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Protein

RelA-associated inhibitor

Gene

Ppp1r13l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6804759 Regulation of TP53 Activity through Association with Co-factors

Names & Taxonomyi

Protein namesi
Recommended name:
RelA-associated inhibitor
Alternative name(s):
Inhibitor of ASPP protein
Short name:
Protein iASPP
NFkB-interacting protein 1
PPP1R13B-like protein
Gene namesi
Name:Ppp1r13lImported
Synonyms:Nkip11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3525053 Ppp1r13l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Ppp1r13l are the cause of the waved 3 phenotype, a recessive mutation characterized by abnormalities of the heart and skin. Affected animals have open eyes at birth and hair abnormalities. They develop focal cardiac necrosis at an early age which progresses to fatal dilated cardiomyopathy. This is due to a 14-bp deletion which gives rise to a truncated protein.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669671 – 824RelA-associated inhibitorAdd BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei119PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei123PhosphothreonineCombined sources1
Modified residuei134PhosphoserineBy similarity1
Modified residuei137Omega-N-methylarginineCombined sources1
Modified residuei142Omega-N-methylarginineCombined sources1
Modified residuei144Omega-N-methylarginineCombined sources1
Modified residuei160Omega-N-methylarginineCombined sources1
Modified residuei167Omega-N-methylarginineCombined sources1
Modified residuei180Omega-N-methylarginineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei205Omega-N-methylarginineCombined sources1
Modified residuei275PhosphothreonineCombined sources1
Modified residuei279PhosphoserineBy similarity1
Modified residuei307PhosphothreonineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Modified residuei340PhosphothreonineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei563PhosphoserineBy similarity1
Modified residuei593PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ5I1X5
MaxQBiQ5I1X5
PaxDbiQ5I1X5
PRIDEiQ5I1X5

PTM databases

iPTMnetiQ5I1X5
PhosphoSitePlusiQ5I1X5

Expressioni

Tissue specificityi

Most abundant in skin with high levels also found in heart, testis and stomach. In E15.5 embryonic heart, expressed at higher levels in atria than ventricles.1 Publication

Gene expression databases

BgeeiENSMUSG00000040734 Expressed in 189 organ(s), highest expression level in ear
ExpressionAtlasiQ5I1X5 baseline and differential
GenevisibleiQ5I1X5 MM

Interactioni

Subunit structurei

Interacts with TP63 and TP73 (By similarity). Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminal part. Interacts with p53/TP53.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237177, 1 interactor
IntActiQ5I1X5, 1 interactor
STRINGi10090.ENSMUSP00000047839

Structurei

3D structure databases

ProteinModelPortaliQ5I1X5
SMRiQ5I1X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati655 – 684ANK 1Sequence analysisAdd BLAST30
Repeati688 – 717ANK 2Sequence analysisAdd BLAST30
Domaini754 – 816SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 598Pro-richSequence analysisAdd BLAST545

Domaini

The N-terminal region is required for cytoplasmic localization.By similarity

Sequence similaritiesi

Belongs to the iASPP family.Sequence analysis

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000112990
HOVERGENiHBG055210
InParanoidiQ5I1X5
OMAiSDWWWAS
OrthoDBiEOG091G0R1R
PhylomeDBiQ5I1X5
TreeFamiTF105545

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028320 iASPP
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24164 PTHR24164, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5I1X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSEAFQHAR DLLDLNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW
60 70 80 90 100
SDSPAPPGAQ AGVPSRMARY STSPVPEHFG SRGSPQKIAT DGIEARFGRS
110 120 130 140 150
ESAPSLHPYS PLSPKGRPSS PRTPIYLQPD TYSSLDRAPS PRPRAFDGAG
160 170 180 190 200
SPHGRAPSPR PGIGPVRQPG PSTPFDYLGR AGSPRGSPLA EGPQAFFPER
210 220 230 240 250
GPSPRPPAAA YDTAGTFGSP LLGAGGSAFT PPLRAQDDST LRRRPPKAWN
260 270 280 290 300
ESDLDVAYEK KSSQTASYER LDVFTRPASP GLQLLPWRES SLDGLGASGK
310 320 330 340 350
DHLTSATLPR NYKVSPLASD RRSDVGSYRR SLGSAGPSGT LPRSWQPVSR
360 370 380 390 400
IPMPPSSPQP RSTPRQRPIP LSMIFKLQNA FWEHGAGRAV LPGSPIFSRA
410 420 430 440 450
PPPKLPPQPP PQPQMQPQPQ PQPQMQPQSQ AQPQTPAPQQ TWSPMNEGLL
460 470 480 490 500
KSPAELEPEP ELEVLLAPVE EAGDADEGTV TRPLSPTRLQ PALPPEAQTV
510 520 530 540 550
PELEEVARVL AEIPRPLKRR GSMEQSPAVA LPPTHKKQYQ QIINRLFHRH
560 570 580 590 600
GGPGPGGPEP ELSTITEGSE ARAGPPAPAP PAPIPPPAPP QSSPPEQPQS
610 620 630 640 650
MEMRSVLRKV GSPRKARRAR LNPLVLLLDA ALTGELDVVQ QAVKEMNDPS
660 670 680 690 700
QPNEEGITAL HNAICGANYP IVDFLIAAGA NVNSPDSHGW TPLHCAASCN
710 720 730 740 750
DTAICTALVQ HGAAIFATTL SDGATAIEKC DPYREGYADC ATYLADVEQS
760 770 780 790 800
MGLMHNGVVY ALWDYSAEFG DELSFREGES VTVLRRDGPE ETDWWWASLH
810 820
GQEGYVPRNY FGLFPRVKSQ RSKI
Length:824
Mass (Da):88,976
Last modified:February 15, 2005 - v1
Checksum:i57AC88589BC8AA8B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVH2D3YVH2_MOUSE
RelA-associated inhibitor
Ppp1r13l
114Annotation score:
D3YXE7D3YXE7_MOUSE
RelA-associated inhibitor
Ppp1r13l
105Annotation score:
D3Z5Q5D3Z5Q5_MOUSE
RelA-associated inhibitor
Ppp1r13l
112Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY869711 mRNA Translation: AAW51145.1
CCDSiCCDS20899.1
RefSeqiNP_001010836.1, NM_001010836.3
XP_006540189.1, XM_006540126.1
XP_006540190.1, XM_006540127.3
XP_006540191.1, XM_006540128.2
XP_006540192.1, XM_006540129.1
UniGeneiMm.333640

Genome annotation databases

EnsembliENSMUST00000047621; ENSMUSP00000047839; ENSMUSG00000040734
GeneIDi333654
KEGGimmu:333654
UCSCiuc009flo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY869711 mRNA Translation: AAW51145.1
CCDSiCCDS20899.1
RefSeqiNP_001010836.1, NM_001010836.3
XP_006540189.1, XM_006540126.1
XP_006540190.1, XM_006540127.3
XP_006540191.1, XM_006540128.2
XP_006540192.1, XM_006540129.1
UniGeneiMm.333640

3D structure databases

ProteinModelPortaliQ5I1X5
SMRiQ5I1X5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237177, 1 interactor
IntActiQ5I1X5, 1 interactor
STRINGi10090.ENSMUSP00000047839

PTM databases

iPTMnetiQ5I1X5
PhosphoSitePlusiQ5I1X5

Proteomic databases

EPDiQ5I1X5
MaxQBiQ5I1X5
PaxDbiQ5I1X5
PRIDEiQ5I1X5

Protocols and materials databases

DNASUi333654
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047621; ENSMUSP00000047839; ENSMUSG00000040734
GeneIDi333654
KEGGimmu:333654
UCSCiuc009flo.1 mouse

Organism-specific databases

CTDi10848
MGIiMGI:3525053 Ppp1r13l

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000112990
HOVERGENiHBG055210
InParanoidiQ5I1X5
OMAiSDWWWAS
OrthoDBiEOG091G0R1R
PhylomeDBiQ5I1X5
TreeFamiTF105545

Enzyme and pathway databases

ReactomeiR-MMU-6804759 Regulation of TP53 Activity through Association with Co-factors

Miscellaneous databases

ChiTaRSiPpp1r13l mouse
PROiPR:Q5I1X5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040734 Expressed in 189 organ(s), highest expression level in ear
ExpressionAtlasiQ5I1X5 baseline and differential
GenevisibleiQ5I1X5 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028320 iASPP
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24164 PTHR24164, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIASPP_MOUSE
AccessioniPrimary (citable) accession number: Q5I1X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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