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Protein

Probable tRNA pseudouridine synthase B

Gene

truB

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1514-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:TK1509
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219701 – 338Probable tRNA pseudouridine synthase BAdd BLAST338

Interactioni

Protein-protein interaction databases

STRINGi69014.TK1509

Structurei

3D structure databases

ProteinModelPortaliQ5JJE8
SMRiQ5JJE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 325PUAUniRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00987 Archaea
COG0130 LUCA
HOGENOMiHOG000231224
InParanoidiQ5JJE8
KOiK11131
OMAiIYQRPPL
OrthoDBiPOG093Z08NS

Family and domain databases

HAMAPiMF_01081 TruB_arch, 1 hit
InterProiView protein in InterPro
IPR012960 Dyskerin-like
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR002478 PUA
IPR015947 PUA-like_sf
IPR004802 tRNA_PsdUridine_synth_B_fam
IPR026326 TruB_arch
IPR032819 TruB_C
IPR004521 Uncharacterised_CHP00451
PANTHERiPTHR23127 PTHR23127, 1 hit
PfamiView protein in Pfam
PF08068 DKCLD, 1 hit
PF01472 PUA, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SMARTiView protein in SMART
SM01136 DKCLD, 1 hit
SM00359 PUA, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00425 CBF5, 1 hit
TIGR00451 unchar_dom_2, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JJE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDEVRRIL PADIKREVVV KDEKAETNPK WGFPPEKRPI EMHIQFGIIN
60 70 80 90 100
LDKPPGPTSH EVVAWVKRIL NLNKAGHGGT LDPKVSGVLP VALERATRVV
110 120 130 140 150
QALLPAGKEY VALMHLHGDV PEDKILAVMR EFQGEIIQRP PLRSAVKRRL
160 170 180 190 200
RTRKVYYIDV LEIEGRDVLF RVGVEAGTYI RSLIHHIGLA LGVGAHMAEL
210 220 230 240 250
RRTRSGPFKE DETLVTLHDL VDYYHFWKED GVEEYFRKAI QPMEKAVEHL
260 270 280 290 300
PKVWIRDSAV AAVTHGADLA VPGVVKLHKG IKKGDLVAIM TLKDELVALG
310 320 330
KAMMTTGEML QKSKGIAVDV DKVFMPRDWY PKLWKEKE
Length:338
Mass (Da):38,215
Last modified:February 15, 2005 - v1
Checksum:i96230D6C1D75EC23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD85698.1
RefSeqiWP_011250460.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD85698; BAD85698; TK1509
GeneIDi3235127
KEGGitko:TK1509
PATRICifig|69014.16.peg.1469

Similar proteinsi

Entry informationi

Entry nameiTRUB_THEKO
AccessioniPrimary (citable) accession number: Q5JJE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 15, 2005
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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