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Protein

Rab-like protein 3

Gene

RABL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi147 – 150GTPBy similarity4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 3
Gene namesi
Name:RABL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144840.8
HGNCiHGNC:18072 RABL3
neXtProtiNX_Q5HYI8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144840
PharmGKBiPA34161

Polymorphism and mutation databases

BioMutaiRABL3
DMDMi74762186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121661 – 236Rab-like protein 3Add BLAST236

Proteomic databases

EPDiQ5HYI8
MaxQBiQ5HYI8
PaxDbiQ5HYI8
PeptideAtlasiQ5HYI8
PRIDEiQ5HYI8
ProteomicsDBi62938
TopDownProteomicsiQ5HYI8

PTM databases

iPTMnetiQ5HYI8
PhosphoSitePlusiQ5HYI8

Expressioni

Gene expression databases

BgeeiENSG00000144840
CleanExiHS_RABL3
ExpressionAtlasiQ5HYI8 baseline and differential
GenevisibleiQ5HYI8 HS

Organism-specific databases

HPAiHPA035150
HPA035151

Interactioni

Protein-protein interaction databases

BioGridi130066, 29 interactors
IntActiQ5HYI8, 30 interactors
MINTiQ5HYI8
STRINGi9606.ENSP00000273375

Structurei

3D structure databases

ProteinModelPortaliQ5HYI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 236Small GTPase-likeAdd BLAST236

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiENOG410IJY5 Eukaryota
ENOG410YR8H LUCA
GeneTreeiENSGT00390000007467
HOGENOMiHOG000006785
HOVERGENiHBG108392
InParanoidiQ5HYI8
KOiK07933
OMAiHKNTRSV
OrthoDBiEOG091G0GUK
PhylomeDBiQ5HYI8
TreeFamiTF320841

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HYI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRVHDY
60 70 80 90 100
KEGTPEEKTY YIELWDVGGS VGSASSVKST RAVFYNSVNG IIFVHDLTNK
110 120 130 140 150
KSSQNLRRWS LEALNRDLVP TGVLVTNGDY DQEQFADNQI PLLVIGTKLD
160 170 180 190 200
QIHETKRHEV LTRTAFLAED FNPEEINLDC TNPRYLAAGS SNAVKLSRFF
210 220 230
DKVIEKRYFL REGNQIPGFP DRKRFGAGTL KSLHYD
Length:236
Mass (Da):26,423
Last modified:February 15, 2005 - v1
Checksum:iB80898B1293C88C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60Y → C in AAH20832 (PubMed:15489334).Curated1
Sequence conflicti163R → T in AAH20832 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293085 mRNA Translation: BAF85774.1
BX647664 mRNA Translation: CAI46059.1
BX647593 mRNA Translation: CAI46064.1
BX647559 mRNA Translation: CAI46095.1
CH471052 Genomic DNA Translation: EAW79521.1
BC020832 mRNA Translation: AAH20832.1
CCDSiCCDS3001.1
RefSeqiNP_776186.2, NM_173825.3
UniGeneiHs.444360

Genome annotation databases

EnsembliENST00000273375; ENSP00000273375; ENSG00000144840
GeneIDi285282
KEGGihsa:285282
UCSCiuc003edx.3 human

Similar proteinsi

Entry informationi

Entry nameiRABL3_HUMAN
AccessioniPrimary (citable) accession number: Q5HYI8
Secondary accession number(s): Q8WUD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 15, 2005
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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