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Entry version 121 (23 Feb 2022)
Sequence version 1 (15 Feb 2005)
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Protein

Separase

Gene

ESP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves SYN1, releasing sister chromatid cohesion. Required for the release of cohesin at anaphase I and anaphase II, whereas the release of cohesin during diplotene and diakinesis occurs in a separase-independent process. Essential for embryo and endosperm development. May play a role in centromeric heterochromatin structure/formation during early meiosis, non-homologous centromere association and radial microtubule system (RMS) formation. May regulate the mitosis-specific cyclin CYCB1-1.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage. EC:3.4.22.49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCell cycle, Cell division, Chromosome partition, Meiosis, Mitosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.49, 399

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C50.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Separase (EC:3.4.22.49)
Alternative name(s):
Protein EXTRA SPINDLE POLES
Short name:
AtESP
Protein RADIALLY SWOLLEN 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESP1
Synonyms:AESP, ESP, RSW4
Ordered Locus Names:At4g22970
ORF Names:F7H19.150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G22970

The Arabidopsis Information Resource

More...
TAIRi
locus:2127238, AT4G22970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryo lethality. Embryos arrested at the globular stage, no cellularization of endosperm nuclei and enlargment of many nuclei and nucleoli resulting in a titan-like phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004235141 – 2180SeparaseAdd BLAST2180

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5IBC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, stems, leaves and buds.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5IBC5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5IBC5, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
13685, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT4G22970.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5IBC5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1937 – 2031Peptidase C50Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1252 – 1283DisorderedSequence analysisAdd BLAST32
Regioni2101 – 2125DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1849, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5IBC5

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVANLWE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5IBC5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005314, Peptidase_C50
IPR030397, SEPARIN_core_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12792, PTHR12792, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51700, SEPARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5IBC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSGDDLRL LSLIDVGDNV FSSFSDYLKP FSTLSTSRKK QDRATTIRAL
60 70 80 90 100
AKQFLPFLNK SISLLPKRLS VANSDKEARE SALDLFRAYE LCLDCLELVS
110 120 130 140 150
AQLACKPHTV QSQRLRMIHC LDVWGLYENV YTEAFKVLEK LRGSDSKSRK
160 170 180 190 200
SRLLPEVQDG DAEMALVVVD AVAAIFRAVA MSQQLDDKRY RKVLLLLEEV
210 220 230 240 250
GGWLRVLDAK VYEKLHRAMV TSMGKCAVSL VREAERFNGD LVISFCDLTV
260 270 280 290 300
KEHYKSALSK DRVYKFAREV LSVLFGFKDR KMSVTIDISM SVLRSLSCQF
310 320 330 340 350
EDESNENLME FFDLVDYCAH KFRAAGDMYC AKVSKKLNEM AAIFVEAIPQ
360 370 380 390 400
LNLVLRLYST GLSITVCNSK LGEIKLEDST DDWKIQAMFD DDARWQSLVS
410 420 430 440 450
LLGMVDSYSG DEGNQTGSSS IGGHRNYNNK THDSCKDRNK ITCWPQYVDA
460 470 480 490 500
LKFLCQPLAD FIYSVKRKIV LETEMSCASA HLITIHDAFL QFCDGCLFLQ
510 520 530 540 550
RCTSDKGDRE IANNKAFLNA AMGAFIVSLR TQLKLEISAH LVEDVIGSPW
560 570 580 590 600
IQSQELKYLI ATLYNIGIVL YRNKELNKAC EALKLCSKVS WRCVELHCHM
610 620 630 640 650
FVNQSSSSDN DLSEDAIMDF VGEACNRCAF YLDILQKCSR RKIRQNIVHI
660 670 680 690 700
LENWLSAEHL IRRLPGPEAI VKQWVKIERE CHTDLDAAGS CTTLYSLLSS
710 720 730 740 750
SQKKSKRGIG KILEQELLAY DRVLPLRSNL GQQTRIKIAD ILLKDVYVTE
760 770 780 790 800
DMHIERARIL IWKARMTRTS GTEHITECIC FLSEAISILG ELHHGPNEEG
810 820 830 840 850
SPSSHMLPIA YCLRAFCTQE ADPNSKKVFQ DISTSLNLWL RILSLDDSGD
860 870 880 890 900
SLPTENIIPL LYNMIDLMSV KGCTELHHHI YQLIFRLFKW KNVKLEVCLA
910 920 930 940 950
MLWECRRLSH ALCPSPISDA FIQTLSENCA DKSTCIDFWM DCLKDSKAKL
960 970 980 990 1000
IGFQQNFHDL HNKDEGPFQS DITIDDIKDA ASELISSASL SGNSSFAAAY
1010 1020 1030 1040 1050
LYYDLCERLI SFGKLSEALS YAKEAYRIRT LIFQDKFKYT AEKHIEKHNE
1060 1070 1080 1090 1100
DGKISEIRTF SIKNFQVYRL LATDFWPCGN FLWDINRCYL SPWSVLQCYL
1110 1120 1130 1140 1150
ESTLQVGILN ELIGNGLEAE TILSWGKAFS CSQSLFPFVV AFSSALGNLY
1160 1170 1180 1190 1200
HKKQCLDLAE KELQNAKEIL IANQRDFSCV KCKLKLEVTL DKQLGDISRK
1210 1220 1230 1240 1250
QIDRVSQTDG FLHAESLFSA ALGKFCCSAW KSCIRSHGEE IAEEIVIDRN
1260 1270 1280 1290 1300
GGEGLGHNSS KTKLSIKEPP GNRGSRRGGR ANKTCLSKDQ DLISEPTSRL
1310 1320 1330 1340 1350
TRSMRHSLRE QCQNRSNVPE VVSKKPNLCD RSVGSRGERV LLDTSNALPG
1360 1370 1380 1390 1400
FCICYKEKRQ QCLSEEVTES GSLNNLVSLK WELCHRKLAS SILVSLGKCL
1410 1420 1430 1440 1450
GDSGRIHLAH EALLHSISVL FKSTWSSHNQ PSVSQLLEFI GKEVTRDVFA
1460 1470 1480 1490 1500
VDRAIILYNL CWLNLRNYHC RKSRSICCDL FHIPFTKLVS WLMLAFVLSG
1510 1520 1530 1540 1550
EVPILFQKVS RLLASLYLLS SSNSEFTFES DGNELSASHW VSFFHQASLG
1560 1570 1580 1590 1600
THLSYHFISN LSQKHKSQCL SDKECTEATC SSCMVPEDLD LPRLAPDRTQ
1610 1620 1630 1640 1650
DLVQFAKEFF INLPSSTIIC ISLLGGALNQ LLQELMHIRS PVCAWVLISR
1660 1670 1680 1690 1700
LNPESQPVAT LLPVDSIVED MSDDSANLSS TEATQVKSLK GPWLCPWGTT
1710 1720 1730 1740 1750
VVDEVAPAFK SILEESHSSS STTEEDTIES RGLWWKKRKK LNHRLGIFLR
1760 1770 1780 1790 1800
NLEASWLGPW RCLLLGEWSN YKLPDSAQKK LVNDLKSKCK MEVNEMLLKV
1810 1820 1830 1840 1850
ILGGGTDNFK GEACVAQLSL RNGCYVGRGG YLYEEDSCKT PTAASNISES
1860 1870 1880 1890 1900
RHELALKLIH DAASKLGQQD GHENREPIIL VLDPEVQMLP WENIPILRKQ
1910 1920 1930 1940 1950
EVYRMPSVGC ISAVLKKRSL QGEPAKSHVA SFPLIDPLDS FYLLNPGGDL
1960 1970 1980 1990 2000
TDTQVTFESW FRDQNFEGKA GSEPSAIELT EALETHDLFL YFGHGSGAQY
2010 2020 2030 2040 2050
IPRREIEKLD NCSATFLMGC SSGSLWLKGC YIPQGVPLSY LLGGSPAIVA
2060 2070 2080 2090 2100
TLWDVTDRDI DRFGKALLEA WLQERSDSSS EGGCSQCESL ANDLAAMTLK
2110 2120 2130 2140 2150
GTKRSRKPSS RNKPAQSDVD GSGKIECNHK HRRKIGSFIA AARDACNLQY
2160 2170 2180
LIGAAPVCYG VPTGITRKKG IDALLPSSSR
Length:2,180
Mass (Da):244,847
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF8E09DA382A9725
GO
Isoform 2 (identifier: Q5IBC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1670-1672: Missing.

Show »
Length:2,177
Mass (Da):244,514
Checksum:i4F0B1E296B5A7AF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B3N4A0A1P8B3N4_ARATH
Separase
ESP AESP, EXTRA SPINDLE POLES, homolog of separase, RADIALLY SWOLLEN 4, RSW4
2,181Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA19812 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79252 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0479341670 – 1672Missing in isoform 2. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY823256 mRNA Translation: AAW32909.1
AL031018 Genomic DNA Translation: CAA19812.1 Sequence problems.
AL161558 Genomic DNA Translation: CAB79252.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84686.1
CP002687 Genomic DNA Translation: AEE84687.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T05128

NCBI Reference Sequences

More...
RefSeqi
NP_001190804.1, NM_001203875.2 [Q5IBC5-2]
NP_194028.2, NM_118426.4 [Q5IBC5-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
828396

Gramene; a comparative resource for plants

More...
Gramenei
AT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G22970

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823256 mRNA Translation: AAW32909.1
AL031018 Genomic DNA Translation: CAA19812.1 Sequence problems.
AL161558 Genomic DNA Translation: CAB79252.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84686.1
CP002687 Genomic DNA Translation: AEE84687.1
PIRiT05128
RefSeqiNP_001190804.1, NM_001203875.2 [Q5IBC5-2]
NP_194028.2, NM_118426.4 [Q5IBC5-1]

3D structure databases

SMRiQ5IBC5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi13685, 1 interactor
STRINGi3702.AT4G22970.1

Protein family/group databases

MEROPSiC50.005

Proteomic databases

PaxDbiQ5IBC5

Genome annotation databases

EnsemblPlantsiAT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]
GeneIDi828396
GrameneiAT4G22970.1; AT4G22970.1; AT4G22970 [Q5IBC5-1]
AT4G22970.2; AT4G22970.2; AT4G22970 [Q5IBC5-2]
KEGGiath:AT4G22970

Organism-specific databases

AraportiAT4G22970
TAIRilocus:2127238, AT4G22970

Phylogenomic databases

eggNOGiKOG1849, Eukaryota
InParanoidiQ5IBC5
OMAiIVANLWE
PhylomeDBiQ5IBC5

Enzyme and pathway databases

BRENDAi3.4.22.49, 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5IBC5

Gene expression databases

ExpressionAtlasiQ5IBC5, baseline and differential
GenevisibleiQ5IBC5, AT

Family and domain databases

InterProiView protein in InterPro
IPR005314, Peptidase_C50
IPR030397, SEPARIN_core_dom
PANTHERiPTHR12792, PTHR12792, 1 hit
PROSITEiView protein in PROSITE
PS51700, SEPARIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5IBC5
Secondary accession number(s): F4JMQ3, O82745
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: February 15, 2005
Last modified: February 23, 2022
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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