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Protein

Cardiolipin synthase 2

Gene

cls2

Organism
Staphylococcus aureus (strain COL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei234UniRule annotation1
Active sitei236UniRule annotation1
Active sitei241UniRule annotation1
Active sitei412UniRule annotation1
Active sitei414UniRule annotation1
Active sitei419UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase 2UniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthase 2UniRule annotation
Gene namesi
Name:cls2
Ordered Locus Names:SACOL2079
OrganismiStaphylococcus aureus (strain COL)
Taxonomic identifieri93062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000530 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalUniRule annotationAdd BLAST21
Transmembranei45 – 65HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012681 – 494Cardiolipin synthase 2Add BLAST494

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2079

Structurei

3D structure databases

ProteinModelPortaliQ5HEB2
SMRiQ5HEB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 256PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini407 – 434PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077402
KOiK06131
OMAiGGHNVGD

Family and domain databases

HAMAPiMF_01916 Cardiolipin_synth_Cls, 1 hit
InterProiView protein in InterPro
IPR030874 Cardiolipin_synth_Firmi
IPR022924 Cardiolipin_synthase
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q5HEB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIELLSIALK HSNIILNSIF IGAFILNLLF AFTIIFMERR SANSIWAWLL
60 70 80 90 100
VLVFLPLFGF ILYLLLGRQI QRDQIFKIDK EDKKGLELIV DEQLAALKNE
110 120 130 140 150
NFSNSNYQIV KFKEMIQMLL YNNAAFLTTD NDLKIYTDGQ EKFDDLIQDI
160 170 180 190 200
RNATDYIHFQ YYIIQNDELG RTILNELGKK AEQGVEVKIL YDDMGSRGLR
210 220 230 240 250
KKGLRPFRNK GGHAEAFFPS KLPLINLRMN NRNHRKIVVI DGQIGYVGGF
260 270 280 290 300
NVGDEYLGKS KKFGYWRDTH LRIVGDAVNA LQLRFILDWN SQATRDHISY
310 320 330 340 350
DDRYFPDVNS GGTIGVQIAS SGPDEEWEQI KYGYLKMISS AKKSIYIQSP
360 370 380 390 400
YFIPDQAFLD SIKIAALGGV DVNIMIPNKP DHPFVFWATL KNAASLLDAG
410 420 430 440 450
VKVFHYDNGF LHSKTLVIDD EIASVGTANM DHRSFTLNFE VNAFIYDQQI
460 470 480 490
AKKLKQAFID DLAVSSELTK ARYAKRSLWI KFKEGISQLL SPIL
Length:494
Mass (Da):56,518
Last modified:February 15, 2005 - v1
Checksum:i81A5D9B7F098990B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000046 Genomic DNA Translation: AAW37041.1
RefSeqiWP_000571549.1, NC_002951.2

Genome annotation databases

EnsemblBacteriaiAAW37041; AAW37041; SACOL2079
KEGGisac:SACOL2079

Similar proteinsi

Entry informationi

Entry nameiCLS2_STAAC
AccessioniPrimary (citable) accession number: Q5HEB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: July 18, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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