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UniProtKB - Q5HGP2 (SEPF_STAAC)
Protein
Cell division protein SepF
Gene
sepF
Organism
Staphylococcus aureus (strain COL)
Status
Functioni
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
UniRule annotationGO - Biological processi
- division septum assembly Source: UniProtKB-KW
- FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
Keywordsi
Biological process | Cell cycle, Cell division, Septation |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein SepFUniRule annotation |
Gene namesi | Name:sepFUniRule annotation Ordered Locus Names:SACOL1202 |
Organismi | Staphylococcus aureus (strain COL) |
Taxonomic identifieri | 93062 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Note: Localizes to the division site, in a FtsZ-dependent manner.UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000334075 | 1 – 187 | Cell division protein SepFAdd BLAST | 187 |
Proteomic databases
PRIDEi | Q5HGP2 |
Interactioni
Subunit structurei
Homodimer.
Interacts with FtsZ.
UniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 97 | DisorderedSequence analysisAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 97 | Polar residuesSequence analysisAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the SepF family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_078499_4_1_9 |
OMAi | ASERHYQ |
Family and domain databases
Gene3Di | 3.30.110.150, 1 hit |
HAMAPi | MF_01197, SepF, 1 hit |
InterProi | View protein in InterPro IPR023052, Cell_div_SepF IPR007561, Cell_div_SepF/SepF-rel IPR038594, SepF-like_sf |
PANTHERi | PTHR35798, PTHR35798, 1 hit |
Pfami | View protein in Pfam PF04472, SepF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5HGP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHLALKDLF SGFFVIDDEE EVEVPDKQQQ VNEAPAKEQS QQTTKQNAIK
60 70 80 90 100
SVPQKSASRY TTTSEERNNR MSNYSKNNSR NVVTMNNATP NNASQESSKM
110 120 130 140 150
CLFEPRVFSD TQDIADELKN RRATLVNLQR IDKVSAKRII DFLSGTVYAI
160 170 180
GGDIQRVGTD IFLCTPDNVE VAGSITDHIE NMEHSFD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000046 Genomic DNA Translation: AAW38039.1 |
RefSeqi | WP_000018608.1, NC_002951.2 |
Genome annotation databases
EnsemblBacteriai | AAW38039; AAW38039; SACOL1202 |
KEGGi | sac:SACOL1202 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000046 Genomic DNA Translation: AAW38039.1 |
RefSeqi | WP_000018608.1, NC_002951.2 |
3D structure databases
SMRi | Q5HGP2 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q5HGP2 |
Genome annotation databases
EnsemblBacteriai | AAW38039; AAW38039; SACOL1202 |
KEGGi | sac:SACOL1202 |
Phylogenomic databases
HOGENOMi | CLU_078499_4_1_9 |
OMAi | ASERHYQ |
Family and domain databases
Gene3Di | 3.30.110.150, 1 hit |
HAMAPi | MF_01197, SepF, 1 hit |
InterProi | View protein in InterPro IPR023052, Cell_div_SepF IPR007561, Cell_div_SepF/SepF-rel IPR038594, SepF-like_sf |
PANTHERi | PTHR35798, PTHR35798, 1 hit |
Pfami | View protein in Pfam PF04472, SepF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SEPF_STAAC | |
Accessioni | Q5HGP2Primary (citable) accession number: Q5HGP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |