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UniProtKB - Q5J8X5 (M4A13_HUMAN)
Protein
Membrane-spanning 4-domains subfamily A member 13
Gene
MS4A13
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in signal transduction as a component of a multimeric receptor complex.
By similarityEnzyme and pathway databases
PathwayCommonsi | Q5J8X5 |
SignaLinki | Q5J8X5 |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane-spanning 4-domains subfamily A member 13Alternative name(s): Testis-expressed transmembrane protein 4 |
Gene namesi | Name:MS4A13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16674, MS4A13 |
neXtProti | NX_Q5J8X5 |
VEuPathDBi | HostDB:ENSG00000204979 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000204979 |
PharmGKBi | PA142671314 |
Miscellaneous databases
Pharosi | Q5J8X5, Tdark |
Genetic variation databases
BioMutai | MS4A13 |
DMDMi | 334302831 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315055 | 1 – 152 | Membrane-spanning 4-domains subfamily A member 13Add BLAST | 152 |
Proteomic databases
PaxDbi | Q5J8X5 |
PeptideAtlasi | Q5J8X5 |
PRIDEi | Q5J8X5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204979, Expressed in left testis and 12 other tissues |
ExpressionAtlasi | Q5J8X5, baseline and differential |
Organism-specific databases
HPAi | ENSG00000204979, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q5J8X5
Protein-protein interaction databases
BioGRIDi | 139008, 61 interactors |
IntActi | Q5J8X5, 60 interactors |
Miscellaneous databases
RNActi | Q5J8X5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MS4A family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RTZG, Eukaryota |
GeneTreei | ENSGT00390000015662 |
HOGENOMi | CLU_144238_0_0_1 |
InParanoidi | Q5J8X5 |
OMAi | GCSLWGI |
OrthoDBi | 1515352at2759 |
PhylomeDBi | Q5J8X5 |
TreeFami | TF353242 |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A |
PANTHERi | PTHR23320, PTHR23320, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5J8X5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIGIFHIFMW YFLLVLYMGQ IKGAFGTYEP VTYKTGCTLW GIFFIIAGVF
60 70 80 90 100
LIRVTKYPTR SGIISTLIIN IICIITTITA VTLTIIELSH FNSVSYRNYG
110 120 130 140 150
QAKLGREVSR ILLFFYGLEF SIALTHSIYS CSNLFRRQND LTSVTEEAES
TP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PPG1 | E9PPG1_HUMAN | Membrane-spanning 4-domains subfami... | MS4A13 | 61 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 102 | A → V in AAQ94112 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062124 | 3 | G → D. Corresponds to variant dbSNP:rs55756397Ensembl. | 1 | |
Natural variantiVAR_062125 | 7 | I → V1 PublicationCorresponds to variant dbSNP:rs10736706Ensembl. | 1 | |
Natural variantiVAR_057654 | 58 | P → L. Corresponds to variant dbSNP:rs6591595Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030477 | 44 – 102 | Missing in isoform 3. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_030476 | 63 – 102 | Missing in isoform 2. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY324188 mRNA Translation: AAQ94112.1 AY324189 mRNA Translation: AAQ94113.1 AY324190 mRNA Translation: AAQ94114.1 AP001034 Genomic DNA No translation available. BC140799 mRNA Translation: AAI40800.1 |
CCDSi | CCDS31571.1 [Q5J8X5-1] CCDS41653.1 [Q5J8X5-2] CCDS60801.1 [Q5J8X5-3] |
RefSeqi | NP_001012417.2, NM_001012417.2 [Q5J8X5-1] NP_001094379.1, NM_001100909.1 [Q5J8X5-2] NP_001265249.1, NM_001278320.1 [Q5J8X5-3] |
Genome annotation databases
Ensembli | ENST00000378185; ENSP00000367427; ENSG00000204979 [Q5J8X5-2] ENST00000378186; ENSP00000367428; ENSG00000204979 ENST00000437058; ENSP00000415535; ENSG00000204979 [Q5J8X5-3] |
GeneIDi | 503497 |
KEGGi | hsa:503497 |
MANE-Selecti | ENST00000378186.7; ENSP00000367428.2; NM_001012417.3; NP_001012417.2 |
UCSCi | uc001nps.4, human [Q5J8X5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY324188 mRNA Translation: AAQ94112.1 AY324189 mRNA Translation: AAQ94113.1 AY324190 mRNA Translation: AAQ94114.1 AP001034 Genomic DNA No translation available. BC140799 mRNA Translation: AAI40800.1 |
CCDSi | CCDS31571.1 [Q5J8X5-1] CCDS41653.1 [Q5J8X5-2] CCDS60801.1 [Q5J8X5-3] |
RefSeqi | NP_001012417.2, NM_001012417.2 [Q5J8X5-1] NP_001094379.1, NM_001100909.1 [Q5J8X5-2] NP_001265249.1, NM_001278320.1 [Q5J8X5-3] |
3D structure databases
SMRi | Q5J8X5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 139008, 61 interactors |
IntActi | Q5J8X5, 60 interactors |
Genetic variation databases
BioMutai | MS4A13 |
DMDMi | 334302831 |
Proteomic databases
PaxDbi | Q5J8X5 |
PeptideAtlasi | Q5J8X5 |
PRIDEi | Q5J8X5 |
Protocols and materials databases
Antibodypediai | 50523, 58 antibodies from 13 providers |
DNASUi | 503497 |
Genome annotation databases
Ensembli | ENST00000378185; ENSP00000367427; ENSG00000204979 [Q5J8X5-2] ENST00000378186; ENSP00000367428; ENSG00000204979 ENST00000437058; ENSP00000415535; ENSG00000204979 [Q5J8X5-3] |
GeneIDi | 503497 |
KEGGi | hsa:503497 |
MANE-Selecti | ENST00000378186.7; ENSP00000367428.2; NM_001012417.3; NP_001012417.2 |
UCSCi | uc001nps.4, human [Q5J8X5-1] |
Organism-specific databases
CTDi | 503497 |
GeneCardsi | MS4A13 |
HGNCi | HGNC:16674, MS4A13 |
HPAi | ENSG00000204979, Tissue enriched (testis) |
neXtProti | NX_Q5J8X5 |
OpenTargetsi | ENSG00000204979 |
PharmGKBi | PA142671314 |
VEuPathDBi | HostDB:ENSG00000204979 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RTZG, Eukaryota |
GeneTreei | ENSGT00390000015662 |
HOGENOMi | CLU_144238_0_0_1 |
InParanoidi | Q5J8X5 |
OMAi | GCSLWGI |
OrthoDBi | 1515352at2759 |
PhylomeDBi | Q5J8X5 |
TreeFami | TF353242 |
Enzyme and pathway databases
PathwayCommonsi | Q5J8X5 |
SignaLinki | Q5J8X5 |
Miscellaneous databases
BioGRID-ORCSi | 503497, 2 hits in 957 CRISPR screens |
ChiTaRSi | MS4A13, human |
GenomeRNAii | 503497 |
Pharosi | Q5J8X5, Tdark |
PROi | PR:Q5J8X5 |
RNActi | Q5J8X5, protein |
Gene expression databases
Bgeei | ENSG00000204979, Expressed in left testis and 12 other tissues |
ExpressionAtlasi | Q5J8X5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A |
PANTHERi | PTHR23320, PTHR23320, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M4A13_HUMAN | |
Accessioni | Q5J8X5Primary (citable) accession number: Q5J8X5 Secondary accession number(s): B2RTS9, Q5J8X3, Q5J8X4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 31, 2011 | |
Last modified: | February 23, 2022 | |
This is version 104 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families