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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Campylobacter jejuni (strain RM1221)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85NucleophileUniRule annotation1

GO - Molecular functioni

  • pseudouridine synthase activity Source: TIGR
  • RNA binding Source: InterPro
  • tRNA pseudouridine synthase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:CJE1631
OrganismiCampylobacter jejuni (strain RM1221)
Taxonomic identifieri195099 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524931 – 372tRNA pseudouridine synthase DAdd BLAST372

Structurei

3D structure databases

ProteinModelPortaliQ5HSX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 330TRUDUniRule annotationAdd BLAST171

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224848
KOiK06176
OMAiLWLWVEK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HSX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLEEENTIF KPLYSLKHSP INAYFSKNSD DFVVRERPLY EFSGKGEHLI
60 70 80 90 100
LHINKKDLTT NEALKILSET SGVKIRDFGY AGFKDKQGST FQYLSMPKKF
110 120 130 140 150
ESFLSNFSHP KLKILETFIH ENKLRIGHLK GNTFFIRLKK VLPSDALKLE
160 170 180 190 200
QALMNLDKQG FTNYFGYQRF GKFGDNYKEG LEILRGKKMK NVKMKEFLIS
210 220 230 240 250
AFQSELFNRY LSKRVELSHF ANDFSEKELI QIYKISKEEA KELKKQEQFF
260 270 280 290 300
KLLKGEVLGH YPFGKCFLCE DLSAELGRFK ARDISAMGLL IGAKAYETGE
310 320 330 340 350
GLALNLENEI FKDTLEFKAK MQGSRRFMWG YLEELKWRYD EEKAHFCIEF
360 370
FLQKGSYATV VLEEILHKNL FE
Length:372
Mass (Da):43,553
Last modified:February 15, 2005 - v1
Checksum:iB483437B8938D698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000025 Genomic DNA Translation: AAW36064.1
RefSeqiWP_002867255.1, NC_003912.7

Genome annotation databases

EnsemblBacteriaiAAW36064; AAW36064; CJE1631
KEGGicjr:CJE1631

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000025 Genomic DNA Translation: AAW36064.1
RefSeqiWP_002867255.1, NC_003912.7

3D structure databases

ProteinModelPortaliQ5HSX3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW36064; AAW36064; CJE1631
KEGGicjr:CJE1631

Phylogenomic databases

HOGENOMiHOG000224848
KOiK06176
OMAiLWLWVEK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_CAMJR
AccessioniPrimary (citable) accession number: Q5HSX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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