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Protein

Alcohol dehydrogenase

Gene

adh

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Short name:
ADH
Gene namesi
Name:adh
Ordered Locus Names:SACOL0660
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730351 – 336Alcohol dehydrogenaseAdd BLAST336

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0660

Structurei

3D structure databases

ProteinModelPortaliQ5HI63
SMRiQ5HI63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4 Bacteria
COG1064 LUCA
HOGENOMiHOG000294685
KOiK13953
OMAiARIPKEC

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR029752 D-isomer_DH_CS1
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HI63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAAVVTKDH KVSIEDKKLR ALKPGEALVQ TEYCGVCHTD LHVKNADFGD
60 70 80 90 100
VTGVTLGHEG IGKVIEVAED VESLKIGDRV SIAWMFESCG RCEYCTTGRE
110 120 130 140 150
TLCRSVKNAG YTVDGAMAEQ VIVTADYAVK VPEKLDPAAA SSITCAGVTT
160 170 180 190 200
YKAVKVSNVK PGQWLGVFGI GGLGNLALQY AKNVMGAKIV AFDINDDKLA
210 220 230 240 250
FAKELGADAI INSKDVDPVA EVMKLTDNKG LDATVVTSVA KTPFNQAVDV
260 270 280 290 300
VKAGARVVAV GLPVDKMNLD IPRLVLDGIE VVGSLVGTRQ DLREAFEFAA
310 320 330
ENKVTPKVQL RKLEEINDIF EEMENGTITG RMVIKF
Length:336
Mass (Da):36,048
Last modified:February 15, 2005 - v1
Checksum:iDB68A432F9E72EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW36350.1
RefSeqiWP_001200748.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW36350; AAW36350; SACOL0660
KEGGisac:SACOL0660

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW36350.1
RefSeqiWP_001200748.1, NC_002951.2

3D structure databases

ProteinModelPortaliQ5HI63
SMRiQ5HI63
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0660

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW36350; AAW36350; SACOL0660
KEGGisac:SACOL0660

Phylogenomic databases

eggNOGiENOG4105DQ4 Bacteria
COG1064 LUCA
HOGENOMiHOG000294685
KOiK13953
OMAiARIPKEC

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR029752 D-isomer_DH_CS1
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_STAAC
AccessioniPrimary (citable) accession number: Q5HI63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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