UniProtKB - Q5HD51 (FNBA_STAAC)
Protein
Fibronectin-binding protein A
Gene
fnbA
Organism
Staphylococcus aureus (strain COL)
Status
Functioni
Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin. This confers to S.aureus the ability to invade endothelial cells. Promotes adherence to and aggregation of activated platelets (By similarity).By similarity
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- pathogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesion, Virulence |
Enzyme and pathway databases
BioCyci | SAUR93062:G1G4B-2754-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Fibronectin-binding protein A |
Gene namesi | Name:fnbA Ordered Locus Names:SACOL2511 |
Organismi | Staphylococcus aureus (strain COL) |
Taxonomic identifieri | 93062 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
- cell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation Note: Anchored to the cell wall by sortase A (By similarity).By similarity
GO - Cellular componenti
- cell wall Source: UniProtKB-SubCell
- extracellular region Source: UniProtKB-KW
- membrane Source: InterPro
Keywords - Cellular componenti
Cell wall, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | Sequence analysisAdd BLAST | 36 | |
ChainiPRO_0000313878 | 37 – 985 | Fibronectin-binding protein AAdd BLAST | 949 | |
PropeptideiPRO_0000313879 | 986 – 1018 | Removed by sortasePROSITE-ProRule annotationAdd BLAST | 33 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 985 | Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Peptidoglycan-anchorFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 545 – 574 | B-1Add BLAST | 30 | |
Repeati | 575 – 604 | B-2Add BLAST | 30 | |
Repeati | 745 – 782 | D-1Add BLAST | 38 | |
Repeati | 783 – 820 | D-2Add BLAST | 38 | |
Repeati | 821 – 859 | D-3Add BLAST | 39 | |
Repeati | 860 – 878 | D-4; truncatedAdd BLAST | 19 | |
Repeati | 879 – 892 | WR 1Add BLAST | 14 | |
Repeati | 893 – 906 | WR 2Add BLAST | 14 | |
Repeati | 907 – 920 | WR 3Add BLAST | 14 | |
Repeati | 921 – 934 | WR 4Add BLAST | 14 | |
Repeati | 935 – 948 | WR 5Add BLAST | 14 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 511 | Ligand-binding A regionAdd BLAST | 475 | |
Regioni | 194 – 511 | Fibrinogen/elastin/tropoelastin-bindingBy similarityAdd BLAST | 318 | |
Regioni | 512 – 872 | Fibronectin-bindingBy similarityAdd BLAST | 361 | |
Regioni | 545 – 604 | 2 X approximate tandem repeatsAdd BLAST | 60 | |
Regioni | 745 – 878 | 4 X approximate tandem repeatsAdd BLAST | 134 | |
Regioni | 879 – 948 | 5 X tandem repeats, Pro-rich (WR)Add BLAST | 70 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 7 – 18 | YSIRK-G/S signaling motifBy similarityAdd BLAST | 12 | |
Motifi | 982 – 986 | LPXTG sorting signalPROSITE-ProRule annotation | 5 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
HOGENOMi | CLU_009849_1_0_9 |
OMAi | FTHVAYI |
Family and domain databases
Gene3Di | 2.60.40.1280, 1 hit |
InterProi | View protein in InterPro IPR011266, Adhesin_Fg-bd_dom_2 IPR008966, Adhesion_dom_sf IPR011252, Fibrogen-bd_dom1 IPR004237, Fibron_repeat-bd IPR019948, Gram-positive_anchor IPR019931, LPXTG_anchor IPR041171, SDR_Ig IPR005877, YSIRK_signal_dom |
Pfami | View protein in Pfam PF17961, Big_8, 1 hit PF02986, Fn_bind, 3 hits PF00746, Gram_pos_anchor, 1 hit PF10425, SdrG_C_C, 1 hit PF04650, YSIRK_signal, 1 hit |
SUPFAMi | SSF49401, SSF49401, 2 hits |
TIGRFAMsi | TIGR01168, YSIRK_signal, 1 hit |
PROSITEi | View protein in PROSITE PS50847, GRAM_POS_ANCHORING, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5HD51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN
60 70 80 90 100
SATDNKTSET QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ
110 120 130 140 150
APQTAQPANI ETVKEEVVKE EAKPQVKETT QSQDNSGDQR QVDLTPKKAT
160 170 180 190 200
QNQVAETQVE VAQPRTASES KPRVTRSADV AEAKEASNAK VETGTDVTSK
210 220 230 240 250
VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG DYFDFTLSNN
260 270 280 290 300
VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE
310 320 330 340 350
LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG
360 370 380 390 400
SIETFNKANN RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF
410 420 430 440 450
EYLGNNEDIA KSVYANTTDT SKFKEVTSNM SGNLNLQNNG SYSLNIENLD
460 470 480 490 500
KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ LYKYYYDRGY TLTWDNGLVL
510 520 530 540 550
YSNKANGNGK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV TTVEEEYDSS
560 570 580 590 600
TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY
610 620 630 640 650
TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD
660 670 680 690 700
EESTKGIVTG AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE
710 720 730 740 750
ITENNHHISH SGLGTENGHG NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN
760 770 780 790 800
QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ IHGQNKGNQS FEEDTEKDKP
810 820 830 840 850
KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY QFGGHNSVDF
860 870 880 890 900
EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV
910 920 930 940 950
PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV
960 970 980 990 1000
EQGKVVTPVI EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL
1010
FSILGLALLR RNKKNHKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000046 Genomic DNA Translation: AAW37290.1 |
RefSeqi | WP_000794589.1, NC_002951.2 |
Genome annotation databases
EnsemblBacteriai | AAW37290; AAW37290; SACOL2511 |
KEGGi | sac:SACOL2511 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000046 Genomic DNA Translation: AAW37290.1 |
RefSeqi | WP_000794589.1, NC_002951.2 |
3D structure databases
SMRi | Q5HD51 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAW37290; AAW37290; SACOL2511 |
KEGGi | sac:SACOL2511 |
Phylogenomic databases
HOGENOMi | CLU_009849_1_0_9 |
OMAi | FTHVAYI |
Enzyme and pathway databases
BioCyci | SAUR93062:G1G4B-2754-MONOMER |
Family and domain databases
Gene3Di | 2.60.40.1280, 1 hit |
InterProi | View protein in InterPro IPR011266, Adhesin_Fg-bd_dom_2 IPR008966, Adhesion_dom_sf IPR011252, Fibrogen-bd_dom1 IPR004237, Fibron_repeat-bd IPR019948, Gram-positive_anchor IPR019931, LPXTG_anchor IPR041171, SDR_Ig IPR005877, YSIRK_signal_dom |
Pfami | View protein in Pfam PF17961, Big_8, 1 hit PF02986, Fn_bind, 3 hits PF00746, Gram_pos_anchor, 1 hit PF10425, SdrG_C_C, 1 hit PF04650, YSIRK_signal, 1 hit |
SUPFAMi | SSF49401, SSF49401, 2 hits |
TIGRFAMsi | TIGR01168, YSIRK_signal, 1 hit |
PROSITEi | View protein in PROSITE PS50847, GRAM_POS_ANCHORING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FNBA_STAAC | |
Accessioni | Q5HD51Primary (citable) accession number: Q5HD51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |