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Protein

ATP-dependent Clp protease ATP-binding subunit ClpC

Gene

clpC

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 215ATPSequence analysis8
Nucleotide bindingi545 – 552ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC
Gene namesi
Name:clpC
Ordered Locus Names:SERP0165
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002696881 – 817ATP-dependent Clp protease ATP-binding subunit ClpCAdd BLAST817

Proteomic databases

PRIDEiQ5HRM8

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0165

Structurei

3D structure databases

ProteinModelPortaliQ5HRM8
SMRiQ5HRM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 452UVRPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 410IAdd BLAST248
Regioni471 – 662IIAdd BLAST192

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C2Z Bacteria
COG0542 LUCA
HOGENOMiHOG000218210
KOiK03696
OMAiHHKVRIK

Family and domain databases

Gene3Di1.10.1780.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004176 Clp_N
IPR036628 Clp_N_dom_sf
IPR001270 ClpA/B
IPR018368 ClpA/B_CS1
IPR028299 ClpA/B_CS2
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF02861 Clp_N, 2 hits
PF10431 ClpB_D2-small, 1 hit
PF02151 UVR, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF81923 SSF81923, 1 hit
PROSITEiView protein in PROSITE
PS00870 CLPAB_1, 1 hit
PS00871 CLPAB_2, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HRM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL
60 70 80 90 100
VSFNITEDKV IEEVEKLIGH GQEQMGTLHY TPRAKKVIEL SMDEARKLHH
110 120 130 140 150
NFVGTEHILL GLIRENEGVA ARVFANLDLN ITKARAQVVK ALGSPEMSNK
160 170 180 190 200
NAQANKSNNT PTLDGLARDL TVIAKDGTLD PVVGRDKEIT RVIEVLSRRT
210 220 230 240 250
KNNPVLIGEP GVGKTAIAEG LAQAIVKNEV PETLKDKRVM SLDMGTVVAG
260 270 280 290 300
TKYRGEFEER LKKVMEEIHQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL
310 320 330 340 350
KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPIQVD EPTVEDTIEI
360 370 380 390 400
LKGLRDRYEA HHRINISDEA LEAAAKLSDR YVSDRFLPDK AIDLIDEASS
410 420 430 440 450
KVRLKSHTTP SNLKEIEQEI DKVKNEKDAA VHAQEFENAA NLRDKQSKLE
460 470 480 490 500
KQYEDAKNEW KNAQGGLDTA LSEENIAEVI AGWTGIPLTK INETESDRLL
510 520 530 540 550
NLEDTLHKRV IGQNDAVNSI SKAVRRARAG LKDPKRPIGS FIFLGPTGVG
560 570 580 590 600
KTELARALAE SMFGEDDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDDGG
610 620 630 640 650
QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRTVDFR
660 670 680 690 700
NTVIIMTSNV GAQELQDQRF AGFGGASEGS DYETVRKTMM KELKNSFRPE
710 720 730 740 750
FLNRVDDIIV FHKLTKDELK EIVTMMVNKL THRLSEQNIN IVVTDKAKEK
760 770 780 790 800
IAEEGYDPEY GARPLIRAIQ KTVEDNLSEL ILDGNKIEGK EVTIDHDGKE
810
FKYDIYEITA KKETTES
Length:817
Mass (Da):91,012
Last modified:February 15, 2005 - v1
Checksum:i76E6455923462294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53548.1
RefSeqiWP_002445729.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW53548; AAW53548; SERP0165
KEGGiser:SERP0165

Similar proteinsi

Entry informationi

Entry nameiCLPC_STAEQ
AccessioniPrimary (citable) accession number: Q5HRM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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