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Protein

Neurensin-2

Gene

Nrsn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in maintenance and/or transport of vesicles.1 Publication

GO - Biological processi

  • nervous system development Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-2
Gene namesi
Name:Nrsn2Imported
Synonyms:Gm123Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684969 Nrsn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705851 – 202Neurensin-2Add BLAST202

Proteomic databases

PaxDbiQ5HZK2
PRIDEiQ5HZK2

PTM databases

iPTMnetiQ5HZK2
PhosphoSitePlusiQ5HZK2

Expressioni

Tissue specificityi

Expressed specifically in brain where it is widely expressed, with highest levels of expression in thalamus and hypothalamus. In brain, found in neural cell bodies and detected in many regions of the limbic system, such as the septum nucleus, horizontal and vertical limbs of the diagonal band, hippocampus, amygdaloid nucleus, and habernula nucleus. Also localizes to small vesicles found in the perinuclear region of Neuro2a and PC12 cells.1 Publication

Developmental stagei

In cerebral cortex first detected at E15.5 with increasing levels of expression observed during postnatal stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000059361 Expressed in 83 organ(s), highest expression level in hypothalamus
CleanExiMM_NRSN2
GenevisibleiQ5HZK2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078260

Structurei

3D structure databases

ProteinModelPortaliQ5HZK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHGJ Eukaryota
ENOG4111B0E LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG080467
InParanoidiQ5HZK2
OMAiSWFSPPA
OrthoDBiEOG091G0K9J
PhylomeDBiQ5HZK2
TreeFamiTF332090

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029701 Nrsn2
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF5 PTHR14796:SF5, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HZK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCSRPCVCS HGTSVEESTW YGFDFYPNLF YNDWLGTTTL PYNPERIPIR
60 70 80 90 100
YINRPWPSLC WKVTVAVASL FLLLGVAALT TGYAVPPKLE LVNESKFSSM
110 120 130 140 150
EDPVADYNQA LMTCRVVGAT LCGVAGIMLA VCLFLIASGW MFQDIKAEPL
160 170 180 190 200
VTETDSPVEV FRDEPEKLSP AFHETSSQSP FLTPPSPFGQ QSVQTSQPQR

DL
Length:202
Mass (Da):22,415
Last modified:February 15, 2005 - v1
Checksum:i9C68F26BD372980C
GO

Sequence cautioni

The sequence BAE24271 differs from that shown. Reason: Frameshift at position 40.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140190 mRNA Translation: BAE24271.1 Frameshift.
AL928568 Genomic DNA No translation available.
BC088982 mRNA Translation: AAH88982.1
CCDSiCCDS16882.1
RefSeqiNP_001009948.1, NM_001009948.1
UniGeneiMm.330667

Genome annotation databases

EnsembliENSMUST00000079278; ENSMUSP00000078260; ENSMUSG00000059361
GeneIDi228777
KEGGimmu:228777
UCSCiuc008nfh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140190 mRNA Translation: BAE24271.1 Frameshift.
AL928568 Genomic DNA No translation available.
BC088982 mRNA Translation: AAH88982.1
CCDSiCCDS16882.1
RefSeqiNP_001009948.1, NM_001009948.1
UniGeneiMm.330667

3D structure databases

ProteinModelPortaliQ5HZK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078260

PTM databases

iPTMnetiQ5HZK2
PhosphoSitePlusiQ5HZK2

Proteomic databases

PaxDbiQ5HZK2
PRIDEiQ5HZK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079278; ENSMUSP00000078260; ENSMUSG00000059361
GeneIDi228777
KEGGimmu:228777
UCSCiuc008nfh.1 mouse

Organism-specific databases

CTDi80023
MGIiMGI:2684969 Nrsn2

Phylogenomic databases

eggNOGiENOG410IHGJ Eukaryota
ENOG4111B0E LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG080467
InParanoidiQ5HZK2
OMAiSWFSPPA
OrthoDBiEOG091G0K9J
PhylomeDBiQ5HZK2
TreeFamiTF332090

Miscellaneous databases

PROiPR:Q5HZK2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059361 Expressed in 83 organ(s), highest expression level in hypothalamus
CleanExiMM_NRSN2
GenevisibleiQ5HZK2 MM

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029701 Nrsn2
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF5 PTHR14796:SF5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRSN2_MOUSE
AccessioniPrimary (citable) accession number: Q5HZK2
Secondary accession number(s): A2AS81, Q3USR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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