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Entry version 96 (02 Jun 2021)
Sequence version 2 (02 Oct 2007)
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Protein

Microtubule-associated tumor suppressor 1 homolog

Gene

Mtus1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated tumor suppressor 1 homolog
Alternative name(s):
AT2 receptor-binding protein
Angiotensin-II type 2 receptor-interacting protein
Coiled-coiled tumor suppressor gene 1 protein
Mitochondrial tumor suppressor 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mtus1
Synonyms:Atbp, Atip, Cctsg1, Kiaa1288, Mtsg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2142572, Mtus1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Mitochondrion, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003051981 – 1210Microtubule-associated tumor suppressor 1 homologAdd BLAST1210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei375PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei1143PhosphoserineBy similarity1
Modified residuei1164PhosphoserineCombined sources1
Modified residuei1185PhosphoserineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1199PhosphoserineBy similarity1
Modified residuei1201PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1204PhosphoserineBy similarity1
Modified residuei1208PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5HZI1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5HZI1

PeptideAtlas

More...
PeptideAtlasi
Q5HZI1

PRoteomics IDEntifications database

More...
PRIDEi
Q5HZI1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
290116 [Q5HZI1-1]
290117 [Q5HZI1-2]
290118 [Q5HZI1-3]
290119 [Q5HZI1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5HZI1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5HZI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in uterus and adrenal gland.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with AGTR2.

Interacts with PTPN6.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091252

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5HZI1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5HZI1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni370 – 404DisorderedSequence analysisAdd BLAST35
Regioni446 – 482DisorderedSequence analysisAdd BLAST37
Regioni513 – 545DisorderedSequence analysisAdd BLAST33
Regioni585 – 618DisorderedSequence analysisAdd BLAST34
Regioni683 – 771DisorderedSequence analysisAdd BLAST89
Regioni1177 – 1210DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili876 – 1171Sequence analysisAdd BLAST296

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi513 – 540Polar residuesSequence analysisAdd BLAST28
Compositional biasi585 – 617Polar residuesSequence analysisAdd BLAST33
Compositional biasi683 – 704Polar residuesSequence analysisAdd BLAST22
Compositional biasi1181 – 1210Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPVG, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5HZI1

Database of Orthologous Groups

More...
OrthoDBi
91479at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5HZI1

TreeFam database of animal gene trees

More...
TreeFami
TF333416

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029786, MTUS1

The PANTHER Classification System

More...
PANTHERi
PTHR24200:SF7, PTHR24200:SF7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5HZI1-1) [UniParc]FASTAAdd to basket
Also known as: ATBP135

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNDDNSDRTE DGSRYVFIRD KNSNPSEYYQ TSLSAQCPSV SHGDWNSDNP
60 70 80 90 100
DAMVVDYEMD PAVDSSESVS LSHQCVEELA YPEPSSDFMG KHEFTMYSEL
110 120 130 140 150
TCQSPALVNT GKPQDLHSNC DSLEAIQDEK FDPLKPCECR SDDDYACGDS
160 170 180 190 200
PEVLELKQTY GMKVDTANYT FIARHDIEQG QPLHAPGGLQ TTVRDRNALS
210 220 230 240 250
SCGRTPPHSS KMYVRGVNYN RENFENLQAT PSKTLNTTFT VISDVLMQTD
260 270 280 290 300
SPDVGVQGQN SLGNVTKEYT DGTRRGLIGE KEIQAVTLVS DGMEVPNGSA
310 320 330 340 350
SQEFYCVSED DPNSETHSHG PYAQQEMGQN LRGTLPNCHV DGECPVLVPA
360 370 380 390 400
FEKSKTRVLG SECKVTVTED PHIDSHDNDS DIQSSTEELT LRSVSGQRGS
410 420 430 440 450
PYEMGWGENG GAICTDKAGC MSTPVEQPPN LSFRLEPAEV KKYNNVENGP
460 470 480 490 500
RDAKRAPNLK GEPTNMPKPN LGKSATKTNT TVGSKVRKTE IISYPTPNFK
510 520 530 540 550
NIKAKVISRS VLQPKDTSIM KDTPSPQVTG GSSPSPGPSK HLTMMNKAPR
560 570 580 590 600
SDFKASKKAE IPINKTHKQQ FNKLITSQAA QVTTHSKNAS LGVPRTTSAT
610 620 630 640 650
KSNQENVDKT GSPHAGSETG SVAAFFQKIK GILPVKMKSS ECLEVTYVSH
660 670 680 690 700
IDQISPEKGE QDGEAPMEKQ ELGKQATNEI FESKSLLVGS APKTSTTPGR
710 720 730 740 750
SSSKPDSRSL RKTPGLKAKV GPTAACLRRK SESRTLGSDR ALSPQRIRRV
760 770 780 790 800
SGSGGHAAIN KYEEKPPKQA FQNGSGPLYL KPLVPRAHSH LLKTSPKGPS
810 820 830 840 850
RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE LAQYKTKCES
860 870 880 890 900
QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH KTLSQELVSL
910 920 930 940 950
RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR TELENRLKDL
960 970 980 990 1000
YTAECEKLQS IYIEEAEKYK TQLQEQFDNL NAAHETTKLE IEASHSEKVE
1010 1020 1030 1040 1050
LLKKTYETSL SEIKKSHEME KKSLEDLLNE KQESLEKQIN DLKSENDALN
1060 1070 1080 1090 1100
ERLKSEEQKQ LSREKANSKN PQVMYLEQEL ESLKAVLEIK NEKLHQQDMK
1110 1120 1130 1140 1150
LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR QLSTEQAALQ
1160 1170 1180 1190 1200
ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG
1210
SFSSPSISPR
Length:1,210
Mass (Da):134,379
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42642BCAE0759B25
GO
Isoform 2 (identifier: Q5HZI1-2) [UniParc]FASTAAdd to basket
Also known as: ATBP50

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT

Show »
Length:440
Mass (Da):50,738
Checksum:i7FE4CC7C854EE926
GO
Isoform 3 (identifier: Q5HZI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT
     977-1011: FDNLNAAHETTKLEIEASHSEKVELLKKTYETSLS → LP

Show »
Length:407
Mass (Da):46,989
Checksum:i5FEA9F591DBF72CE
GO
Isoform 4 (identifier: Q5HZI1-4) [UniParc]FASTAAdd to basket
Also known as: ATBP60

The sequence of this isoform differs from the canonical sequence as follows:
     1-690: Missing.
     691-754: APKTSTTPGR...QRIRRVSGSG → MTIPGGFRSC...LLATLTRKKS

Show »
Length:520
Mass (Da):59,167
Checksum:iE3D57A7993B2F0AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1L9A0A0R4J1L9_MOUSE
Microtubule-associated tumor suppre...
Mtus1
1,210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J0N9A0A0R4J0N9_MOUSE
Microtubule-associated tumor suppre...
Mtus1
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J147A0A0R4J147_MOUSE
Microtubule-associated tumor suppre...
Mtus1
520Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q8N4E9Q8N4_MOUSE
Microtubule-associated tumor suppre...
Mtus1
759Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q593F6Q593_MOUSE
Microtubule-associated tumor suppre...
Mtus1
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2H5D3Z2H5_MOUSE
Microtubule-associated tumor suppre...
Mtus1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z7B3D3Z7B3_MOUSE
Microtubule-associated tumor suppre...
Mtus1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2Y9D3Z2Y9_MOUSE
Microtubule-associated tumor suppre...
Mtus1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH41777 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH42206 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti401P → S in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti401P → S in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti426E → K in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti426E → K in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti455R → S in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti455R → S in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti519I → V in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti519I → V in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti525S → N in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti525S → N in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti541H → Q in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti541H → Q in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti553F → L in AAH89009 (PubMed:15489334).Curated1
Sequence conflicti556S → G in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti556S → G in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti600T → A in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti600T → A in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti646T → A in BAE25537 (PubMed:16141072).Curated1
Sequence conflicti867T → N in AAD49746 (PubMed:15123706).Curated1
Sequence conflicti867T → N in AAT45892 (PubMed:15539617).Curated1
Sequence conflicti919A → T in AAT45893 (PubMed:15539617).Curated1
Sequence conflicti919A → T in AAT45894 (PubMed:15539617).Curated1
Sequence conflicti919A → T in BAC26996 (PubMed:16141072).Curated1
Sequence conflicti919A → T in BAC27517 (PubMed:16141072).Curated1
Sequence conflicti919A → T in AAH43321 (PubMed:15489334).Curated1
Sequence conflicti919A → T in AAH89009 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q5HZI1-2)
Sequence conflicti22Missing in BAC27517 (PubMed:16141072).Curated1
Sequence conflicti29S → P in BAC27517 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0282791 – 767Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST767
Alternative sequenceiVSP_0282801 – 690Missing in isoform 4. 2 PublicationsAdd BLAST690
Alternative sequenceiVSP_028281691 – 754APKTS…VSGSG → MTIPGGFRSCTETDISSTIF INSTLTPPAGSERQYDATLL ALLVVGSYSLCIIPLLATLT RKKS in isoform 4. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_028282768 – 810KQAFQ…TAFNS → MLLSPKFSLSTIHVRLTAKG LLRNLRLPSGLRKNTVIFHT in isoform 2 and isoform 3. 5 PublicationsAdd BLAST43
Alternative sequenceiVSP_028283977 – 1011FDNLN…ETSLS → LP in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF173380 mRNA Translation: AAD49746.1
AY626781 mRNA Translation: AAT45892.1
AY626782 mRNA Translation: AAT45893.1
AY626783 mRNA Translation: AAT45894.1
AY246699 mRNA Translation: AAO88908.1
AF493235 mRNA Translation: AAQ06609.1
AK129324 mRNA Translation: BAC98134.1 Different initiation.
AK030510 mRNA Translation: BAC26996.1
AK031693 mRNA Translation: BAC27517.1
AK143781 mRNA Translation: BAE25537.1
BC041777 mRNA Translation: AAH41777.1 Different initiation.
BC042206 mRNA Translation: AAH42206.1 Different initiation.
BC043321 mRNA Translation: AAH43321.1
BC089009 mRNA Translation: AAH89009.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40328.1 [Q5HZI1-1]
CCDS40329.1 [Q5HZI1-4]
CCDS40330.1 [Q5HZI1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001005863.1, NM_001005863.2
NP_001005864.1, NM_001005864.3
NP_001005865.2, NM_001005865.3
NP_001273342.1, NM_001286413.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
102103

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:102103

UCSC genome browser

More...
UCSCi
uc009lnk.2, mouse [Q5HZI1-2]
uc009lnl.2, mouse [Q5HZI1-4]
uc009lnm.1, mouse [Q5HZI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173380 mRNA Translation: AAD49746.1
AY626781 mRNA Translation: AAT45892.1
AY626782 mRNA Translation: AAT45893.1
AY626783 mRNA Translation: AAT45894.1
AY246699 mRNA Translation: AAO88908.1
AF493235 mRNA Translation: AAQ06609.1
AK129324 mRNA Translation: BAC98134.1 Different initiation.
AK030510 mRNA Translation: BAC26996.1
AK031693 mRNA Translation: BAC27517.1
AK143781 mRNA Translation: BAE25537.1
BC041777 mRNA Translation: AAH41777.1 Different initiation.
BC042206 mRNA Translation: AAH42206.1 Different initiation.
BC043321 mRNA Translation: AAH43321.1
BC089009 mRNA Translation: AAH89009.1
CCDSiCCDS40328.1 [Q5HZI1-1]
CCDS40329.1 [Q5HZI1-4]
CCDS40330.1 [Q5HZI1-2]
RefSeqiNP_001005863.1, NM_001005863.2
NP_001005864.1, NM_001005864.3
NP_001005865.2, NM_001005865.3
NP_001273342.1, NM_001286413.1

3D structure databases

SMRiQ5HZI1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091252

PTM databases

iPTMnetiQ5HZI1
PhosphoSitePlusiQ5HZI1

Proteomic databases

jPOSTiQ5HZI1
PaxDbiQ5HZI1
PeptideAtlasiQ5HZI1
PRIDEiQ5HZI1
ProteomicsDBi290116 [Q5HZI1-1]
290117 [Q5HZI1-2]
290118 [Q5HZI1-3]
290119 [Q5HZI1-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
102103

Genome annotation databases

GeneIDi102103
KEGGimmu:102103
UCSCiuc009lnk.2, mouse [Q5HZI1-2]
uc009lnl.2, mouse [Q5HZI1-4]
uc009lnm.1, mouse [Q5HZI1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57509
MGIiMGI:2142572, Mtus1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QPVG, Eukaryota
InParanoidiQ5HZI1
OrthoDBi91479at2759
PhylomeDBiQ5HZI1
TreeFamiTF333416

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
102103, 2 hits in 50 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mtus1, mouse

Protein Ontology

More...
PROi
PR:Q5HZI1
RNActiQ5HZI1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR029786, MTUS1
PANTHERiPTHR24200:SF7, PTHR24200:SF7, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTUS1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5HZI1
Secondary accession number(s): Q3UP60
, Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 2, 2021
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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