMKED GWVKVESTDV SDLLHQYREA
NQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP28062 | PSB8_HUMAN | Proteasome subunit beta type-8 | PSMB8 LMP7, PSMB5i, RING10, Y2 | 276 | Annotation score: | ||
X5D2R7 | X5D2R7_HUMAN | Proteasome subunit beta | PSMB8 PSM8 | 276 | Annotation score: | ||
A0A140T998 | A0A140T998_HUMAN | Proteasome subunit beta type-8 | PSMB8 | 252 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL669918 Genomic DNA No translation available. AL671681 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. BX682530 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CT009502 Genomic DNA No translation available. |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL669918 Genomic DNA No translation available. AL671681 Genomic DNA No translation available. AL935043 Genomic DNA No translation available. BX088556 Genomic DNA No translation available. BX682530 Genomic DNA No translation available. BX927138 Genomic DNA No translation available. CR762476 Genomic DNA No translation available. CT009502 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5JNW7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q5JNW7, 3 interactors |
Proteomic databases
MaxQBi | Q5JNW7 |
PRIDEi | Q5JNW7 |
ProteomicsDBi | 62991 |
Protocols and materials databases
Antibodypediai | 28713, 391 antibodies |
Genome annotation databases
Organism-specific databases
HGNCi | HGNC:9545, PSMB8 |
NIAGADSi | ENSG00000204264 |
OpenTargetsi | ENSG00000204264 |
VEuPathDBi | HostDB:ENSG00000204264.8 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157293 |
Miscellaneous databases
ChiTaRSi | PSMB8, human |
Gene expression databases
Bgeei | ENSG00000204264, Expressed in granulocyte and 199 other tissues |
ExpressionAtlasi | Q5JNW7, baseline and differential |
Family and domain databases
Gene3Di | 3.60.20.10, 2 hits |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR035705, Proteasome_beta8 IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF53, PTHR11599:SF53, 2 hits |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS51476, PROTEASOME_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JNW7_HUMAN | |
Accessioni | Q5JNW7Primary (citable) accession number: Q5JNW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 10, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |