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Protein

Glucagon-like peptide 2 receptor

Gene

Glp2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

  • glucagon receptor activity Source: MGI
  • G protein-coupled peptide receptor activity Source: GO_Central
  • peptide hormone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:Glp2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2136733 Glp2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 135ExtracellularBy similarityAdd BLAST135
Transmembranei136 – 160Helical; Name=1By similarityAdd BLAST25
Topological domaini161 – 172CytoplasmicBy similarityAdd BLAST12
Transmembranei173 – 197Helical; Name=2By similarityAdd BLAST25
Topological domaini198 – 223ExtracellularBy similarityAdd BLAST26
Transmembranei224 – 247Helical; Name=3By similarityAdd BLAST24
Topological domaini248 – 261CytoplasmicBy similarityAdd BLAST14
Transmembranei262 – 283Helical; Name=4By similarityAdd BLAST22
Topological domaini284 – 301ExtracellularBy similarityAdd BLAST18
Transmembranei302 – 324Helical; Name=5By similarityAdd BLAST23
Topological domaini325 – 348CytoplasmicBy similarityAdd BLAST24
Transmembranei349 – 367Helical; Name=6By similarityAdd BLAST19
Topological domaini368 – 379ExtracellularBy similarityAdd BLAST12
Transmembranei380 – 400Helical; Name=7By similarityAdd BLAST21
Topological domaini401 – 512CytoplasmicBy similarityAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071111 – 512Glucagon-like peptide 2 receptorAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 65By similarity
Disulfide bondi56 ↔ 97By similarity
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 119By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5IXF8
PRIDEiQ5IXF8

PTM databases

PhosphoSitePlusiQ5IXF8

Expressioni

Gene expression databases

BgeeiENSMUSG00000049928 Expressed in 19 organ(s), highest expression level in foregut-midgut junction
CleanExiMM_GLP2R
ExpressionAtlasiQ5IXF8 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061560

Structurei

3D structure databases

ProteinModelPortaliQ5IXF8
SMRiQ5IXF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiQ5IXF8
KOiK04582
OMAiDDQVEGF
OrthoDBiEOG091G0NF8
PhylomeDBiQ5IXF8
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR039125 GLP2R
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF269 PTHR12011:SF269, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5IXF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLWGPGTP FLALLLLVSI KQVTTGSLLE ETVQKWAQYK ETCLKDLLEK
60 70 80 90 100
PSGVFCNGTF DKYVCWPHSF PGNVSVPCPS YLPWWNKESP GRAYRHCLAQ
110 120 130 140 150
GTWQKQENST DTWQDESECS ENHSFKQNVD HYHHTLLSTL QLMYTVGYSL
160 170 180 190 200
SLISLFLALT LFLFLRKLHC TRNYIHMNLF ASFILRALVV LVKDMVFYNS
210 220 230 240 250
YSRRPDSESG WMSYLSEISA SCRSVQVLLH YFVGTNHLWL LVEGLYLHAL
260 270 280 290 300
LEPTVLPERR LWPKYLVVGW AFPMLFVIPW IFVRASLENT GCWAVNENKK
310 320 330 340 350
IWWIIRGPIL LCVTVNFFIF LKILKLLISK FRAHQMCFRD YKYRLAKSTL
360 370 380 390 400
LLILLMGVHE FLFTFFTDDQ VQGFSRLIRL FIQLTLSSFH GFLVALQYGF
410 420 430 440 450
ASREVKAELR KTWGRFLLAR HWGCRACVLG KNFRFLGKCS KKLSEGDGAE
460 470 480 490 500
TLQKLQSSGV SSHLTAGNLR DHGAQPHRGR GAWPRASSLS ESSEGDFTLA
510
NTMEEILEES EI
Length:512
Mass (Da):59,105
Last modified:October 2, 2007 - v2
Checksum:iB7CBEE79F0267867
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BM22Q8BM22_MOUSE
Glucagon-like peptide 2 receptor
Glp2r
304Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263P → H in AAT46060 (Ref. 1) Curated1
Sequence conflicti459 – 460GV → AF in AAT46060 (Ref. 1) Curated2
Sequence conflicti485R → L in AAT46060 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605231 mRNA Translation: AAT46060.1
AL646097 Genomic DNA No translation available.
CCDSiCCDS24860.1
RefSeqiNP_783612.2, NM_175681.3
UniGeneiMm.118883

Genome annotation databases

EnsembliENSMUST00000051765; ENSMUSP00000061560; ENSMUSG00000049928
GeneIDi93896
KEGGimmu:93896
UCSCiuc007jna.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605231 mRNA Translation: AAT46060.1
AL646097 Genomic DNA No translation available.
CCDSiCCDS24860.1
RefSeqiNP_783612.2, NM_175681.3
UniGeneiMm.118883

3D structure databases

ProteinModelPortaliQ5IXF8
SMRiQ5IXF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061560

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ5IXF8

Proteomic databases

PaxDbiQ5IXF8
PRIDEiQ5IXF8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051765; ENSMUSP00000061560; ENSMUSG00000049928
GeneIDi93896
KEGGimmu:93896
UCSCiuc007jna.1 mouse

Organism-specific databases

CTDi9340
MGIiMGI:2136733 Glp2r

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiQ5IXF8
KOiK04582
OMAiDDQVEGF
OrthoDBiEOG091G0NF8
PhylomeDBiQ5IXF8
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Miscellaneous databases

ChiTaRSiGlp2r mouse
PROiPR:Q5IXF8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049928 Expressed in 19 organ(s), highest expression level in foregut-midgut junction
CleanExiMM_GLP2R
ExpressionAtlasiQ5IXF8 baseline and differential

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR039125 GLP2R
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF269 PTHR12011:SF269, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLP2R_MOUSE
AccessioniPrimary (citable) accession number: Q5IXF8
Secondary accession number(s): Q5SU65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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