UniProtKB - Q5HYW3 (RTL5_HUMAN)
Protein
Retrotransposon Gag-like protein 5
Gene
RTL5
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
RTL5 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q5HYW3 |
Names & Taxonomyi
Protein namesi | Recommended name: Retrotransposon Gag-like protein 5ImportedAlternative name(s): Retrotransposon gag domain-containing protein 4Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000242732.4 |
HGNCi | HGNC:29430, RTL5 |
neXtProti | NX_Q5HYW3 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 340526 |
OpenTargetsi | ENSG00000242732 |
PharmGKBi | PA134992098 |
Miscellaneous databases
Pharosi | Q5HYW3, Tdark |
Polymorphism and mutation databases
BioMutai | RTL5 |
DMDMi | 74741563 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259629 | 1 – 569 | Retrotransposon Gag-like protein 5Add BLAST | 569 |
Proteomic databases
MassIVEi | Q5HYW3 |
PaxDbi | Q5HYW3 |
PeptideAtlasi | Q5HYW3 |
PRIDEi | Q5HYW3 |
ProteomicsDBi | 62963 |
PTM databases
iPTMneti | Q5HYW3 |
PhosphoSitePlusi | Q5HYW3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000242732, Expressed in cerebellar hemisphere and 194 other tissues |
Genevisiblei | Q5HYW3, HS |
Organism-specific databases
HPAi | ENSG00000242732, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000476792 |
Miscellaneous databases
RNActi | Q5HYW3, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 124 – 129 | Poly-Pro | 6 | |
Compositional biasi | 375 – 409 | Glu-richAdd BLAST | 35 |
Phylogenomic databases
eggNOGi | ENOG502QPW5, Eukaryota |
GeneTreei | ENSGT00940000163191 |
HOGENOMi | CLU_039587_0_0_1 |
InParanoidi | Q5HYW3 |
OMAi | PFLCWPP |
OrthoDBi | 82879at2759 |
PhylomeDBi | Q5HYW3 |
TreeFami | TF337113 |
Family and domain databases
InterProi | View protein in InterPro IPR032549, DUF4939 IPR032567, LDOC1-rel |
PANTHERi | PTHR15503, PTHR15503, 1 hit |
Pfami | View protein in Pfam PF16297, DUF4939, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5HYW3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEASGNLNS LRMANVALRE ELNALRGENA NLGLQLGRAL AEVNSLRGNV
60 70 80 90 100
SSYIRWPVPI VPVLAEENLE FALSEIEVIP GGELPFLCRP PPRAEPDCIS
110 120 130 140 150
DDLLINVIQD RSTPDGPADP PLLPIPPPPA LPPPASKEPP PQPPLAPLER
160 170 180 190 200
PEIEPFSGDP VYLAEFLMQL ETFIADHEVH FPGGAERVAF LISFFTGEAK
210 220 230 240 250
DWAISVTQEG SPLHANFPRF LDEIRKEFCG PIPPRVAKKA IRKLKQGHCT
260 270 280 290 300
LGSYADAFQF LAQFLSWDDC RLQNQFLKGL SEFFRKELLW STEMADLDEL
310 320 330 340 350
ILECVEIERK VRVPKPIPLP GVRNIIFPFA PSPNEEESED EEYYSEDEDQ
360 370 380 390 400
EARRHRLHSK DQRKRMRAFQ QEMKEKEEEE MKKEEEMKKK EEKEEEEEEE
410 420 430 440 450
MKQKEEEEEI RNKNEEEGES KDEEDEDEDG GQKPEGEPQQ DPGTEETYGE
460 470 480 490 500
VEEEPLDEAQ DDDLDELMEM EPTFVHASSQ TSGPTSGYHA ENFLGASPPI
510 520 530 540 550
IQPSRRRNQN RVPLLEGLPG TNSPFYSSPQ LIRRTGRLGQ RQVRRRPPVL
560
FRLTPRQGGH RAARGRIRV
Sequence cautioni
The sequence BAC02710 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051319 | 420 | S → R. Corresponds to variant dbSNP:rs6624595Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB082532 mRNA Translation: BAC02710.1 Different initiation. BX119917 Genomic DNA No translation available. BC151224 mRNA Translation: AAI51225.1 AL359579 mRNA Translation: CAB94872.2 |
CCDSi | CCDS55446.1 |
PIRi | T50613 |
RefSeqi | NP_001019626.1, NM_001024455.3 |
Genome annotation databases
Ensembli | ENST00000479991; ENSP00000418667; ENSG00000242732 ENST00000609883; ENSP00000476792; ENSG00000242732 |
GeneIDi | 340526 |
KEGGi | hsa:340526 |
UCSCi | uc004eaj.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB082532 mRNA Translation: BAC02710.1 Different initiation. BX119917 Genomic DNA No translation available. BC151224 mRNA Translation: AAI51225.1 AL359579 mRNA Translation: CAB94872.2 |
CCDSi | CCDS55446.1 |
PIRi | T50613 |
RefSeqi | NP_001019626.1, NM_001024455.3 |
3D structure databases
SMRi | Q5HYW3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000476792 |
PTM databases
iPTMneti | Q5HYW3 |
PhosphoSitePlusi | Q5HYW3 |
Polymorphism and mutation databases
BioMutai | RTL5 |
DMDMi | 74741563 |
Proteomic databases
MassIVEi | Q5HYW3 |
PaxDbi | Q5HYW3 |
PeptideAtlasi | Q5HYW3 |
PRIDEi | Q5HYW3 |
ProteomicsDBi | 62963 |
Protocols and materials databases
Antibodypediai | 51779, 39 antibodies |
Genome annotation databases
Ensembli | ENST00000479991; ENSP00000418667; ENSG00000242732 ENST00000609883; ENSP00000476792; ENSG00000242732 |
GeneIDi | 340526 |
KEGGi | hsa:340526 |
UCSCi | uc004eaj.3, human |
Organism-specific databases
CTDi | 340526 |
DisGeNETi | 340526 |
EuPathDBi | HostDB:ENSG00000242732.4 |
GeneCardsi | RTL5 |
HGNCi | HGNC:29430, RTL5 |
HPAi | ENSG00000242732, Low tissue specificity |
neXtProti | NX_Q5HYW3 |
OpenTargetsi | ENSG00000242732 |
PharmGKBi | PA134992098 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPW5, Eukaryota |
GeneTreei | ENSGT00940000163191 |
HOGENOMi | CLU_039587_0_0_1 |
InParanoidi | Q5HYW3 |
OMAi | PFLCWPP |
OrthoDBi | 82879at2759 |
PhylomeDBi | Q5HYW3 |
TreeFami | TF337113 |
Enzyme and pathway databases
PathwayCommonsi | Q5HYW3 |
Miscellaneous databases
BioGRID-ORCSi | 340526, 3 hits in 469 CRISPR screens |
GenomeRNAii | 340526 |
Pharosi | Q5HYW3, Tdark |
PROi | PR:Q5HYW3 |
RNActi | Q5HYW3, protein |
Gene expression databases
Bgeei | ENSG00000242732, Expressed in cerebellar hemisphere and 194 other tissues |
Genevisiblei | Q5HYW3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032549, DUF4939 IPR032567, LDOC1-rel |
PANTHERi | PTHR15503, PTHR15503, 1 hit |
Pfami | View protein in Pfam PF16297, DUF4939, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTL5_HUMAN | |
Accessioni | Q5HYW3Primary (citable) accession number: Q5HYW3 Secondary accession number(s): A7E2W7, Q8NCM4, Q9NPX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations