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Protein

Guanylate kinase

Gene

gmk

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:SACOL1221
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706031 – 207Guanylate kinaseAdd BLAST207

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL1221

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi19 – 28Combined sources10
Turni51 – 53Combined sources3
Helixi60 – 68Combined sources9
Beta strandi72 – 78Combined sources7
Beta strandi81 – 86Combined sources6
Helixi87 – 95Combined sources9
Beta strandi99 – 103Combined sources5
Helixi106 – 108Combined sources3
Helixi109 – 115Combined sources7
Beta strandi119 – 125Combined sources7
Helixi151 – 155Combined sources5
Helixi157 – 163Combined sources7
Beta strandi165 – 169Combined sources5
Helixi173 – 188Combined sources16
Helixi191 – 196Combined sources6
Helixi198 – 204Combined sources7

3D structure databases

ProteinModelPortaliQ5HGM3
SMRiQ5HGM3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5HGM3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 185Guanylate kinase-likeUniRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HGM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNEKGLLIV LSGPSGVGKG TVRKRIFEDP STSYKYSISM TTRQMREGEV
60 70 80 90 100
DGVDYFFKTR DAFEALIKDD QFIEYAEYVG NYYGTPVQYV KDTMDEGHDV
110 120 130 140 150
FLEIEVEGAK QVRKKFPDAL FIFLAPPSLE HLRERLVGRG TESDEKIQSR
160 170 180 190 200
INEARKEVEM MNLYDYVVVN DEVELAKNRI QCIVEAEHLK RERVEAKYRK

MILEAKK
Length:207
Mass (Da):24,037
Last modified:February 15, 2005 - v1
Checksum:iF17991AA47238DC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW38058.1
RefSeqiWP_000368227.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW38058; AAW38058; SACOL1221
KEGGisac:SACOL1221

Similar proteinsi

Entry informationi

Entry nameiKGUA_STAAC
AccessioniPrimary (citable) accession number: Q5HGM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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