Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 196

Gene

TMEM196

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 196
Gene namesi
Name:TMEM196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000173452.13
HGNCiHGNC:22431 TMEM196
neXtProtiNX_Q5HYL7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi256130
OpenTargetsiENSG00000173452
PharmGKBiPA162406335

Polymorphism and mutation databases

BioMutaiTMEM196
DMDMi166988175

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172561 – 178Transmembrane protein 196Add BLAST178

Proteomic databases

PaxDbiQ5HYL7
PeptideAtlasiQ5HYL7
PRIDEiQ5HYL7
ProteomicsDBi62950
62951 [Q5HYL7-2]
62952 [Q5HYL7-3]
62953 [Q5HYL7-4]

PTM databases

iPTMnetiQ5HYL7
PhosphoSitePlusiQ5HYL7

Expressioni

Gene expression databases

BgeeiENSG00000173452 Expressed in 75 organ(s), highest expression level in forebrain
CleanExiHS_TMEM196
ExpressionAtlasiQ5HYL7 baseline and differential
GenevisibleiQ5HYL7 HS

Organism-specific databases

HPAiHPA043163

Interactioni

Protein-protein interaction databases

BioGridi129140, 3 interactors
IntActiQ5HYL7, 1 interactor
STRINGi9606.ENSP00000384234

Structurei

3D structure databases

ProteinModelPortaliQ5HYL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK3M Eukaryota
ENOG4111I12 LUCA
GeneTreeiENSGT00390000015529
HOGENOMiHOG000081760
HOVERGENiHBG108580
InParanoidiQ5HYL7
KOiK22195
PhylomeDBiQ5HYL7
TreeFamiTF332520

Family and domain databases

InterProiView protein in InterPro
IPR037661 TMEM196
PANTHERiPTHR28681 PTHR28681, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5HYL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCTSGQIIGS LLVLSVLEIG LGVSSVAVGA VSFSLALREH KPQLGDSSPV
60 70 80 90 100
WSGVCFLLCG ICGILCAKKK SGLVMILFSA CCICGLIGGI LNFQFLRAVT
110 120 130 140 150
KKTSSLYPLH LASMSLACIG IGGCTLSSWL TCRLASYEQR RMFSEREHSL
160 170
HHSHEMAEKE ITDNMSNGGP QLIFNGRV
Note: No experimental confirmation available.
Length:178
Mass (Da):19,025
Last modified:February 5, 2008 - v2
Checksum:iE73C72CD628CE960
GO
Isoform 2 (identifier: Q5HYL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.
Show »
Length:104
Mass (Da):11,538
Checksum:i178F01D36C6F99D8
GO
Isoform 3 (identifier: Q5HYL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     160-178: EITDNMSNGGPQLIFNGRV → IEGY

Note: No experimental confirmation available.
Show »
Length:89
Mass (Da):9,957
Checksum:i55969687F272119A
GO
Isoform 4 (identifier: Q5HYL7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-55: Missing.

Show »
Length:172
Mass (Da):18,394
Checksum:i93302B068BB086ED
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WNR7B7WNR7_HUMAN
Transmembrane protein 196
TMEM196
179Annotation score:
F8WE15F8WE15_HUMAN
Transmembrane protein 196
TMEM196
111Annotation score:

Sequence cautioni

The sequence BX648384 differs from that shown. Reason: Frameshift at position 72.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158E → G in BX648384 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0309281 – 74Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST74
Alternative sequenceiVSP_03920850 – 55Missing in isoform 4. 1 Publication6
Alternative sequenceiVSP_030929160 – 178EITDN…FNGRV → IEGY in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647256 mRNA Translation: CAI46055.1
BX648384 mRNA No translation available.
AC004543 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93715.1
CH471073 Genomic DNA Translation: EAW93716.1
BC030104 mRNA Translation: AAH30104.1
CCDSiCCDS34607.2 [Q5HYL7-4]
RefSeqiNP_689987.3, NM_152774.3 [Q5HYL7-4]
XP_011513552.1, XM_011515250.2 [Q5HYL7-1]
UniGeneiHs.487670

Genome annotation databases

EnsembliENST00000405764; ENSP00000384234; ENSG00000173452 [Q5HYL7-4]
ENST00000433641; ENSP00000406460; ENSG00000173452 [Q5HYL7-3]
ENST00000493519; ENSP00000438368; ENSG00000173452 [Q5HYL7-2]
GeneIDi256130
KEGGihsa:256130
UCSCiuc011jyg.3 human [Q5HYL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647256 mRNA Translation: CAI46055.1
BX648384 mRNA No translation available.
AC004543 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93715.1
CH471073 Genomic DNA Translation: EAW93716.1
BC030104 mRNA Translation: AAH30104.1
CCDSiCCDS34607.2 [Q5HYL7-4]
RefSeqiNP_689987.3, NM_152774.3 [Q5HYL7-4]
XP_011513552.1, XM_011515250.2 [Q5HYL7-1]
UniGeneiHs.487670

3D structure databases

ProteinModelPortaliQ5HYL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129140, 3 interactors
IntActiQ5HYL7, 1 interactor
STRINGi9606.ENSP00000384234

PTM databases

iPTMnetiQ5HYL7
PhosphoSitePlusiQ5HYL7

Polymorphism and mutation databases

BioMutaiTMEM196
DMDMi166988175

Proteomic databases

PaxDbiQ5HYL7
PeptideAtlasiQ5HYL7
PRIDEiQ5HYL7
ProteomicsDBi62950
62951 [Q5HYL7-2]
62952 [Q5HYL7-3]
62953 [Q5HYL7-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405764; ENSP00000384234; ENSG00000173452 [Q5HYL7-4]
ENST00000433641; ENSP00000406460; ENSG00000173452 [Q5HYL7-3]
ENST00000493519; ENSP00000438368; ENSG00000173452 [Q5HYL7-2]
GeneIDi256130
KEGGihsa:256130
UCSCiuc011jyg.3 human [Q5HYL7-1]

Organism-specific databases

CTDi256130
DisGeNETi256130
EuPathDBiHostDB:ENSG00000173452.13
GeneCardsiTMEM196
H-InvDBiHIX0006504
HGNCiHGNC:22431 TMEM196
HPAiHPA043163
neXtProtiNX_Q5HYL7
OpenTargetsiENSG00000173452
PharmGKBiPA162406335
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK3M Eukaryota
ENOG4111I12 LUCA
GeneTreeiENSGT00390000015529
HOGENOMiHOG000081760
HOVERGENiHBG108580
InParanoidiQ5HYL7
KOiK22195
PhylomeDBiQ5HYL7
TreeFamiTF332520

Miscellaneous databases

ChiTaRSiTMEM196 human
GenomeRNAii256130
PROiPR:Q5HYL7

Gene expression databases

BgeeiENSG00000173452 Expressed in 75 organ(s), highest expression level in forebrain
CleanExiHS_TMEM196
ExpressionAtlasiQ5HYL7 baseline and differential
GenevisibleiQ5HYL7 HS

Family and domain databases

InterProiView protein in InterPro
IPR037661 TMEM196
PANTHERiPTHR28681 PTHR28681, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM196_HUMAN
AccessioniPrimary (citable) accession number: Q5HYL7
Secondary accession number(s): Q8N6I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again