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UniProtKB - Q5JDY1 (GGGPS_THEKO)
Protein
Geranylgeranylglyceryl phosphate synthase
Gene
TK1026
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Functioni
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
UniRule annotation1 PublicationCatalytic activityi
- (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphateUniRule annotation1 PublicationEC:2.5.1.41UniRule annotation1 Publication
Cofactori
Mg2+UniRule annotation
: glycerophospholipid metabolism Pathwayi
This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 26 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 55 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- imidazoleglycerol-phosphate synthase activity Source: GO_Central
- magnesium ion binding Source: UniProtKB-UniRule
- phosphoglycerol geranylgeranyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- glycerophospholipid biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00940 |
Names & Taxonomyi
Protein namesi | Recommended name: Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation1 Publication)Short name: GGGP synthaseUniRule annotation Short name: GGGPSUniRule annotation Alternative name(s): (S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation Phosphoglycerol geranylgeranyltransferaseUniRule annotation |
Gene namesi | Ordered Locus Names:TK1026 |
Organismi | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) |
Taxonomic identifieri | 69014 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 143 | W → A: Forms homodimers. Shows almost wild-type activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000138742 | 1 – 252 | Geranylgeranylglyceryl phosphate synthaseAdd BLAST | 252 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 174 – 180 | Glycerol-1-phosphate bindingUniRule annotation | 7 | |
Regioni | 205 – 206 | Glycerol-1-phosphate bindingUniRule annotation | 2 | |
Regioni | 227 – 228 | Glycerol-1-phosphate bindingUniRule annotation | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG01085, Archaea |
HOGENOMi | CLU_068610_0_0_2 |
InParanoidi | Q5JDY1 |
OMAi | ADAIFFM |
OrthoDBi | 94629at2157 |
PhylomeDBi | Q5JDY1 |
Family and domain databases
CDDi | cd02812, PcrB_like, 1 hit |
Gene3Di | 3.20.20.390, 1 hit |
HAMAPi | MF_00112, GGGP_HepGP_synthase, 1 hit |
InterProi | View protein in InterPro IPR038597, GGGP/HepGP_synthase_sf IPR008205, GGGP_HepGP_synthase IPR010946, GGGP_synth |
Pfami | View protein in Pfam PF01884, PcrB, 1 hit |
TIGRFAMsi | TIGR01769, GGGP, 1 hit TIGR01768, GGGP-family, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5JDY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKLGKVETY IHEKLEREKL HFVLLDPDDV SPELAGELAS MSEEVGVDAI
60 70 80 90 100
MVGGSTGAEG EVLDSVVRAI KESSNLPVIL FPGSHGGISK YADAIFFMSL
110 120 130 140 150
LNSRNPFFIT GAQALGAFQV KRYGIEPIPM AYLIIEPGET VGWVGDAKPI
160 170 180 190 200
PRHKPKIAAA YALAGQYLGM RLVYLEAGSG APQPVPPEMI GLVKRVIDVP
210 220 230 240 250
LIVGGGIRTE EQARAAVKAG ADIIVTGTAI EKAGSVEKAR EKLEELNRGV
KG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP006878 Genomic DNA Translation: BAD85215.1 |
RefSeqi | WP_011249977.1, NC_006624.1 |
Genome annotation databases
EnsemblBacteriai | BAD85215; BAD85215; TK1026 |
GeneIDi | 3235036 |
KEGGi | tko:TK1026 |
PATRICi | fig|69014.16.peg.1004 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP006878 Genomic DNA Translation: BAD85215.1 |
RefSeqi | WP_011249977.1, NC_006624.1 |
3D structure databases
SMRi | Q5JDY1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 69014.TK1026 |
Genome annotation databases
EnsemblBacteriai | BAD85215; BAD85215; TK1026 |
GeneIDi | 3235036 |
KEGGi | tko:TK1026 |
PATRICi | fig|69014.16.peg.1004 |
Phylogenomic databases
eggNOGi | arCOG01085, Archaea |
HOGENOMi | CLU_068610_0_0_2 |
InParanoidi | Q5JDY1 |
OMAi | ADAIFFM |
OrthoDBi | 94629at2157 |
PhylomeDBi | Q5JDY1 |
Enzyme and pathway databases
UniPathwayi | UPA00940 |
Family and domain databases
CDDi | cd02812, PcrB_like, 1 hit |
Gene3Di | 3.20.20.390, 1 hit |
HAMAPi | MF_00112, GGGP_HepGP_synthase, 1 hit |
InterProi | View protein in InterPro IPR038597, GGGP/HepGP_synthase_sf IPR008205, GGGP_HepGP_synthase IPR010946, GGGP_synth |
Pfami | View protein in Pfam PF01884, PcrB, 1 hit |
TIGRFAMsi | TIGR01769, GGGP, 1 hit TIGR01768, GGGP-family, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GGGPS_THEKO | |
Accessioni | Q5JDY1Primary (citable) accession number: Q5JDY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families