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Entry version 133 (11 Dec 2019)
Sequence version 2 (25 Nov 2008)
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Protein

Zinc finger protein 667

Gene

ZNF667

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri144 – 166C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri555 – 577C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri583 – 605C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 667
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF667
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198046.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28854 ZNF667

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611024 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5HYK9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63934

Open Targets

More...
OpenTargetsi
ENSG00000198046

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670514

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5HYK9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF667

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273933

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002518971 – 610Zinc finger protein 667Add BLAST610

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5HYK9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5HYK9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5HYK9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5HYK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5HYK9

PeptideAtlas

More...
PeptideAtlasi
Q5HYK9

PRoteomics IDEntifications database

More...
PRIDEi
Q5HYK9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62949

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5HYK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5HYK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198046 Expressed in 186 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5HYK9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5HYK9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030731
HPA046673

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122002, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5HYK9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q5HYK9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000439402

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5HYK9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5HYK9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 437C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri555 – 577C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri583 – 605C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
ENOG41112RA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000021477

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5HYK9

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNKSGQS

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5HYK9

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q5HYK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSARGKSKS KAPITFGDLA IYFSQEEWEW LSPIQKDLYE DVMLENYRNL
60 70 80 90 100
VSLGLSFRRP NVITLLEKGK APWMVEPVRR RRAPDSGSKC ETKKLPPNQC
110 120 130 140 150
NKSGQSICQK LVSAQQKAPT RKSGCNKNSV LVKPKKGHSG KKPLKCNDCG
160 170 180 190 200
KTFSRSFSLK LHQNIHTGEK PFECSNCRKA FRQISSILLH QRIHSGKKSH
210 220 230 240 250
ECNKCGESFN QRTTLILHMR IHDGKEILDC GKALSQCQSF NIHQKIHVVG
260 270 280 290 300
NVCQCRKCGK AFNQMSSLLL HKKIHNGKKT HKYNKCGRGF KKKSVFVVHK
310 320 330 340 350
RIHAGEKIPE NAKALSQSLQ QRSHHLENPF KCRKCGKLFN RISPLMLHQR
360 370 380 390 400
IHTSEKPYKC DKCDKFFRRL STLILHLRIH NGEKLYRCNK CEKVCNRHSS
410 420 430 440 450
LIQHQKVHTK KKKLFECKEC GKMFSGTANL KIHQNIHSEE KPFKCNKCSK
460 470 480 490 500
VFGRQSFLIE HQRIHTGEKP YQCEECGKAF SHRISLTRHK RIHTEDRPYE
510 520 530 540 550
CDQCGKAFSQ SAHLAQHERI HTGEKPYTCK TCGKAFSQRT SLILHERSHT
560 570 580 590 600
GEKPYECNEC GKAFSSGSDL IRHQRSHSSE KPYECSKCGK AYSRSSSLIR
610
HQNTHSEEKA
Length:610
Mass (Da):70,161
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i658048EF4605B884
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERY5K7ERY5_HUMAN
Zinc finger protein 667
ZNF667
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIE0K7EIE0_HUMAN
Zinc finger protein 667
ZNF667
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ15K7EQ15_HUMAN
Zinc finger protein 667
ZNF667
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX02M0QX02_HUMAN
Zinc finger protein 667
ZNF667
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFC3A0A0D9SFC3_HUMAN
Zinc finger protein 667
ZNF667
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH74898 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH74899 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139S → P in CAI46040 (PubMed:17974005).Curated1
Sequence conflicti512A → T in AK024073 (PubMed:14702039).Curated1
Sequence conflicti593S → G in AK024073 (PubMed:14702039).Curated1
Sequence conflicti593S → G in CAI46040 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047330134P → L3 PublicationsCorresponds to variant dbSNP:rs35914474Ensembl.1
Natural variantiVAR_027716260K → R. Corresponds to variant dbSNP:rs3760849Ensembl.1
Natural variantiVAR_027717540T → A. Corresponds to variant dbSNP:rs12610019Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024073 mRNA No translation available.
AK056508 mRNA Translation: BAG51734.1
BX647401 mRNA Translation: CAI46040.1
AC006116 Genomic DNA No translation available.
AC013256 Genomic DNA No translation available.
BC074898 mRNA Translation: AAH74898.2 Different initiation.
BC074899 mRNA Translation: AAH74899.2 Different initiation.
BC136388 mRNA Translation: AAI36389.1
BC150593 mRNA Translation: AAI50594.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12944.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308285.1, NM_001321356.1
NP_071386.3, NM_022103.3
XP_011525510.1, XM_011527208.1
XP_011525511.1, XM_011527209.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292069; ENSP00000292069; ENSG00000198046
ENST00000504904; ENSP00000439402; ENSG00000198046

Database of genes from NCBI RefSeq genomes

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GeneIDi
63934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63934

UCSC genome browser

More...
UCSCi
uc002qnd.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024073 mRNA No translation available.
AK056508 mRNA Translation: BAG51734.1
BX647401 mRNA Translation: CAI46040.1
AC006116 Genomic DNA No translation available.
AC013256 Genomic DNA No translation available.
BC074898 mRNA Translation: AAH74898.2 Different initiation.
BC074899 mRNA Translation: AAH74899.2 Different initiation.
BC136388 mRNA Translation: AAI36389.1
BC150593 mRNA Translation: AAI50594.1
CCDSiCCDS12944.1
RefSeqiNP_001308285.1, NM_001321356.1
NP_071386.3, NM_022103.3
XP_011525510.1, XM_011527208.1
XP_011525511.1, XM_011527209.1

3D structure databases

SMRiQ5HYK9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122002, 2 interactors
IntActiQ5HYK9, 2 interactors
MINTiQ5HYK9
STRINGi9606.ENSP00000439402

PTM databases

iPTMnetiQ5HYK9
PhosphoSitePlusiQ5HYK9

Polymorphism and mutation databases

BioMutaiZNF667
DMDMi215273933

Proteomic databases

EPDiQ5HYK9
jPOSTiQ5HYK9
MassIVEiQ5HYK9
MaxQBiQ5HYK9
PaxDbiQ5HYK9
PeptideAtlasiQ5HYK9
PRIDEiQ5HYK9
ProteomicsDBi62949

Genome annotation databases

EnsembliENST00000292069; ENSP00000292069; ENSG00000198046
ENST00000504904; ENSP00000439402; ENSG00000198046
GeneIDi63934
KEGGihsa:63934
UCSCiuc002qnd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63934
DisGeNETi63934
EuPathDBiHostDB:ENSG00000198046.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF667
HGNCiHGNC:28854 ZNF667
HPAiHPA030731
HPA046673
MIMi611024 gene
neXtProtiNX_Q5HYK9
OpenTargetsiENSG00000198046
PharmGKBiPA142670514

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
ENOG41112RA LUCA
GeneTreeiENSGT00390000021477
HOGENOMiHOG000234617
InParanoidiQ5HYK9
KOiK09228
OMAiCNKSGQS
OrthoDBi1318335at2759
PhylomeDBiQ5HYK9
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF667 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63934
PharosiQ5HYK9 Tbio

Protein Ontology

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PROi
PR:Q5HYK9
RNActiQ5HYK9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198046 Expressed in 186 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ5HYK9 baseline and differential
GenevisibleiQ5HYK9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN667_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5HYK9
Secondary accession number(s): B2RMS6
, B9EK36, Q6B093, Q9H807
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 25, 2008
Last modified: December 11, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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