Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Octanoyl-[GcvH]:protein N-octanoyltransferase

Gene

lipL

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Catalytic activityi

[Glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146Acyl-thioester intermediateUniRule annotation1
Sitei158Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyl-[GcvH]:protein N-octanoyltransferaseUniRule annotation (EC:2.3.1.204UniRule annotation)
Alternative name(s):
Octanoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lipLUniRule annotation
Ordered Locus Names:SERP0237
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004108461 – 279Octanoyl-[GcvH]:protein N-octanoyltransferaseAdd BLAST279

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0237

Structurei

3D structure databases

ProteinModelPortaliQ5HRF6
SMRiQ5HRF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 247BPL/LPL catalyticPROSITE-ProRule annotationAdd BLAST207

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105JGI Bacteria
COG0095 LUCA
HOGENOMiHOG000078071
KOiK16869
OMAiVVRTWVH

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HRF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLATKYFNQ INWRYVDHSS GLEPMQSFAF DDTFSESVGK DLSCNVVRTW
60 70 80 90 100
IHQHTVILGI HDSRLPFLSD GIRFLTDEQG YNAIVRNSGG LGVVLDQGIL
110 120 130 140 150
NISLIFKGQT ETTIDEAFTV MYLLISKMFE DEDVSIDTKE IEQSYCPGKF
160 170 180 190 200
DLSINDKKFA GISQRRVRGG IAVQIYLCIE GSGSERALMM QQFYQRALKG
210 220 230 240 250
QTTKFHYPDI DPSCMASLET LLNREIKVQD VMFLLLYALK DLGANLNMDP
260 270
ITEDEWTRYE GYYDKMLERN AKINEKLDF
Length:279
Mass (Da):31,976
Last modified:February 15, 2005 - v1
Checksum:iD24CF7E7DAB9B217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53632.1
RefSeqiWP_002445773.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW53632; AAW53632; SERP0237
KEGGiser:SERP0237

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53632.1
RefSeqiWP_002445773.1, NC_002976.3

3D structure databases

ProteinModelPortaliQ5HRF6
SMRiQ5HRF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP0237

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW53632; AAW53632; SERP0237
KEGGiser:SERP0237

Phylogenomic databases

eggNOGiENOG4105JGI Bacteria
COG0095 LUCA
HOGENOMiHOG000078071
KOiK16869
OMAiVVRTWVH

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIPL_STAEQ
AccessioniPrimary (citable) accession number: Q5HRF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: February 15, 2005
Last modified: October 10, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again