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Protein

Protein FAM76B

Gene

FAM76B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM76B
Gene namesi
Name:FAM76B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000077458.12
HGNCiHGNC:28492 FAM76B
neXtProtiNX_Q5HYJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000077458
PharmGKBiPA142671838

Polymorphism and mutation databases

BioMutaiFAM76B
DMDMi296439347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002457632 – 339Protein FAM76BAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei215PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5HYJ3
MaxQBiQ5HYJ3
PaxDbiQ5HYJ3
PeptideAtlasiQ5HYJ3
PRIDEiQ5HYJ3
ProteomicsDBi62940
62941 [Q5HYJ3-2]

PTM databases

iPTMnetiQ5HYJ3
PhosphoSitePlusiQ5HYJ3

Expressioni

Gene expression databases

BgeeiENSG00000077458 Expressed in 196 organ(s), highest expression level in sperm
CleanExiHS_FAM76B
ExpressionAtlasiQ5HYJ3 baseline and differential
GenevisibleiQ5HYJ3 HS

Organism-specific databases

HPAiHPA036608

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi126816, 19 interactors
IntActiQ5HYJ3, 19 interactors
MINTiQ5HYJ3
STRINGi9606.ENSP00000351631

Structurei

3D structure databases

ProteinModelPortaliQ5HYJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili248 – 328Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 160Poly-Ser10
Compositional biasi167 – 187His-richAdd BLAST21
Compositional biasi171 – 180Poly-His10

Domaini

The polyhistidine repeat acts as a targeting signal to nuclear speckles.1 Publication

Sequence similaritiesi

Belongs to the FAM76 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3990 Eukaryota
ENOG410YE53 LUCA
GeneTreeiENSGT00390000014462
HOGENOMiHOG000231316
HOVERGENiHBG080224
InParanoidiQ5HYJ3
OMAiKYGPPVQ
OrthoDBiEOG091G0LJR
PhylomeDBiQ5HYJ3
TreeFamiTF313644

Family and domain databases

InterProiView protein in InterPro
IPR032017 FAM76
IPR029661 FAM76B
PANTHERiPTHR12606:SF24 PTHR12606:SF24, 1 hit
PfamiView protein in Pfam
PF16046 FAM76, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5HYJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASALYACT KCTQRYPFEE LSQGQQLCKE CRIAHPIVKC TYCRSEFQQE
60 70 80 90 100
SKTNTICKKC AQNVKQFGTP KPCQYCNIIA AFIGTKCQRC TNSEKKYGPP
110 120 130 140 150
QTCEQCKQQC AFDRKEEGRR KVDGKLLCWL CTLSYKRVLQ KTKEQRKSLG
160 170 180 190 200
SSHSNSSSSS LTEKDQHHPK HHHHHHHHHH RHSSSHHKIS NLSPEEEQGL
210 220 230 240 250
WKQSHKSSAT IQNETPKKKP KLESKPSNGD SSSINQSADS GGTDNFVLIS
260 270 280 290 300
QLKEEVMSLK RLLQQRDQTI LEKDKKLTEL KADFQYQESN LRTKMNSMEK
310 320 330
AHKETVEQLQ AKNRELLKQV AALSKGKKFD KSGSILTSP
Length:339
Mass (Da):38,708
Last modified:May 18, 2010 - v3
Checksum:i4ED7FEE05F23790C
GO
Isoform 2 (identifier: Q5HYJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-233: SSS → RSM
     234-339: Missing.

Show »
Length:233
Mass (Da):26,771
Checksum:i3080A28B11A7C341
GO
Isoform 3 (identifier: Q5HYJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-339: SSSINQSADS...DKSGSILTSP → RCM

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,787
Checksum:i309BA28B11A7C341
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H215F5H215_HUMAN
Protein FAM76B
FAM76B
91Annotation score:
F5GX09F5GX09_HUMAN
Protein FAM76B
FAM76B
338Annotation score:
F5H5F4F5H5F4_HUMAN
Protein FAM76B
FAM76B
49Annotation score:
F5H6T9F5H6T9_HUMAN
Protein FAM76B
FAM76B
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228N → K in CAI46088 (PubMed:17974005).Curated1
Sequence conflicti328K → E in CAI46088 (PubMed:17974005).Curated1
Sequence conflicti333G → R in CAI46088 (PubMed:17974005).Curated1
Isoform 2 (identifier: Q5HYJ3-2)
Sequence conflicti232S → C in AAH26013 (PubMed:16554811).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057354231 – 339SSSIN…ILTSP → RCM in isoform 3. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_022679231 – 233SSS → RSM in isoform 2. 1 Publication3
Alternative sequenceiVSP_022680234 – 339Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313727 mRNA Translation: BAG36469.1
BX647586 mRNA Translation: CAI46088.1
AP001877 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66962.1
CH471065 Genomic DNA Translation: EAW66963.1
BC026013 mRNA Translation: AAH26013.1
BC028727 mRNA Translation: AAH28727.1
CCDSiCCDS41700.1 [Q5HYJ3-1]
RefSeqiNP_653265.3, NM_144664.4 [Q5HYJ3-1]
UniGeneiHs.288304

Genome annotation databases

EnsembliENST00000358780; ENSP00000351631; ENSG00000077458 [Q5HYJ3-1]
ENST00000398187; ENSP00000381248; ENSG00000077458 [Q5HYJ3-3]
ENST00000543641; ENSP00000444087; ENSG00000077458 [Q5HYJ3-3]
GeneIDi143684
KEGGihsa:143684
UCSCiuc001pfn.3 human [Q5HYJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313727 mRNA Translation: BAG36469.1
BX647586 mRNA Translation: CAI46088.1
AP001877 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66962.1
CH471065 Genomic DNA Translation: EAW66963.1
BC026013 mRNA Translation: AAH26013.1
BC028727 mRNA Translation: AAH28727.1
CCDSiCCDS41700.1 [Q5HYJ3-1]
RefSeqiNP_653265.3, NM_144664.4 [Q5HYJ3-1]
UniGeneiHs.288304

3D structure databases

ProteinModelPortaliQ5HYJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126816, 19 interactors
IntActiQ5HYJ3, 19 interactors
MINTiQ5HYJ3
STRINGi9606.ENSP00000351631

PTM databases

iPTMnetiQ5HYJ3
PhosphoSitePlusiQ5HYJ3

Polymorphism and mutation databases

BioMutaiFAM76B
DMDMi296439347

Proteomic databases

EPDiQ5HYJ3
MaxQBiQ5HYJ3
PaxDbiQ5HYJ3
PeptideAtlasiQ5HYJ3
PRIDEiQ5HYJ3
ProteomicsDBi62940
62941 [Q5HYJ3-2]

Protocols and materials databases

DNASUi143684
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358780; ENSP00000351631; ENSG00000077458 [Q5HYJ3-1]
ENST00000398187; ENSP00000381248; ENSG00000077458 [Q5HYJ3-3]
ENST00000543641; ENSP00000444087; ENSG00000077458 [Q5HYJ3-3]
GeneIDi143684
KEGGihsa:143684
UCSCiuc001pfn.3 human [Q5HYJ3-1]

Organism-specific databases

CTDi143684
EuPathDBiHostDB:ENSG00000077458.12
GeneCardsiFAM76B
H-InvDBiHIX0010043
HGNCiHGNC:28492 FAM76B
HPAiHPA036608
neXtProtiNX_Q5HYJ3
OpenTargetsiENSG00000077458
PharmGKBiPA142671838
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3990 Eukaryota
ENOG410YE53 LUCA
GeneTreeiENSGT00390000014462
HOGENOMiHOG000231316
HOVERGENiHBG080224
InParanoidiQ5HYJ3
OMAiKYGPPVQ
OrthoDBiEOG091G0LJR
PhylomeDBiQ5HYJ3
TreeFamiTF313644

Miscellaneous databases

GeneWikiiFAM76B
GenomeRNAii143684
PROiPR:Q5HYJ3

Gene expression databases

BgeeiENSG00000077458 Expressed in 196 organ(s), highest expression level in sperm
CleanExiHS_FAM76B
ExpressionAtlasiQ5HYJ3 baseline and differential
GenevisibleiQ5HYJ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR032017 FAM76
IPR029661 FAM76B
PANTHERiPTHR12606:SF24 PTHR12606:SF24, 1 hit
PfamiView protein in Pfam
PF16046 FAM76, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA76B_HUMAN
AccessioniPrimary (citable) accession number: Q5HYJ3
Secondary accession number(s): B2R9C2, Q6PIU3, Q8TC53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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