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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:SERP0681
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622361 – 325Pyruvate dehydrogenase E1 component subunit betaAdd BLAST325

Proteomic databases

PRIDEiQ5HQ75

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi176279.SERP0681

Structurei

3D structure databases

ProteinModelPortaliQ5HQ75
SMRiQ5HQ75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CPP Bacteria
COG0022 LUCA
HOGENOMiHOG000281451
KOiK00162
OMAiSRMRHHC

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HQ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQMTMVQAI NDALKSELKR DEDVLVFGED VGVNGGVFRV TEGLQKEFGE
60 70 80 90 100
DRVFDTPLAE SGIGGLALGL AVTGFRPVME IQFLGFVYEV FDEVAGQIAR
110 120 130 140 150
TRFRSGGTKP APVTIRTPFG GGVHTPELHA DNLEGILAQS PGLKVVIPSG
160 170 180 190 200
PYDAKGLLIS SIQSNDPVVY LEHMKLYRSF REEVPEEEYK IDIGKANVKK
210 220 230 240 250
EGNDITLISY GAMVQESLKA AEELEKDGYS VEVIDLRTVQ PIDIDTLVAS
260 270 280 290 300
VEKTGRAVVV QEAQRQAGVG AQVAAELAER AILSLEAPIA RVAASDTIYP
310 320
FTQAENVWLP NKKDIIEQAK ATLEF
Length:325
Mass (Da):35,293
Last modified:February 15, 2005 - v1
Checksum:i01A6E5FB2D9C1CCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW54053.1
RefSeqiWP_001831654.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW54053; AAW54053; SERP0681
KEGGiser:SERP0681

Similar proteinsi

Entry informationi

Entry nameiODPB_STAEQ
AccessioniPrimary (citable) accession number: Q5HQ75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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