UniProtKB - Q5J7N1 (Q5J7N1_MOUSE)
Protein
Submitted name:
Kras protein
Gene
Kras
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- GDP binding Source: Ensembl
- GMP binding Source: Ensembl
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- LRR domain binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- cytokine-mediated signaling pathway Source: Ensembl
- female pregnancy Source: Ensembl
- liver development Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cellular senescence Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of MAP kinase activity Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of nitric-oxide synthase activity Source: Ensembl
- regulation of protein stability Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to isolation stress Source: Ensembl
- response to mineralocorticoid Source: Ensembl
Keywordsi
Ligand | GTP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Kras proteinImportedSubmitted name: p21BImported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:96680, Kras |
Subcellular locationi
Mitochondrion
- mitochondrion Source: Ensembl
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: Ensembl
Other locations
- membrane raft Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030265, Expressed in ureteric bud tip and 304 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 167 – 188 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 170 – 188 | BasicSequence analysisAdd BLAST | 19 |
Phylogenomic databases
HOGENOMi | CLU_041217_9_8_1 |
OMAi | EYKLVVM |
OrthoDBi | 1259506at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5J7N1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QELARSYGIP FIETSAKTRQ
160 170 180
GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SRTRCTVM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC141051 mRNA Translation: AAI41052.1 AY487807 mRNA Translation: AAS58056.1 AK164065 mRNA Translation: BAE37609.1 |
RefSeqi | NP_067259.4, NM_021284.6 |
Genome annotation databases
GeneIDi | 16653 |
KEGGi | mmu:16653 |
UCSCi | uc009erh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC141051 mRNA Translation: AAI41052.1 AY487807 mRNA Translation: AAS58056.1 AK164065 mRNA Translation: BAE37609.1 |
RefSeqi | NP_067259.4, NM_021284.6 |
3D structure databases
SMRi | Q5J7N1 |
ModBasei | Search... |
PTM databases
SwissPalmi | Q5J7N1 |
Proteomic databases
MaxQBi | Q5J7N1 |
Protocols and materials databases
Antibodypediai | 24248, 843 antibodies |
Genome annotation databases
GeneIDi | 16653 |
KEGGi | mmu:16653 |
UCSCi | uc009erh.2, mouse |
Organism-specific databases
CTDi | 3845 |
MGIi | MGI:96680, Kras |
Phylogenomic databases
HOGENOMi | CLU_041217_9_8_1 |
OMAi | EYKLVVM |
OrthoDBi | 1259506at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16653, 6 hits in 22 CRISPR screens |
ChiTaRSi | Kras, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030265, Expressed in ureteric bud tip and 304 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5J7N1_MOUSE | |
Accessioni | Q5J7N1Primary (citable) accession number: Q5J7N1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |