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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

COQ5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117S-adenosyl-L-methionineUniRule annotation1
Binding sitei171S-adenosyl-L-methionineUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • methylation Source: UniProtKB
  • ubiquinone biosynthetic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000110871-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2142789 Ubiquinol biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00232

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COQ5UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110871.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28722 COQ5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616359 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5HYK3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84274

Open Targets

More...
OpenTargetsi
ENSG00000110871

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485438

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COQ5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90111987

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 42MitochondrionUniRule annotationAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022862843 – 3272-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialAdd BLAST285

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5HYK3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5HYK3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5HYK3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5HYK3

PeptideAtlas

More...
PeptideAtlasi
Q5HYK3

PRoteomics IDEntifications database

More...
PRIDEi
Q5HYK3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62942
62943 [Q5HYK3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5HYK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5HYK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in liver, lung, placenta and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110871 Expressed in 99 organ(s), highest expression level in muscle of leg

CleanEx database of gene expression profiles

More...
CleanExi
HS_COQ5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5HYK3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5HYK3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049487

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124001, 30 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3642 CoQ biosynthetic complex

Protein interaction database and analysis system

More...
IntActi
Q5HYK3, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288532

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5HYK3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5HYK3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni199 – 200S-adenosyl-L-methionine bindingUniRule annotation2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1540 Eukaryota
COG2226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000249463

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081303

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5HYK3

KEGG Orthology (KO)

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KOi
K06127

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRNFENL

Database of Orthologous Groups

More...
OrthoDBi
1125002at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5HYK3

TreeFam database of animal gene trees

More...
TreeFami
TF106217

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01813 MenG_UbiE_methyltr, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01209 Ubie_methyltran, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01934 MenG_MenH_UbiE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5HYK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPGSCALW SYCGRGWSRA MRGCQLLGLR SSWPGDLLSA RLLSQEKRAA
60 70 80 90 100
ETHFGFETVS EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW
110 120 130 140 150
KMHPLPGTQL LDVAGGTGDI AFRFLNYVQS QHQRKQKRQL RAQQNLSWEE
160 170 180 190 200
IAKEYQNEED SLGGSRVVVC DINKEMLKVG KQKALAQGYR AGLAWVLGDA
210 220 230 240 250
EELPFDDDKF DIYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFSQV
260 270 280 290 300
NNPLISRLYD LYSFQVIPVL GEVIAGDWKS YQYLVESIRR FPSQEEFKDM
310 320
IEDAGFHKVT YESLTSGIVA IHSGFKL
Length:327
Mass (Da):37,140
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D601DF6E74FFCC4
GO
Isoform 2 (identifier: Q5HYK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-170: Missing.
     189-327: YRAGLAWVLG...IVAIHSGFKL → HDRRCRLSQG...GIWSVSLLNC

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):27,914
Checksum:iFBE03D6ED4624CF9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DP72B4DP72_HUMAN
2-methoxy-6-polyprenyl-1,4-benzoqui...
COQ5
253Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVX6F8VVX6_HUMAN
2-methoxy-6-polyprenyl-1,4-benzoqui...
COQ5
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVD5F8VVD5_HUMAN
2-methoxy-6-polyprenyl-1,4-benzoqui...
COQ5
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP53F8VP53_HUMAN
2-methoxy-6-polyprenyl-1,4-benzoqui...
COQ5
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVW7F8VVW7_HUMAN
2-methoxy-6-polyprenyl-1,4-benzoqui...
COQ5
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG38046 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78K → R in CAI46073 (PubMed:17974005).Curated1
Sequence conflicti171D → G in BAG38046 (PubMed:14702039).Curated1
Sequence conflicti291F → S in AAH04916 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025702152A → T3 PublicationsCorresponds to variant dbSNP:rs3742049Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017681119 – 170Missing in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_017682189 – 327YRAGL…SGFKL → HDRRCRLSQGDLRKSNIRHC GHSFWLQTLIPFLSWSMNQS YPVESLELKDNLANETAAEH LLLRIRALDSCLNRTVSKWK NKFLSLFYSFLWSCFSPSPR GIWSVSLLNC in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU700459 mRNA Translation: ACD75052.1
AK057777 mRNA Translation: BAB71567.1
AK222610 mRNA Translation: BAD96330.1
AK293656 mRNA Translation: BAG57105.1
AK315681 mRNA Translation: BAG38046.1 Different initiation.
BX647562 mRNA Translation: CAI46073.1
CH471054 Genomic DNA Translation: EAW98198.1
BC004916 mRNA Translation: AAH04916.2
BC107874 mRNA Translation: AAI07875.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31912.1 [Q5HYK3-1]

NCBI Reference Sequences

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RefSeqi
NP_115690.3, NM_032314.3 [Q5HYK3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.17250

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288532; ENSP00000288532; ENSG00000110871 [Q5HYK3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84274

UCSC genome browser

More...
UCSCi
uc001tyn.4 human [Q5HYK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU700459 mRNA Translation: ACD75052.1
AK057777 mRNA Translation: BAB71567.1
AK222610 mRNA Translation: BAD96330.1
AK293656 mRNA Translation: BAG57105.1
AK315681 mRNA Translation: BAG38046.1 Different initiation.
BX647562 mRNA Translation: CAI46073.1
CH471054 Genomic DNA Translation: EAW98198.1
BC004916 mRNA Translation: AAH04916.2
BC107874 mRNA Translation: AAI07875.1
CCDSiCCDS31912.1 [Q5HYK3-1]
RefSeqiNP_115690.3, NM_032314.3 [Q5HYK3-1]
UniGeneiHs.17250

3D structure databases

ProteinModelPortaliQ5HYK3
SMRiQ5HYK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124001, 30 interactors
ComplexPortaliCPX-3642 CoQ biosynthetic complex
IntActiQ5HYK3, 13 interactors
STRINGi9606.ENSP00000288532

PTM databases

iPTMnetiQ5HYK3
PhosphoSitePlusiQ5HYK3

Polymorphism and mutation databases

BioMutaiCOQ5
DMDMi90111987

Proteomic databases

EPDiQ5HYK3
jPOSTiQ5HYK3
MaxQBiQ5HYK3
PaxDbiQ5HYK3
PeptideAtlasiQ5HYK3
PRIDEiQ5HYK3
ProteomicsDBi62942
62943 [Q5HYK3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288532; ENSP00000288532; ENSG00000110871 [Q5HYK3-1]
GeneIDi84274
KEGGihsa:84274
UCSCiuc001tyn.4 human [Q5HYK3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84274
DisGeNETi84274
EuPathDBiHostDB:ENSG00000110871.14

GeneCards: human genes, protein and diseases

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GeneCardsi
COQ5
HGNCiHGNC:28722 COQ5
HPAiHPA049487
MIMi616359 gene
neXtProtiNX_Q5HYK3
OpenTargetsiENSG00000110871
PharmGKBiPA143485438

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1540 Eukaryota
COG2226 LUCA
GeneTreeiENSGT00390000001654
HOGENOMiHOG000249463
HOVERGENiHBG081303
InParanoidiQ5HYK3
KOiK06127
OMAiVRNFENL
OrthoDBi1125002at2759
PhylomeDBiQ5HYK3
TreeFamiTF106217

Enzyme and pathway databases

UniPathwayi
UPA00232

BioCyciMetaCyc:ENSG00000110871-MONOMER
ReactomeiR-HSA-2142789 Ubiquinol biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COQ5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84274

Protein Ontology

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PROi
PR:Q5HYK3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110871 Expressed in 99 organ(s), highest expression level in muscle of leg
CleanExiHS_COQ5
ExpressionAtlasiQ5HYK3 baseline and differential
GenevisibleiQ5HYK3 HS

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOQ5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5HYK3
Secondary accession number(s): B2RDU9
, B3GK62, B4DEJ4, Q32Q28, Q53HH0, Q96LV1, Q9BSP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: January 16, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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