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Entry version 127 (02 Jun 2021)
Sequence version 1 (15 Feb 2005)
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Protein

RelA-associated inhibitor

Gene

Ppp1r13l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6804759, Regulation of TP53 Activity through Association with Co-factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RelA-associated inhibitor
Alternative name(s):
Inhibitor of ASPP protein
Short name:
Protein iASPP
NFkB-interacting protein 1
PPP1R13B-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppp1r13lImported
Synonyms:Nkip11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3525053, Ppp1r13l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Ppp1r13l are the cause of the waved 3 phenotype, a recessive mutation characterized by abnormalities of the heart and skin. Affected animals have open eyes at birth and hair abnormalities. They develop focal cardiac necrosis at an early age which progresses to fatal dilated cardiomyopathy. This is due to a 14-bp deletion which gives rise to a truncated protein.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669671 – 824RelA-associated inhibitorAdd BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei119PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei123PhosphothreonineCombined sources1
Modified residuei134PhosphoserineBy similarity1
Modified residuei137Omega-N-methylarginineCombined sources1
Modified residuei142Omega-N-methylarginineCombined sources1
Modified residuei144Omega-N-methylarginineCombined sources1
Modified residuei160Omega-N-methylarginineCombined sources1
Modified residuei167Omega-N-methylarginineCombined sources1
Modified residuei180Omega-N-methylarginineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei205Omega-N-methylarginineCombined sources1
Modified residuei275PhosphothreonineCombined sources1
Modified residuei279PhosphoserineBy similarity1
Modified residuei307PhosphothreonineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Modified residuei340PhosphothreonineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei563PhosphoserineBy similarity1
Modified residuei593PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5I1X5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5I1X5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5I1X5

PRoteomics IDEntifications database

More...
PRIDEi
Q5I1X5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
267079

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5I1X5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5I1X5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundant in skin with high levels also found in heart, testis and stomach. In E15.5 embryonic heart, expressed at higher levels in atria than ventricles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040734, Expressed in ear and 218 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5I1X5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TP63 and TP73 (By similarity).

Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminal part.

Interacts (via SH3 domain and ANK repeats) with p53/TP53; the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
237177, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5I1X5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047839

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5I1X5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5I1X5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati655 – 684ANK 1Sequence analysisAdd BLAST30
Repeati688 – 717ANK 2Sequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini754 – 816SH3PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni48 – 87DisorderedSequence analysisAdd BLAST40
Regioni99 – 271DisorderedSequence analysisAdd BLAST173
Regioni291 – 370DisorderedSequence analysisAdd BLAST80
Regioni388 – 501DisorderedSequence analysisAdd BLAST114
Regioni547 – 614DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 258Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi348 – 365Pro residuesSequence analysisAdd BLAST18
Compositional biasi396 – 426Pro residuesSequence analysisAdd BLAST31
Compositional biasi427 – 447Polar residuesSequence analysisAdd BLAST21
Compositional biasi574 – 596Pro residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region is required for cytoplasmic localization.By similarity
The ANK repeats and the SH3 domain are required for specific interactions with p53/TP53.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the iASPP family.Sequence analysis

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0515, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019814_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5I1X5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAFWEQG

Database of Orthologous Groups

More...
OrthoDBi
1041229at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5I1X5

TreeFam database of animal gene trees

More...
TreeFami
TF105545

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11952, SH3_iASPP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR028320, iASPP
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR042722, SH3_iASPP

The PANTHER Classification System

More...
PANTHERi
PTHR24164, PTHR24164, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF14604, SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5I1X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSEAFQHAR DLLDLNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW
60 70 80 90 100
SDSPAPPGAQ AGVPSRMARY STSPVPEHFG SRGSPQKIAT DGIEARFGRS
110 120 130 140 150
ESAPSLHPYS PLSPKGRPSS PRTPIYLQPD TYSSLDRAPS PRPRAFDGAG
160 170 180 190 200
SPHGRAPSPR PGIGPVRQPG PSTPFDYLGR AGSPRGSPLA EGPQAFFPER
210 220 230 240 250
GPSPRPPAAA YDTAGTFGSP LLGAGGSAFT PPLRAQDDST LRRRPPKAWN
260 270 280 290 300
ESDLDVAYEK KSSQTASYER LDVFTRPASP GLQLLPWRES SLDGLGASGK
310 320 330 340 350
DHLTSATLPR NYKVSPLASD RRSDVGSYRR SLGSAGPSGT LPRSWQPVSR
360 370 380 390 400
IPMPPSSPQP RSTPRQRPIP LSMIFKLQNA FWEHGAGRAV LPGSPIFSRA
410 420 430 440 450
PPPKLPPQPP PQPQMQPQPQ PQPQMQPQSQ AQPQTPAPQQ TWSPMNEGLL
460 470 480 490 500
KSPAELEPEP ELEVLLAPVE EAGDADEGTV TRPLSPTRLQ PALPPEAQTV
510 520 530 540 550
PELEEVARVL AEIPRPLKRR GSMEQSPAVA LPPTHKKQYQ QIINRLFHRH
560 570 580 590 600
GGPGPGGPEP ELSTITEGSE ARAGPPAPAP PAPIPPPAPP QSSPPEQPQS
610 620 630 640 650
MEMRSVLRKV GSPRKARRAR LNPLVLLLDA ALTGELDVVQ QAVKEMNDPS
660 670 680 690 700
QPNEEGITAL HNAICGANYP IVDFLIAAGA NVNSPDSHGW TPLHCAASCN
710 720 730 740 750
DTAICTALVQ HGAAIFATTL SDGATAIEKC DPYREGYADC ATYLADVEQS
760 770 780 790 800
MGLMHNGVVY ALWDYSAEFG DELSFREGES VTVLRRDGPE ETDWWWASLH
810 820
GQEGYVPRNY FGLFPRVKSQ RSKI
Length:824
Mass (Da):88,976
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57AC88589BC8AA8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVH2D3YVH2_MOUSE
RelA-associated inhibitor
Ppp1r13l
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXE7D3YXE7_MOUSE
RelA-associated inhibitor
Ppp1r13l
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5Q5D3Z5Q5_MOUSE
RelA-associated inhibitor
Ppp1r13l
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY869711 mRNA Translation: AAW51145.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20899.1

NCBI Reference Sequences

More...
RefSeqi
NP_001010836.1, NM_001010836.3
XP_006540189.1, XM_006540126.1
XP_006540190.1, XM_006540127.3
XP_006540191.1, XM_006540128.2
XP_006540192.1, XM_006540129.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047621; ENSMUSP00000047839; ENSMUSG00000040734

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
333654

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:333654

UCSC genome browser

More...
UCSCi
uc009flo.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY869711 mRNA Translation: AAW51145.1
CCDSiCCDS20899.1
RefSeqiNP_001010836.1, NM_001010836.3
XP_006540189.1, XM_006540126.1
XP_006540190.1, XM_006540127.3
XP_006540191.1, XM_006540128.2
XP_006540192.1, XM_006540129.1

3D structure databases

SMRiQ5I1X5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi237177, 2 interactors
IntActiQ5I1X5, 1 interactor
STRINGi10090.ENSMUSP00000047839

PTM databases

iPTMnetiQ5I1X5
PhosphoSitePlusiQ5I1X5

Proteomic databases

EPDiQ5I1X5
MaxQBiQ5I1X5
PaxDbiQ5I1X5
PRIDEiQ5I1X5
ProteomicsDBi267079

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31307, 254 antibodies

The DNASU plasmid repository

More...
DNASUi
333654

Genome annotation databases

EnsembliENSMUST00000047621; ENSMUSP00000047839; ENSMUSG00000040734
GeneIDi333654
KEGGimmu:333654
UCSCiuc009flo.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10848
MGIiMGI:3525053, Ppp1r13l

Phylogenomic databases

eggNOGiKOG0515, Eukaryota
GeneTreeiENSGT00940000160551
HOGENOMiCLU_019814_0_0_1
InParanoidiQ5I1X5
OMAiNAFWEQG
OrthoDBi1041229at2759
PhylomeDBiQ5I1X5
TreeFamiTF105545

Enzyme and pathway databases

ReactomeiR-MMU-6804759, Regulation of TP53 Activity through Association with Co-factors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
333654, 0 hits in 52 CRISPR screens

Protein Ontology

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PROi
PR:Q5I1X5
RNActiQ5I1X5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000040734, Expressed in ear and 218 other tissues
GenevisibleiQ5I1X5, MM

Family and domain databases

CDDicd11952, SH3_iASPP, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR028320, iASPP
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR042722, SH3_iASPP
PANTHERiPTHR24164, PTHR24164, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF14604, SH3_9, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIASPP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5I1X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 15, 2005
Last modified: June 2, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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