Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ESAT-6 secretion machinery protein EssC

Gene

essC

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the ESAT-6 secretion system (Ess). Required for the secretion of EsxA and EsxB.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi672 – 679ATPPROSITE-ProRule annotation8
Nucleotide bindingi1014 – 1021ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processVirulence
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ESAT-6 secretion machinery protein EssCBy similarity
Gene namesi
Name:essCBy similarity
Ordered Locus Names:SACOL0276
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229CytoplasmicBy similarityAdd BLAST229
Transmembranei230 – 252HelicalSequence analysisAdd BLAST23
Topological domaini253 – 256ExtracellularBy similarity4
Transmembranei257 – 279HelicalSequence analysisAdd BLAST23
Topological domaini280 – 1479CytoplasmicBy similarityAdd BLAST1200

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000983291 – 1479ESAT-6 secretion machinery protein EssCAdd BLAST1479

Proteomic databases

PRIDEiQ5HJ86

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0276

Structurei

3D structure databases

ProteinModelPortaliQ5HJ86
SMRiQ5HJ86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini652 – 846FtsK 1PROSITE-ProRule annotationAdd BLAST195
Domaini997 – 1183FtsK 2PROSITE-ProRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the EssC family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EC2 Bacteria
COG1674 LUCA
HOGENOMiHOG000119940
KOiK03466
OMAiWEWMKWL

Family and domain databases

InterProiView protein in InterPro
IPR023839 Firmicutes_EssC_C
IPR022206 Firmicutes_EssC_N
IPR002543 FtsK_dom
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF01580 FtsK_SpoIIIE, 2 hits
PF12538 FtsK_SpoIIIE_N, 1 hit
SUPFAMiSSF49879 SSF49879, 2 hits
SSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR03928 T7_EssCb_Firm, 1 hit
PROSITEiView protein in PROSITE
PS50901 FTSK, 2 hits

Sequencei

Sequence statusi: Complete.

Q5HJ86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG
60 70 80 90 100
TWQANHTSIN KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGPNA
110 120 130 140 150
YDDMVIQSLM NAIIIKDFQS IQESQYVRIV HDKNTDVYIN YELQEQLTNK
160 170 180 190 200
AYIGDHIYVE GIWLEVQADG LNVLSQNTVA SSLIRLTQEM PHAQADDYNT
210 220 230 240 250
YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL VMIALTVVIF
260 270 280 290 300
LVRPIGIYIL MMIGMSTVTI VFGITTYFSE KKKYNKDVEK REKDYKAYLD
310 320 330 340 350
NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH
360 370 380 390 400
YKLGIANVEK SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND
410 420 430 440 450
LNHGPIAYIG ARHLILEELE KMLIQLSTFH SYHDLEFLFV TREDEVETLK
460 470 480 490 500
WARWLPHMTL RGQNIRGFVY NQRTRDQILT SIYSMIKERI QAVRERSRSN
510 520 530 540 550
EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI FVEDVIESLP
560 570 580 590 600
EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
610 620 630 640 650
HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG
660 670 680 690 700
KDDILSLNLH EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF
710 720 730 740 750
LLIDYKGGGM ANLFKDLVHL VGTITNLDGD EAMRALTSIK AELRKRQRLF
760 770 780 790 800
GEHDVNHINQ YHKLFKEGIA TEPMPHLFII SDEFAELKSE QPDFMKELVS
810 820 830 840 850
TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ DRQDSNEILK
860 870 880 890 900
TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
910 920 930 940 950
MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK
960 970 980 990 1000
RPWLPPLPEN VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM
1010 1020 1030 1040 1050
VLQLKKAGHI ALIGSPGYGR TTFLHNIIFD VARHHRPDQA HMYLFDFGTN
1060 1070 1080 1090 1100
GLMPVTDIPH VADYFTVDQE DKIAKAIRIF NDEIDRRKKI LSQYRVTSIS
1110 1120 1130 1140 1150
EYRKLTGETI PHVFILIDNF DAVKDSPFQE VFENMMIKMT REGLALDMQV
1160 1170 1180 1190 1200
TLTASRANAM KTPMYINMKT RIAMFLYDKS EVSNVVGQQK FAVKDVVGRA
1210 1220 1230 1240 1250
LLSSDDNVSF HIGQPFKHDE TKSYNDQIND EVSAMTEFYK GETPNDIPMM
1260 1270 1280 1290 1300
PDEIKYEDYR ESLNLPDIVA NGALPIGLDY EGVTLQKIKL TEPAMISSEN
1310 1320 1330 1340 1350
PREIAHIAEI MMKEIDILNE KYAICIADSS GEFKAYRHQV ANFAEEREDI
1360 1370 1380 1390 1400
KAIHQLMIED LKQREMDGPF EKDSLYIIND FKTFIDCTYI PEDDVKKLIT
1410 1420 1430 1440 1450
KGPELGLNIL FVGIHKELID AYDKQIDVAR KMINQFSIGI RISDQQFFKF
1460 1470
RFIQREPVIK ENEAYMVANQ AYQKIRWFK
Length:1,479
Mass (Da):170,931
Last modified:February 15, 2005 - v1
Checksum:i0EC13F663848BBCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW38830.1
RefSeqiWP_000549278.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW38830; AAW38830; SACOL0276
KEGGisac:SACOL0276

Similar proteinsi

Entry informationi

Entry nameiESSC_STAAC
AccessioniPrimary (citable) accession number: Q5HJ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again