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Protein

Metaxin-3

Gene

MTX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could function in transport of proteins into the mitochondrion.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Metaxin-3
Gene namesi
Name:MTX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177034.14
HGNCiHGNC:24812 MTX3
neXtProtiNX_Q5HYI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi345778
OpenTargetsiENSG00000177034
PharmGKBiPA134924631

Polymorphism and mutation databases

BioMutaiMTX3
DMDMi189029218

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371001 – 312Metaxin-3Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5HYI7
MaxQBiQ5HYI7
PaxDbiQ5HYI7
PeptideAtlasiQ5HYI7
PRIDEiQ5HYI7
ProteomicsDBi62935
62936 [Q5HYI7-2]
62937 [Q5HYI7-4]

PTM databases

iPTMnetiQ5HYI7
PhosphoSitePlusiQ5HYI7

Expressioni

Gene expression databases

BgeeiENSG00000177034 Expressed in 202 organ(s), highest expression level in deltoid
CleanExiHS_MTX3
GenevisibleiQ5HYI7 HS

Organism-specific databases

HPAiHPA047858
HPA062061

Interactioni

Subunit structurei

Part of a large protein complex spanning both mitochondrial membranes termed the mitochondrial intermembrane space bridging (MIB) complex.1 Publication

Protein-protein interaction databases

BioGridi131365, 28 interactors
IntActiQ5HYI7, 7 interactors
STRINGi9606.ENSP00000423600

Structurei

3D structure databases

ProteinModelPortaliQ5HYI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metaxin family.Curated

Phylogenomic databases

eggNOGiKOG3028 Eukaryota
ENOG41100SS LUCA
GeneTreeiENSGT00530000063166
HOGENOMiHOG000237279
HOVERGENiHBG001655
InParanoidiQ5HYI7
KOiK17776
OMAiPMELSCW
OrthoDBiEOG091G0CWZ
PhylomeDBiQ5HYI7
TreeFamiTF313422

Family and domain databases

InterProiView protein in InterPro
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR017410 Metaxin
IPR033468 Metaxin_GST
IPR019564 Sam37/metaxin_N
PfamiView protein in Pfam
PF17171 GST_C_6, 1 hit
PF10568 Tom37, 1 hit
PIRSFiPIRSF038150 Metaxin, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5HYI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPLELSCW GGGWGLPSVH SESLVVMAYA KFSGAPLKVN VIDNTWRGSR
60 70 80 90 100
GDVPILTTED DMVSQPAKIL NFLRKQKYNA DYELSAKQGA DTLAYIALLE
110 120 130 140 150
EKLLPAVLHT FWVESDNYFT VTKPWFASQI PFPLSLILPG RMSKGALNRI
160 170 180 190 200
LLTRGQPPLY HLREVEAQIY RDAKECLNLL SNRLGTSQFF FGDTPSTLDA
210 220 230 240 250
YVFGFLAPLY KVRFPKVQLQ EHLKQLSNLC RFCDDILSSY FRLSLGGISP
260 270 280 290 300
AGQETVDANL QKLTQLVNKE SNLIEKMDDN LRQSPQLPPR KLPTLKLTPA
310
EEENNSFQRL SP
Length:312
Mass (Da):35,093
Last modified:May 20, 2008 - v2
Checksum:i3B9BAB7CF64FF8EF
GO
Isoform 2 (identifier: Q5HYI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-158: KGALNRILLTRGQPP → QQILSSRAGTHMLRK
     159-312: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,569
Checksum:iD1F883A663D02D5A
GO
Isoform 3 (identifier: Q5HYI7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-248: GI → DG
     249-312: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):27,901
Checksum:iBF7859179F6F9AF5
GO
Isoform 4 (identifier: Q5HYI7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:251
Mass (Da):28,608
Checksum:iE3C9240EDD986AC0
GO

Sequence cautioni

The sequence CAD97995 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50R → K in CAI46098 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043600238S → R. Corresponds to variant dbSNP:rs9293796Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468241 – 61Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_033893144 – 158KGALN…RGQPP → QQILSSRAGTHMLRK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_033894159 – 312Missing in isoform 2. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_036207247 – 248GI → DG in isoform 3. 1 Publication2
Alternative sequenceiVSP_036208249 – 312Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296864 mRNA Translation: BAG59427.1
BX538064 mRNA Translation: CAD97995.1 Different initiation.
BX647596 mRNA Translation: CAI46098.1
AC112184 Genomic DNA No translation available.
CCDSiCCDS47239.2 [Q5HYI7-4]
CCDS54872.1 [Q5HYI7-5]
CCDS87308.1 [Q5HYI7-1]
RefSeqiNP_001010891.4, NM_001010891.4 [Q5HYI7-4]
NP_001161213.1, NM_001167741.1 [Q5HYI7-5]
XP_005248552.1, XM_005248495.3
UniGeneiHs.531418

Genome annotation databases

EnsembliENST00000509852; ENSP00000423302; ENSG00000177034 [Q5HYI7-4]
ENST00000512528; ENSP00000424798; ENSG00000177034 [Q5HYI7-1]
ENST00000512560; ENSP00000423600; ENSG00000177034 [Q5HYI7-5]
ENST00000617335; ENSP00000484157; ENSG00000177034 [Q5HYI7-2]
GeneIDi345778
KEGGihsa:345778
UCSCiuc003kge.5 human [Q5HYI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296864 mRNA Translation: BAG59427.1
BX538064 mRNA Translation: CAD97995.1 Different initiation.
BX647596 mRNA Translation: CAI46098.1
AC112184 Genomic DNA No translation available.
CCDSiCCDS47239.2 [Q5HYI7-4]
CCDS54872.1 [Q5HYI7-5]
CCDS87308.1 [Q5HYI7-1]
RefSeqiNP_001010891.4, NM_001010891.4 [Q5HYI7-4]
NP_001161213.1, NM_001167741.1 [Q5HYI7-5]
XP_005248552.1, XM_005248495.3
UniGeneiHs.531418

3D structure databases

ProteinModelPortaliQ5HYI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131365, 28 interactors
IntActiQ5HYI7, 7 interactors
STRINGi9606.ENSP00000423600

PTM databases

iPTMnetiQ5HYI7
PhosphoSitePlusiQ5HYI7

Polymorphism and mutation databases

BioMutaiMTX3
DMDMi189029218

Proteomic databases

EPDiQ5HYI7
MaxQBiQ5HYI7
PaxDbiQ5HYI7
PeptideAtlasiQ5HYI7
PRIDEiQ5HYI7
ProteomicsDBi62935
62936 [Q5HYI7-2]
62937 [Q5HYI7-4]

Protocols and materials databases

DNASUi345778
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509852; ENSP00000423302; ENSG00000177034 [Q5HYI7-4]
ENST00000512528; ENSP00000424798; ENSG00000177034 [Q5HYI7-1]
ENST00000512560; ENSP00000423600; ENSG00000177034 [Q5HYI7-5]
ENST00000617335; ENSP00000484157; ENSG00000177034 [Q5HYI7-2]
GeneIDi345778
KEGGihsa:345778
UCSCiuc003kge.5 human [Q5HYI7-1]

Organism-specific databases

CTDi345778
DisGeNETi345778
EuPathDBiHostDB:ENSG00000177034.14
GeneCardsiMTX3
HGNCiHGNC:24812 MTX3
HPAiHPA047858
HPA062061
neXtProtiNX_Q5HYI7
OpenTargetsiENSG00000177034
PharmGKBiPA134924631
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3028 Eukaryota
ENOG41100SS LUCA
GeneTreeiENSGT00530000063166
HOGENOMiHOG000237279
HOVERGENiHBG001655
InParanoidiQ5HYI7
KOiK17776
OMAiPMELSCW
OrthoDBiEOG091G0CWZ
PhylomeDBiQ5HYI7
TreeFamiTF313422

Miscellaneous databases

ChiTaRSiMTX3 human
GenomeRNAii345778
PROiPR:Q5HYI7

Gene expression databases

BgeeiENSG00000177034 Expressed in 202 organ(s), highest expression level in deltoid
CleanExiHS_MTX3
GenevisibleiQ5HYI7 HS

Family and domain databases

InterProiView protein in InterPro
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR017410 Metaxin
IPR033468 Metaxin_GST
IPR019564 Sam37/metaxin_N
PfamiView protein in Pfam
PF17171 GST_C_6, 1 hit
PF10568 Tom37, 1 hit
PIRSFiPIRSF038150 Metaxin, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTX3_HUMAN
AccessioniPrimary (citable) accession number: Q5HYI7
Secondary accession number(s): B4DL65
, E9PB57, Q7Z380, Q8NB92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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