UniProtKB - Q5HZE4 (MTNA_RAT)
Protein
Methylthioribose-1-phosphate isomerase
Gene
Mri1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation
Catalytic activityi
- EC:5.3.1.23UniRule annotation
: L-methionine biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- Methylthioribose-1-phosphate isomerase (Mri1)
- Methylthioribulose-1-phosphate dehydratase (Apip)
- Enolase-phosphatase E1 (Enoph1)
- Enolase-phosphatase E1 (Enoph1)
- 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (Adi1)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 168 | Transition state stabilizerUniRule annotation | 1 | |
Active sitei | 248 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- identical protein binding Source: RGD
- S-methyl-5-thioribose-1-phosphate isomerase activity Source: GO_Central
GO - Biological processi
- L-methionine salvage from methylthioadenosine Source: GO_Central
- L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Biological process | Amino-acid biosynthesis, Methionine biosynthesis |
Enzyme and pathway databases
Reactomei | R-RNO-1237112, Methionine salvage pathway |
UniPathwayi | UPA00904;UER00874 |
Names & Taxonomyi
Protein namesi | Recommended name: Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)Short name: M1PiUniRule annotation Short name: MTR-1-P isomeraseUniRule annotation Alternative name(s): S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation |
Gene namesi | Name:Mri1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307789, Mri1 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- fibrillar center Source: Ensembl
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317327 | 1 – 369 | Methylthioribose-1-phosphate isomeraseAdd BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 158 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 366 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
jPOSTi | Q5HZE4 |
PaxDbi | Q5HZE4 |
PRIDEi | Q5HZE4 |
PTM databases
iPTMneti | Q5HZE4 |
PhosphoSitePlusi | Q5HZE4 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000026211, Expressed in pancreas and 22 other tissues |
Genevisiblei | Q5HZE4, RN |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003762 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1468, Eukaryota |
GeneTreei | ENSGT00390000013732 |
HOGENOMi | CLU_016218_1_3_1 |
InParanoidi | Q5HZE4 |
OMAi | CETRPLN |
OrthoDBi | 1410886at2759 |
PhylomeDBi | Q5HZE4 |
TreeFami | TF300852 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
HAMAPi | MF_01678, Salvage_MtnA, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR005251, IF-M1Pi IPR042529, IF_2B-like_C IPR011559, Initiation_fac_2B_a/b/d IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00524, eIF-2B_rel, 1 hit TIGR00512, salvage_mtnA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5HZE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLEAIRYSP GSLQILDQLQ LPEHCHYETL SSVQQAREAI RAMKVRGAPA
60 70 80 90 100
IALVGCLSLA VELQAGAGGP GLAALVAFVR DQLSLLVAAR PTAVNMARAA
110 120 130 140 150
RDLTHMAARE AELEGATEET VRERVIRFAE DMLEKDLKDN RSIGDLGARH
160 170 180 190 200
LLEQTNPRGG KVTVLTHCNT GALATAGYGT ALGVIRSLHE MGRLEHTFCT
210 220 230 240 250
ETRPYNQGAR LTAFELVYEK IPATLITDSM AAAAMVHQGV SAVVVGADRV
260 270 280 290 300
VANGDTANKI GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIVIEER
310 320 330 340 350
PSQELTDLNG VRIAAQGIRV WNPAFDVTPH ELITGGIITE LGVFAPEELR
360
AALSATIFSE GQTLDSPQM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089060 mRNA Translation: AAH89060.1 |
RefSeqi | NP_001010947.1, NM_001010947.1 |
Genome annotation databases
Ensembli | ENSRNOT00000003762; ENSRNOP00000003762; ENSRNOG00000026211 |
GeneIDi | 288912 |
KEGGi | rno:288912 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089060 mRNA Translation: AAH89060.1 |
RefSeqi | NP_001010947.1, NM_001010947.1 |
3D structure databases
SMRi | Q5HZE4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003762 |
PTM databases
iPTMneti | Q5HZE4 |
PhosphoSitePlusi | Q5HZE4 |
Proteomic databases
jPOSTi | Q5HZE4 |
PaxDbi | Q5HZE4 |
PRIDEi | Q5HZE4 |
Genome annotation databases
Ensembli | ENSRNOT00000003762; ENSRNOP00000003762; ENSRNOG00000026211 |
GeneIDi | 288912 |
KEGGi | rno:288912 |
Organism-specific databases
CTDi | 84245 |
RGDi | 1307789, Mri1 |
Phylogenomic databases
eggNOGi | KOG1468, Eukaryota |
GeneTreei | ENSGT00390000013732 |
HOGENOMi | CLU_016218_1_3_1 |
InParanoidi | Q5HZE4 |
OMAi | CETRPLN |
OrthoDBi | 1410886at2759 |
PhylomeDBi | Q5HZE4 |
TreeFami | TF300852 |
Enzyme and pathway databases
UniPathwayi | UPA00904;UER00874 |
Reactomei | R-RNO-1237112, Methionine salvage pathway |
Miscellaneous databases
PROi | PR:Q5HZE4 |
Gene expression databases
Bgeei | ENSRNOG00000026211, Expressed in pancreas and 22 other tissues |
Genevisiblei | Q5HZE4, RN |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
HAMAPi | MF_01678, Salvage_MtnA, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR005251, IF-M1Pi IPR042529, IF_2B-like_C IPR011559, Initiation_fac_2B_a/b/d IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00524, eIF-2B_rel, 1 hit TIGR00512, salvage_mtnA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTNA_RAT | |
Accessioni | Q5HZE4Primary (citable) accession number: Q5HZE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families