UniProtKB - Q5HZI1 (MTUS1_MOUSE)

BLAST

>sp|Q5HZI1|MTUS1_MOUSE Microtubule-associated tumor suppressor 1 homolog OS=Mus musculus OX=10090 GN=Mtus1 PE=1 SV=2
MNDDNSDRTEDGSRYVFIRDKNSNPSEYYQTSLSAQCPSVSHGDWNSDNPDAMVVDYEMD
PAVDSSESVSLSHQCVEELAYPEPSSDFMGKHEFTMYSELTCQSPALVNTGKPQDLHSNC
DSLEAIQDEKFDPLKPCECRSDDDYACGDSPEVLELKQTYGMKVDTANYTFIARHDIEQG
QPLHAPGGLQTTVRDRNALSSCGRTPPHSSKMYVRGVNYNRENFENLQATPSKTLNTTFT
VISDVLMQTDSPDVGVQGQNSLGNVTKEYTDGTRRGLIGEKEIQAVTLVSDGMEVPNGSA
SQEFYCVSEDDPNSETHSHGPYAQQEMGQNLRGTLPNCHVDGECPVLVPAFEKSKTRVLG
SECKVTVTEDPHIDSHDNDSDIQSSTEELTLRSVSGQRGSPYEMGWGENGGAICTDKAGC
MSTPVEQPPNLSFRLEPAEVKKYNNVENGPRDAKRAPNLKGEPTNMPKPNLGKSATKTNT
TVGSKVRKTEIISYPTPNFKNIKAKVISRSVLQPKDTSIMKDTPSPQVTGGSSPSPGPSK
HLTMMNKAPRSDFKASKKAEIPINKTHKQQFNKLITSQAAQVTTHSKNASLGVPRTTSAT
KSNQENVDKTGSPHAGSETGSVAAFFQKIKGILPVKMKSSECLEVTYVSHIDQISPEKGE
QDGEAPMEKQELGKQATNEIFESKSLLVGSAPKTSTTPGRSSSKPDSRSLRKTPGLKAKV
GPTAACLRRKSESRTLGSDRALSPQRIRRVSGSGGHAAINKYEEKPPKQAFQNGSGPLYL
KPLVPRAHSHLLKTSPKGPSRKSLFTAFNSVEKGRQKNPRSLCIQTQTAPDVLSSERTLE
LAQYKTKCESQSGFILHLRQLLSRGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVSL
RGELVAASSACEKLEKARADLQTAYQEFVQKLNQQHQTDRTELENRLKDLYTAECEKLQS
IYIEEAEKYKTQLQEQFDNLNAAHETTKLEIEASHSEKVELLKKTYETSLSEIKKSHEME
KKSLEDLLNEKQESLEKQINDLKSENDALNERLKSEEQKQLSREKANSKNPQVMYLEQEL
ESLKAVLEIKNEKLHQQDMKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISR
QLSTEQAALQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRNSG
SFSSPSISPR

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History
Entry version 84 (07 Nov 2018)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
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Protein

Microtubule-associated tumor suppressor 1 homolog

Gene

Mtus1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation.3 Publications

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
regulation of macrophage chemotaxis
Source: MGI
Inferred from direct assayⁱ
- 23565185

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Microtubule-associated tumor suppressor 1 homolog Alternative name(s): AT2 receptor-binding protein Angiotensin-II type 2 receptor-interacting protein Coiled-coiled tumor suppressor gene 1 protein Mitochondrial tumor suppressor 1 homolog
Gene namesⁱ	Name:Mtus1 Synonyms:Atbp, Atip, Cctsg1, Kiaa1288, Mtsg1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2142572 Mtus1

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane, Mitochondrion, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305198	1 – 1210	Microtubule-associated tumor suppressor 1 homologAdd BLAST		1210

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	375	PhosphoserineCombined sources	1
Modified residueⁱ	380	PhosphoserineCombined sources	1
Modified residueⁱ	393	PhosphoserineBy similarity	1
Modified residueⁱ	621	PhosphoserineBy similarity	1
Modified residueⁱ	1143	PhosphoserineBy similarity	1
Modified residueⁱ	1164	PhosphoserineCombined sources	1
Modified residueⁱ	1185	PhosphoserineCombined sources	1
Modified residueⁱ	1195	PhosphoserineCombined sources	1
Modified residueⁱ	1199	PhosphoserineBy similarity	1
Modified residueⁱ	1201	PhosphoserineCombined sources	1
Modified residueⁱ	1203	PhosphoserineCombined sources	1
Modified residueⁱ	1204	PhosphoserineBy similarity	1
Modified residueⁱ	1208	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q5HZI1
PeptideAtlas More...PeptideAtlasⁱ	Q5HZI1
PRIDEⁱ	Q5HZI1

PTM databases

iPTMnetⁱ	Q5HZI1
PhosphoSitePlusⁱ	Q5HZI1

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, with highest levels in uterus and adrenal gland.1 Publication

Gene expression databases

CleanExⁱ	MM_MTUS1

CleanExⁱ

MM_MTUS1

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with AGTR2. Interacts with PTPN6.3 Publications

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5HZI1
SMRⁱ	Q5HZI1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	876 – 1171	Sequence analysisAdd BLAST		296

Sequence similaritiesⁱ

Belongs to the MTUS1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IEXM Eukaryota ENOG41118DX LUCA
HOVERGENⁱ	HBG108158
InParanoidⁱ	Q5HZI1
PhylomeDBⁱ	Q5HZI1
TreeFamⁱ	TF333416

Family and domain databases

InterProⁱ	View protein in InterPro IPR029786 MTUS1
PANTHERⁱ	PTHR24200:SF7 PTHR24200:SF7, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5HZI1-1) [UniParc]FASTA Add to basket

Also known as: ATBP135

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MNDDNSDRTE DGSRYVFIRD KNSNPSEYYQ TSLSAQCPSV SHGDWNSDNP 
        60         70         80         90        100
DAMVVDYEMD PAVDSSESVS LSHQCVEELA YPEPSSDFMG KHEFTMYSEL 
       110        120        130        140        150
TCQSPALVNT GKPQDLHSNC DSLEAIQDEK FDPLKPCECR SDDDYACGDS 
       160        170        180        190        200
PEVLELKQTY GMKVDTANYT FIARHDIEQG QPLHAPGGLQ TTVRDRNALS 
       210        220        230        240        250
SCGRTPPHSS KMYVRGVNYN RENFENLQAT PSKTLNTTFT VISDVLMQTD 
       260        270        280        290        300
SPDVGVQGQN SLGNVTKEYT DGTRRGLIGE KEIQAVTLVS DGMEVPNGSA 
       310        320        330        340        350
SQEFYCVSED DPNSETHSHG PYAQQEMGQN LRGTLPNCHV DGECPVLVPA 
       360        370        380        390        400
FEKSKTRVLG SECKVTVTED PHIDSHDNDS DIQSSTEELT LRSVSGQRGS 
       410        420        430        440        450
PYEMGWGENG GAICTDKAGC MSTPVEQPPN LSFRLEPAEV KKYNNVENGP 
       460        470        480        490        500
RDAKRAPNLK GEPTNMPKPN LGKSATKTNT TVGSKVRKTE IISYPTPNFK 
       510        520        530        540        550
NIKAKVISRS VLQPKDTSIM KDTPSPQVTG GSSPSPGPSK HLTMMNKAPR 
       560        570        580        590        600
SDFKASKKAE IPINKTHKQQ FNKLITSQAA QVTTHSKNAS LGVPRTTSAT 
       610        620        630        640        650
KSNQENVDKT GSPHAGSETG SVAAFFQKIK GILPVKMKSS ECLEVTYVSH 
       660        670        680        690        700
IDQISPEKGE QDGEAPMEKQ ELGKQATNEI FESKSLLVGS APKTSTTPGR 
       710        720        730        740        750
SSSKPDSRSL RKTPGLKAKV GPTAACLRRK SESRTLGSDR ALSPQRIRRV 
       760        770        780        790        800
SGSGGHAAIN KYEEKPPKQA FQNGSGPLYL KPLVPRAHSH LLKTSPKGPS 
       810        820        830        840        850
RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE LAQYKTKCES 
       860        870        880        890        900
QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH KTLSQELVSL 
       910        920        930        940        950
RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR TELENRLKDL 
       960        970        980        990       1000
YTAECEKLQS IYIEEAEKYK TQLQEQFDNL NAAHETTKLE IEASHSEKVE 
      1010       1020       1030       1040       1050
LLKKTYETSL SEIKKSHEME KKSLEDLLNE KQESLEKQIN DLKSENDALN 
      1060       1070       1080       1090       1100
ERLKSEEQKQ LSREKANSKN PQVMYLEQEL ESLKAVLEIK NEKLHQQDMK 
      1110       1120       1130       1140       1150
LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR QLSTEQAALQ 
      1160       1170       1180       1190       1200
ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG 
      1210
SFSSPSISPR

Length:1,210

Mass (Da):134,379

Last modified:October 2, 2007 - v2

Checksum:ⁱ42642BCAE0759B25

Isoform 2 (identifier: Q5HZI1-2) [UniParc]FASTA Add to basket

Also known as: ATBP50

The sequence of this isoform differs from the canonical sequence as follows:
1-767: Missing.
768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT

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        10         20         30         40         50
MLLSPKFSLS TIHVRLTAKG LLRNLRLPSG LRKNTVIFHT VEKGRQKNPR 
        60         70         80         90        100
SLCIQTQTAP DVLSSERTLE LAQYKTKCES QSGFILHLRQ LLSRGNTKFE 
       110        120        130        140        150
ALTVVIQHLL SEREEALKQH KTLSQELVSL RGELVAASSA CEKLEKARAD 
       160        170        180        190        200
LQTAYQEFVQ KLNQQHQTDR TELENRLKDL YTAECEKLQS IYIEEAEKYK 
       210        220        230        240        250
TQLQEQFDNL NAAHETTKLE IEASHSEKVE LLKKTYETSL SEIKKSHEME 
       260        270        280        290        300
KKSLEDLLNE KQESLEKQIN DLKSENDALN ERLKSEEQKQ LSREKANSKN 
       310        320        330        340        350
PQVMYLEQEL ESLKAVLEIK NEKLHQQDMK LMKMEKLVDN NTALVDKLKR 
       360        370        380        390        400
FQQENEELKA RMDKHMAISR QLSTEQAALQ ESLEKESKVN KRLSMENEEL 
       410        420        430        440
LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG SFSSPSISPR

Show »

Length:440

Mass (Da):50,738

Checksum:ⁱ7FE4CC7C854EE926

Isoform 3 (identifier: Q5HZI1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT
     977-1011: FDNLNAAHETTKLEIEASHSEKVELLKKTYETSLS → LP

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        10         20         30         40         50
MLLSPKFSLS TIHVRLTAKG LLRNLRLPSG LRKNTVIFHT VEKGRQKNPR 
        60         70         80         90        100
SLCIQTQTAP DVLSSERTLE LAQYKTKCES QSGFILHLRQ LLSRGNTKFE 
       110        120        130        140        150
ALTVVIQHLL SEREEALKQH KTLSQELVSL RGELVAASSA CEKLEKARAD 
       160        170        180        190        200
LQTAYQEFVQ KLNQQHQTDR TELENRLKDL YTAECEKLQS IYIEEAEKYK 
       210        220        230        240        250
TQLQEQLPEI KKSHEMEKKS LEDLLNEKQE SLEKQINDLK SENDALNERL 
       260        270        280        290        300
KSEEQKQLSR EKANSKNPQV MYLEQELESL KAVLEIKNEK LHQQDMKLMK 
       310        320        330        340        350
MEKLVDNNTA LVDKLKRFQQ ENEELKARMD KHMAISRQLS TEQAALQESL 
       360        370        380        390        400
EKESKVNKRL SMENEELLWK LHNGDLCSPK RSPTSSAIPF QSPRNSGSFS 

SPSISPR

Show »

Length:407

Mass (Da):46,989

Checksum:ⁱ5FEA9F591DBF72CE

Isoform 4 (identifier: Q5HZI1-4) [UniParc]FASTA Add to basket

Also known as: ATBP60

The sequence of this isoform differs from the canonical sequence as follows:
1-690: Missing.
691-754: APKTSTTPGR...QRIRRVSGSG → MTIPGGFRSC...LLATLTRKKS

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        10         20         30         40         50
MTIPGGFRSC TETDISSTIF INSTLTPPAG SERQYDATLL ALLVVGSYSL 
        60         70         80         90        100
CIIPLLATLT RKKSGHAAIN KYEEKPPKQA FQNGSGPLYL KPLVPRAHSH 
       110        120        130        140        150
LLKTSPKGPS RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE 
       160        170        180        190        200
LAQYKTKCES QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH 
       210        220        230        240        250
KTLSQELVSL RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR 
       260        270        280        290        300
TELENRLKDL YTAECEKLQS IYIEEAEKYK TQLQEQFDNL NAAHETTKLE 
       310        320        330        340        350
IEASHSEKVE LLKKTYETSL SEIKKSHEME KKSLEDLLNE KQESLEKQIN 
       360        370        380        390        400
DLKSENDALN ERLKSEEQKQ LSREKANSKN PQVMYLEQEL ESLKAVLEIK 
       410        420        430        440        450
NEKLHQQDMK LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR 
       460        470        480        490        500
QLSTEQAALQ ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA 
       510        520
IPFQSPRNSG SFSSPSISPR

Show »

Length:520

Mass (Da):59,167

Checksum:ⁱE3D57A7993B2F0AA

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0R4J1L9	A0A0R4J1L9_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	1,210	Annotation score:
A0A0R4J0N9	A0A0R4J0N9_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	440	Annotation score:
D3Z2H5	D3Z2H5_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	92	Annotation score:
A0A0R4J147	A0A0R4J147_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	520	Annotation score:
D3Z7B3	D3Z7B3_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	123	Annotation score:
E9Q8N4	E9Q8N4_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	759	Annotation score:
F6Q593	F6Q593_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	214	Annotation score:
D3Z2Y9	D3Z2Y9_MOUSE	Microtubule-associated tumor suppre... Microtubule-associated tumor suppressor 1 homolog	Mtus1	38	Annotation score:

Sequence cautionⁱ

The sequence AAH41777 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH42206 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC98134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	401	P → S in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	401	P → S in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	426	E → K in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	426	E → K in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	455	R → S in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	455	R → S in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	519	I → V in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	519	I → V in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	525	S → N in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	525	S → N in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	541	H → Q in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	541	H → Q in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	553	F → L in AAH89009 (PubMed:15489334).Curated	1
Sequence conflictⁱ	556	S → G in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	556	S → G in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	600	T → A in AAH41777 (PubMed:15489334).Curated	1
Sequence conflictⁱ	600	T → A in AAH42206 (PubMed:15489334).Curated	1
Sequence conflictⁱ	646	T → A in BAE25537 (PubMed:16141072).Curated	1
Sequence conflictⁱ	867	T → N in AAD49746 (PubMed:15123706).Curated	1
Sequence conflictⁱ	867	T → N in AAT45892 (PubMed:15539617).Curated	1
Sequence conflictⁱ	919	A → T in AAT45893 (PubMed:15539617).Curated	1
Sequence conflictⁱ	919	A → T in AAT45894 (PubMed:15539617).Curated	1
Sequence conflictⁱ	919	A → T in BAC26996 (PubMed:16141072).Curated	1
Sequence conflictⁱ	919	A → T in BAC27517 (PubMed:16141072).Curated	1
Sequence conflictⁱ	919	A → T in AAH43321 (PubMed:15489334).Curated	1
Sequence conflictⁱ	919	A → T in AAH89009 (PubMed:15489334).Curated	1
Isoform 2 (identifier: Q5HZI1-2)
Sequence conflictⁱ	22	Missing in BAC27517 (PubMed:16141072).Curated	1
Sequence conflictⁱ	29	S → P in BAC27517 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_028279	1 – 767	Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST	767
Alternative sequenceⁱVSP_028280	1 – 690	Missing in isoform 4. 2 PublicationsAdd BLAST	690
Alternative sequenceⁱVSP_028281	691 – 754	APKTS…VSGSG → MTIPGGFRSCTETDISSTIF INSTLTPPAGSERQYDATLL ALLVVGSYSLCIIPLLATLT RKKS in isoform 4. 2 PublicationsAdd BLAST	64
Alternative sequenceⁱVSP_028282	768 – 810	KQAFQ…TAFNS → MLLSPKFSLSTIHVRLTAKG LLRNLRLPSGLRKNTVIFHT in isoform 2 and isoform 3. 5 PublicationsAdd BLAST	43
Alternative sequenceⁱVSP_028283	977 – 1011	FDNLN…ETSLS → LP in isoform 3. 1 PublicationAdd BLAST	35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF173380 mRNA Translation: AAD49746.1 AY626781 mRNA Translation: AAT45892.1 AY626782 mRNA Translation: AAT45893.1 AY626783 mRNA Translation: AAT45894.1 AY246699 mRNA Translation: AAO88908.1 AF493235 mRNA Translation: AAQ06609.1 AK129324 mRNA Translation: BAC98134.1 Different initiation. AK030510 mRNA Translation: BAC26996.1 AK031693 mRNA Translation: BAC27517.1 AK143781 mRNA Translation: BAE25537.1 BC041777 mRNA Translation: AAH41777.1 Different initiation. BC042206 mRNA Translation: AAH42206.1 Different initiation. BC043321 mRNA Translation: AAH43321.1 BC089009 mRNA Translation: AAH89009.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40328.1 [Q5HZI1-1] CCDS40329.1 [Q5HZI1-4] CCDS40330.1 [Q5HZI1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005863.1, NM_001005863.2 NP_001005864.1, NM_001005864.3 NP_001005865.2, NM_001005865.3 NP_001273342.1, NM_001286413.1
UniGeneⁱ	Mm.149438

Genome annotation databases

GeneIDⁱ	102103
KEGGⁱ	mmu:102103
UCSC genome browser More...UCSCⁱ	uc009lnk.2 mouse [Q5HZI1-2] uc009lnl.2 mouse [Q5HZI1-4] uc009lnm.1 mouse [Q5HZI1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5HZI1	Microtubule-associated tumor suppressor 1 homolog (Fragment)		MOUSE		759	UniRef100_Q5HZI1

Protein	Similar proteins		Species	Score	Length	Source
Q5HZI1	Microtubule-associated tumor suppressor 1 homolog (Fragment)		MOUSE		759	UniRef90_Q5HZI1
UPI000A315D9B		MUSCR		1210
Microtubule-associated tumor suppressor 1 homolog		MOUSE		1210
Q5HZI1-2	Microtubule-associated tumor suppressor 1 homolog		MOUSE		440	UniRef90_Q5HZI1-2
UPI000A319AFF		MUSCR		510
UPI000A30F104		MUSPA		440
UPI000A31B33F		MUSCR		440
Q5HZI1-4	Microtubule-associated tumor suppressor 1 homolog		RAT		440	UniRef90_Q5HZI1-4
Microtubule-associated tumor suppressor 1 homolog		MOUSE		520
UPI000A311135		MUSPA		520
UPI00038C5680		MICOH		519
UPI0004ED3759		NANGA		519
+7

Protein	Similar proteins		Species	Score	Length	Source
Q5HZI1	Microtubule-associated tumor suppressor 1 homolog (Fragment)		MOUSE		759	UniRef50_Q5HZI1
Growth factor inhibitor		RAT		1210
Uncharacterized protein		CAVPO		1181
microtubule-associated tumor suppressor 1 isoform X2		DIPOR		1208
UPI000A315D9B		MUSCR		1210
+14
Q5HZI1-2	Isoform 6 of Microtubule-associated tumor suppressor 1		HUMAN		517	UniRef50_Q9ULD2-6
Microtubule-associated tumor suppressor 1 homolog		RAT		440
Microtubule-associated tumor suppressor 1 homolog		BOVIN		467
Uncharacterized protein		CERAT		517
Uncharacterized protein		RHIRO		517
+258
Q5HZI1-3	Uncharacterized protein		LATCH		330	UniRef50_Q5HZI1-3
Uncharacterized protein		MACFA		494
UPI0009E50290		central bearded dragon		443
UPI0008130FF5		MANJA		406
UPI0003C180A0		LATCH		400
+2
Q5HZI1-4	Isoform 6 of Microtubule-associated tumor suppressor 1		HUMAN		517	UniRef50_Q9ULD2-6
Microtubule-associated tumor suppressor 1 homolog		RAT		440
Microtubule-associated tumor suppressor 1 homolog		BOVIN		467
Uncharacterized protein		CERAT		517
Uncharacterized protein		RHIRO		517
+258

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF173380 mRNA Translation: AAD49746.1 AY626781 mRNA Translation: AAT45892.1 AY626782 mRNA Translation: AAT45893.1 AY626783 mRNA Translation: AAT45894.1 AY246699 mRNA Translation: AAO88908.1 AF493235 mRNA Translation: AAQ06609.1 AK129324 mRNA Translation: BAC98134.1 Different initiation. AK030510 mRNA Translation: BAC26996.1 AK031693 mRNA Translation: BAC27517.1 AK143781 mRNA Translation: BAE25537.1 BC041777 mRNA Translation: AAH41777.1 Different initiation. BC042206 mRNA Translation: AAH42206.1 Different initiation. BC043321 mRNA Translation: AAH43321.1 BC089009 mRNA Translation: AAH89009.1
CCDSⁱ	CCDS40328.1 [Q5HZI1-1] CCDS40329.1 [Q5HZI1-4] CCDS40330.1 [Q5HZI1-2]
RefSeqⁱ	NP_001005863.1, NM_001005863.2 NP_001005864.1, NM_001005864.3 NP_001005865.2, NM_001005865.3 NP_001273342.1, NM_001286413.1
UniGeneⁱ	Mm.149438

3D structure databases

ProteinModelPortalⁱ	Q5HZI1
SMRⁱ	Q5HZI1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q5HZI1
PhosphoSitePlusⁱ	Q5HZI1

Proteomic databases

PaxDbⁱ	Q5HZI1
PeptideAtlasⁱ	Q5HZI1
PRIDEⁱ	Q5HZI1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	102103
KEGGⁱ	mmu:102103
UCSCⁱ	uc009lnk.2 mouse [Q5HZI1-2] uc009lnl.2 mouse [Q5HZI1-4] uc009lnm.1 mouse [Q5HZI1-1]

Organism-specific databases

CTDⁱ	57509
MGIⁱ	MGI:2142572 Mtus1
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEXM Eukaryota ENOG41118DX LUCA
HOVERGENⁱ	HBG108158
InParanoidⁱ	Q5HZI1
PhylomeDBⁱ	Q5HZI1
TreeFamⁱ	TF333416

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q5HZI1
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_MTUS1

CleanExⁱ

MM_MTUS1

Family and domain databases

InterProⁱ	View protein in InterPro IPR029786 MTUS1
PANTHERⁱ	PTHR24200:SF7 PTHR24200:SF7, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTUS1_MOUSE
Accessionⁱ	Q5HZI1Primary (citable) accession number: Q5HZI1 Secondary accession number(s): Q3UP60 Q8C0C8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	November 7, 2018
	This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q5HZI1 (MTUS1_MOUSE)

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Microtubule-associated tumor suppressor 1 homolog

Mtus1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Mitochondrion

Nucleus

Cytoskeleton

Golgi apparatus

Mitochondrion

Nucleus

Plasma Membrane

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Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ