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Protein

Acyl carrier protein

Gene

acpP

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Biological processi

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Short name:
ACPUniRule annotation
Gene namesi
Name:acpPUniRule annotation
Ordered Locus Names:SACOL1247
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001801881 – 77Acyl carrier proteinAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.UniRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL1247

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Helixi19 – 21Combined sources3
Turni28 – 31Combined sources4
Helixi36 – 49Combined sources14
Helixi56 – 59Combined sources4
Helixi65 – 72Combined sources8

3D structure databases

ProteinModelPortaliQ5HGK0
SMRiQ5HGK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76CarrierPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VNB Bacteria
COG0236 LUCA
HOGENOMiHOG000178184
KOiK02078
OMAiDQIKPES

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HGK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFDKVKDI IVDRLGVDAD KVTEDASFKD DLGADSLDIA ELVMELEDEF
60 70
GTEIPDEEAE KINTVGDAVK FINSLEK
Length:77
Mass (Da):8,549
Last modified:February 15, 2005 - v1
Checksum:i11B458391E5BB83E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW38081.1
RefSeqiWP_000426914.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW38081; AAW38081; SACOL1247
KEGGisac:SACOL1247

Similar proteinsi

Entry informationi

Entry nameiACP_STAAC
AccessioniPrimary (citable) accession number: Q5HGK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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