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Entry version 105 (16 Oct 2019)
Sequence version 1 (15 Feb 2005)
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Protein

Retrotransposon Gag-like protein 5

Gene

RTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

RTL5 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon Gag-like protein 5Imported
Alternative name(s):
Retrotransposon gag domain-containing protein 4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL5Imported
Synonyms:KIAA2001, RGAG4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29430 RTL5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5HYW3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
340526

Open Targets

More...
OpenTargetsi
ENSG00000242732

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134992098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5HYW3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74741563

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002596291 – 569Retrotransposon Gag-like protein 5Add BLAST569

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5HYW3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5HYW3

PeptideAtlas

More...
PeptideAtlasi
Q5HYW3

PRoteomics IDEntifications database

More...
PRIDEi
Q5HYW3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5HYW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5HYW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000242732 Expressed in 182 organ(s), highest expression level in cerebellar hemisphere

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5HYW3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003652

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000476792

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5HYW3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 129Poly-Pro6
Compositional biasi375 – 409Glu-richAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J99I Eukaryota
ENOG41117C1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163191

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000147823

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5HYW3

Identification of Orthologs from Complete Genome Data

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OMAi
SSYIRWP

Database of Orthologous Groups

More...
OrthoDBi
82879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5HYW3

TreeFam database of animal gene trees

More...
TreeFami
TF337113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel

The PANTHER Classification System

More...
PANTHERi
PTHR15503 PTHR15503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16297 DUF4939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5HYW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEASGNLNS LRMANVALRE ELNALRGENA NLGLQLGRAL AEVNSLRGNV
60 70 80 90 100
SSYIRWPVPI VPVLAEENLE FALSEIEVIP GGELPFLCRP PPRAEPDCIS
110 120 130 140 150
DDLLINVIQD RSTPDGPADP PLLPIPPPPA LPPPASKEPP PQPPLAPLER
160 170 180 190 200
PEIEPFSGDP VYLAEFLMQL ETFIADHEVH FPGGAERVAF LISFFTGEAK
210 220 230 240 250
DWAISVTQEG SPLHANFPRF LDEIRKEFCG PIPPRVAKKA IRKLKQGHCT
260 270 280 290 300
LGSYADAFQF LAQFLSWDDC RLQNQFLKGL SEFFRKELLW STEMADLDEL
310 320 330 340 350
ILECVEIERK VRVPKPIPLP GVRNIIFPFA PSPNEEESED EEYYSEDEDQ
360 370 380 390 400
EARRHRLHSK DQRKRMRAFQ QEMKEKEEEE MKKEEEMKKK EEKEEEEEEE
410 420 430 440 450
MKQKEEEEEI RNKNEEEGES KDEEDEDEDG GQKPEGEPQQ DPGTEETYGE
460 470 480 490 500
VEEEPLDEAQ DDDLDELMEM EPTFVHASSQ TSGPTSGYHA ENFLGASPPI
510 520 530 540 550
IQPSRRRNQN RVPLLEGLPG TNSPFYSSPQ LIRRTGRLGQ RQVRRRPPVL
560
FRLTPRQGGH RAARGRIRV
Length:569
Mass (Da):64,711
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF48B4A215DC99DE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC02710 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051319420S → R. Corresponds to variant dbSNP:rs6624595Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB082532 mRNA Translation: BAC02710.1 Different initiation.
BX119917 Genomic DNA No translation available.
BC151224 mRNA Translation: AAI51225.1
AL359579 mRNA Translation: CAB94872.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55446.1

Protein sequence database of the Protein Information Resource

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PIRi
T50613

NCBI Reference Sequences

More...
RefSeqi
NP_001019626.1, NM_001024455.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000479991; ENSP00000418667; ENSG00000242732
ENST00000609883; ENSP00000476792; ENSG00000242732

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340526

UCSC genome browser

More...
UCSCi
uc004eaj.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082532 mRNA Translation: BAC02710.1 Different initiation.
BX119917 Genomic DNA No translation available.
BC151224 mRNA Translation: AAI51225.1
AL359579 mRNA Translation: CAB94872.2
CCDSiCCDS55446.1
PIRiT50613
RefSeqiNP_001019626.1, NM_001024455.3

3D structure databases

SMRiQ5HYW3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000476792

PTM databases

iPTMnetiQ5HYW3
PhosphoSitePlusiQ5HYW3

Polymorphism and mutation databases

BioMutaiRTL5
DMDMi74741563

Proteomic databases

MassIVEiQ5HYW3
PaxDbiQ5HYW3
PeptideAtlasiQ5HYW3
PRIDEiQ5HYW3
ProteomicsDBi62963

Genome annotation databases

EnsembliENST00000479991; ENSP00000418667; ENSG00000242732
ENST00000609883; ENSP00000476792; ENSG00000242732
GeneIDi340526
KEGGihsa:340526
UCSCiuc004eaj.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340526
DisGeNETi340526

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTL5
HGNCiHGNC:29430 RTL5
HPAiHPA003652
neXtProtiNX_Q5HYW3
OpenTargetsiENSG00000242732
PharmGKBiPA134992098

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J99I Eukaryota
ENOG41117C1 LUCA
GeneTreeiENSGT00940000163191
HOGENOMiHOG000147823
InParanoidiQ5HYW3
OMAiSSYIRWP
OrthoDBi82879at2759
PhylomeDBiQ5HYW3
TreeFamiTF337113

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340526
PharosiQ5HYW3

Protein Ontology

More...
PROi
PR:Q5HYW3

Gene expression databases

BgeeiENSG00000242732 Expressed in 182 organ(s), highest expression level in cerebellar hemisphere
GenevisibleiQ5HYW3 HS

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTL5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5HYW3
Secondary accession number(s): A7E2W7, Q8NCM4, Q9NPX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: October 16, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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