UniProtKB - Q5IS48 (DVL1_PANTR)
Segment polarity protein dishevelled homolog DVL-1
DVL1
Functioni
GO - Molecular functioni
- frizzled binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: GO_Central
- intracellular signal transduction Source: InterPro
- planar cell polarity pathway involved in neural tube closure Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Segment polarity protein dishevelled homolog DVL-1Short name: Dishevelled-1 Alternative name(s): DSH homolog 1 |
Gene namesi | Name:DVL1 |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity
Cytosol
- cytosol Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145744 | 1 – 670 | Segment polarity protein dishevelled homolog DVL-1Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 194 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q5IS48 |
PRIDEi | Q5IS48 |
Interactioni
Subunit structurei
Interacts with CXXC4.
Interacts (via PDZ domain) with NXN (By similarity).
Interacts with BRD7 and INVS.
Interacts (via PDZ domain) with VANGL1 and VANGL2 (via C-terminus).
Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1.
Interacts with CYLD (By similarity).
Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers.
Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity).
Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity).
Interacts (via PDZ domain) with TMEM88.
Interacts with DCDC2.
Interacts with FOXK2 (By similarity).
Interacts with PKD1 (via extracellular domain) (By similarity).
Interacts (via PDZ domain) with CCDC88C/DAPLE; competes with CCDC88C for binding to frizzled receptor FZD7 and dissociates from CCDC88C following initiation of non-canonical Wnt signaling when CCDC88C displaces DVL1 from ligand-activated FZD7 (By similarity).
By similarityGO - Molecular functioni
- frizzled binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000055553 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 85 | DIXPROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 251 – 323 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 400 – 474 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 221 – 224 | Poly-Arg | 4 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
InParanoidi | Q5IS48 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK
60 70 80 90 100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT
110 120 130 140 150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR
160 170 180 190 200
RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST
210 220 230 240 250
SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV
260 270 280 290 300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
310 320 330 340 350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP
360 370 380 390 400
RADPVRPIDP AAWLSHTAAL TGALPRYELE EAPLTVKSDM SAVVRVMQLP
410 420 430 440 450
DSGLEIRDRM WLKITIANAV IGADVVDWLY THVEGFKERR EARKYASSLL
460 470 480 490 500
KHGFLRHTVN KITFSEQCYY VFGDLCSNLA TLNLNSGSSG ASDQDTLAPL
510 520 530 540 550
PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST GSQQSEGSKS
560 570 580 590 600
SGSTRSSRRA PGREKERRAA GAGGSGSESD HTAPSGVGSS WRERPAGQLS
610 620 630 640 650
RGSSPRSQAS ATAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG
660 670
SRQSFQKAMG NPCEFFVDIM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY665280 mRNA Translation: AAV74318.1 |
RefSeqi | NP_001012432.1, NM_001012430.1 |
Genome annotation databases
GeneIDi | 457191 |
KEGGi | ptr:457191 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY665280 mRNA Translation: AAV74318.1 |
RefSeqi | NP_001012432.1, NM_001012430.1 |
3D structure databases
SMRi | Q5IS48 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000055553 |
Proteomic databases
PaxDbi | Q5IS48 |
PRIDEi | Q5IS48 |
Genome annotation databases
GeneIDi | 457191 |
KEGGi | ptr:457191 |
Organism-specific databases
CTDi | 1855 |
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
InParanoidi | Q5IS48 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DVL1_PANTR | |
Accessioni | Q5IS48Primary (citable) accession number: Q5IS48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families