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Protein

DNA polymerase sliding clamp 2

Gene

pcn2

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

Activity regulationi

Inhibited by interaction with the PCNA inhibitor TIP.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-UniRule
  • DNA polymerase processivity factor activity Source: GO_Central
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-580-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clamp 2UniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homolog 2UniRule annotation
Short name:
PCNA 2UniRule annotation
Gene namesi
Name:pcn2UniRule annotation
Ordered Locus Names:TK0582
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492091 – 253DNA polymerase sliding clamp 2Add BLAST253

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Interacts with TIP (PubMed:24728986).UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-15908562,EBI-15908562

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59609N
STRINGi69014.TK0582

Structurei

Secondary structure

1253
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5JFD3
SMRiQ5JFD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
InParanoidiQ5JFD3
KOiK04802
OMAiINTQKEH
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JFD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFEIVFDSA REFESLIATL EKFFDEAVFQ VNMEGIQMRA IDPSRVVLVD
60 70 80 90 100
LNLPEMLFSK YSVESEEAIA FDLKRFLKVL KLARSRDTLV LRKGGENFLE
110 120 130 140 150
VGLLGDENTW FKLPLIDANT PEIEIPSLPW TVKAVVLAGA LKRAVKAAKL
160 170 180 190 200
VSDSIYFMAT PEKLTFKAEG NDSEVRTVLT MEDPGLLDLE HKMTKAKSAY
210 220 230 240 250
GVAYLEDILR SLADADEVII RFGFDIPLLL KYMVRDAGEV SFLIAPRVEE

GRS
Length:253
Mass (Da):28,447
Last modified:February 15, 2005 - v1
Checksum:i2460EF12BE490CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD84771.1
RefSeqiWP_011249537.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD84771; BAD84771; TK0582
GeneIDi3235115
KEGGitko:TK0582
PATRICifig|69014.16.peg.567

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD84771.1
RefSeqiWP_011249537.1, NC_006624.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LX2X-ray2.40A/B/C1-253[»]
ProteinModelPortaliQ5JFD3
SMRiQ5JFD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59609N
STRINGi69014.TK0582

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84771; BAD84771; TK0582
GeneIDi3235115
KEGGitko:TK0582
PATRICifig|69014.16.peg.567

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
InParanoidiQ5JFD3
KOiK04802
OMAiINTQKEH
OrthoDBiPOG093Z0814

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-580-MONOMER

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA2_THEKO
AccessioniPrimary (citable) accession number: Q5JFD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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