Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 98 (29 Sep 2021)
Sequence version 1 (15 Feb 2005)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Hydrogenase expression/formation protein HypE

Gene

TK1993

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi42Magnesium 1Combined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei42AMP; via carbonyl oxygenCombined sources1
Metal bindingi43Magnesium 2Combined sources1
Metal bindingi43Magnesium 3Combined sources1
Metal bindingi59Magnesium 4Combined sources1
Metal bindingi59Magnesium 5Combined sources1
Binding sitei59ATPCombined sources1
Binding sitei59ATP analogCombined sources1
Metal bindingi84Magnesium 2Combined sources1
Metal bindingi84Magnesium 4Combined sources1
Binding sitei84ATPCombined sources1
Binding sitei84ATP analogCombined sources1
Binding sitei97AMPCombined sources1
Binding sitei97ATPCombined sources1
Binding sitei97ATP analogCombined sources1
Metal bindingi132Magnesium 5Combined sources1
Metal bindingi158Magnesium 1Combined sources1
Metal bindingi158Magnesium 3Combined sources1
Metal bindingi219Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi219Magnesium 3; via carbonyl oxygenCombined sources1
Metal bindingi221Magnesium 2Combined sources1
Binding sitei224AMPCombined sources1
Binding sitei338ATPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi42 – 43ATPCombined sources2
Nucleotide bindingi42 – 43ATP analogCombined sources2
Nucleotide bindingi130 – 133AMPCombined sources4
Nucleotide bindingi130 – 133ATPCombined sources4
Nucleotide bindingi130 – 133ATP analogCombined sources4
Nucleotide bindingi223 – 224ATPCombined sources2
Nucleotide bindingi223 – 224ATP analogCombined sources2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hydrogenase expression/formation protein HypEImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:TK1993Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69014 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000536 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59991N

Protein interaction database and analysis system

More...
IntActi
Q5JII7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
69014.TK1993

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5JII7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5JII7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 151AIRSInterPro annotationAdd BLAST110
Domaini162 – 314AIRS_CInterPro annotationAdd BLAST153

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HypE family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG00636, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_049733_0_0_2

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JII7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGNGGKE

Database of Orthologous Groups

More...
OrthoDBi
34102at2157

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JII7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02197, HypE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.10, 1 hit
3.90.650.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011854, HypE
IPR010918, PurM-like_C_dom
IPR036676, PurM-like_C_sf
IPR016188, PurM-like_N
IPR036921, PurM-like_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30303, PTHR30303, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00586, AIRS, 1 hit
PF02769, AIRS_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005644, Hdrgns_mtr_HypE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55326, SSF55326, 1 hit
SSF56042, SSF56042, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02124, hypE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5JII7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEKIKLEHG AGGEIMEELL RDVILKTLTL KSAGGIGLDA LDDGATIPFG
60 70 80 90 100
DKHIVFTIDG HTVKPLFFPG GDIGRLAVSG TVNDLAVMGA EPIALANSMI
110 120 130 140 150
IGEGLDMEVL KRVLKSMDET AREVPVPIVT GDTKVVEDKI EMFVITAGIG
160 170 180 190 200
IAEHPVSDAG AKVGDAVLVS GTIGDHGIAL MSHREGIAFE TELKSDVAPI
210 220 230 240 250
WDVVKAVAET IGWENIHAMK DPTRAGLSNA LNEIARKSNV GILVREADIP
260 270 280 290 300
IRPEVRAASE MLGISPYDVA NEGKVVMVVA REYAEEALEA MRKTEKGRNA
310 320 330
AIIGEVIADY RGKVLLETGI GGKRFMEPPE GDPVPRIC
Length:338
Mass (Da):35,911
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i240003AA7F119471
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD86182.1

NCBI Reference Sequences

More...
RefSeqi
WP_011250943.1, NC_006624.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAD86182; BAD86182; TK1993

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3235054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tko:TK1993

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|69014.16.peg.1946

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD86182.1
RefSeqiWP_011250943.1, NC_006624.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z1EX-ray1.55A1-338[»]
2Z1FX-ray1.70A1-338[»]
3VYSX-ray2.35C1-338[»]
3VYTX-ray2.25C1-338[»]
3VYUX-ray2.75C1-338[»]
3WJPX-ray1.53A1-338[»]
3WJQX-ray1.65A1-338[»]
3WJRX-ray1.86A1-338[»]
SMRiQ5JII7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59991N
IntActiQ5JII7, 2 interactors
STRINGi69014.TK1993

Genome annotation databases

EnsemblBacteriaiBAD86182; BAD86182; TK1993
GeneIDi3235054
KEGGitko:TK1993
PATRICifig|69014.16.peg.1946

Phylogenomic databases

eggNOGiarCOG00636, Archaea
HOGENOMiCLU_049733_0_0_2
InParanoidiQ5JII7
OMAiCGNGGKE
OrthoDBi34102at2157
PhylomeDBiQ5JII7

Miscellaneous databases

EvolutionaryTraceiQ5JII7

Family and domain databases

CDDicd02197, HypE, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
InterProiView protein in InterPro
IPR011854, HypE
IPR010918, PurM-like_C_dom
IPR036676, PurM-like_C_sf
IPR016188, PurM-like_N
IPR036921, PurM-like_N_sf
PANTHERiPTHR30303, PTHR30303, 1 hit
PfamiView protein in Pfam
PF00586, AIRS, 1 hit
PF02769, AIRS_C, 1 hit
PIRSFiPIRSF005644, Hdrgns_mtr_HypE, 1 hit
SUPFAMiSSF55326, SSF55326, 1 hit
SSF56042, SSF56042, 1 hit
TIGRFAMsiTIGR02124, hypE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5JII7_THEKO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JII7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 29, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again