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Protein

Uncharacterized protein KIAA2026

Gene

KIAA2026

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA2026
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000183354.11
HGNCiHGNC:23378 KIAA2026
neXtProtiNX_Q5HYC2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183354
PharmGKBiPA134907262

Polymorphism and mutation databases

BioMutaiKIAA2026
DMDMi298286816

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889221 – 2103Uncharacterized protein KIAA2026Add BLAST2103

Proteomic databases

EPDiQ5HYC2
MaxQBiQ5HYC2
PaxDbiQ5HYC2
PeptideAtlasiQ5HYC2
PRIDEiQ5HYC2
ProteomicsDBi62929
62930 [Q5HYC2-2]

PTM databases

iPTMnetiQ5HYC2
PhosphoSitePlusiQ5HYC2

Expressioni

Gene expression databases

BgeeiENSG00000183354 Expressed in 205 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_KIAA2026
ExpressionAtlasiQ5HYC2 baseline and differential
GenevisibleiQ5HYC2 HS

Organism-specific databases

HPAiHPA002109

Interactioni

Protein-protein interaction databases

BioGridi127672, 5 interactors
IntActiQ5HYC2, 5 interactors
STRINGi9606.ENSP00000382815

Structurei

3D structure databases

ProteinModelPortaliQ5HYC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi673 – 756Lys-richAdd BLAST84
Compositional biasi1307 – 1421Ser-richAdd BLAST115

Phylogenomic databases

eggNOGiENOG410IIP1 Eukaryota
ENOG410YKW1 LUCA
GeneTreeiENSGT00390000011483
HOGENOMiHOG000169712
HOVERGENiHBG108717
InParanoidiQ5HYC2
OMAiWLPIDLH
OrthoDBiEOG091G06OJ
PhylomeDBiQ5HYC2
TreeFamiTF336184

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR036427 Bromodomain-like_sf
SUPFAMiSSF47370 SSF47370, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5HYC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL
60 70 80 90 100
EDADDQEEEM EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP
110 120 130 140 150
FLQPLGGVAT AEEEVAEGPR SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ
160 170 180 190 200
YGGITEFVAD FRLMLETCYR LHGVDHWISK QGQKLEMMLE QKLALLSRHL
210 220 230 240 250
REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT SGVFESIMVQ
260 270 280 290 300
VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET
310 320 330 340 350
MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS
360 370 380 390 400
PPHRRPTLHR RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC
410 420 430 440 450
PQFFKVLGEV NPLEEKPFHE LPFYQKVWLL KGLCDFVYET QKEVQDAVLG
460 470 480 490 500
QPIHECREVI LGYDYLENAY VHFPQFCGAD VRIYKQRPFQ APEFPIPPIK
510 520 530 540 550
IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE NNFDPACCPA
560 570 580 590 600
KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG
610 620 630 640 650
FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD
660 670 680 690 700
HPEINCHKVV RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL
710 720 730 740 750
QRKREGLHSL AFKSYKPEIQ NKLLIIKKKA KHKKHKSGKK SVSKKAITKK
760 770 780 790 800
RKTVIKSPTV PEFQLICTNL DELRELITKI ENELKDLENS RKKSGKWYHR
810 820 830 840 850
RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY DDFRRQPDHD
860 870 880 890 900
TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL
910 920 930 940 950
SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR
960 970 980 990 1000
KKAKLSTNET TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ
1010 1020 1030 1040 1050
KGTKPIQALL AKNIGNKVTL TNQLPPSTGR NALAVEKPVL SPPEASPIKP
1060 1070 1080 1090 1100
ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN SSVKIQVQPM VDPKTGEKIM
1110 1120 1130 1140 1150
QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP QTTNINSSLA
1160 1170 1180 1190 1200
SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS
1210 1220 1230 1240 1250
VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS
1260 1270 1280 1290 1300
SFNCFAQQTA DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ
1310 1320 1330 1340 1350
NSPNTVSSSS VFTFAPQLQA FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ
1360 1370 1380 1390 1400
TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG DLGHVIDKTS HMPSSPLKSS
1410 1420 1430 1440 1450
ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ QVDYITKSYP
1460 1470 1480 1490 1500
VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG
1510 1520 1530 1540 1550
VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL
1560 1570 1580 1590 1600
IPSTVGTPIK INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ
1610 1620 1630 1640 1650
NVTPKGEDKS SKGYILPLST SGNSVPVSSN FVSQNITPVN ESVVSSARAV
1660 1670 1680 1690 1700
NVLSVTGANL SLGSFPVTSA SASAGAQPPV LVSGNDTSSR IMPILSNRLC
1710 1720 1730 1740 1750
SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL QIPVTVALPT
1760 1770 1780 1790 1800
PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN
1810 1820 1830 1840 1850
VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI
1860 1870 1880 1890 1900
HTASAPSNVT SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP
1910 1920 1930 1940 1950
PQGLGAGSHV LLISTNPKYG APLVLNSGQG IQSTPIDNSA QKITLASNNS
1960 1970 1980 1990 2000
LSGQPLQHPL RSPTKFINSF GNASSIPTVH TSPQLINTTA KVPVPPPVPT
2010 2020 2030 2040 2050
VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD PPVKKLLVSP
2060 2070 2080 2090 2100
EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR

AAS
Length:2,103
Mass (Da):228,087
Last modified:June 15, 2010 - v2
Checksum:i211E99364884045A
GO
Isoform 2 (identifier: Q5HYC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-794: Missing.

Show »
Length:2,073
Mass (Da):224,546
Checksum:iC15E6DA756FA6F6E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4E5F5H4E5_HUMAN
Uncharacterized protein KIAA2026
KIAA2026
617Annotation score:
H0YGV4H0YGV4_HUMAN
Uncharacterized protein KIAA2026
KIAA2026
131Annotation score:
H0YFF4H0YFF4_HUMAN
Uncharacterized protein KIAA2026
KIAA2026
207Annotation score:

Sequence cautioni

The sequence AAI36847 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI45993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039334765 – 794Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162384 Genomic DNA No translation available.
AL353606 Genomic DNA No translation available.
AL365360 Genomic DNA No translation available.
BX648372 mRNA Translation: CAI45993.1 Different initiation.
BC136846 mRNA Translation: AAI36847.1 Different initiation.
AB095946 mRNA Translation: BAC23122.1
RefSeqiNP_001017969.2, NM_001017969.2 [Q5HYC2-1]
XP_005251442.1, XM_005251385.2 [Q5HYC2-2]
XP_011516063.1, XM_011517761.2
XP_016869821.1, XM_017014332.1
XP_016869822.1, XM_017014333.1
XP_016869823.1, XM_017014334.1
UniGeneiHs.535060

Genome annotation databases

EnsembliENST00000381461; ENSP00000370870; ENSG00000183354 [Q5HYC2-2]
ENST00000399933; ENSP00000382815; ENSG00000183354 [Q5HYC2-1]
GeneIDi158358
KEGGihsa:158358
UCSCiuc003zjq.5 human [Q5HYC2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162384 Genomic DNA No translation available.
AL353606 Genomic DNA No translation available.
AL365360 Genomic DNA No translation available.
BX648372 mRNA Translation: CAI45993.1 Different initiation.
BC136846 mRNA Translation: AAI36847.1 Different initiation.
AB095946 mRNA Translation: BAC23122.1
RefSeqiNP_001017969.2, NM_001017969.2 [Q5HYC2-1]
XP_005251442.1, XM_005251385.2 [Q5HYC2-2]
XP_011516063.1, XM_011517761.2
XP_016869821.1, XM_017014332.1
XP_016869822.1, XM_017014333.1
XP_016869823.1, XM_017014334.1
UniGeneiHs.535060

3D structure databases

ProteinModelPortaliQ5HYC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127672, 5 interactors
IntActiQ5HYC2, 5 interactors
STRINGi9606.ENSP00000382815

PTM databases

iPTMnetiQ5HYC2
PhosphoSitePlusiQ5HYC2

Polymorphism and mutation databases

BioMutaiKIAA2026
DMDMi298286816

Proteomic databases

EPDiQ5HYC2
MaxQBiQ5HYC2
PaxDbiQ5HYC2
PeptideAtlasiQ5HYC2
PRIDEiQ5HYC2
ProteomicsDBi62929
62930 [Q5HYC2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381461; ENSP00000370870; ENSG00000183354 [Q5HYC2-2]
ENST00000399933; ENSP00000382815; ENSG00000183354 [Q5HYC2-1]
GeneIDi158358
KEGGihsa:158358
UCSCiuc003zjq.5 human [Q5HYC2-1]

Organism-specific databases

CTDi158358
EuPathDBiHostDB:ENSG00000183354.11
GeneCardsiKIAA2026
HGNCiHGNC:23378 KIAA2026
HPAiHPA002109
neXtProtiNX_Q5HYC2
OpenTargetsiENSG00000183354
PharmGKBiPA134907262
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIP1 Eukaryota
ENOG410YKW1 LUCA
GeneTreeiENSGT00390000011483
HOGENOMiHOG000169712
HOVERGENiHBG108717
InParanoidiQ5HYC2
OMAiWLPIDLH
OrthoDBiEOG091G06OJ
PhylomeDBiQ5HYC2
TreeFamiTF336184

Miscellaneous databases

ChiTaRSiKIAA2026 human
GenomeRNAii158358
PROiPR:Q5HYC2

Gene expression databases

BgeeiENSG00000183354 Expressed in 205 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_KIAA2026
ExpressionAtlasiQ5HYC2 baseline and differential
GenevisibleiQ5HYC2 HS

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR036427 Bromodomain-like_sf
SUPFAMiSSF47370 SSF47370, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2026_HUMAN
AccessioniPrimary (citable) accession number: Q5HYC2
Secondary accession number(s): A8MTP2
, B9EGW7, Q4VXA2, Q8IVE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 15, 2010
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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