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UniProtKB - Q5HYW3 (RTL5_HUMAN)

Entry version 115 (29 Sep 2021)
Sequence version 1 (15 Feb 2005)
Previous versions | rss
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Protein

Retrotransposon Gag-like protein 5

Gene

RTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

RTL5 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5HYW3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon Gag-like protein 5Imported
Alternative name(s):
Retrotransposon gag domain-containing protein 4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL5Imported
Synonyms:KIAA2001, RGAG4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29430, RTL5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5HYW3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000242732

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		340526

Open Targets

More...OpenTargetsi		ENSG00000242732

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5HYW3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RTL5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74741563

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002596291 – 569Retrotransposon Gag-like protein 5Add BLAST569

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5HYW3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5HYW3

PeptideAtlas

More...PeptideAtlasi		Q5HYW3

PRoteomics IDEntifications database

More...PRIDEi		Q5HYW3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5HYW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5HYW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000242732, Expressed in cerebellar hemisphere and 195 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5HYW3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000242732, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131065, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000476792

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5HYW3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5HYW3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni115 – 151DisorderedSequence analysisAdd BLAST37
Regioni323 – 506DisorderedSequence analysisAdd BLAST184

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 150Pro residuesSequence analysisAdd BLAST34
Compositional biasi364 – 397Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi446 – 468Acidic residuesSequence analysisAdd BLAST23
Compositional biasi474 – 488Polar residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPW5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163191

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039587_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5HYW3

Identification of Orthologs from Complete Genome Data

More...OMAi		WPEIEPF

Database of Orthologous Groups

More...OrthoDBi		82879at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5HYW3

TreeFam database of animal gene trees

More...TreeFami		TF337113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032549, DUF4939
IPR032567, LDOC1-rel

The PANTHER Classification System

More...PANTHERi		PTHR15503, PTHR15503, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16297, DUF4939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5HYW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEASGNLNS LRMANVALRE ELNALRGENA NLGLQLGRAL AEVNSLRGNV 
        60         70         80         90        100
SSYIRWPVPI VPVLAEENLE FALSEIEVIP GGELPFLCRP PPRAEPDCIS 
       110        120        130        140        150
DDLLINVIQD RSTPDGPADP PLLPIPPPPA LPPPASKEPP PQPPLAPLER 
       160        170        180        190        200
PEIEPFSGDP VYLAEFLMQL ETFIADHEVH FPGGAERVAF LISFFTGEAK 
       210        220        230        240        250
DWAISVTQEG SPLHANFPRF LDEIRKEFCG PIPPRVAKKA IRKLKQGHCT 
       260        270        280        290        300
LGSYADAFQF LAQFLSWDDC RLQNQFLKGL SEFFRKELLW STEMADLDEL 
       310        320        330        340        350
ILECVEIERK VRVPKPIPLP GVRNIIFPFA PSPNEEESED EEYYSEDEDQ 
       360        370        380        390        400
EARRHRLHSK DQRKRMRAFQ QEMKEKEEEE MKKEEEMKKK EEKEEEEEEE 
       410        420        430        440        450
MKQKEEEEEI RNKNEEEGES KDEEDEDEDG GQKPEGEPQQ DPGTEETYGE 
       460        470        480        490        500
VEEEPLDEAQ DDDLDELMEM EPTFVHASSQ TSGPTSGYHA ENFLGASPPI 
       510        520        530        540        550
IQPSRRRNQN RVPLLEGLPG TNSPFYSSPQ LIRRTGRLGQ RQVRRRPPVL 
       560 
FRLTPRQGGH RAARGRIRV
Length:569
Mass (Da):64,711
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF48B4A215DC99DE
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC02710 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051319420S → R. Corresponds to variant dbSNP:rs6624595Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB082532 mRNA Translation: BAC02710.1 Different initiation.
BX119917 Genomic DNA No translation available.
BC151224 mRNA Translation: AAI51225.1
AL359579 mRNA Translation: CAB94872.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55446.1

Protein sequence database of the Protein Information Resource

More...PIRi		T50613

NCBI Reference Sequences

More...RefSeqi		NP_001019626.1, NM_001024455.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000479991; ENSP00000418667; ENSG00000242732
ENST00000609883; ENSP00000476792; ENSG00000242732

Database of genes from NCBI RefSeq genomes

More...GeneIDi		340526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:340526

UCSC genome browser

More...UCSCi		uc004eaj.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082532 mRNA Translation: BAC02710.1 Different initiation.
BX119917 Genomic DNA No translation available.
BC151224 mRNA Translation: AAI51225.1
AL359579 mRNA Translation: CAB94872.2
CCDSiCCDS55446.1
PIRiT50613
RefSeqiNP_001019626.1, NM_001024455.3

3D structure databases

SMRiQ5HYW3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131065, 2 interactors
STRINGi9606.ENSP00000476792

PTM databases

iPTMnetiQ5HYW3
PhosphoSitePlusiQ5HYW3

Genetic variation databases

BioMutaiRTL5
DMDMi74741563

Proteomic databases

MassIVEiQ5HYW3
PaxDbiQ5HYW3
PeptideAtlasiQ5HYW3
PRIDEiQ5HYW3
ProteomicsDBi62963

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51779, 39 antibodies

The DNASU plasmid repository

More...DNASUi		340526

Genome annotation databases

EnsembliENST00000479991; ENSP00000418667; ENSG00000242732
ENST00000609883; ENSP00000476792; ENSG00000242732
GeneIDi340526
KEGGihsa:340526
UCSCiuc004eaj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		340526
DisGeNETi340526

GeneCards: human genes, protein and diseases

More...GeneCardsi		RTL5
HGNCiHGNC:29430, RTL5
HPAiENSG00000242732, Low tissue specificity
neXtProtiNX_Q5HYW3
OpenTargetsiENSG00000242732
PharmGKBiPA134992098
VEuPathDBiHostDB:ENSG00000242732

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPW5, Eukaryota
GeneTreeiENSGT00940000163191
HOGENOMiCLU_039587_0_0_1
InParanoidiQ5HYW3
OMAiWPEIEPF
OrthoDBi82879at2759
PhylomeDBiQ5HYW3
TreeFamiTF337113

Enzyme and pathway databases

PathwayCommonsiQ5HYW3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		340526, 6 hits in 635 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		340526
PharosiQ5HYW3, Tdark

Protein Ontology

More...PROi		PR:Q5HYW3
RNActiQ5HYW3, protein

Gene expression databases

BgeeiENSG00000242732, Expressed in cerebellar hemisphere and 195 other tissues
GenevisibleiQ5HYW3, HS

Family and domain databases

InterProiView protein in InterPro
IPR032549, DUF4939
IPR032567, LDOC1-rel
PANTHERiPTHR15503, PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297, DUF4939, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5HYW3
Secondary accession number(s): A7E2W7, Q8NCM4, Q9NPX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: September 29, 2021
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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