UniProtKB - Q5HZI1 (MTUS1_MOUSE)
Protein
Microtubule-associated tumor suppressor 1 homolog
Gene
Mtus1
Organism
Mus musculus (Mouse)
Status
Functioni
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation.3 Publications
GO - Molecular functioni
- microtubule binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- regulation of macrophage chemotaxis Source: MGI
Keywordsi
Biological process | Cell cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Microtubule-associated tumor suppressor 1 homologAlternative name(s): AT2 receptor-binding protein Angiotensin-II type 2 receptor-interacting protein Coiled-coiled tumor suppressor gene 1 protein Mitochondrial tumor suppressor 1 homolog |
Gene namesi | Name:Mtus1 Synonyms:Atbp, Atip, Cctsg1, Kiaa1288, Mtsg1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2142572, Mtus1 |
Subcellular locationi
Golgi apparatus
Mitochondrion
- Mitochondrion By similarity
Plasma membrane
Nucleus
Note: In neurons, translocates into the nucleus after treatment with angiotensin-II.
Cytoskeleton
- microtubule cytoskeleton Source: MGI
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, Membrane, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305198 | 1 – 1210 | Microtubule-associated tumor suppressor 1 homologAdd BLAST | 1210 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 375 | PhosphoserineCombined sources | 1 | |
Modified residuei | 380 | PhosphoserineCombined sources | 1 | |
Modified residuei | 393 | PhosphoserineBy similarity | 1 | |
Modified residuei | 621 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1164 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1185 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1195 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1204 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1208 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q5HZI1 |
PaxDbi | Q5HZI1 |
PeptideAtlasi | Q5HZI1 |
PRIDEi | Q5HZI1 |
PTM databases
iPTMneti | Q5HZI1 |
PhosphoSitePlusi | Q5HZI1 |
Expressioni
Tissue specificityi
Ubiquitously expressed, with highest levels in uterus and adrenal gland.1 Publication
Interactioni
Subunit structurei
Homodimer.
Interacts with AGTR2.
Interacts with PTPN6.
3 PublicationsGO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000091252 |
Miscellaneous databases
RNActi | Q5HZI1, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 876 – 1171 | Sequence analysisAdd BLAST | 296 |
Sequence similaritiesi
Belongs to the MTUS1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QPVG, Eukaryota |
InParanoidi | Q5HZI1 |
OrthoDBi | 91479at2759 |
PhylomeDBi | Q5HZI1 |
TreeFami | TF333416 |
Family and domain databases
InterProi | View protein in InterPro IPR029786, MTUS1 |
PANTHERi | PTHR24200:SF7, PTHR24200:SF7, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5HZI1-1) [UniParc]FASTAAdd to basket
Also known as: ATBP135
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNDDNSDRTE DGSRYVFIRD KNSNPSEYYQ TSLSAQCPSV SHGDWNSDNP
60 70 80 90 100
DAMVVDYEMD PAVDSSESVS LSHQCVEELA YPEPSSDFMG KHEFTMYSEL
110 120 130 140 150
TCQSPALVNT GKPQDLHSNC DSLEAIQDEK FDPLKPCECR SDDDYACGDS
160 170 180 190 200
PEVLELKQTY GMKVDTANYT FIARHDIEQG QPLHAPGGLQ TTVRDRNALS
210 220 230 240 250
SCGRTPPHSS KMYVRGVNYN RENFENLQAT PSKTLNTTFT VISDVLMQTD
260 270 280 290 300
SPDVGVQGQN SLGNVTKEYT DGTRRGLIGE KEIQAVTLVS DGMEVPNGSA
310 320 330 340 350
SQEFYCVSED DPNSETHSHG PYAQQEMGQN LRGTLPNCHV DGECPVLVPA
360 370 380 390 400
FEKSKTRVLG SECKVTVTED PHIDSHDNDS DIQSSTEELT LRSVSGQRGS
410 420 430 440 450
PYEMGWGENG GAICTDKAGC MSTPVEQPPN LSFRLEPAEV KKYNNVENGP
460 470 480 490 500
RDAKRAPNLK GEPTNMPKPN LGKSATKTNT TVGSKVRKTE IISYPTPNFK
510 520 530 540 550
NIKAKVISRS VLQPKDTSIM KDTPSPQVTG GSSPSPGPSK HLTMMNKAPR
560 570 580 590 600
SDFKASKKAE IPINKTHKQQ FNKLITSQAA QVTTHSKNAS LGVPRTTSAT
610 620 630 640 650
KSNQENVDKT GSPHAGSETG SVAAFFQKIK GILPVKMKSS ECLEVTYVSH
660 670 680 690 700
IDQISPEKGE QDGEAPMEKQ ELGKQATNEI FESKSLLVGS APKTSTTPGR
710 720 730 740 750
SSSKPDSRSL RKTPGLKAKV GPTAACLRRK SESRTLGSDR ALSPQRIRRV
760 770 780 790 800
SGSGGHAAIN KYEEKPPKQA FQNGSGPLYL KPLVPRAHSH LLKTSPKGPS
810 820 830 840 850
RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE LAQYKTKCES
860 870 880 890 900
QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH KTLSQELVSL
910 920 930 940 950
RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR TELENRLKDL
960 970 980 990 1000
YTAECEKLQS IYIEEAEKYK TQLQEQFDNL NAAHETTKLE IEASHSEKVE
1010 1020 1030 1040 1050
LLKKTYETSL SEIKKSHEME KKSLEDLLNE KQESLEKQIN DLKSENDALN
1060 1070 1080 1090 1100
ERLKSEEQKQ LSREKANSKN PQVMYLEQEL ESLKAVLEIK NEKLHQQDMK
1110 1120 1130 1140 1150
LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR QLSTEQAALQ
1160 1170 1180 1190 1200
ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG
1210
SFSSPSISPR
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J1L9 | A0A0R4J1L9_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 1,210 | Annotation score: | ||
A0A0R4J0N9 | A0A0R4J0N9_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 440 | Annotation score: | ||
A0A0R4J147 | A0A0R4J147_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 520 | Annotation score: | ||
E9Q8N4 | E9Q8N4_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 759 | Annotation score: | ||
F6Q593 | F6Q593_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 214 | Annotation score: | ||
D3Z2H5 | D3Z2H5_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 92 | Annotation score: | ||
D3Z7B3 | D3Z7B3_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 123 | Annotation score: | ||
D3Z2Y9 | D3Z2Y9_MOUSE | Microtubule-associated tumor suppre... | Mtus1 | 38 | Annotation score: |
Sequence cautioni
The sequence AAH41777 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH42206 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98134 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 401 | P → S in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 401 | P → S in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 426 | E → K in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 426 | E → K in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 455 | R → S in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 455 | R → S in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 519 | I → V in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 519 | I → V in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 525 | S → N in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 525 | S → N in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 541 | H → Q in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 541 | H → Q in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 553 | F → L in AAH89009 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 556 | S → G in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 556 | S → G in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 600 | T → A in AAH41777 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 600 | T → A in AAH42206 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 646 | T → A in BAE25537 (PubMed:16141072).Curated | 1 | ||
Sequence conflicti | 867 | T → N in AAD49746 (PubMed:15123706).Curated | 1 | ||
Sequence conflicti | 867 | T → N in AAT45892 (PubMed:15539617).Curated | 1 | ||
Sequence conflicti | 919 | A → T in AAT45893 (PubMed:15539617).Curated | 1 | ||
Sequence conflicti | 919 | A → T in AAT45894 (PubMed:15539617).Curated | 1 | ||
Sequence conflicti | 919 | A → T in BAC26996 (PubMed:16141072).Curated | 1 | ||
Sequence conflicti | 919 | A → T in BAC27517 (PubMed:16141072).Curated | 1 | ||
Sequence conflicti | 919 | A → T in AAH43321 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 919 | A → T in AAH89009 (PubMed:15489334).Curated | 1 | ||
Isoform 2 (identifier: Q5HZI1-2) | |||||
Sequence conflicti | 22 | Missing in BAC27517 (PubMed:16141072).Curated | 1 | ||
Sequence conflicti | 29 | S → P in BAC27517 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028279 | 1 – 767 | Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST | 767 | |
Alternative sequenceiVSP_028280 | 1 – 690 | Missing in isoform 4. 2 PublicationsAdd BLAST | 690 | |
Alternative sequenceiVSP_028281 | 691 – 754 | APKTS…VSGSG → MTIPGGFRSCTETDISSTIF INSTLTPPAGSERQYDATLL ALLVVGSYSLCIIPLLATLT RKKS in isoform 4. 2 PublicationsAdd BLAST | 64 | |
Alternative sequenceiVSP_028282 | 768 – 810 | KQAFQ…TAFNS → MLLSPKFSLSTIHVRLTAKG LLRNLRLPSGLRKNTVIFHT in isoform 2 and isoform 3. 5 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_028283 | 977 – 1011 | FDNLN…ETSLS → LP in isoform 3. 1 PublicationAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF173380 mRNA Translation: AAD49746.1 AY626781 mRNA Translation: AAT45892.1 AY626782 mRNA Translation: AAT45893.1 AY626783 mRNA Translation: AAT45894.1 AY246699 mRNA Translation: AAO88908.1 AF493235 mRNA Translation: AAQ06609.1 AK129324 mRNA Translation: BAC98134.1 Different initiation. AK030510 mRNA Translation: BAC26996.1 AK031693 mRNA Translation: BAC27517.1 AK143781 mRNA Translation: BAE25537.1 BC041777 mRNA Translation: AAH41777.1 Different initiation. BC042206 mRNA Translation: AAH42206.1 Different initiation. BC043321 mRNA Translation: AAH43321.1 BC089009 mRNA Translation: AAH89009.1 |
CCDSi | CCDS40328.1 [Q5HZI1-1] CCDS40329.1 [Q5HZI1-4] CCDS40330.1 [Q5HZI1-2] |
RefSeqi | NP_001005863.1, NM_001005863.2 NP_001005864.1, NM_001005864.3 NP_001005865.2, NM_001005865.3 NP_001273342.1, NM_001286413.1 |
Genome annotation databases
GeneIDi | 102103 |
KEGGi | mmu:102103 |
UCSCi | uc009lnk.2, mouse [Q5HZI1-2] uc009lnl.2, mouse [Q5HZI1-4] uc009lnm.1, mouse [Q5HZI1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF173380 mRNA Translation: AAD49746.1 AY626781 mRNA Translation: AAT45892.1 AY626782 mRNA Translation: AAT45893.1 AY626783 mRNA Translation: AAT45894.1 AY246699 mRNA Translation: AAO88908.1 AF493235 mRNA Translation: AAQ06609.1 AK129324 mRNA Translation: BAC98134.1 Different initiation. AK030510 mRNA Translation: BAC26996.1 AK031693 mRNA Translation: BAC27517.1 AK143781 mRNA Translation: BAE25537.1 BC041777 mRNA Translation: AAH41777.1 Different initiation. BC042206 mRNA Translation: AAH42206.1 Different initiation. BC043321 mRNA Translation: AAH43321.1 BC089009 mRNA Translation: AAH89009.1 |
CCDSi | CCDS40328.1 [Q5HZI1-1] CCDS40329.1 [Q5HZI1-4] CCDS40330.1 [Q5HZI1-2] |
RefSeqi | NP_001005863.1, NM_001005863.2 NP_001005864.1, NM_001005864.3 NP_001005865.2, NM_001005865.3 NP_001273342.1, NM_001286413.1 |
3D structure databases
SMRi | Q5HZI1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000091252 |
PTM databases
iPTMneti | Q5HZI1 |
PhosphoSitePlusi | Q5HZI1 |
Proteomic databases
jPOSTi | Q5HZI1 |
PaxDbi | Q5HZI1 |
PeptideAtlasi | Q5HZI1 |
PRIDEi | Q5HZI1 |
Genome annotation databases
GeneIDi | 102103 |
KEGGi | mmu:102103 |
UCSCi | uc009lnk.2, mouse [Q5HZI1-2] uc009lnl.2, mouse [Q5HZI1-4] uc009lnm.1, mouse [Q5HZI1-1] |
Organism-specific databases
CTDi | 57509 |
MGIi | MGI:2142572, Mtus1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPVG, Eukaryota |
InParanoidi | Q5HZI1 |
OrthoDBi | 91479at2759 |
PhylomeDBi | Q5HZI1 |
TreeFami | TF333416 |
Miscellaneous databases
BioGRID-ORCSi | 102103, 1 hit in 15 CRISPR screens |
ChiTaRSi | Mtus1, mouse |
PROi | PR:Q5HZI1 |
RNActi | Q5HZI1, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR029786, MTUS1 |
PANTHERi | PTHR24200:SF7, PTHR24200:SF7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTUS1_MOUSE | |
Accessioni | Q5HZI1Primary (citable) accession number: Q5HZI1 Secondary accession number(s): Q3UP60 Q8C0C8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families