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Protein

Probable malate:quinone oxidoreductase 2

Gene

mqo2

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 4 (mqo4), Probable malate:quinone oxidoreductase 3 (mqo3), Probable malate:quinone oxidoreductase 2 (mqo2), Probable malate:quinone oxidoreductase 1 (mqo1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 2UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 2UniRule annotation
Malate dehydrogenase [quinone] 2UniRule annotation
Gene namesi
Name:mqo2UniRule annotation
Ordered Locus Names:SERP2312
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287541 – 498Probable malate:quinone oxidoreductase 2Add BLAST498

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2312

Structurei

3D structure databases

ProteinModelPortaliQ5HKN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT Bacteria
COG0579 LUCA
HOGENOMiHOG000109379
KOiK00116
OMAiFLICTNP

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HKN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKESKNVV IIGAGVLSTT FGSMIKELEP DWNIKLYERL DRPGIESSNE
60 70 80 90 100
RNNAGTGHAA LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS
110 120 130 140 150
GNISNPRDFI NPLPHISFVR GKNNVKFLKN RYEAMRNFPM FDNIEYTEDI
160 170 180 190 200
EEMRKWMPLM MTGRTGNEIM AASKIDEGTD VNYGELTRKM AKSIEKHPNA
210 220 230 240 250
DVQYNHEVIN FNRRKDGIWE VKVKNRNSGD VETVLADYVF IGAGGGAIPL
260 270 280 290 300
LQKTGIPESK HLGGFPISGQ FLICTNPDVI NEHDVKVYGK EPPGTPPMTV
310 320 330 340 350
PHLDTRYIDG ERTLLFGPFA NIGPKFLRNG SNLDLFKSVK PYNITTLLAS
360 370 380 390 400
AVKNLPLIKY SIDQVLMTKE GCMNHLRTFY PEARDEDWQL YTAGKRVQVI
410 420 430 440 450
KDTKEHGKGF IQFGTEVVNS KDHSVIALLG ESPGASTSVS VALEVLEKNF
460 470 480 490
AEYEKDWTPK LQKMIPSYGK SLIDDVKLMR ATRKQTSKDL ELNYYESK
Length:498
Mass (Da):56,220
Last modified:February 15, 2005 - v1
Checksum:i909F6319BBA4A823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53215.1
RefSeqiWP_002470281.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW53215; AAW53215; SERP2312
KEGGiser:SERP2312

Similar proteinsi

Entry informationi

Entry nameiMQO2_STAEQ
AccessioniPrimary (citable) accession number: Q5HKN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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