UniProtKB - Q5HYW2 (NHSL2_HUMAN)
Protein
NHS-like protein 2
Gene
NHSL2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell differentiation Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q5HYW2 |
Names & Taxonomyi
Protein namesi | Recommended name: NHS-like protein 2Curated |
Gene namesi | Name:NHSL2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204131.8 |
HGNCi | HGNC:33737, NHSL2 |
neXtProti | NX_Q5HYW2 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 340527 |
OpenTargetsi | ENSG00000204131 |
Miscellaneous databases
Pharosi | Q5HYW2, Tdark |
Polymorphism and mutation databases
BioMutai | NHSL2 |
DMDMi | 74741562 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341355 | 1 – 1225 | NHS-like protein 2Add BLAST | 1225 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 500 | PhosphoserineBy similarity | 1 | |
Modified residuei | 576 | PhosphoserineBy similarity | 1 | |
Modified residuei | 691 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1054 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5HYW2 |
jPOSTi | Q5HYW2 |
MassIVEi | Q5HYW2 |
PaxDbi | Q5HYW2 |
PeptideAtlasi | Q5HYW2 |
PRIDEi | Q5HYW2 |
ProteomicsDBi | 62962 |
PTM databases
iPTMneti | Q5HYW2 |
PhosphoSitePlusi | Q5HYW2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204131, Expressed in sural nerve and 168 other tissues |
ExpressionAtlasi | Q5HYW2, baseline and differential |
Genevisiblei | Q5HYW2, HS |
Organism-specific databases
HPAi | ENSG00000204131, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Hide detailsQ5HYW2
Protein-protein interaction databases
IntActi | Q5HYW2, 42 interactors |
STRINGi | 9606.ENSP00000424079 |
Miscellaneous databases
RNActi | Q5HYW2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 651 – 801 | Ser-richAdd BLAST | 151 |
Sequence similaritiesi
Belongs to the NHS family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQ7S, Eukaryota |
GeneTreei | ENSGT00950000182963 |
InParanoidi | Q5HYW2 |
OMAi | LEFILMP |
OrthoDBi | 82879at2759 |
PhylomeDBi | Q5HYW2 |
Family and domain databases
InterProi | View protein in InterPro IPR024845, NHS_fam |
Pfami | View protein in Pfam PF15273, NHS, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5HYW2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPFYRRTVVP QRLCPRNPPQ QLAELRDVSH LAALSLLRQL ADLCGHSLAL
60 70 80 90 100
LEDLEGHLLA LGRRTDSLYR RTVRLRRRLP CRLLGPEEDE EELAAANSGR
110 120 130 140 150
ENATATAHSR SSWRQPVNVF LSSGRPPSVE ELLREAQLNL QSLLQEEYEE
160 170 180 190 200
QYSEARLVGQ TFRSSDEATK PTPNPRPQSA RRLEFILMPT KRQLSEDETT
210 220 230 240 250
TQGVRAPEAS LSLSTTADKQ TAWNSLFPLP ILEEKRWPQL CSTQSDIVPI
260 270 280 290 300
NISGQQFDKH ASLRHSLFNT ETAVNPKSTL RRRRTIIGFS NFSQRDQGHS
310 320 330 340 350
NSPAGSVAHS TTSDIRPSHS VPEGVHGRVA VGQDARFPSL TSPVLRTPSS
360 370 380 390 400
EPDEPHQARS GPNPPGMESM GMVYSVPSSC NGPTESTFST SWKGDAFTYM
410 420 430 440 450
TPSATSQSNQ VNENGKNPSC GNSWVSLNKV PPLVPKEAAT LLVARDNPAG
460 470 480 490 500
CSGSAGYPER LIQQRHMPER PSKIGLLTSG TSRLETGPGG ASRFRERSLS
510 520 530 540 550
VPTDSGTTDV DYDEEQKANE ACALPFASTS SEGSNSADNI ASLSAQQEAQ
560 570 580 590 600
HRRQRSKSIS LRKAKKKPSP PTRSVSLVKD EPGLLPEGGS ALPKDQRPKS
610 620 630 640 650
LCLSLEHQGH HSSHPDAQGH PAIPNHKDPE STQFSHHWYL TDWKSGDTYQ
660 670 680 690 700
SLSSSSTATG TTVIECTQVQ GSSESLASPS TSRATTPSQL SIEVEAREIS
710 720 730 740 750
SPGRPPGLMS PSSGYSSQSE TPTPTVSMSL TLGHLPPPSS SVRVRPVVPE
760 770 780 790 800
RKSSLPPTSP MEKFPKSRLS FDLPLTSSPN LDLSGMSISI RSKTKVSRHH
810 820 830 840 850
SETNFGVKLA QKTNPNQPIM PMVTQSDLRS VRLRSVSKSE PEDDIESPEY
860 870 880 890 900
AEEPRAEEVF TLPERKTKPP VAEKPPVARR PPSLVHKPPS VPEEYALTSP
910 920 930 940 950
TLAMPPRSSI QHARPLPQDS YTVVRKPKPS SFPDGRSPGE STAPSSLVFT
960 970 980 990 1000
PFASSSDAFF SGTQQPPQGS VEDEGPKVRV LPERISLQSQ EEAEKKKGKI
1010 1020 1030 1040 1050
PPPVPKKPSV LYLPLTSPTA QMEAYVAEPR LPLSPIITLE EDTKCPATGD
1060 1070 1080 1090 1100
DLQSLGQRVT STPQADSERE ASPLGSSVEP GTEEKSLISD KTAEWIAEDD
1110 1120 1130 1140 1150
DDVFVASRTT EDLFTVIHRS KRKLLGWKEP GEAFVGGRTS SHSPIKNTAE
1160 1170 1180 1190 1200
SPISESTATA GSGSSANLDA GRNDDFKALL QKKGSKATPR SRPSAAELLK
1210 1220
TTNPLARRII AQFSKDYETT DNPST
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YW69 | A0A0J9YW69_HUMAN | NHS-like protein 2 | NHSL2 | 835 | Annotation score: | ||
A0A0J9YY72 | A0A0J9YY72_HUMAN | NHS-like protein 2 | NHSL2 | 950 | Annotation score: | ||
A0A1W2PQQ1 | A0A1W2PQQ1_HUMAN | NHS-like protein 2 | NHSL2 | 1,133 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044057 | 901 | T → I. Corresponds to variant dbSNP:rs7061150Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060098 | 1 – 366 | Missing in isoform 2. Add BLAST | 366 | |
Alternative sequenceiVSP_060099 | 1076 – 1225 | Missing in isoform 2. Add BLAST | 150 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX119917 Genomic DNA No translation available. AL929401 Genomic DNA No translation available. BC136756 mRNA Translation: AAI36757.1 |
CCDSi | CCDS87759.1 [Q5HYW2-1] |
RefSeqi | NP_001013649.2, NM_001013627.2 [Q5HYW2-1] |
Genome annotation databases
Ensembli | ENST00000510661; ENSP00000424079; ENSG00000204131 [Q5HYW2-2] ENST00000633930; ENSP00000488668; ENSG00000204131 [Q5HYW2-1] |
GeneIDi | 340527 |
KEGGi | hsa:340527 |
UCSCi | uc004eak.1, human [Q5HYW2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX119917 Genomic DNA No translation available. AL929401 Genomic DNA No translation available. BC136756 mRNA Translation: AAI36757.1 |
CCDSi | CCDS87759.1 [Q5HYW2-1] |
RefSeqi | NP_001013649.2, NM_001013627.2 [Q5HYW2-1] |
3D structure databases
SMRi | Q5HYW2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q5HYW2, 42 interactors |
STRINGi | 9606.ENSP00000424079 |
PTM databases
iPTMneti | Q5HYW2 |
PhosphoSitePlusi | Q5HYW2 |
Polymorphism and mutation databases
BioMutai | NHSL2 |
DMDMi | 74741562 |
Proteomic databases
EPDi | Q5HYW2 |
jPOSTi | Q5HYW2 |
MassIVEi | Q5HYW2 |
PaxDbi | Q5HYW2 |
PeptideAtlasi | Q5HYW2 |
PRIDEi | Q5HYW2 |
ProteomicsDBi | 62962 |
Protocols and materials databases
Antibodypediai | 35138, 14 antibodies |
Genome annotation databases
Ensembli | ENST00000510661; ENSP00000424079; ENSG00000204131 [Q5HYW2-2] ENST00000633930; ENSP00000488668; ENSG00000204131 [Q5HYW2-1] |
GeneIDi | 340527 |
KEGGi | hsa:340527 |
UCSCi | uc004eak.1, human [Q5HYW2-1] |
Organism-specific databases
CTDi | 340527 |
DisGeNETi | 340527 |
EuPathDBi | HostDB:ENSG00000204131.8 |
GeneCardsi | NHSL2 |
HGNCi | HGNC:33737, NHSL2 |
HPAi | ENSG00000204131, Tissue enhanced (brain) |
neXtProti | NX_Q5HYW2 |
OpenTargetsi | ENSG00000204131 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ7S, Eukaryota |
GeneTreei | ENSGT00950000182963 |
InParanoidi | Q5HYW2 |
OMAi | LEFILMP |
OrthoDBi | 82879at2759 |
PhylomeDBi | Q5HYW2 |
Enzyme and pathway databases
PathwayCommonsi | Q5HYW2 |
Miscellaneous databases
BioGRID-ORCSi | 340527, 0 hits in 86 CRISPR screens |
ChiTaRSi | NHSL2, human |
GenomeRNAii | 340527 |
Pharosi | Q5HYW2, Tdark |
PROi | PR:Q5HYW2 |
RNActi | Q5HYW2, protein |
Gene expression databases
Bgeei | ENSG00000204131, Expressed in sural nerve and 168 other tissues |
ExpressionAtlasi | Q5HYW2, baseline and differential |
Genevisiblei | Q5HYW2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024845, NHS_fam |
Pfami | View protein in Pfam PF15273, NHS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NHSL2_HUMAN | |
Accessioni | Q5HYW2Primary (citable) accession number: Q5HYW2 Secondary accession number(s): A0A0J9YY34, B2RN94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 100 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations