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Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene

Slc38a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.By similarity

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • amino acid transmembrane transport Source: GO_Central
  • bone development Source: MGI
  • sodium ion transport Source: UniProtKB-KW

Keywordsi

Biological processAmino-acid transport, Ion transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919305 Slc38a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 31HelicalSequence analysisAdd BLAST23
Transmembranei36 – 58HelicalSequence analysisAdd BLAST23
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189761 – 1090Putative sodium-coupled neutral amino acid transporter 10Add BLAST1090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei441PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei769PhosphothreonineBy similarity1
Modified residuei887PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5I012
PeptideAtlasiQ5I012
PRIDEiQ5I012

PTM databases

iPTMnetiQ5I012
PhosphoSitePlusiQ5I012

Expressioni

Gene expression databases

BgeeiENSMUSG00000061306 Expressed in 328 organ(s), highest expression level in prostate gland
CleanExiMM_SLC38A10
ExpressionAtlasiQ5I012 baseline and differential
GenevisibleiQ5I012 MM

Interactioni

Protein-protein interaction databases

BioGridi215121, 1 interactor
STRINGi10090.ENSMUSP00000099307

Structurei

3D structure databases

ProteinModelPortaliQ5I012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOVERGENiHBG097690
InParanoidiQ5I012
KOiK14996
OMAiIGDIGPH
PhylomeDBiQ5I012
TreeFamiTF320116

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5I012-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAASTSKWG LITNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT
60 70 80 90 100
HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF
110 120 130 140 150
YVVIGDLGSN FFAPLLGLQV TRTVRVFLLF AVSLFIVLPL SLQRNMMASI
160 170 180 190 200
QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRQVSYIR WEGVFRCVPI
210 220 230 240 250
FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF YVMVGFFGYV
260 270 280 290 300
SFTDATTGNV LIHFPSNPVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL
310 320 330 340 350
FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG
360 370 380 390 400
ATMGSLICFI CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVTEE
410 420 430 440 450
APLDLTQEAR SGHRGDAEGA MKVEAARLSV QDPVVVVAED SQEKLKPAED
460 470 480 490 500
KEVLEQAQIK GPVDVPGGEA PKEKQEAAQL DRPGQGIAVP MGEAHRHEPP
510 520 530 540 550
IPHDKVVVDE GQDQEGPEEK KPPPRLPDEG DPAGRGQGAP PLPESEKEKQ
560 570 580 590 600
EPERGGEGKR PGQVLAVGET EHPQKVPEAN GQPPVQPRKE DSRPGNRDPQ
610 620 630 640 650
PAAQARDSVE LKALAADDGR EPAQKAGGAL WKPVESAAES DAGGKAGLPV
660 670 680 690 700
QRPEAAEQRE KKEAEQQGGD QAGSKLEAEI KKLVAEAGRA EMLDHAVLLQ
710 720 730 740 750
VIQEQQVQQK RLLDQQEKLL AVIEEQHKEI RQQRQEGEED KPKPADVQPE
760 770 780 790 800
PGVAVLRGQE EEAEHAGETL GDDPSQPLQP VLGAPRGRPA PSQDMGQHLP
810 820 830 840 850
GEVKVLPGRD LADLPAGGSE TEPQGAPIDL REDPKAAIKA AGAGKELVPG
860 870 880 890 900
DLEAVHKAAP PEVPKSPEKQ VAKAVAGQRQ DVFGEGSEER KETGKEAMAP
910 920 930 940 950
GADTQKEAVQ PLVGAEAKDT KSRQSGPTKA PVQTQAKFHP EPQAIFDTGQ
960 970 980 990 1000
GSHPEVRSEA PRAVHIPPEE QHKGKGGAAI QEAKQRPDPN SGPKLAVPAG
1010 1020 1030 1040 1050
QKPENAKPNR DLKVQAGSDL RRRRRDLASH PEQELAPKDG VIISFNSLPN
1060 1070 1080 1090
VQVNDLRSAL DTQLRQAAGA ALQVVHSRQI KQLSGDLEEA
Length:1,090
Mass (Da):117,194
Last modified:February 26, 2008 - v2
Checksum:i15321AFC6FCDBDA9
GO
Isoform 2 (identifier: Q5I012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-745: Missing.

Show »
Length:1,089
Mass (Da):117,123
Checksum:iF8094792E2952E13
GO
Isoform 3 (identifier: Q5I012-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.

Show »
Length:1,082
Mass (Da):116,341
Checksum:i9410B2CD25B4ACD5
GO
Isoform 4 (identifier: Q5I012-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.
     745-745: Missing.

Show »
Length:1,081
Mass (Da):116,270
Checksum:iBAA176D89B8452F1
GO
Isoform 5 (identifier: Q5I012-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-408: VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE → GLPTEPWLSWYSLYRPGWPRTQGSPDSHPEC
     409-1090: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):44,779
Checksum:i539548A91CDA6A99
GO
Isoform 6 (identifier: Q5I012-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-428: VVLWVGLGIL...GAMKVEAARL → DLESCRRQPS...GRAPGFISTC
     429-1090: Missing.

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):46,430
Checksum:iF6211EECE1EC0CC6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QNE8J3QNE8_MOUSE
Putative sodium-coupled neutral ami...
Slc38a10
1,090Annotation score:

Sequence cautioni

The sequence AAH43299 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295A → T in BAC27777 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031328378 – 428VVLWV…EAARL → DLESCRRQPSGRGCLGLSDM GGATLTTVPGPEVRANQRGM SGRAPGFISTC in isoform 6. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_031329378 – 408VVLWV…DLTQE → GLPTEPWLSWYSLYRPGWPR TQGSPDSHPEC in isoform 5. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_031330409 – 1090Missing in isoform 5. 1 PublicationAdd BLAST682
Alternative sequenceiVSP_031331429 – 1090Missing in isoform 6. 1 PublicationAdd BLAST662
Alternative sequenceiVSP_031332678 – 685Missing in isoform 3 and isoform 4. 2 Publications8
Alternative sequenceiVSP_031333745Missing in isoform 2 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007977 mRNA Translation: BAB25384.1
AK032245 mRNA Translation: BAC27777.1
AK090050 mRNA Translation: BAC41066.1
AK159948 mRNA Translation: BAE35504.1
AL807824 Genomic DNA No translation available.
BC043299 mRNA Translation: AAH43299.1 Different initiation.
BC082300 mRNA Translation: AAH82300.1
BC088811 mRNA Translation: AAH88811.1
CCDSiCCDS25728.1 [Q5I012-1]
CCDS49000.1 [Q5I012-3]
CCDS49001.1 [Q5I012-5]
CCDS49002.1 [Q5I012-6]
RefSeqiNP_001158270.1, NM_001164798.1 [Q5I012-2]
NP_001158271.1, NM_001164799.1 [Q5I012-3]
NP_001158272.1, NM_001164800.1 [Q5I012-4]
NP_001158273.1, NM_001164801.1 [Q5I012-6]
NP_001158274.1, NM_001164802.1 [Q5I012-5]
NP_077211.4, NM_024249.5 [Q5I012-1]
UniGeneiMm.253403

Genome annotation databases

EnsembliENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306 [Q5I012-3]
ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306 [Q5I012-6]
ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306 [Q5I012-5]
ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306 [Q5I012-1]
GeneIDi72055
KEGGimmu:72055
UCSCiuc007mrv.2 mouse [Q5I012-1]
uc007mrw.2 mouse [Q5I012-3]
uc007mrx.2 mouse [Q5I012-2]
uc007mry.2 mouse [Q5I012-4]
uc007mrz.2 mouse [Q5I012-5]
uc007msa.2 mouse [Q5I012-6]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007977 mRNA Translation: BAB25384.1
AK032245 mRNA Translation: BAC27777.1
AK090050 mRNA Translation: BAC41066.1
AK159948 mRNA Translation: BAE35504.1
AL807824 Genomic DNA No translation available.
BC043299 mRNA Translation: AAH43299.1 Different initiation.
BC082300 mRNA Translation: AAH82300.1
BC088811 mRNA Translation: AAH88811.1
CCDSiCCDS25728.1 [Q5I012-1]
CCDS49000.1 [Q5I012-3]
CCDS49001.1 [Q5I012-5]
CCDS49002.1 [Q5I012-6]
RefSeqiNP_001158270.1, NM_001164798.1 [Q5I012-2]
NP_001158271.1, NM_001164799.1 [Q5I012-3]
NP_001158272.1, NM_001164800.1 [Q5I012-4]
NP_001158273.1, NM_001164801.1 [Q5I012-6]
NP_001158274.1, NM_001164802.1 [Q5I012-5]
NP_077211.4, NM_024249.5 [Q5I012-1]
UniGeneiMm.253403

3D structure databases

ProteinModelPortaliQ5I012
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215121, 1 interactor
STRINGi10090.ENSMUSP00000099307

PTM databases

iPTMnetiQ5I012
PhosphoSitePlusiQ5I012

Proteomic databases

PaxDbiQ5I012
PeptideAtlasiQ5I012
PRIDEiQ5I012

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306 [Q5I012-3]
ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306 [Q5I012-6]
ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306 [Q5I012-5]
ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306 [Q5I012-1]
GeneIDi72055
KEGGimmu:72055
UCSCiuc007mrv.2 mouse [Q5I012-1]
uc007mrw.2 mouse [Q5I012-3]
uc007mrx.2 mouse [Q5I012-2]
uc007mry.2 mouse [Q5I012-4]
uc007mrz.2 mouse [Q5I012-5]
uc007msa.2 mouse [Q5I012-6]

Organism-specific databases

CTDi124565
MGIiMGI:1919305 Slc38a10

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOVERGENiHBG097690
InParanoidiQ5I012
KOiK14996
OMAiIGDIGPH
PhylomeDBiQ5I012
TreeFamiTF320116

Miscellaneous databases

ChiTaRSiSlc38a10 mouse
PROiPR:Q5I012
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061306 Expressed in 328 organ(s), highest expression level in prostate gland
CleanExiMM_SLC38A10
ExpressionAtlasiQ5I012 baseline and differential
GenevisibleiQ5I012 MM

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS38AA_MOUSE
AccessioniPrimary (citable) accession number: Q5I012
Secondary accession number(s): A2AMZ5
, Q3TVW4, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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