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UniProtKB - Q5HPW0 (FABG_STAEQ)
Protein
3-oxoacyl-[acyl-carrier-protein] reductase FabG
Gene
fabG
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Functioni
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
By similarityCatalytic activityi
- EC:1.1.1.100
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 87 | NADP; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 139 | SubstrateBy similarity | 1 | |
Active sitei | 152 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 185 | NADP; via amide nitrogen and carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 9 – 12 | NADPBy similarity | 4 | |
Nucleotide bindingi | 60 – 61 | NADPBy similarity | 2 | |
Nucleotide bindingi | 152 – 156 | NADPBy similarity | 5 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
- NAD binding Source: InterPro
- NADP binding Source: UniProtKB
GO - Biological processi
- fatty acid elongation Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)Alternative name(s): 3-ketoacyl-acyl carrier protein reductase Beta-Ketoacyl-acyl carrier protein reductase Beta-ketoacyl-ACP reductase |
Gene namesi | Name:fabG Ordered Locus Names:SERP0797 |
Organismi | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) |
Taxonomic identifieri | 176279 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054690 | 1 – 244 | 3-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST | 244 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 176279.SERP0797 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
HOGENOMi | CLU_010194_1_3_9 |
OMAi | QLLMRMS |
OrthoDBi | 1601931at2 |
Family and domain databases
InterProi | View protein in InterPro IPR011284, 3oxo_ACP_reduc IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01830, 3oxo_ACP_reduc, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5HPW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKSALVTGA SRGIGRSIAL QLAEEGYNVA VNYAGSKDKA EAVVEEIKAK
60 70 80 90 100
GVESFAIQAN VAKGDEVKEM IKEVVSQFGS VDVLVNNAGI TKDNLLMRMK
110 120 130 140 150
EQEWDDVIDT NLKGVFNCIQ KVTPQMLRQR SGAIINLTSI VGAMGNPGQA
160 170 180 190 200
NYVATKAGVI GLTKTAAREL ASRGITVNAV APGFIVSDMT NALSDDLKDQ
210 220 230 240
MLEQIPLKRF GEDTDIANTV AFLASDKAKY ITGQTIHVNG GMYM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000029 Genomic DNA Translation: AAW54128.1 |
RefSeqi | WP_001830161.1, NC_002976.3 |
Genome annotation databases
EnsemblBacteriai | AAW54128; AAW54128; SERP0797 |
GeneIDi | 50018956 |
KEGGi | ser:SERP0797 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000029 Genomic DNA Translation: AAW54128.1 |
RefSeqi | WP_001830161.1, NC_002976.3 |
3D structure databases
SMRi | Q5HPW0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 176279.SERP0797 |
Genome annotation databases
EnsemblBacteriai | AAW54128; AAW54128; SERP0797 |
GeneIDi | 50018956 |
KEGGi | ser:SERP0797 |
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
HOGENOMi | CLU_010194_1_3_9 |
OMAi | QLLMRMS |
OrthoDBi | 1601931at2 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Family and domain databases
InterProi | View protein in InterPro IPR011284, 3oxo_ACP_reduc IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01830, 3oxo_ACP_reduc, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABG_STAEQ | |
Accessioni | Q5HPW0Primary (citable) accession number: Q5HPW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families