Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.By similarity

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.By similarity
7,8-dihydroneopterin = 7,8-dihydromonapterin.By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Dihydroneopterin aldolase (folB)
  4. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22SubstrateBy similarity1
Binding sitei54SubstrateBy similarity1
Active sitei100Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase
Biological processFolate biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00154

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolase (EC:4.1.2.25By similarity)
Short name:
DHNA
Alternative name(s):
7,8-dihydroneopterin 2'-epimerase
7,8-dihydroneopterin aldolase
7,8-dihydroneopterin epimerase (EC:5.1.99.8By similarity)
Dihydroneopterin epimerase
Gene namesi
Name:folB
Ordered Locus Names:SERP0154
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682851 – 121Dihydroneopterin aldolaseAdd BLAST121

Interactioni

Subunit structurei

Homooctamer. Four molecules assemble into a ring, and two rings come together to give a cylinder with a hole of at least 13 a diameter (By similarity).By similarity

Protein-protein interaction databases

STRINGi176279.SERP0154

Structurei

3D structure databases

ProteinModelPortaliQ5HRN9
SMRiQ5HRN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 74Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the DHNA family.Curated

Phylogenomic databases

eggNOGiENOG4105KRF Bacteria
COG1539 LUCA
HOGENOMiHOG000217628
KOiK01633
OMAiFYAYHGV

Family and domain databases

CDDicd00534 DHNA_DHNTPE, 1 hit
InterProiView protein in InterPro
IPR006156 Dihydroneopterin_aldolase
IPR006157 FolB_dom
PfamiView protein in Pfam
PF02152 FolB, 1 hit
SMARTiView protein in SMART
SM00905 FolB, 1 hit
TIGRFAMsiTIGR00525 folB, 1 hit
TIGR00526 folB_dom, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HRN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDIIFLNGM RFYGYHGVLA AENDIGQIFV VDITLKVDLS YAGQSDDVKD
60 70 80 90 100
TVNYGEVYKD VKSIVEGPRS CLIEHLAERI AKHINSHYNR VMETKVRITK
110 120
ENPPIPGHYD GVGIEIVREN D
Length:121
Mass (Da):13,694
Last modified:February 15, 2005 - v1
Checksum:iE9963A5D126D5EB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53523.1
RefSeqiWP_001832204.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW53523; AAW53523; SERP0154
KEGGiser:SERP0154

Similar proteinsi

Entry informationi

Entry nameiFOLB_STAEQ
AccessioniPrimary (citable) accession number: Q5HRN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again