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UniProtKB - Q5IBC5 (ESP1_ARATH)

Entry version 121 (23 Feb 2022)
Sequence version 1 (15 Feb 2005)
Previous versions | rss
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Protein

Separase

Gene

ESP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves SYN1, releasing sister chromatid cohesion. Required for the release of cohesin at anaphase I and anaphase II, whereas the release of cohesin during diplotene and diakinesis occurs in a separase-independent process. Essential for embryo and endosperm development. May play a role in centromeric heterochromatin structure/formation during early meiosis, non-homologous centromere association and radial microtubule system (RMS) formation. May regulate the mitosis-specific cyclin CYCB1-1.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage. EC:3.4.22.49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCell cycle, Cell division, Chromosome partition, Meiosis, Mitosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.49, 399

Protein family/group databases

MEROPS protease database

More...MEROPSi		C50.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Separase (EC:3.4.22.49)
Alternative name(s):
Protein EXTRA SPINDLE POLES
Short name:
AtESP
Protein RADIALLY SWOLLEN 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESP1
Synonyms:AESP, ESP, RSW4
Ordered Locus Names:At4g22970
ORF Names:F7H19.150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT4G22970

The Arabidopsis Information Resource

More...TAIRi		locus:2127238, AT4G22970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryo lethality. Embryos arrested at the globular stage, no cellularization of endosperm nuclei and enlargment of many nuclei and nucleoli resulting in a titan-like phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004235141 – 2180SeparaseAdd BLAST2180

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5IBC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, stems, leaves and buds.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5IBC5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5IBC5, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		13685, 1 interactor

STRING: functional protein association networks

More...STRINGi		3702.AT4G22970.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5IBC5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1937 – 2031Peptidase C50Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1252 – 1283DisorderedSequence analysisAdd BLAST32
Regioni2101 – 2125DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1849, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5IBC5

Identification of Orthologs from Complete Genome Data

More...OMAi		IVANLWE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5IBC5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005314, Peptidase_C50
IPR030397, SEPARIN_core_dom

The PANTHER Classification System

More...PANTHERi		PTHR12792, PTHR12792, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51700, SEPARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5IBC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSGDDLRL LSLIDVGDNV FSSFSDYLKP FSTLSTSRKK QDRATTIRAL 
        60         70         80         90        100
AKQFLPFLNK SISLLPKRLS VANSDKEARE SALDLFRAYE LCLDCLELVS 
       110        120        130        140        150
AQLACKPHTV QSQRLRMIHC LDVWGLYENV YTEAFKVLEK LRGSDSKSRK 
       160        170        180        190        200
SRLLPEVQDG DAEMALVVVD AVAAIFRAVA MSQQLDDKRY RKVLLLLEEV 
       210        220        230        240        250
GGWLRVLDAK VYEKLHRAMV TSMGKCAVSL VREAERFNGD LVISFCDLTV 
       260        270        280        290        300
KEHYKSALSK DRVYKFAREV LSVLFGFKDR KMSVTIDISM SVLRSLSCQF 
       310        320        330        340        350
EDESNENLME FFDLVDYCAH KFRAAGDMYC AKVSKKLNEM AAIFVEAIPQ 
       360        370        380        390        400
LNLVLRLYST GLSITVCNSK LGEIKLEDST DDWKIQAMFD DDARWQSLVS 
       410        420        430        440        450
LLGMVDSYSG DEGNQTGSSS IGGHRNYNNK THDSCKDRNK ITCWPQYVDA 
       460        470        480        490        500
LKFLCQPLAD FIYSVKRKIV LETEMSCASA HLITIHDAFL QFCDGCLFLQ 
       510        520        530        540        550
RCTSDKGDRE IANNKAFLNA AMGAFIVSLR TQLKLEISAH LVEDVIGSPW 
       560        570        580        590        600
IQSQELKYLI ATLYNIGIVL YRNKELNKAC EALKLCSKVS WRCVELHCHM 
       610        620        630        640        650
FVNQSSSSDN DLSEDAIMDF VGEACNRCAF YLDILQKCSR RKIRQNIVHI 
       660        670        680        690        700
LENWLSAEHL IRRLPGPEAI VKQWVKIERE CHTDLDAAGS CTTLYSLLSS 
       710        720        730        740        750
SQKKSKRGIG KILEQELLAY DRVLPLRSNL GQQTRIKIAD ILLKDVYVTE 
       760        770        780        790        800
DMHIERARIL IWKARMTRTS GTEHITECIC FLSEAISILG ELHHGPNEEG 
       810        820        830        840        850
SPSSHMLPIA YCLRAFCTQE ADPNSKKVFQ DISTSLNLWL RILSLDDSGD 
       860        870        880        890        900
SLPTENIIPL LYNMIDLMSV KGCTELHHHI YQLIFRLFKW KNVKLEVCLA 
       910        920        930        940        950
MLWECRRLSH ALCPSPISDA FIQTLSENCA DKSTCIDFWM DCLKDSKAKL 
       960        970        980        990       1000
IGFQQNFHDL HNKDEGPFQS DITIDDIKDA ASELISSASL SGNSSFAAAY 
      1010       1020       1030       1040       1050
LYYDLCERLI SFGKLSEALS YAKEAYRIRT LIFQDKFKYT AEKHIEKHNE 
      1060       1070       1080       1090       1100
DGKISEIRTF SIKNFQVYRL LATDFWPCGN FLWDINRCYL SPWSVLQCYL 
      1110       1120       1130       1140       1150
ESTLQVGILN ELIGNGLEAE TILSWGKAFS CSQSLFPFVV AFSSALGNLY 
      1160       1170       1180       1190       1200
HKKQCLDLAE KELQNAKEIL IANQRDFSCV KCKLKLEVTL DKQLGDISRK 
      1210       1220       1230       1240       1250
QIDRVSQTDG FLHAESLFSA ALGKFCCSAW KSCIRSHGEE IAEEIVIDRN 
      1260       1270       1280       1290       1300
GGEGLGHNSS KTKLSIKEPP GNRGSRRGGR ANKTCLSKDQ DLISEPTSRL 
      1310       1320       1330       1340       1350
TRSMRHSLRE QCQNRSNVPE VVSKKPNLCD RSVGSRGERV LLDTSNALPG 
      1360       1370       1380       1390       1400
FCICYKEKRQ QCLSEEVTES GSLNNLVSLK WELCHRKLAS SILVSLGKCL 
      1410       1420       1430       1440       1450
GDSGRIHLAH EALLHSISVL FKSTWSSHNQ PSVSQLLEFI GKEVTRDVFA 
      1460       1470       1480       1490       1500
VDRAIILYNL CWLNLRNYHC RKSRSICCDL FHIPFTKLVS WLMLAFVLSG 
      1510       1520       1530       1540       1550
EVPILFQKVS RLLASLYLLS SSNSEFTFES DGNELSASHW VSFFHQASLG 
      1560       1570       1580       1590       1600
THLSYHFISN LSQKHKSQCL SDKECTEATC SSCMVPEDLD LPRLAPDRTQ 
      1610       1620       1630       1640       1650
DLVQFAKEFF INLPSSTIIC ISLLGGALNQ LLQELMHIRS PVCAWVLISR 
      1660       1670       1680       1690       1700
LNPESQPVAT LLPVDSIVED MSDDSANLSS TEATQVKSLK GPWLCPWGTT 
      1710       1720       1730       1740       1750
VVDEVAPAFK SILEESHSSS STTEEDTIES RGLWWKKRKK LNHRLGIFLR 
      1760       1770       1780       1790       1800
NLEASWLGPW RCLLLGEWSN YKLPDSAQKK LVNDLKSKCK MEVNEMLLKV 
      1810       1820       1830       1840       1850
ILGGGTDNFK GEACVAQLSL RNGCYVGRGG YLYEEDSCKT PTAASNISES 
      1860       1870       1880       1890       1900
RHELALKLIH DAASKLGQQD GHENREPIIL VLDPEVQMLP WENIPILRKQ 
      1910       1920       1930       1940       1950
EVYRMPSVGC ISAVLKKRSL QGEPAKSHVA SFPLIDPLDS FYLLNPGGDL 
      1960       1970       1980       1990       2000
TDTQVTFESW FRDQNFEGKA GSEPSAIELT EALETHDLFL YFGHGSGAQY 
      2010       2020       2030       2040       2050
IPRREIEKLD NCSATFLMGC SSGSLWLKGC YIPQGVPLSY LLGGSPAIVA 
      2060       2070       2080       2090       2100
TLWDVTDRDI DRFGKALLEA WLQERSDSSS EGGCSQCESL ANDLAAMTLK 
      2110       2120       2130       2140       2150
GTKRSRKPSS RNKPAQSDVD GSGKIECNHK HRRKIGSFIA AARDACNLQY 
      2160       2170       2180
LIGAAPVCYG VPTGITRKKG IDALLPSSSR
Length:2,180
Mass (Da):244,847
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF8E09DA382A9725
GO
Isoform 2 (identifier: Q5IBC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1670-1672: Missing.

Show »
Length:2,177
Mass (Da):244,514
Checksum:i4F0B1E296B5A7AF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B3N4A0A1P8B3N4_ARATH
Separase
ESP AESP, EXTRA SPINDLE POLES, homolog of separase, RADIALLY SWOLLEN 4, RSW4
2,181Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA19812 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79252 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0479341670 – 1672Missing in isoform 2. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY823256 mRNA Translation: AAW32909.1
AL031018 Genomic DNA Translation: CAA19812.1 Sequence problems.
AL161558 Genomic DNA Translation: CAB79252.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84686.1
CP002687 Genomic DNA Translation: AEE84687.1

Protein sequence database of the Protein Information Resource

More...PIRi		T05128

NCBI Reference Sequences

More...RefSeqi		NP_001190804.1, NM_001203875.2 [Q5IBC5-2]
NP_194028.2, NM_118426.4 [Q5IBC5-1]

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		828396

Gramene; a comparative resource for plants

More...Gramenei		AT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT4G22970

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823256 mRNA Translation: AAW32909.1
AL031018 Genomic DNA Translation: CAA19812.1 Sequence problems.
AL161558 Genomic DNA Translation: CAB79252.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84686.1
CP002687 Genomic DNA Translation: AEE84687.1
PIRiT05128
RefSeqiNP_001190804.1, NM_001203875.2 [Q5IBC5-2]
NP_194028.2, NM_118426.4 [Q5IBC5-1]

3D structure databases

SMRiQ5IBC5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi13685, 1 interactor
STRINGi3702.AT4G22970.1

Protein family/group databases

MEROPSiC50.005

Proteomic databases

PaxDbiQ5IBC5

Genome annotation databases

EnsemblPlantsiAT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]
GeneIDi828396
GrameneiAT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]
KEGGiath:AT4G22970

Organism-specific databases

AraportiAT4G22970
TAIRilocus:2127238, AT4G22970

Phylogenomic databases

eggNOGiKOG1849, Eukaryota
InParanoidiQ5IBC5
OMAiIVANLWE
PhylomeDBiQ5IBC5

Enzyme and pathway databases

BRENDAi3.4.22.49, 399

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q5IBC5

Gene expression databases

ExpressionAtlasiQ5IBC5, baseline and differential
GenevisibleiQ5IBC5, AT

Family and domain databases

InterProiView protein in InterPro
IPR005314, Peptidase_C50
IPR030397, SEPARIN_core_dom
PANTHERiPTHR12792, PTHR12792, 1 hit
PROSITEiView protein in PROSITE
PS51700, SEPARIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5IBC5
Secondary accession number(s): F4JMQ3, O82745
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: February 15, 2005
Last modified: February 23, 2022
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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