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Entry version 99 (12 Aug 2020)
Sequence version 2 (10 Apr 2019)
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Protein

NHS-like protein 2

Gene

NHSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell differentiation Source: GO_Central

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5HYW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NHS-like protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NHSL2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204131.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33737, NHSL2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5HYW2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
340527

Open Targets

More...
OpenTargetsi
ENSG00000204131

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5HYW2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NHSL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74741562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413551 – 1225NHS-like protein 2Add BLAST1225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei500PhosphoserineBy similarity1
Modified residuei576PhosphoserineBy similarity1
Modified residuei691PhosphoserineBy similarity1
Modified residuei1054PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5HYW2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5HYW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5HYW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5HYW2

PeptideAtlas

More...
PeptideAtlasi
Q5HYW2

PRoteomics IDEntifications database

More...
PRIDEi
Q5HYW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62962

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5HYW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5HYW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204131, Expressed in sural nerve and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5HYW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5HYW2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204131, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5HYW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi651 – 801Ser-richAdd BLAST151

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NHS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ7S, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182963

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5HYW2

KEGG Orthology (KO)

More...
KOi
K24144

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEFILMP

Database of Orthologous Groups

More...
OrthoDBi
82879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5HYW2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024845, NHS_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15273, NHS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5HYW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFYRRTVVP QRLCPRNPPQ QLAELRDVSH LAALSLLRQL ADLCGHSLAL
60 70 80 90 100
LEDLEGHLLA LGRRTDSLYR RTVRLRRRLP CRLLGPEEDE EELAAANSGR
110 120 130 140 150
ENATATAHSR SSWRQPVNVF LSSGRPPSVE ELLREAQLNL QSLLQEEYEE
160 170 180 190 200
QYSEARLVGQ TFRSSDEATK PTPNPRPQSA RRLEFILMPT KRQLSEDETT
210 220 230 240 250
TQGVRAPEAS LSLSTTADKQ TAWNSLFPLP ILEEKRWPQL CSTQSDIVPI
260 270 280 290 300
NISGQQFDKH ASLRHSLFNT ETAVNPKSTL RRRRTIIGFS NFSQRDQGHS
310 320 330 340 350
NSPAGSVAHS TTSDIRPSHS VPEGVHGRVA VGQDARFPSL TSPVLRTPSS
360 370 380 390 400
EPDEPHQARS GPNPPGMESM GMVYSVPSSC NGPTESTFST SWKGDAFTYM
410 420 430 440 450
TPSATSQSNQ VNENGKNPSC GNSWVSLNKV PPLVPKEAAT LLVARDNPAG
460 470 480 490 500
CSGSAGYPER LIQQRHMPER PSKIGLLTSG TSRLETGPGG ASRFRERSLS
510 520 530 540 550
VPTDSGTTDV DYDEEQKANE ACALPFASTS SEGSNSADNI ASLSAQQEAQ
560 570 580 590 600
HRRQRSKSIS LRKAKKKPSP PTRSVSLVKD EPGLLPEGGS ALPKDQRPKS
610 620 630 640 650
LCLSLEHQGH HSSHPDAQGH PAIPNHKDPE STQFSHHWYL TDWKSGDTYQ
660 670 680 690 700
SLSSSSTATG TTVIECTQVQ GSSESLASPS TSRATTPSQL SIEVEAREIS
710 720 730 740 750
SPGRPPGLMS PSSGYSSQSE TPTPTVSMSL TLGHLPPPSS SVRVRPVVPE
760 770 780 790 800
RKSSLPPTSP MEKFPKSRLS FDLPLTSSPN LDLSGMSISI RSKTKVSRHH
810 820 830 840 850
SETNFGVKLA QKTNPNQPIM PMVTQSDLRS VRLRSVSKSE PEDDIESPEY
860 870 880 890 900
AEEPRAEEVF TLPERKTKPP VAEKPPVARR PPSLVHKPPS VPEEYALTSP
910 920 930 940 950
TLAMPPRSSI QHARPLPQDS YTVVRKPKPS SFPDGRSPGE STAPSSLVFT
960 970 980 990 1000
PFASSSDAFF SGTQQPPQGS VEDEGPKVRV LPERISLQSQ EEAEKKKGKI
1010 1020 1030 1040 1050
PPPVPKKPSV LYLPLTSPTA QMEAYVAEPR LPLSPIITLE EDTKCPATGD
1060 1070 1080 1090 1100
DLQSLGQRVT STPQADSERE ASPLGSSVEP GTEEKSLISD KTAEWIAEDD
1110 1120 1130 1140 1150
DDVFVASRTT EDLFTVIHRS KRKLLGWKEP GEAFVGGRTS SHSPIKNTAE
1160 1170 1180 1190 1200
SPISESTATA GSGSSANLDA GRNDDFKALL QKKGSKATPR SRPSAAELLK
1210 1220
TTNPLARRII AQFSKDYETT DNPST
Length:1,225
Mass (Da):133,286
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84681065AD4F7D5E
GO
Isoform 2 (identifier: Q5HYW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.
     1076-1225: Missing.

Show »
Length:709
Mass (Da):76,301
Checksum:iFE6F060EB13DF34B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YW69A0A0J9YW69_HUMAN
NHS-like protein 2
NHSL2
835Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY72A0A0J9YY72_HUMAN
NHS-like protein 2
NHSL2
950Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQQ1A0A1W2PQQ1_HUMAN
NHS-like protein 2
NHSL2
1,133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044057901T → I. Corresponds to variant dbSNP:rs7061150Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0600981 – 366Missing in isoform 2. Add BLAST366
Alternative sequenceiVSP_0600991076 – 1225Missing in isoform 2. Add BLAST150

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX119917 Genomic DNA No translation available.
AL929401 Genomic DNA No translation available.
BC136756 mRNA Translation: AAI36757.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS87759.1 [Q5HYW2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001013649.2, NM_001013627.2 [Q5HYW2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000510661; ENSP00000424079; ENSG00000204131 [Q5HYW2-2]
ENST00000633930; ENSP00000488668; ENSG00000204131 [Q5HYW2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340527

UCSC genome browser

More...
UCSCi
uc004eak.1, human [Q5HYW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX119917 Genomic DNA No translation available.
AL929401 Genomic DNA No translation available.
BC136756 mRNA Translation: AAI36757.1
CCDSiCCDS87759.1 [Q5HYW2-1]
RefSeqiNP_001013649.2, NM_001013627.2 [Q5HYW2-1]

3D structure databases

SMRiQ5HYW2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ5HYW2, 42 interactors
STRINGi9606.ENSP00000424079

PTM databases

iPTMnetiQ5HYW2
PhosphoSitePlusiQ5HYW2

Polymorphism and mutation databases

BioMutaiNHSL2
DMDMi74741562

Proteomic databases

EPDiQ5HYW2
jPOSTiQ5HYW2
MassIVEiQ5HYW2
PaxDbiQ5HYW2
PeptideAtlasiQ5HYW2
PRIDEiQ5HYW2
ProteomicsDBi62962

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
35138, 14 antibodies

Genome annotation databases

EnsembliENST00000510661; ENSP00000424079; ENSG00000204131 [Q5HYW2-2]
ENST00000633930; ENSP00000488668; ENSG00000204131 [Q5HYW2-1]
GeneIDi340527
KEGGihsa:340527
UCSCiuc004eak.1, human [Q5HYW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340527
DisGeNETi340527
EuPathDBiHostDB:ENSG00000204131.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NHSL2
HGNCiHGNC:33737, NHSL2
HPAiENSG00000204131, Tissue enhanced (brain)
neXtProtiNX_Q5HYW2
OpenTargetsiENSG00000204131

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQ7S, Eukaryota
GeneTreeiENSGT00950000182963
InParanoidiQ5HYW2
KOiK24144
OMAiLEFILMP
OrthoDBi82879at2759
PhylomeDBiQ5HYW2

Enzyme and pathway databases

PathwayCommonsiQ5HYW2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
340527, 0 hits in 93 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NHSL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340527
PharosiQ5HYW2, Tdark

Protein Ontology

More...
PROi
PR:Q5HYW2
RNActiQ5HYW2, protein

Gene expression databases

BgeeiENSG00000204131, Expressed in sural nerve and 168 other tissues
ExpressionAtlasiQ5HYW2, baseline and differential
GenevisibleiQ5HYW2, HS

Family and domain databases

InterProiView protein in InterPro
IPR024845, NHS_fam
PfamiView protein in Pfam
PF15273, NHS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHSL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5HYW2
Secondary accession number(s): A0A0J9YY34, B2RN94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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