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UniProtKB - Q5JES6 (TYW32_THEKO)
Protein
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2
Gene
taw3-2
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Functioni
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
UniRule annotationCatalytic activityi
- 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.282UniRule annotation
GO - Molecular functioni
- tRNA methyltransferase activity Source: InterPro
GO - Biological processi
- wybutosine biosynthetic process Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2UniRule annotation (EC:2.1.1.282UniRule annotation)Alternative name(s): tRNA wyosine derivatives biosynthesis protein Taw3 2UniRule annotation |
Gene namesi | Name:taw3-2UniRule annotation Ordered Locus Names:TK1907 |
Organismi | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) |
Taxonomic identifieri | 69014 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157101 | 1 – 212 | tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2Add BLAST | 212 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TYW3 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_0_2 |
InParanoidi | Q5JES6 |
OMAi | GFKYTTF |
OrthoDBi | 118297at2157 |
PhylomeDBi | Q5JES6 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5JES6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAKREALQS LFTAMRDGKV DGDIIDLLLL INSIKGIYTT SSCSGRIGII
60 70 80 90 100
EEPALGAKPL SRWLIKVHRP IEFEEAKEAL KNAKEGIIFL KSQPPIFHVV
110 120 130 140 150
AEDLEKARKL HELGLASGFK YTTFKVISKR YLVEINATEY LTAPLGRDGR
160 170 180 190 200
VLVDDGYLRF AVEIGNEMLR RSKGRLPRLE ENFRRLREEL GTDELFYELV
210
EEYKIRENWE LP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP006878 Genomic DNA Translation: BAD86096.1 |
RefSeqi | WP_011250858.1, NC_006624.1 |
Genome annotation databases
EnsemblBacteriai | BAD86096; BAD86096; TK1907 |
GeneIDi | 3234934 |
KEGGi | tko:TK1907 |
PATRICi | fig|69014.16.peg.1864 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP006878 Genomic DNA Translation: BAD86096.1 |
RefSeqi | WP_011250858.1, NC_006624.1 |
3D structure databases
AlphaFoldDBi | Q5JES6 |
SMRi | Q5JES6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 69014.TK1907 |
Genome annotation databases
EnsemblBacteriai | BAD86096; BAD86096; TK1907 |
GeneIDi | 3234934 |
KEGGi | tko:TK1907 |
PATRICi | fig|69014.16.peg.1864 |
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_0_2 |
InParanoidi | Q5JES6 |
OMAi | GFKYTTF |
OrthoDBi | 118297at2157 |
PhylomeDBi | Q5JES6 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TYW32_THEKO | |
Accessioni | Q5JES6Primary (citable) accession number: Q5JES6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | May 25, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families