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Protein

Fidgetin

Gene

FIGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei489ATP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi529 – 534ATPBy similarity6

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule-severing ATPase activity Source: GO_Central
  • protein C-terminus binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fidgetin
Gene namesi
Name:FIGN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000182263.13
HGNCiHGNC:13285 FIGN
MIMi605295 gene
neXtProtiNX_Q5HY92

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi532K → A: Inhibits the ability to sever and depolymerize microtubules. 1 Publication1

Organism-specific databases

DisGeNETi55137
OpenTargetsiENSG00000182263
PharmGKBiPA28147

Polymorphism and mutation databases

BioMutaiFIGN
DMDMi115502199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002507481 – 759FidgetinAdd BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei400PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5HY92
PaxDbiQ5HY92
PeptideAtlasiQ5HY92
PRIDEiQ5HY92
ProteomicsDBi62925

PTM databases

iPTMnetiQ5HY92
PhosphoSitePlusiQ5HY92

Expressioni

Gene expression databases

BgeeiENSG00000182263 Expressed in 186 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_FIGN
ExpressionAtlasiQ5HY92 baseline and differential
GenevisibleiQ5HY92 HS

Organism-specific databases

HPAiHPA034987
HPA057919

Interactioni

Subunit structurei

Interacts with AKAP8 (via C-terminus).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120441, 3 interactors
IntActiQ5HY92, 2 interactors
STRINGi9606.ENSP00000333836

Structurei

3D structure databases

ProteinModelPortaliQ5HY92
SMRiQ5HY92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi202 – 291Pro-richAdd BLAST90

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0740 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00570000078874
HOGENOMiHOG000225145
HOVERGENiHBG061204
InParanoidiQ5HY92
OMAiIVHASFL
OrthoDBiEOG091G0Q8J
PhylomeDBiQ5HY92
TreeFamiTF105015

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5HY92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISSTSVYGL KMQWTPEHAQ WPEQHFDITS TTRSPAHKVE AYRGHLQRTY
60 70 80 90 100
QYAWANDDIS ALTASNLLKK YAEKYSGILE GPVDRPVLSN YSDTPSGLVN
110 120 130 140 150
GRKNESEPWQ PSLNSEAVYP MNCVPDVITA SKAGVSSALP PADVSASIGS
160 170 180 190 200
SPGVASNLTE PSYSSSTCGS HTVPSLHAGL PSQEYAPGYN GSYLHSTYSS
210 220 230 240 250
QPAPALPSPH PSPLHSSGLL QPPPPPPPPP ALVPGYNGTS NLSSYSYPSA
260 270 280 290 300
SYPPQTAVGS GYSPGGAPPP PSAYLPSGIP APTPLPPTTV PGYTYQGHGL
310 320 330 340 350
TPIAPSALTN SSASSLKRKA FYMAGQGDMD SSYGNYSYGQ QRSTQSPMYR
360 370 380 390 400
MPDNSISNTN RGNGFDRSAE TSSLAFKPTK QLMSSEQQRK FSSQSSRALT
410 420 430 440 450
PPSYSTAKNS LGSRSSESFG KYTSPVMSEH GDEHRQLLSH PMQGPGLRAA
460 470 480 490 500
TSSNHSVDEQ LKNTDTHLID LVTNEIITQG PPVDWNDIAG LDLVKAVIKE
510 520 530 540 550
EVLWPVLRSD AFSGLTALPR SILLFGPRGT GKTLLGRCIA SQLGATFFKI
560 570 580 590 600
AGSGLVAKWL GEAEKIIHAS FLVARCRQPS VIFVSDIDML LSSQVNEEHS
610 620 630 640 650
PVSRMRTEFL MQLDTVLTSA EDQIVVICAT SKPEEIDESL RRYFMKRLLI
660 670 680 690 700
PLPDSTARHQ IIVQLLSQHN YCLNDKEFAL LVQRTEGFSG LDVAHLCQEA
710 720 730 740 750
VVGPLHAMPA TDLSAIMPSQ LRPVTYQDFE NAFCKIQPSI SQKELDMYVE

WNKMFGCSQ
Length:759
Mass (Da):82,146
Last modified:October 3, 2006 - v2
Checksum:i68E1C4C8CA66AE2A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZS6B8ZZS6_HUMAN
Fidgetin
FIGN
29Annotation score:

Sequence cautioni

The sequence AAX81992 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91590 differs from that shown. Reason: Frameshift at position 71.Curated
The sequence BAA91590 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15231 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti713L → I in CAI45980 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02761396S → L. Corresponds to variant dbSNP:rs2231902Ensembl.1
Natural variantiVAR_027614448R → C. Corresponds to variant dbSNP:rs2231904Ensembl.1
Natural variantiVAR_027615565K → R. Corresponds to variant dbSNP:rs2231905Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001267 mRNA Translation: BAA91590.1 Sequence problems.
AK025747 mRNA Translation: BAB15231.1 Different initiation.
AK125324 mRNA Translation: BAG54182.1
BX649105 mRNA Translation: CAI45980.1
AC093727 Genomic DNA Translation: AAX81992.1 Sequence problems.
CCDSiCCDS2221.2
RefSeqiNP_060556.2, NM_018086.3
UniGeneiHs.593650

Genome annotation databases

EnsembliENST00000333129; ENSP00000333836; ENSG00000182263
GeneIDi55137
KEGGihsa:55137
UCSCiuc002uck.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001267 mRNA Translation: BAA91590.1 Sequence problems.
AK025747 mRNA Translation: BAB15231.1 Different initiation.
AK125324 mRNA Translation: BAG54182.1
BX649105 mRNA Translation: CAI45980.1
AC093727 Genomic DNA Translation: AAX81992.1 Sequence problems.
CCDSiCCDS2221.2
RefSeqiNP_060556.2, NM_018086.3
UniGeneiHs.593650

3D structure databases

ProteinModelPortaliQ5HY92
SMRiQ5HY92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120441, 3 interactors
IntActiQ5HY92, 2 interactors
STRINGi9606.ENSP00000333836

PTM databases

iPTMnetiQ5HY92
PhosphoSitePlusiQ5HY92

Polymorphism and mutation databases

BioMutaiFIGN
DMDMi115502199

Proteomic databases

EPDiQ5HY92
PaxDbiQ5HY92
PeptideAtlasiQ5HY92
PRIDEiQ5HY92
ProteomicsDBi62925

Protocols and materials databases

DNASUi55137
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333129; ENSP00000333836; ENSG00000182263
GeneIDi55137
KEGGihsa:55137
UCSCiuc002uck.2 human

Organism-specific databases

CTDi55137
DisGeNETi55137
EuPathDBiHostDB:ENSG00000182263.13
GeneCardsiFIGN
HGNCiHGNC:13285 FIGN
HPAiHPA034987
HPA057919
MIMi605295 gene
neXtProtiNX_Q5HY92
OpenTargetsiENSG00000182263
PharmGKBiPA28147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0740 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00570000078874
HOGENOMiHOG000225145
HOVERGENiHBG061204
InParanoidiQ5HY92
OMAiIVHASFL
OrthoDBiEOG091G0Q8J
PhylomeDBiQ5HY92
TreeFamiTF105015

Miscellaneous databases

GenomeRNAii55137
PROiPR:Q5HY92
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182263 Expressed in 186 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_FIGN
ExpressionAtlasiQ5HY92 baseline and differential
GenevisibleiQ5HY92 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIGN_HUMAN
AccessioniPrimary (citable) accession number: Q5HY92
Secondary accession number(s): B3KWM0, Q9H6M5, Q9NVZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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