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Protein

Transmembrane protein 120A

Gene

Tmem120a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Necessary for efficient adipogenesis.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Alternative name(s):
Transmembrane protein induced by tumor necrosis factor alpha
Gene namesi
Name:Tmem120a
Synonyms:Tmpit
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311474 Tmem120a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 135ExtracellularSequence analysisAdd BLAST135
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 162CytoplasmicSequence analysis6
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 190ExtracellularSequence analysis7
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 273CytoplasmicSequence analysisAdd BLAST62
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305ExtracellularSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 343CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093411 – 343Transmembrane protein 120AAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5HZE2
PRIDEiQ5HZE2

PTM databases

PhosphoSitePlusiQ5HZE2

Expressioni

Gene expression databases

BgeeiENSRNOG00000001441 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ5HZE2 RN

Interactioni

Subunit structurei

Homooligomer and heterooligomer with TMEM120B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001960

Structurei

3D structure databases

SMRiQ5HZE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758 Eukaryota
ENOG410XT6G LUCA
GeneTreeiENSGT00390000007848
HOGENOMiHOG000267032
HOVERGENiHBG108532
InParanoidiQ5HZE2
OMAiHHYLSCA
OrthoDBiEOG091G0BVA
PhylomeDBiQ5HZE2
TreeFamiTF313552

Family and domain databases

InterProiView protein in InterPro
IPR012926 TMPIT
PANTHERiPTHR21433 PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851 TMPIT, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HZE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRVKLEEL TKLQDNCTNS
60 70 80 90 100
ITRQKKRLQE LALVLKKCRP SLPSESLEAA QELESQIKER QGLFFDMEAY
110 120 130 140 150
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILIVISFT
160 170 180 190 200
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS
210 220 230 240 250
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA
260 270 280 290 300
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
310 320 330 340
ECKEWQVLMC GLPFLLLFLG NFFTTLRVVH QKFHSQQHGS KKD
Length:343
Mass (Da):40,657
Last modified:February 15, 2005 - v1
Checksum:i9949CE5A59B3912C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089063 mRNA Translation: AAH89063.1
RefSeqiNP_001010945.1, NM_001010945.1
UniGeneiRn.6288

Genome annotation databases

EnsembliENSRNOT00000001960; ENSRNOP00000001960; ENSRNOG00000001441
GeneIDi288591
KEGGirno:288591
UCSCiRGD:1311474 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089063 mRNA Translation: AAH89063.1
RefSeqiNP_001010945.1, NM_001010945.1
UniGeneiRn.6288

3D structure databases

SMRiQ5HZE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001960

PTM databases

PhosphoSitePlusiQ5HZE2

Proteomic databases

PaxDbiQ5HZE2
PRIDEiQ5HZE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001960; ENSRNOP00000001960; ENSRNOG00000001441
GeneIDi288591
KEGGirno:288591
UCSCiRGD:1311474 rat

Organism-specific databases

CTDi83862
RGDi1311474 Tmem120a

Phylogenomic databases

eggNOGiKOG4758 Eukaryota
ENOG410XT6G LUCA
GeneTreeiENSGT00390000007848
HOGENOMiHOG000267032
HOVERGENiHBG108532
InParanoidiQ5HZE2
OMAiHHYLSCA
OrthoDBiEOG091G0BVA
PhylomeDBiQ5HZE2
TreeFamiTF313552

Miscellaneous databases

PROiPR:Q5HZE2

Gene expression databases

BgeeiENSRNOG00000001441 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ5HZE2 RN

Family and domain databases

InterProiView protein in InterPro
IPR012926 TMPIT
PANTHERiPTHR21433 PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851 TMPIT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT120A_RAT
AccessioniPrimary (citable) accession number: Q5HZE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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