UniProtKB - Q5J7N5 (Q5J7N5_CHICK)
Protein
Submitted name:
Transcription factor FOXL2
Gene
FOXL2
Organism
Gallus gallus (Chicken)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 47 – 141 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- cysteine-type endopeptidase regulator activity involved in apoptotic process Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- estrogen receptor binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- ubiquitin conjugating enzyme binding Source: Ensembl
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- apoptotic DNA fragmentation Source: UniProtKB
- cell differentiation Source: GO_Central
- embryonic eye morphogenesis Source: Ensembl
- extraocular skeletal muscle development Source: Ensembl
- female somatic sex determination Source: Ensembl
- granulosa cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- oocyte growth Source: Ensembl
- ovarian follicle development Source: Ensembl
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- positive regulation of follicle-stimulating hormone secretion Source: Ensembl
- positive regulation of luteinizing hormone secretion Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- single fertilization Source: Ensembl
- uterus development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-GGA-3232118, SUMOylation of transcription factors |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor FOXL2Imported |
Gene namesi | Name:FOXL2Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Extracellular region or secreted
- intercellular bridge Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSGALG00000021009, Expressed in heart and 4 other tissues |
Interactioni
GO - Molecular functioni
- estrogen receptor binding Source: Ensembl
- ubiquitin conjugating enzyme binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000033127 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 141 | Fork-headInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 48 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 240 – 267 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 43 | PolyampholyteSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162075 |
HOGENOMi | CLU_023357_1_0_1 |
OMAi | HCSYWEH |
OrthoDBi | 1270467at2759 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5J7N5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSGYADGEE DAVAMLAHDG GGSKEPERGK EELSAEKGPE KPDPSQKPPY
60 70 80 90 100
SYVALIAMAI RESAEKRLTL SGIYQYIISK FPFYEKNKKG WQNSIRHNLS
110 120 130 140 150
LNECFIKVPR EGGGERKGNY WTLDPACEDM FEKGNYRRRR RMKRPFRPPP
160 170 180 190 200
THFQPGKSLF GPDGYGYLSP PKYLQSTFMN NSWPLPQPPA PVPYASCQMS
210 220 230 240 250
GGSVSPVNVK GLSGPASYGP YSRVQSVALP GMVNSYNGVA HPHHPHAHHP
260 270 280 290 300
QQLGPASPAP PAAPAANGAG LQFACARQPA ELSVMHCSYW EHDSKHGALH
SRIDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000526 Genomic DNA No translation available. AY487165 mRNA Translation: AAS58057.1 |
RefSeqi | NP_001012630.1, NM_001012612.1 |
Genome annotation databases
Ensembli | ENSGALT00000082274; ENSGALP00000045929; ENSGALG00000029282 |
GeneIDi | 503512 |
KEGGi | gga:503512 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000526 Genomic DNA No translation available. AY487165 mRNA Translation: AAS58057.1 |
RefSeqi | NP_001012630.1, NM_001012612.1 |
3D structure databases
SMRi | Q5J7N5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000033127 |
Genome annotation databases
Ensembli | ENSGALT00000082274; ENSGALP00000045929; ENSGALG00000029282 |
GeneIDi | 503512 |
KEGGi | gga:503512 |
Organism-specific databases
CTDi | 668 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162075 |
HOGENOMi | CLU_023357_1_0_1 |
OMAi | HCSYWEH |
OrthoDBi | 1270467at2759 |
TreeFami | TF316127 |
Enzyme and pathway databases
Reactomei | R-GGA-3232118, SUMOylation of transcription factors |
Gene expression databases
Bgeei | ENSGALG00000021009, Expressed in heart and 4 other tissues |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5J7N5_CHICK | |
Accessioni | Q5J7N5Primary (citable) accession number: Q5J7N5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |